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The map label for this gene is vacB1 [H]

Identifier: 125624388

GI number: 125624388

Start: 1560360

End: 1562819

Strand: Reverse

Name: vacB1 [H]

Synonym: llmg_1586

Alternate gene names: 125624388

Gene position: 1562819-1560360 (Counterclockwise)

Preceding gene: 125624389

Following gene: 125624387

Centisome position: 61.78

GC content: 37.64

Gene sequence:

>2460_bases
ATGAGTATTAGAGAAGTAATTATGGACTATCTTGAGAATAGTTCAAAAAAAGCTCTGTCAGTGGAAGAATTGTCAGTTGC
TTTACATATGAATAAGGCCAAAGATTACAAAGTTTTTGTTAAAACTTTGGCTTCACTAGAAGCTGAACACTTGCTTCATT
TTACTGCTAAAGGGAAAGTAGAATTAGCAGAACAAGAGGAAGCAAAAGTAGTTATCAGCGGGATTTTCCGAGCAAATGCG
GCTGGATTTGGTTTTGTAAGTATTGATGCTGACGAACCAGACGTCTTTATTGGACGCGGGCAAACAGGTTTTGCACTTGA
TGGAGATGAGGTTTTCATTGAGATTGATAAGAATGCCAACTCCCTAAAAGGAACGGCTGCCGAGGGGCATGTTGTTGAAA
TTATCCGTCATGAGCTTCATCAAGTCGTTGGAACTTTTGTTGCTTTAAATGATGAAGAAAAAGAGCAAACTGGACTGATT
GGTTTCGTTAAATCTAGAAATAAAAAAATTCCTTATCGGGTATATCTGGGTGATGAAGGACTCAAACCAGAAAATAAGGC
AATTGTTCGTGTAGAAATCACACATCATCCTGATAAAGAATTTCCTCAAACCATGCAAGGACTGGTAACGGAAATTATTG
GACAGGCAAATGACCAAGGGATAGATGTGTTAGAAGTTTTGGCTTCAATGGATATTGTATCAGAATTTCCAAAAGAGGTT
TTGGAGCAGGCTGATTCAGTGCCAGAAGAAGTGCCAGAGAGTGAAATTGCGGGTCGAGTTGATTATCGTAATGAAATTAC
GTTCACAATTGACGGAGCTGATGCCAAAGACCTTGATGATGCTGTCCATGCCAAACGTTTAGGAAATGGGAATTATGAAT
TAGGTGTTCATATTGCGGATGTTTCCCACTACGTAACGGAAAATTCACCTTTAGATAAAGAAGCTTACGAACGTGGAACA
TCAGTCTATGTTACTGACAGAGTGGTACCAATGTTGCCAGAGCGTTTATCAAATGGGATTTGTTCATTGAACCCACGTTT
GAATCGCTTGACTCAATCCTGCGTGATGGAAATTAGCCCAGAAGGTCGAGTGGTTAATTATCAAATTTCACAATCAATTA
TTAAGACAACTGAAAGAATGACTTATGATGCGGTCAATCAAATGATTGCAGGAGATAAAGACACGCTTGAAAAGTATGCT
AAAATTGCTGATTCTGTAAAAATCATGGTTGAAATCCATCATATTTTAGAAGCGATGCGTAAACAACGTGGAGCCATTGA
TTTCGACACGGTAGAGGCAAAAATCATTGTAAATGAAAAAGGCTTACCTATTGAAATTAGAAAACGCAGTCGTGGCATTG
CTGAACGAATGATTGAATCATTCATGCTTGAAGCCAATGAAACGGTGGCCACTCATTTTGAAGCACATGGCTTGCCATTT
ATTTATCGGATTCACGAGCAACCAAAAGCAGATAGATTACAAAGATTTATTGATTTTGCAGCAACATTTGGAATGCAAAT
TGAAGGAACCTCAAACGGAATTGATCAAAAAGTTTTACAAGCCTTCATGAAAAAAATCAAAGGGCAACCGGGTGAAATGG
TCTTGTCAACGATGCTATTGCGCAGTATGCAACAAGCTCGTTATTCAGAAAATAATGAGGGTCACTTTGGTTTAGCTGCC
GAAAATTATACTCACTTTACCTCACCTATTCGTCGTTATCCTGATTTATTGGTTCATCGTTTGATTCGTGAAATTGGTGC
GGGTAAAATTCCAGCAAATCTTTTACAAAAATGGGAAGAAAAAATCCCAGAAATTGCGGAGCACTCTAGTCATCGTGAAC
GTCGAGCGGTTGATGCTGAACGTGAAGTTGAAAAAATGAAAAAAGCCGAGTTCATGGAAGAACATGTGGACGAAGAGTTT
GAAGGAATTATTGCTTCAGTCACTCGTTTTGGTATGTTTATTGAACTTGAAAATACAATCGAAGGATTAGTTCATATTTC
AACGTTGAAGGGAGATTATTTCACTTATCATGAGCGAATGTTAGCTTTGATTGGTGAAAGAACAGGATTGACTTTTAAAA
TTGGTCAACCAATTAAAATCAAAGTCGTCAAAGCGGATAAGATGACTGGCGAAATTGACTTTGAGTACCTTCCATCAGAA
TTAGATTTGATTGATAAATCGGCTAAAGCTAAGAAAAAGCCTGAATCTAAAGGTCGCAAAAAATCAAATCAATCCCTTAA
AGTTAAATCTGTCGCACCAAAAGCTGCTGGTAAAGCTGGCAGTAAATCAAAAGAGGGTAGAAGTACTGATGGAAAACCTG
AATTTGATAAGAAAAAGAAAAAATCGGGCAAAAAACCTTTTTATAGCAAAACTGCCAAAGGTAAATTTACTGACAAAAAA
GAGAATGGCAAAAAATTTACTGATGGAAGAAAAAAGCACACAAAAGACCTTAAATTTTGA

Upstream 100 bases:

>100_bases
TATTAGCTAAAAATCGAGCCAATATTTAAAAATATTATAATAAGAAAGGGGCTTCTTGTCCGATTTTTGTGGTCAAGAAA
GCTCACTTGAGAGAATAAAA

Downstream 100 bases:

>100_bases
AAGAAGAAGAAATGAAAACTTTGAATTTAAATAAAACAGCATTAGTCATCATCGATTTGCAAAAAGGAATTGCTGGTCGT
GAAGGTTTTGCTCCTTATTC

Product: putative exoribonuclease R

Products: NA

Alternate protein names: RNase R 1; VacB protein homolog 1 [H]

Number of amino acids: Translated: 819; Mature: 818

Protein sequence:

>819_residues
MSIREVIMDYLENSSKKALSVEELSVALHMNKAKDYKVFVKTLASLEAEHLLHFTAKGKVELAEQEEAKVVISGIFRANA
AGFGFVSIDADEPDVFIGRGQTGFALDGDEVFIEIDKNANSLKGTAAEGHVVEIIRHELHQVVGTFVALNDEEKEQTGLI
GFVKSRNKKIPYRVYLGDEGLKPENKAIVRVEITHHPDKEFPQTMQGLVTEIIGQANDQGIDVLEVLASMDIVSEFPKEV
LEQADSVPEEVPESEIAGRVDYRNEITFTIDGADAKDLDDAVHAKRLGNGNYELGVHIADVSHYVTENSPLDKEAYERGT
SVYVTDRVVPMLPERLSNGICSLNPRLNRLTQSCVMEISPEGRVVNYQISQSIIKTTERMTYDAVNQMIAGDKDTLEKYA
KIADSVKIMVEIHHILEAMRKQRGAIDFDTVEAKIIVNEKGLPIEIRKRSRGIAERMIESFMLEANETVATHFEAHGLPF
IYRIHEQPKADRLQRFIDFAATFGMQIEGTSNGIDQKVLQAFMKKIKGQPGEMVLSTMLLRSMQQARYSENNEGHFGLAA
ENYTHFTSPIRRYPDLLVHRLIREIGAGKIPANLLQKWEEKIPEIAEHSSHRERRAVDAEREVEKMKKAEFMEEHVDEEF
EGIIASVTRFGMFIELENTIEGLVHISTLKGDYFTYHERMLALIGERTGLTFKIGQPIKIKVVKADKMTGEIDFEYLPSE
LDLIDKSAKAKKKPESKGRKKSNQSLKVKSVAPKAAGKAGSKSKEGRSTDGKPEFDKKKKKSGKKPFYSKTAKGKFTDKK
ENGKKFTDGRKKHTKDLKF

Sequences:

>Translated_819_residues
MSIREVIMDYLENSSKKALSVEELSVALHMNKAKDYKVFVKTLASLEAEHLLHFTAKGKVELAEQEEAKVVISGIFRANA
AGFGFVSIDADEPDVFIGRGQTGFALDGDEVFIEIDKNANSLKGTAAEGHVVEIIRHELHQVVGTFVALNDEEKEQTGLI
GFVKSRNKKIPYRVYLGDEGLKPENKAIVRVEITHHPDKEFPQTMQGLVTEIIGQANDQGIDVLEVLASMDIVSEFPKEV
LEQADSVPEEVPESEIAGRVDYRNEITFTIDGADAKDLDDAVHAKRLGNGNYELGVHIADVSHYVTENSPLDKEAYERGT
SVYVTDRVVPMLPERLSNGICSLNPRLNRLTQSCVMEISPEGRVVNYQISQSIIKTTERMTYDAVNQMIAGDKDTLEKYA
KIADSVKIMVEIHHILEAMRKQRGAIDFDTVEAKIIVNEKGLPIEIRKRSRGIAERMIESFMLEANETVATHFEAHGLPF
IYRIHEQPKADRLQRFIDFAATFGMQIEGTSNGIDQKVLQAFMKKIKGQPGEMVLSTMLLRSMQQARYSENNEGHFGLAA
ENYTHFTSPIRRYPDLLVHRLIREIGAGKIPANLLQKWEEKIPEIAEHSSHRERRAVDAEREVEKMKKAEFMEEHVDEEF
EGIIASVTRFGMFIELENTIEGLVHISTLKGDYFTYHERMLALIGERTGLTFKIGQPIKIKVVKADKMTGEIDFEYLPSE
LDLIDKSAKAKKKPESKGRKKSNQSLKVKSVAPKAAGKAGSKSKEGRSTDGKPEFDKKKKKSGKKPFYSKTAKGKFTDKK
ENGKKFTDGRKKHTKDLKF
>Mature_818_residues
SIREVIMDYLENSSKKALSVEELSVALHMNKAKDYKVFVKTLASLEAEHLLHFTAKGKVELAEQEEAKVVISGIFRANAA
GFGFVSIDADEPDVFIGRGQTGFALDGDEVFIEIDKNANSLKGTAAEGHVVEIIRHELHQVVGTFVALNDEEKEQTGLIG
FVKSRNKKIPYRVYLGDEGLKPENKAIVRVEITHHPDKEFPQTMQGLVTEIIGQANDQGIDVLEVLASMDIVSEFPKEVL
EQADSVPEEVPESEIAGRVDYRNEITFTIDGADAKDLDDAVHAKRLGNGNYELGVHIADVSHYVTENSPLDKEAYERGTS
VYVTDRVVPMLPERLSNGICSLNPRLNRLTQSCVMEISPEGRVVNYQISQSIIKTTERMTYDAVNQMIAGDKDTLEKYAK
IADSVKIMVEIHHILEAMRKQRGAIDFDTVEAKIIVNEKGLPIEIRKRSRGIAERMIESFMLEANETVATHFEAHGLPFI
YRIHEQPKADRLQRFIDFAATFGMQIEGTSNGIDQKVLQAFMKKIKGQPGEMVLSTMLLRSMQQARYSENNEGHFGLAAE
NYTHFTSPIRRYPDLLVHRLIREIGAGKIPANLLQKWEEKIPEIAEHSSHRERRAVDAEREVEKMKKAEFMEEHVDEEFE
GIIASVTRFGMFIELENTIEGLVHISTLKGDYFTYHERMLALIGERTGLTFKIGQPIKIKVVKADKMTGEIDFEYLPSEL
DLIDKSAKAKKKPESKGRKKSNQSLKVKSVAPKAAGKAGSKSKEGRSTDGKPEFDKKKKKSGKKPFYSKTAKGKFTDKKE
NGKKFTDGRKKHTKDLKF

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=400, Percent_Identity=33.75, Blast_Score=216, Evalue=8e-56,
Organism=Homo sapiens, GI190014625, Length=401, Percent_Identity=31.6708229426434, Blast_Score=191, Evalue=3e-48,
Organism=Homo sapiens, GI190014623, Length=401, Percent_Identity=31.6708229426434, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI19115966, Length=492, Percent_Identity=28.2520325203252, Blast_Score=150, Evalue=5e-36,
Organism=Homo sapiens, GI219521928, Length=492, Percent_Identity=28.2520325203252, Blast_Score=150, Evalue=5e-36,
Organism=Homo sapiens, GI156105695, Length=327, Percent_Identity=26.2996941896024, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI156105693, Length=188, Percent_Identity=29.2553191489362, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI87082383, Length=726, Percent_Identity=33.1955922865014, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1787542, Length=591, Percent_Identity=27.072758037225, Blast_Score=152, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17553506, Length=381, Percent_Identity=33.5958005249344, Blast_Score=199, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI212645896, Length=484, Percent_Identity=29.1322314049587, Blast_Score=180, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324552, Length=459, Percent_Identity=30.0653594771242, Blast_Score=175, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6320499, Length=327, Percent_Identity=23.8532110091743, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323943, Length=351, Percent_Identity=24.2165242165242, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649634, Length=614, Percent_Identity=29.1530944625407, Blast_Score=205, Evalue=9e-53,
Organism=Drosophila melanogaster, GI19922976, Length=378, Percent_Identity=30.952380952381, Blast_Score=162, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24654597, Length=378, Percent_Identity=30.952380952381, Blast_Score=162, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24654592, Length=378, Percent_Identity=30.6878306878307, Blast_Score=162, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 92114; Mature: 91983

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIREVIMDYLENSSKKALSVEELSVALHMNKAKDYKVFVKTLASLEAEHLLHFTAKGKV
CCHHHHHHHHHHCCCCCCEEHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCE
ELAEQEEAKVVISGIFRANAAGFGFVSIDADEPDVFIGRGQTGFALDGDEVFIEIDKNAN
EECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCEECCCEEEEEECCCCC
SLKGTAAEGHVVEIIRHELHQVVGTFVALNDEEKEQTGLIGFVKSRNKKIPYRVYLGDEG
CCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHCCEEEEECCCCCCCCEEEEECCCC
LKPENKAIVRVEITHHPDKEFPQTMQGLVTEIIGQANDQGIDVLEVLASMDIVSEFPKEV
CCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LEQADSVPEEVPESEIAGRVDYRNEITFTIDGADAKDLDDAVHAKRLGNGNYELGVHIAD
HHHHCCCHHHCCHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEEC
VSHYVTENSPLDKEAYERGTSVYVTDRVVPMLPERLSNGICSLNPRLNRLTQSCVMEISP
HHHHHCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHCCCCEECCHHHHHHHHHHHHEECC
EGRVVNYQISQSIIKTTERMTYDAVNQMIAGDKDTLEKYAKIADSVKIMVEIHHILEAMR
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQRGAIDFDTVEAKIIVNEKGLPIEIRKRSRGIAERMIESFMLEANETVATHFEAHGLPF
HHCCCCCEECEEEEEEECCCCCCEEEHHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCCE
IYRIHEQPKADRLQRFIDFAATFGMQIEGTSNGIDQKVLQAFMKKIKGQPGEMVLSTMLL
EEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
RSMQQARYSENNEGHFGLAAENYTHFTSPIRRYPDLLVHRLIREIGAGKIPANLLQKWEE
HHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KIPEIAEHSSHRERRAVDAEREVEKMKKAEFMEEHVDEEFEGIIASVTRFGMFIELENTI
HHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHH
EGLVHISTLKGDYFTYHERMLALIGERTGLTFKIGQPIKIKVVKADKMTGEIDFEYLPSE
CCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCCCCEECCCH
LDLIDKSAKAKKKPESKGRKKSNQSLKVKSVAPKAAGKAGSKSKEGRSTDGKPEFDKKKK
HHHHHCHHHHCCCCHHHCCCCCCCCEEEEECCCHHCCCCCCCCCCCCCCCCCCCHHHHHH
KSGKKPFYSKTAKGKFTDKKENGKKFTDGRKKHTKDLKF
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
SIREVIMDYLENSSKKALSVEELSVALHMNKAKDYKVFVKTLASLEAEHLLHFTAKGKV
CHHHHHHHHHHCCCCCCEEHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCE
ELAEQEEAKVVISGIFRANAAGFGFVSIDADEPDVFIGRGQTGFALDGDEVFIEIDKNAN
EECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCEECCCEEEEEECCCCC
SLKGTAAEGHVVEIIRHELHQVVGTFVALNDEEKEQTGLIGFVKSRNKKIPYRVYLGDEG
CCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHCCEEEEECCCCCCCCEEEEECCCC
LKPENKAIVRVEITHHPDKEFPQTMQGLVTEIIGQANDQGIDVLEVLASMDIVSEFPKEV
CCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LEQADSVPEEVPESEIAGRVDYRNEITFTIDGADAKDLDDAVHAKRLGNGNYELGVHIAD
HHHHCCCHHHCCHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEEC
VSHYVTENSPLDKEAYERGTSVYVTDRVVPMLPERLSNGICSLNPRLNRLTQSCVMEISP
HHHHHCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHCCCCEECCHHHHHHHHHHHHEECC
EGRVVNYQISQSIIKTTERMTYDAVNQMIAGDKDTLEKYAKIADSVKIMVEIHHILEAMR
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQRGAIDFDTVEAKIIVNEKGLPIEIRKRSRGIAERMIESFMLEANETVATHFEAHGLPF
HHCCCCCEECEEEEEEECCCCCCEEEHHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCCE
IYRIHEQPKADRLQRFIDFAATFGMQIEGTSNGIDQKVLQAFMKKIKGQPGEMVLSTMLL
EEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
RSMQQARYSENNEGHFGLAAENYTHFTSPIRRYPDLLVHRLIREIGAGKIPANLLQKWEE
HHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KIPEIAEHSSHRERRAVDAEREVEKMKKAEFMEEHVDEEFEGIIASVTRFGMFIELENTI
HHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHH
EGLVHISTLKGDYFTYHERMLALIGERTGLTFKIGQPIKIKVVKADKMTGEIDFEYLPSE
CCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCCCCEECCCH
LDLIDKSAKAKKKPESKGRKKSNQSLKVKSVAPKAAGKAGSKSKEGRSTDGKPEFDKKKK
HHHHHCHHHHCCCCHHHCCCCCCCCEEEEECCCHHCCCCCCCCCCCCCCCCCCCHHHHHH
KSGKKPFYSKTAKGKFTDKKENGKKFTDGRKKHTKDLKF
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]