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The map label for this gene is parC [H]

Identifier: 125624338

GI number: 125624338

Start: 1505890

End: 1508364

Strand: Reverse

Name: parC [H]

Synonym: llmg_1534

Alternate gene names: 125624338

Gene position: 1508364-1505890 (Counterclockwise)

Preceding gene: 125624339

Following gene: 125624336

Centisome position: 59.63

GC content: 38.06

Gene sequence:

>2475_bases
ATGTCAAACATTCAAACCTTACCATTAGAAGATATAATGGGCGACCGATTTGGTCGATATTCAAAATATATCATTCAGGA
GCGGGCGCTACCCGACATCCGTGATGGTTTAAAACCCGTACAGCGTCGAATTCTTTATTCGATGAACAAAGACGGAAATA
CCTTTGATAAGTCCTACCGTAAGTCAGCCAAATCGGTCGGGAACGTCATGGGTAATTTTCACCCACATGGTGATAGCTCA
ATTTATGAAGCAATGATTCGGATGAGTCAAGACTGGAAAATGGGCGAACCTTTAATTGAAATGCACGGGAATAACGGTTC
AATGGATGGTGATCCACCTGCCGCAATGCGTTATACAGAAGCTCGTCTCTCAGAAATTTCTGGTTACCTTTTATCAGATA
TTGAGAAAGATACCGTAAGTCAGGCTTGGAACTTTGATGATACAGAGAAAGAACCAACCGTTTTACCAGCTGCTTTTCCA
AATCTTTTAGTCAATGGTTCAACCGGGATATCAGCCGGTTATGCCACAGATATTCCTCCTCATAATCTTGGCGAAGTGAT
TGATGCCACTATTCACATGATTGACCACCCTAAAGTCGATGTTGACAAAATCATGGAATTTTTACCTGGACCCGATTTTC
CTACTGGCGGAATCATTCAAGGGAAAGGCGAGATTAGAAAAGCTTATGAAAAAGGTAAAGGCCGCATTGTTGTTCGTTCA
AAAGTTGATATTGAACCAATGAAAGGTGGGCGTGAGCAACTTATCGTCACTGAAATTCCATTTGAATTAAATAAAGCAAA
TTTGGTCAAGAAAATTGATGATGTTCGTGTCAATGCAAAAGTCCCAGGTATTGCTGAAGTTCGTGATGAATCTGACCGCG
AAGGATTGCGGATTGCAATTGAATTGAAAAAAGAAGCCGATAGTCAACTTGTTTTAAATTACTTGTTTAAAAATACTGAT
TTACAAGTGAATTATAACTTTAACATGGTTGCTATTGACAACATGACACCTGTCCAAACCGGCGTTTTGCAAATGCTACG
TTCTTACGTAAAACATCGGGAAGATGTCATCATCAAACGCTCGCAATTTGACCTAAATAAAGCGGAAAAAAGACTTCACT
TAGTTGAAGGATTGATTCGTATGGTTTCCATTTTAGATGAAGTGGTGGCAACGATTCGTGCTTCTGAAAATAAAGCAGAC
GCTAAAGAAAATATTAAAGTTTCATTTGGATTTACTGAAGAACAAGCCGAAGCTATTGTTACTTTACAACTTTATCGTTT
GACAAATACCGACATTGTCACTTTGCAAAATGAACAAGCAGAGTTAGAACAAAAAATTCTTGAACTTAAAGCAATTATTA
ATGACGAACGGACACTCTTTAATTTAATGAAGCGCGAACTGCGTGAAGTGAAGAAAAAATTTGCCAGACCACGCCGTAGT
GAACTTCAAGATGAAGTGCAAACCATTGAGATAGAAGCTAGTGAATTGATTGTCGCTGAAGATACTGTCGTTTCAGTAAC
TCGTTCAGGTTATATCAAACGAACATCACCTCGGTCATTTGCTTCATCAGCACTTGAAGAAATCGGGAAACGTGATGATG
ACGAGTTGCTTTACTATGCTAATGCTAAAACAACACAGCATCTCTTGATTTTCACAAATCTTGGTAATGTGATTTACCGT
CCAATTCATGAACTTTCTGACATTCGCTGGAAGGATATTGGAGAACATTTGTCACAAAGTCTTTCTAATTTTTCATCTGA
TGAAAAAGTAATTTATGTTCAAATTGTTGATGCATTTGCAGGTGAAAATCTAGTCGTGGTTACACGAAATGGACAAATTA
AACAAATTGAACGTGAAAGTTTTTCACCATGGCGAACTTACCGCTCGAAATCAACTCCTTATGCTAAACTTAAAGGAAAT
GATGATGAAGTTGTGCTCATTAGTCCTGTTCAATTTACTGACCTCATGCTTATTTCTGAAAATGGCTATGCCCTCCGCTT
TAATCTGGATGATGTCCCAGTCTTGGGTGCTAGAGCAGCAGGTGTGAAGGCAATGAATCTTAAAAATGATGATAAGATAA
AAGCAGCTTTCTTTGTCAACTCAAATAGTTGGTATCTGTTGACTCAACGGGCATTTATCAAACGAGTTAAAACAGAGGAT
ATTCCAGCCACATCACGAGCAAATCGAGGTCTTCAAGTTTTAAGAACATTGAAGACAAATAACCATAAAGTCTTTGCGGC
TGGTTTAATCAATTCAACTGCTGATTTATCAGCATTGACCGAAGAATTAGATTTGTTCAGTCAAGCTAAAGCACCAGCGA
CAAAAGAAACTGATGAACAAGTATTAGAAGTTATCAGTGAGACTGGCAAGAAATATGATATTAATTTGTGCGATTTATCA
TTATCAGATCGAACAAGCAATGGACATCCAATTGCTGATGACCTTGAAAAAATTGCAAGCGTAAAAATACGATAA

Upstream 100 bases:

>100_bases
GATAGACTAGAAGAACTGTCAGTAAAAATCATTCTTATTATAAGTTAATAAAAAAATTAGTATAAAAATTAAAGAAATTT
TCTAAAAAGAAAGTTGAAAT

Downstream 100 bases:

>100_bases
AAAAATCAGCTTTTGCTGATTTTTTTTATTGTCTTCGACCAATAATATAACGAAAGAGGGCGGCATATAGTAGCCAAAGA
ATGATACAGGCGCCAATAAT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 824; Mature: 823

Protein sequence:

>824_residues
MSNIQTLPLEDIMGDRFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFDKSYRKSAKSVGNVMGNFHPHGDSS
IYEAMIRMSQDWKMGEPLIEMHGNNGSMDGDPPAAMRYTEARLSEISGYLLSDIEKDTVSQAWNFDDTEKEPTVLPAAFP
NLLVNGSTGISAGYATDIPPHNLGEVIDATIHMIDHPKVDVDKIMEFLPGPDFPTGGIIQGKGEIRKAYEKGKGRIVVRS
KVDIEPMKGGREQLIVTEIPFELNKANLVKKIDDVRVNAKVPGIAEVRDESDREGLRIAIELKKEADSQLVLNYLFKNTD
LQVNYNFNMVAIDNMTPVQTGVLQMLRSYVKHREDVIIKRSQFDLNKAEKRLHLVEGLIRMVSILDEVVATIRASENKAD
AKENIKVSFGFTEEQAEAIVTLQLYRLTNTDIVTLQNEQAELEQKILELKAIINDERTLFNLMKRELREVKKKFARPRRS
ELQDEVQTIEIEASELIVAEDTVVSVTRSGYIKRTSPRSFASSALEEIGKRDDDELLYYANAKTTQHLLIFTNLGNVIYR
PIHELSDIRWKDIGEHLSQSLSNFSSDEKVIYVQIVDAFAGENLVVVTRNGQIKQIERESFSPWRTYRSKSTPYAKLKGN
DDEVVLISPVQFTDLMLISENGYALRFNLDDVPVLGARAAGVKAMNLKNDDKIKAAFFVNSNSWYLLTQRAFIKRVKTED
IPATSRANRGLQVLRTLKTNNHKVFAAGLINSTADLSALTEELDLFSQAKAPATKETDEQVLEVISETGKKYDINLCDLS
LSDRTSNGHPIADDLEKIASVKIR

Sequences:

>Translated_824_residues
MSNIQTLPLEDIMGDRFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFDKSYRKSAKSVGNVMGNFHPHGDSS
IYEAMIRMSQDWKMGEPLIEMHGNNGSMDGDPPAAMRYTEARLSEISGYLLSDIEKDTVSQAWNFDDTEKEPTVLPAAFP
NLLVNGSTGISAGYATDIPPHNLGEVIDATIHMIDHPKVDVDKIMEFLPGPDFPTGGIIQGKGEIRKAYEKGKGRIVVRS
KVDIEPMKGGREQLIVTEIPFELNKANLVKKIDDVRVNAKVPGIAEVRDESDREGLRIAIELKKEADSQLVLNYLFKNTD
LQVNYNFNMVAIDNMTPVQTGVLQMLRSYVKHREDVIIKRSQFDLNKAEKRLHLVEGLIRMVSILDEVVATIRASENKAD
AKENIKVSFGFTEEQAEAIVTLQLYRLTNTDIVTLQNEQAELEQKILELKAIINDERTLFNLMKRELREVKKKFARPRRS
ELQDEVQTIEIEASELIVAEDTVVSVTRSGYIKRTSPRSFASSALEEIGKRDDDELLYYANAKTTQHLLIFTNLGNVIYR
PIHELSDIRWKDIGEHLSQSLSNFSSDEKVIYVQIVDAFAGENLVVVTRNGQIKQIERESFSPWRTYRSKSTPYAKLKGN
DDEVVLISPVQFTDLMLISENGYALRFNLDDVPVLGARAAGVKAMNLKNDDKIKAAFFVNSNSWYLLTQRAFIKRVKTED
IPATSRANRGLQVLRTLKTNNHKVFAAGLINSTADLSALTEELDLFSQAKAPATKETDEQVLEVISETGKKYDINLCDLS
LSDRTSNGHPIADDLEKIASVKIR
>Mature_823_residues
SNIQTLPLEDIMGDRFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFDKSYRKSAKSVGNVMGNFHPHGDSSI
YEAMIRMSQDWKMGEPLIEMHGNNGSMDGDPPAAMRYTEARLSEISGYLLSDIEKDTVSQAWNFDDTEKEPTVLPAAFPN
LLVNGSTGISAGYATDIPPHNLGEVIDATIHMIDHPKVDVDKIMEFLPGPDFPTGGIIQGKGEIRKAYEKGKGRIVVRSK
VDIEPMKGGREQLIVTEIPFELNKANLVKKIDDVRVNAKVPGIAEVRDESDREGLRIAIELKKEADSQLVLNYLFKNTDL
QVNYNFNMVAIDNMTPVQTGVLQMLRSYVKHREDVIIKRSQFDLNKAEKRLHLVEGLIRMVSILDEVVATIRASENKADA
KENIKVSFGFTEEQAEAIVTLQLYRLTNTDIVTLQNEQAELEQKILELKAIINDERTLFNLMKRELREVKKKFARPRRSE
LQDEVQTIEIEASELIVAEDTVVSVTRSGYIKRTSPRSFASSALEEIGKRDDDELLYYANAKTTQHLLIFTNLGNVIYRP
IHELSDIRWKDIGEHLSQSLSNFSSDEKVIYVQIVDAFAGENLVVVTRNGQIKQIERESFSPWRTYRSKSTPYAKLKGND
DEVVLISPVQFTDLMLISENGYALRFNLDDVPVLGARAAGVKAMNLKNDDKIKAAFFVNSNSWYLLTQRAFIKRVKTEDI
PATSRANRGLQVLRTLKTNNHKVFAAGLINSTADLSALTEELDLFSQAKAPATKETDEQVLEVISETGKKYDINLCDLSL
SDRTSNGHPIADDLEKIASVKIR

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=182, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI19913408, Length=188, Percent_Identity=26.5957446808511, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788562, Length=770, Percent_Identity=35.3246753246753, Blast_Score=470, Evalue=1e-133,
Organism=Escherichia coli, GI1789396, Length=521, Percent_Identity=38.5796545105566, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI212645845, Length=397, Percent_Identity=23.9294710327456, Blast_Score=74, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=173, Percent_Identity=28.3236994219653, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 92909; Mature: 92778

