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The map label for this gene is lacA [C]

Identifier: 125624415

GI number: 125624415

Start: 1587246

End: 1587899

Strand: Reverse

Name: lacA [C]

Synonym: llmg_1615

Alternate gene names: 125624415

Gene position: 1587899-1587246 (Counterclockwise)

Preceding gene: 125624416

Following gene: 125624414

Centisome position: 62.78

GC content: 36.39

Gene sequence:

>654_bases
ATGAACCGTTATTACCTTGTAAAAGAAGATGGCACAAAAATAGAAAATCCCAAGATTAATGGCCTAACTGTTGAATTTTT
AGGAAACGACTCGCTTGTAGAAATTTCCGAGGGTTCTGTTTTTGAAAATACGAAACTTTCGCTTGCTTCTGAGTCAAAAA
TTATCATAAAAAAAACAAGTTTCTACGGCATACGTAATACTTGGATTGATGCCAGTCCCGGAGGTATTGTGCGAAATTTA
TTTATTGATGAAGGGGCTCAATTTGTGAGAGCGACCTTTGTCATGCGTGATGAAGATAATCTTAAAATTACGATTGGTAA
AAATTGTATGCTAGCAGCCGATGTTCTTTTCCGTGCATCAGATGGTCATCAGATTTACGATTTAGAAAACCTACAAGTTT
TCAATAAATCCAAAGAAATTCGTATTGAAGATAACGTTTGGATGGGGAATTCGGTTCGTATCTTAAAAGGAAGCTTGATT
AAACAAGGAAGTATTATCGGATTAGGTGCCATTGTCGCTAAGCAATTTCAAGAAGAAAATGTGGCGATTGCAGGTAATCC
TGCCCAAATTGTAAAGCGCAATGTGGCTTGGAGTAAAGATTATATTTGGGATTATAAAGACACTTACCAACAAGATGAAA
GTAGAGCAGCGTAA

Upstream 100 bases:

>100_bases
GATGTGATTATCGCAAACCGGATGACAGAGGAATTAAAAGCTGTGGACTCAAAAGTTTATACGAGAGATTTGTATAGAAG
GGACTAGATTGGAATAAACG

Downstream 100 bases:

>100_bases
ATTTTTGCGGTGAAAACAGATGAAAATCATGTGCTTTGGCGAGTAAGTCAAGAATCCTCTTATTTGGTAATTATGCGTGA
AGGTGTAGGAAATCAGGTAG

Product: putative acetyltransferase

Products: CoA; aacetyl-beta-D-galactoside [C]

Alternate protein names: Maltose Acetyltransferase; Transferase Hexapeptide Repeat Containing Protein; Maltose O-Acetyltransferase; Hexapeptide Repeat-Containing Protein Acetyltransferase; Maltose Acetyltransferase-Like Protein; Capsule O-Acetyl Transferase; Transferase; Acetyltransferase- Like Protein; Methyltransferase Type; Transferase Hexapeptide Repeat-Containing Protein; O-Acetyl Transferase; Acetyltransferase With Hexapeptide Repeat; Hexapaptide Repeat-Containing Transferase; Acetyltransferase-Like Protein; Acetyltransferase CysE/LacA/LpxA/NodL Family

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MNRYYLVKEDGTKIENPKINGLTVEFLGNDSLVEISEGSVFENTKLSLASESKIIIKKTSFYGIRNTWIDASPGGIVRNL
FIDEGAQFVRATFVMRDEDNLKITIGKNCMLAADVLFRASDGHQIYDLENLQVFNKSKEIRIEDNVWMGNSVRILKGSLI
KQGSIIGLGAIVAKQFQEENVAIAGNPAQIVKRNVAWSKDYIWDYKDTYQQDESRAA

Sequences:

>Translated_217_residues
MNRYYLVKEDGTKIENPKINGLTVEFLGNDSLVEISEGSVFENTKLSLASESKIIIKKTSFYGIRNTWIDASPGGIVRNL
FIDEGAQFVRATFVMRDEDNLKITIGKNCMLAADVLFRASDGHQIYDLENLQVFNKSKEIRIEDNVWMGNSVRILKGSLI
KQGSIIGLGAIVAKQFQEENVAIAGNPAQIVKRNVAWSKDYIWDYKDTYQQDESRAA
>Mature_217_residues
MNRYYLVKEDGTKIENPKINGLTVEFLGNDSLVEISEGSVFENTKLSLASESKIIIKKTSFYGIRNTWIDASPGGIVRNL
FIDEGAQFVRATFVMRDEDNLKITIGKNCMLAADVLFRASDGHQIYDLENLQVFNKSKEIRIEDNVWMGNSVRILKGSLI
KQGSIIGLGAIVAKQFQEENVAIAGNPAQIVKRNVAWSKDYIWDYKDTYQQDESRAA

Specific function: May Assist Cellular Detoxification By Acetylating Nonmetabolizable Pyranosides, Thereby Preventing Their Reentry Into The Cell. [C]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.3.1.18 [C]

Molecular weight: Translated: 24435; Mature: 24435

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRYYLVKEDGTKIENPKINGLTVEFLGNDSLVEISEGSVFENTKLSLASESKIIIKKTS
CCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEECCCCEECCCEEEECCCCEEEEEEEE
FYGIRNTWIDASPGGIVRNLFIDEGAQFVRATFVMRDEDNLKITIGKNCMLAADVLFRAS
ECEEEEEEECCCCCCEEEEEEHHCCCCEEEEEEEEECCCCEEEEECCCEEEEEEEEEECC
DGHQIYDLENLQVFNKSKEIRIEDNVWMGNSVRILKGSLIKQGSIIGLGAIVAKQFQEEN
CCCEEEEECCEEEECCCCEEEEECCEEECCCEEEEECCEECCCCEEEHHHHHHHHHHHCC
VAIAGNPAQIVKRNVAWSKDYIWDYKDTYQQDESRAA
EEEECCHHHHHEECCCCCCCEEECCHHHHCCCCCCCC
>Mature Secondary Structure
MNRYYLVKEDGTKIENPKINGLTVEFLGNDSLVEISEGSVFENTKLSLASESKIIIKKTS
CCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEECCCCEECCCEEEECCCCEEEEEEEE
FYGIRNTWIDASPGGIVRNLFIDEGAQFVRATFVMRDEDNLKITIGKNCMLAADVLFRAS
ECEEEEEEECCCCCCEEEEEEHHCCCCEEEEEEEEECCCCEEEEECCCEEEEEEEEEECC
DGHQIYDLENLQVFNKSKEIRIEDNVWMGNSVRILKGSLIKQGSIIGLGAIVAKQFQEEN
CCCEEEEECCEEEECCCCEEEEECCEEECCCEEEEECCEECCCCEEEHHHHHHHHHHHCC
VAIAGNPAQIVKRNVAWSKDYIWDYKDTYQQDESRAA
EEEECCHHHHHEECCCCCCCEEECCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: MgSO4; Mn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1500 {isopropyl} 1200 {isopropyl} 770 {isopropyl} 360 {isopropyl} 0.18 {acetyl-CoA}} 0.049 {acetyl-CoA}} 0.045 {acetyl-CoA}} 0.04 {acetyl-CoA}} [C]

Substrates: Acetyl-CoA; a beta-D-galactoside [C]

Specific reaction: Acetyl-CoA + a beta-D-galactoside = CoA + aacetyl-beta-D-galactoside [C]

General reaction: Acyl group transfer [C]

Inhibitor: 1, 10-Phenanthroline; Acetyl-CoA; Co2+; CoA; Cu2+; MgSO4; Mn2+; p-Chloromercuribenzoate; Zn2+ [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA