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The map label for this gene is clsA [H]

Identifier: 125624361

GI number: 125624361

Start: 1530044

End: 1531489

Strand: Reverse

Name: clsA [H]

Synonym: llmg_1558

Alternate gene names: 125624361

Gene position: 1531489-1530044 (Counterclockwise)

Preceding gene: 125624362

Following gene: 125624360

Centisome position: 60.55

GC content: 34.92

Gene sequence:

>1446_bases
ATGAGTTTTATTGCACTTTTTGAGCTGGCACTTTTTTTTCTTAATGTTATTTTATCCTTTGTCATTATTTTTAGGGAAAG
AAAATCAACAGCAGCAACTTGGTCATGGCTCTTTGTAGTTAATTTATTGCCGATTATAGGCTTTATTTTATATTTACTCA
TTGGTCGTGGAATTTCACATTATCGTATTTTTAAAGACCGTAAAAGGTTTCAACTTGGCTTTGAAAAACAACTTGAACAT
GCGGAGAAATCATATACAGATAGATTGTTTATTGAAAAAATGAGAAAAAATCATGTGATTGGTCAACTAATTCACATGCT
TTATGTTGAAGAAAAATCGATTATTTCAACAAATACTGGTGTCAAAATTTTTAATGATGGGCGCCAGAAATTTAACGCTT
TGATAGAAGATATAAATCAAGCCAAGCATCATGTCCATATGGAATATTATATTTTTAGAATGGATCGAATGGGACATGAA
ATCTACGATGCCTTACTGGCAGCCGCAAAGCGTGGAGTAGAAGTCAAACTTTTAATTGACGCTTGGGGTTCAAATAAGAC
TAAAATGTCCAGCTTTAAAGAGCTTCAAGAAGCTGGTGGACATGTGGCTCAATTTTTCCCTTTGATTATGCCCTTAGTTA
ATCCCCGAACAAATTACCGTTTGCACCGTAAAATCGTTGTGATTGATGGTGTAGTTGGCTATACAGGGGGATTCAATGTC
GGTGATGAATATTCTTCAATTACGAAAAAATTTGGATATTGGCGTGACAATCATTTGAGATTGACTGGTGATATTGTTTA
TAGCTTACAGCATCGTTTTATTTTAGACTGGAATTCACAACATCATTTTGAAGTGACTGAGGGAGAACCTTATTTTCCAG
ATTCTATTGTTGAAGGACATGTAGCGACTCAACTTGTGACTTCTGGTCCAGATGAGGATAAAGAGCAAATCAAATTGACT
TACATGAAGATGATTTCTGGTGCTGAACGAGAAATTATCATTCAAACGCCCTATTATATTCCTTCTGATGCCTTGCATGA
GTCAATAAAATTGGCCCTTTTATCAGGTGTACAAGTTAAAATGTTAATTCCTAACAAGCCAGACCATCCGCTGGTTTACT
GGGCGACATATTTCCATGCCGCTGATTTAGTTAAATATGGTGCCAAGGTTTATACTTATGAAAATGGATTTGTTCATTCT
AAAACGTTAATTATTGATGGAGAGTATGCCTCAGTTGGTTCGGCAAATTTGGATTATCGAAGCTTACAATTATGTTTTGA
AGCAAATGTTGTTATTTATGATTATGATATTTCACAAAAATTGCGAAATGATTTTATGAAAGACTTGAAGTTAAGCCGTC
CATTGACTTTAGAGCGTTATGAAGAAAGATCAAAACTGATCCGTTTTAAGGAAGGACTGGCTCGCTTAATTGCACCAATG
CTTTGA

Upstream 100 bases:

>100_bases
TGAAAAAATGAAACCTAAGTAAACAATGAGGATTATCAACAAAAGGGCTTGTTTTTTGTTATAATGGAAGGAGTAAACTG
GGGGATTGGGAGAAATTATT

Downstream 100 bases:

>100_bases
TTTAGAAACTAAGATAGAGCAAAAATTATCATTTGGAATGATAAGATGAAAATGGAGGAAAGAGATGGACAATAAACTCA
ATATTGTAATCATTACAGGA

Product: cardiolipin synthetase

Products: NA

Alternate protein names: CL synthase 2 [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MSFIALFELALFFLNVILSFVIIFRERKSTAATWSWLFVVNLLPIIGFILYLLIGRGISHYRIFKDRKRFQLGFEKQLEH
AEKSYTDRLFIEKMRKNHVIGQLIHMLYVEEKSIISTNTGVKIFNDGRQKFNALIEDINQAKHHVHMEYYIFRMDRMGHE
IYDALLAAAKRGVEVKLLIDAWGSNKTKMSSFKELQEAGGHVAQFFPLIMPLVNPRTNYRLHRKIVVIDGVVGYTGGFNV
GDEYSSITKKFGYWRDNHLRLTGDIVYSLQHRFILDWNSQHHFEVTEGEPYFPDSIVEGHVATQLVTSGPDEDKEQIKLT
YMKMISGAEREIIIQTPYYIPSDALHESIKLALLSGVQVKMLIPNKPDHPLVYWATYFHAADLVKYGAKVYTYENGFVHS
KTLIIDGEYASVGSANLDYRSLQLCFEANVVIYDYDISQKLRNDFMKDLKLSRPLTLERYEERSKLIRFKEGLARLIAPM
L

Sequences:

>Translated_481_residues
MSFIALFELALFFLNVILSFVIIFRERKSTAATWSWLFVVNLLPIIGFILYLLIGRGISHYRIFKDRKRFQLGFEKQLEH
AEKSYTDRLFIEKMRKNHVIGQLIHMLYVEEKSIISTNTGVKIFNDGRQKFNALIEDINQAKHHVHMEYYIFRMDRMGHE
IYDALLAAAKRGVEVKLLIDAWGSNKTKMSSFKELQEAGGHVAQFFPLIMPLVNPRTNYRLHRKIVVIDGVVGYTGGFNV
GDEYSSITKKFGYWRDNHLRLTGDIVYSLQHRFILDWNSQHHFEVTEGEPYFPDSIVEGHVATQLVTSGPDEDKEQIKLT
YMKMISGAEREIIIQTPYYIPSDALHESIKLALLSGVQVKMLIPNKPDHPLVYWATYFHAADLVKYGAKVYTYENGFVHS
KTLIIDGEYASVGSANLDYRSLQLCFEANVVIYDYDISQKLRNDFMKDLKLSRPLTLERYEERSKLIRFKEGLARLIAPM
L
>Mature_480_residues
SFIALFELALFFLNVILSFVIIFRERKSTAATWSWLFVVNLLPIIGFILYLLIGRGISHYRIFKDRKRFQLGFEKQLEHA
EKSYTDRLFIEKMRKNHVIGQLIHMLYVEEKSIISTNTGVKIFNDGRQKFNALIEDINQAKHHVHMEYYIFRMDRMGHEI
YDALLAAAKRGVEVKLLIDAWGSNKTKMSSFKELQEAGGHVAQFFPLIMPLVNPRTNYRLHRKIVVIDGVVGYTGGFNVG
DEYSSITKKFGYWRDNHLRLTGDIVYSLQHRFILDWNSQHHFEVTEGEPYFPDSIVEGHVATQLVTSGPDEDKEQIKLTY
MKMISGAEREIIIQTPYYIPSDALHESIKLALLSGVQVKMLIPNKPDHPLVYWATYFHAADLVKYGAKVYTYENGFVHSK
TLIIDGEYASVGSANLDYRSLQLCFEANVVIYDYDISQKLRNDFMKDLKLSRPLTLERYEERSKLIRFKEGLARLIAPML

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=492, Percent_Identity=28.2520325203252, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI1787007, Length=337, Percent_Identity=32.3442136498516, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI87081826, Length=381, Percent_Identity=25.4593175853018, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR015679
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 55834; Mature: 55703

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIALFELALFFLNVILSFVIIFRERKSTAATWSWLFVVNLLPIIGFILYLLIGRGISH
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
YRIFKDRKRFQLGFEKQLEHAEKSYTDRLFIEKMRKNHVIGQLIHMLYVEEKSIISTNTG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCC
VKIFNDGRQKFNALIEDINQAKHHVHMEYYIFRMDRMGHEIYDALLAAAKRGVEVKLLID
EEEECCHHHHHHHHHHHHHHHHHHEEHHHEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEE
AWGSNKTKMSSFKELQEAGGHVAQFFPLIMPLVNPRTNYRLHRKIVVIDGVVGYTGGFNV
ECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEECEEECCCCCCC
GDEYSSITKKFGYWRDNHLRLTGDIVYSLQHRFILDWNSQHHFEVTEGEPYFPDSIVEGH
CCHHHHHHHHHCCCCCCCEEEEHHHHEEECCEEEEECCCCCCEEECCCCCCCCHHHHCCH
VATQLVTSGPDEDKEQIKLTYMKMISGAEREIIIQTPYYIPSDALHESIKLALLSGVQVK
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEE
MLIPNKPDHPLVYWATYFHAADLVKYGAKVYTYENGFVHSKTLIIDGEYASVGSANLDYR
EECCCCCCCCEEEEHHHHHHHHHHHCCCEEEEECCCEEEEEEEEEECCCCCCCCCCCCHH
SLQLCFEANVVIYDYDISQKLRNDFMKDLKLSRPLTLERYEERSKLIRFKEGLARLIAPM
HEEEEEECCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
L
C
>Mature Secondary Structure 
SFIALFELALFFLNVILSFVIIFRERKSTAATWSWLFVVNLLPIIGFILYLLIGRGISH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
YRIFKDRKRFQLGFEKQLEHAEKSYTDRLFIEKMRKNHVIGQLIHMLYVEEKSIISTNTG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCC
VKIFNDGRQKFNALIEDINQAKHHVHMEYYIFRMDRMGHEIYDALLAAAKRGVEVKLLID
EEEECCHHHHHHHHHHHHHHHHHHEEHHHEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEE
AWGSNKTKMSSFKELQEAGGHVAQFFPLIMPLVNPRTNYRLHRKIVVIDGVVGYTGGFNV
ECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEECEEECCCCCCC
GDEYSSITKKFGYWRDNHLRLTGDIVYSLQHRFILDWNSQHHFEVTEGEPYFPDSIVEGH
CCHHHHHHHHHCCCCCCCEEEEHHHHEEECCEEEEECCCCCCEEECCCCCCCCHHHHCCH
VATQLVTSGPDEDKEQIKLTYMKMISGAEREIIIQTPYYIPSDALHESIKLALLSGVQVK
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEE
MLIPNKPDHPLVYWATYFHAADLVKYGAKVYTYENGFVHSKTLIIDGEYASVGSANLDYR
EECCCCCCCCEEEEHHHHHHHHHHHCCCEEEEECCCEEEEEEEEEECCCCCCCCCCCCHH
SLQLCFEANVVIYDYDISQKLRNDFMKDLKLSRPLTLERYEERSKLIRFKEGLARLIAPM
HEEEEEECCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9150240; 9384377 [H]