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIQTLPLEDIMGDRFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFDKSYR
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KSAKSVGNVMGNFHPHGDSSIYEAMIRMSQDWKMGEPLIEMHGNNGSMDGDPPAAMRYTE
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHH
ARLSEISGYLLSDIEKDTVSQAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPP
HHHHHHCCHHHHHCCHHHHHHCCCCCCCCCCCCEECCCCCCEEEECCCCCCCCCCCCCCC
HNLGEVIDATIHMIDHPKVDVDKIMEFLPGPDFPTGGIIQGKGEIRKAYEKGKGRIVVRS
CCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCEEEEEE
KVDIEPMKGGREQLIVTEIPFELNKANLVKKIDDVRVNAKVPGIAEVRDESDREGLRIAI
ECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCEEECCCCCHHHHCCCCCCCCEEEEE
ELKKEADSQLVLNYLFKNTDLQVNYNFNMVAIDNMTPVQTGVLQMLRSYVKHREDVIIKR
EECCCCCHHHHHHHHHCCCCEEEEECEEEEEECCCCCHHHHHHHHHHHHHHCCHHEEEEC
SQFDLNKAEKRLHLVEGLIRMVSILDEVVATIRASENKADAKENIKVSFGFTEEQAEAIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHCEEE
TLQLYRLTNTDIVTLQNEQAELEQKILELKAIINDERTLFNLMKRELREVKKKFARPRRS
EEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHH
ELQDEVQTIEIEASELIVAEDTVVSVTRSGYIKRTSPRSFASSALEEIGKRDDDELLYYA
HHHHHHHEEEEECCEEEEECCCEEEEECCCCEEECCCHHHHHHHHHHHCCCCCCCEEEEE
NAKTTQHLLIFTNLGNVIYRPIHELSDIRWKDIGEHLSQSLSNFSSDEKVIYVQIVDAFA
CCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEHHC
GENLVVVTRNGQIKQIERESFSPWRTYRSKSTPYAKLKGNDDEVVLISPVQFTDLMLISE
CCCEEEEECCCCEEEHHHHCCCHHHHHCCCCCCEEEECCCCCCEEEECCCCEEEEEEEEC
NGYALRFNLDDVPVLGARAAGVKAMNLKNDDKIKAAFFVNSNSWYLLTQRAFIKRVKTED
CCEEEEEECCCCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCEEEEEHHHHHHHHCCCC
IPATSRANRGLQVLRTLKTNNHKVFAAGLINSTADLSALTEELDLFSQAKAPATKETDEQ
CCCCHHCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
VLEVISETGKKYDINLCDLSLSDRTSNGHPIADDLEKIASVKIR
HHHHHHHCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SNIQTLPLEDIMGDRFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFDKSYR
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KSAKSVGNVMGNFHPHGDSSIYEAMIRMSQDWKMGEPLIEMHGNNGSMDGDPPAAMRYTE
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHH
ARLSEISGYLLSDIEKDTVSQAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPP
HHHHHHCCHHHHHCCHHHHHHCCCCCCCCCCCCEECCCCCCEEEECCCCCCCCCCCCCCC
HNLGEVIDATIHMIDHPKVDVDKIMEFLPGPDFPTGGIIQGKGEIRKAYEKGKGRIVVRS
CCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCEEEEEE
KVDIEPMKGGREQLIVTEIPFELNKANLVKKIDDVRVNAKVPGIAEVRDESDREGLRIAI
ECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCEEECCCCCHHHHCCCCCCCCEEEEE
ELKKEADSQLVLNYLFKNTDLQVNYNFNMVAIDNMTPVQTGVLQMLRSYVKHREDVIIKR
EECCCCCHHHHHHHHHCCCCEEEEECEEEEEECCCCCHHHHHHHHHHHHHHCCHHEEEEC
SQFDLNKAEKRLHLVEGLIRMVSILDEVVATIRASENKADAKENIKVSFGFTEEQAEAIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHCEEE
TLQLYRLTNTDIVTLQNEQAELEQKILELKAIINDERTLFNLMKRELREVKKKFARPRRS
EEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHH
ELQDEVQTIEIEASELIVAEDTVVSVTRSGYIKRTSPRSFASSALEEIGKRDDDELLYYA
HHHHHHHEEEEECCEEEEECCCEEEEECCCCEEECCCHHHHHHHHHHHCCCCCCCEEEEE
NAKTTQHLLIFTNLGNVIYRPIHELSDIRWKDIGEHLSQSLSNFSSDEKVIYVQIVDAFA
CCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEHHC
GENLVVVTRNGQIKQIERESFSPWRTYRSKSTPYAKLKGNDDEVVLISPVQFTDLMLISE
CCCEEEEECCCCEEEHHHHCCCHHHHHCCCCCCEEEECCCCCCEEEECCCCEEEEEEEEC
NGYALRFNLDDVPVLGARAAGVKAMNLKNDDKIKAAFFVNSNSWYLLTQRAFIKRVKTED
CCEEEEEECCCCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCEEEEEHHHHHHHHCCCC
IPATSRANRGLQVLRTLKTNNHKVFAAGLINSTADLSALTEELDLFSQAKAPATKETDEQ
CCCCHHCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
VLEVISETGKKYDINLCDLSLSDRTSNGHPIADDLEKIASVKIR
HHHHHHHCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]