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The map label for this gene is gyrA [H]

Identifier: 125624259

GI number: 125624259

Start: 1419268

End: 1421778

Strand: Reverse

Name: gyrA [H]

Synonym: llmg_1451

Alternate gene names: 125624259

Gene position: 1421778-1419268 (Counterclockwise)

Preceding gene: 125624260

Following gene: 125624258

Centisome position: 56.21

GC content: 40.14

Gene sequence:

>2511_bases
ATGAGATTTTACAAGGCAAACATGCAAGACAAAAATGTTATCAATGTCAATTTAGTTGAGGAGATGAAGACGTCATTTCG
TGACTATGCAATGTCAGTTATCGTTGCACGGGCACTTCCTGATGTACGTGATGGATTAAAACCCGTTCACCGTCGTATTC
TCTACGGAATGAATGAACTGGGGAATACTCCAGATAAACCTCATAAAAAATCGGCTCGTATTGTCGGTGAAGTTATGGGT
AAATATCACCCACATGGAGACAGTTCAATCTATGAAGCAATGGTACGTATGGCTCAATGGTGGTCTTATCGTCATATGCT
TGCTGACGGACACGGTAACTTTGGTTCAATGGACGGCGACGGTGCCGCAGCAATGCGTTATACCGAAGCTCGTTTAAGTA
AAATTGCCATGGAAATGTTGCGAGATATCAACAAAAATACCGTTGATTTCATGGACAATTTCGATGGAACTGAACGTGAA
CCACTTGTTTTACCTGCTCGTTTCCCAAACCTTTTAGTTAATGGAACCACAGGGATTGCCGTTGGGATGGCAACAAACAT
TCCACCGCATAACCTTGGTGAAACGATTGATGCAGTAGATATGCTTATGGAAAACCCAGAAGCTTCCGTTACTGATTTGA
TGTCTGTCATTCCTGGTCCTGACTTCCCAACAGGGGCTTTGGTTATGGGTAAATCTGGGATTCGTCGTGCTTATGAAACT
GGTAAAGGTTCAATTACATTACGTGCAAAAACCCACATTGAAGAAATGGCTGGTGGAAAAGAACGCATTGTTGTGACTGA
ATTACCATATATGGTTAACAAGGCGCGCTTGGTTGAACATATTGTTCGTTTGAACCATGAAAAACGTATTGAGGGCTTGA
CTGCGGTTCGTGATGAATCAAACCGTGAAGGAATTCGTGTGGTTATTGAAGTGCGTCGTGACTTATCAGCACACGTTATC
CTAAATAATCTTTTCAAACTGACAAGTTTGCAAACTTCATTTGGTTTCAACATGTTGGCTATCGAAAAAGGAATTCCTAA
AATTCTTTCTTTGAAAGAAATTTTAGTTGATTATATTGAACATCAAATAGAAGTTGTCGAACGTCGTACAGCCTTTGATA
AAGCACGTGCAGAAGCACGGGCACATATCTTAGAAGGTTTACGTATCGCTCTTGATAATATTGACCGTATCATCACAATT
ATCCGTGAATCACAAACTGATGCTATTGCTCAAAAAACAATGATGGATGAATTCCTCTTGTCTGAGAAACAATCACAAGC
CATTCTTGATATGCGTTTGCGTCGTTTGACAGGTTTGGAACGTGACAAAATTGAAGCTGAATATCAAGATTTAGTTGCTT
TGATTGCTGACTTGACGGATATTTTAGCAAAACCTGAACGAGTTAAGAAAATTATTCGTGAAGAATTAGAAGAAGTTAAA
CGTAAATTTGCTGACAAACGTCGAACAGAATTGTTAGTTGGTGAGGTTCTTACTCTTGAAGATGAAGATTTGATTGAGGA
AGAAGATGTATTGATTACTTTATCAAATAAAGGATATATCAAACGTTTGGCTAACGATGAATTCCGTGCTCAAAATCGCG
GGGGACGTGGTGTTCAAGGAATGGGTATGTCCGATGATGACTTCGTTCAACATTTGGTATCTACATCAACACATGATCAT
TTACTCTTCTTTACAAATCTTGGACGTGTCTACCGAATGAAAGGATATGAAATTCCTGAATATGGTCGGACAGCTAAGGG
CTTACCAATTGTCAATCTCTTAAAACTTGATGATGGTGAAAAAATTGCAACAATCATCAATGTTGACCGTGACCAAGCGG
CGAAATATCTCTTCTTCACAACACGCAACGGAATTGTTAAACGAACTTCAACGAGTCAATTTAGCAATATTCGGACAAAT
GGTTTGAAGGCTTTGAAACTTCGTGATGGCGATGAGTTGATTAATGTGCTTAGAACTTCGGGTGAAGATGAGGTTATTAT
CGGGACTCACTTAGGTTACTCTGTTCGTTTCAAAGGTGCCATTGTTCGCGATATGGGCCGTGCTGCAGCTGGAGTCAAGG
GGGTTAACCTCCGAGAAGGTGACTTTGTTGTTGGAACTTCAAGAATTGATGACAATCAAGAAGTCCTTGTTATCTCAGAA
AATGGTCTTGGTAAACGAACTCAAGCTTCGGAATATCCAACAAAAGGCCGTGGTGGTAAAGGGATGAAAGTCATGAATGT
CACAGAAAGAACTGGTAAATTAGCTGGTTTAACTGCAGTCAATGGTGACGAAGACTTGATGGTCATTACAGATACAGGGG
TTATTATCCGTACAAATGTGGCTAATATTTCTCAAACTGGTCGTGCAGCCCAAGGGGTTAAAGTAATGCGACTTGATGAT
GAAGCACAAATTGTAACTTTTGCACTTGTAGATCCAGTAATCGAAGAGGAAGAAACTGACTCGCCAGAAGTTACTGACGA
AGCTCTTTCTACTGACACAAATGAAGAATAA

Upstream 100 bases:

>100_bases
GCTGACTTTTTGTGCGAATTTTGGTATAATATAGATAATCTGTTTGTCAATTGGGACAAACTCTTCCGAAAGCAAGAAAG
GAAAGTAAAATTTCATTTTA

Downstream 100 bases:

>100_bases
ATAAAATGAAAGTCTGCCAGTTACTGACAGACTTTCTGATTAAATAAATGGTGCTGACTAGTCTGTCAGTAAAAATTGAA
CATGAAAAAAATAATAATTT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 836; Mature: 836

Protein sequence:

>836_residues
MRFYKANMQDKNVINVNLVEEMKTSFRDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGNTPDKPHKKSARIVGEVMG
KYHPHGDSSIYEAMVRMAQWWSYRHMLADGHGNFGSMDGDGAAAMRYTEARLSKIAMEMLRDINKNTVDFMDNFDGTERE
PLVLPARFPNLLVNGTTGIAVGMATNIPPHNLGETIDAVDMLMENPEASVTDLMSVIPGPDFPTGALVMGKSGIRRAYET
GKGSITLRAKTHIEEMAGGKERIVVTELPYMVNKARLVEHIVRLNHEKRIEGLTAVRDESNREGIRVVIEVRRDLSAHVI
LNNLFKLTSLQTSFGFNMLAIEKGIPKILSLKEILVDYIEHQIEVVERRTAFDKARAEARAHILEGLRIALDNIDRIITI
IRESQTDAIAQKTMMDEFLLSEKQSQAILDMRLRRLTGLERDKIEAEYQDLVALIADLTDILAKPERVKKIIREELEEVK
RKFADKRRTELLVGEVLTLEDEDLIEEEDVLITLSNKGYIKRLANDEFRAQNRGGRGVQGMGMSDDDFVQHLVSTSTHDH
LLFFTNLGRVYRMKGYEIPEYGRTAKGLPIVNLLKLDDGEKIATIINVDRDQAAKYLFFTTRNGIVKRTSTSQFSNIRTN
GLKALKLRDGDELINVLRTSGEDEVIIGTHLGYSVRFKGAIVRDMGRAAAGVKGVNLREGDFVVGTSRIDDNQEVLVISE
NGLGKRTQASEYPTKGRGGKGMKVMNVTERTGKLAGLTAVNGDEDLMVITDTGVIIRTNVANISQTGRAAQGVKVMRLDD
EAQIVTFALVDPVIEEEETDSPEVTDEALSTDTNEE

Sequences:

>Translated_836_residues
MRFYKANMQDKNVINVNLVEEMKTSFRDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGNTPDKPHKKSARIVGEVMG
KYHPHGDSSIYEAMVRMAQWWSYRHMLADGHGNFGSMDGDGAAAMRYTEARLSKIAMEMLRDINKNTVDFMDNFDGTERE
PLVLPARFPNLLVNGTTGIAVGMATNIPPHNLGETIDAVDMLMENPEASVTDLMSVIPGPDFPTGALVMGKSGIRRAYET
GKGSITLRAKTHIEEMAGGKERIVVTELPYMVNKARLVEHIVRLNHEKRIEGLTAVRDESNREGIRVVIEVRRDLSAHVI
LNNLFKLTSLQTSFGFNMLAIEKGIPKILSLKEILVDYIEHQIEVVERRTAFDKARAEARAHILEGLRIALDNIDRIITI
IRESQTDAIAQKTMMDEFLLSEKQSQAILDMRLRRLTGLERDKIEAEYQDLVALIADLTDILAKPERVKKIIREELEEVK
RKFADKRRTELLVGEVLTLEDEDLIEEEDVLITLSNKGYIKRLANDEFRAQNRGGRGVQGMGMSDDDFVQHLVSTSTHDH
LLFFTNLGRVYRMKGYEIPEYGRTAKGLPIVNLLKLDDGEKIATIINVDRDQAAKYLFFTTRNGIVKRTSTSQFSNIRTN
GLKALKLRDGDELINVLRTSGEDEVIIGTHLGYSVRFKGAIVRDMGRAAAGVKGVNLREGDFVVGTSRIDDNQEVLVISE
NGLGKRTQASEYPTKGRGGKGMKVMNVTERTGKLAGLTAVNGDEDLMVITDTGVIIRTNVANISQTGRAAQGVKVMRLDD
EAQIVTFALVDPVIEEEETDSPEVTDEALSTDTNEE
>Mature_836_residues
MRFYKANMQDKNVINVNLVEEMKTSFRDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGNTPDKPHKKSARIVGEVMG
KYHPHGDSSIYEAMVRMAQWWSYRHMLADGHGNFGSMDGDGAAAMRYTEARLSKIAMEMLRDINKNTVDFMDNFDGTERE
PLVLPARFPNLLVNGTTGIAVGMATNIPPHNLGETIDAVDMLMENPEASVTDLMSVIPGPDFPTGALVMGKSGIRRAYET
GKGSITLRAKTHIEEMAGGKERIVVTELPYMVNKARLVEHIVRLNHEKRIEGLTAVRDESNREGIRVVIEVRRDLSAHVI
LNNLFKLTSLQTSFGFNMLAIEKGIPKILSLKEILVDYIEHQIEVVERRTAFDKARAEARAHILEGLRIALDNIDRIITI
IRESQTDAIAQKTMMDEFLLSEKQSQAILDMRLRRLTGLERDKIEAEYQDLVALIADLTDILAKPERVKKIIREELEEVK
RKFADKRRTELLVGEVLTLEDEDLIEEEDVLITLSNKGYIKRLANDEFRAQNRGGRGVQGMGMSDDDFVQHLVSTSTHDH
LLFFTNLGRVYRMKGYEIPEYGRTAKGLPIVNLLKLDDGEKIATIINVDRDQAAKYLFFTTRNGIVKRTSTSQFSNIRTN
GLKALKLRDGDELINVLRTSGEDEVIIGTHLGYSVRFKGAIVRDMGRAAAGVKGVNLREGDFVVGTSRIDDNQEVLVISE
NGLGKRTQASEYPTKGRGGKGMKVMNVTERTGKLAGLTAVNGDEDLMVITDTGVIIRTNVANISQTGRAAQGVKVMRLDD
EAQIVTFALVDPVIEEEETDSPEVTDEALSTDTNEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=341, Percent_Identity=25.8064516129032, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788562, Length=846, Percent_Identity=48.936170212766, Blast_Score=809, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=624, Percent_Identity=37.6602564102564, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=379, Percent_Identity=23.7467018469657, Blast_Score=69, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=341, Percent_Identity=25.5131964809384, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136538, Length=398, Percent_Identity=23.8693467336683, Blast_Score=71, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93496; Mature: 93496

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00572 GLYCOSYL_HYDROL_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFYKANMQDKNVINVNLVEEMKTSFRDYAMSVIVARALPDVRDGLKPVHRRILYGMNEL
CCEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
GNTPDKPHKKSARIVGEVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLADGHGNFGSMDGD
CCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GAAAMRYTEARLSKIAMEMLRDINKNTVDFMDNFDGTEREPLVLPARFPNLLVNGTTGIA
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEECCCCCEEEECCCCEE
VGMATNIPPHNLGETIDAVDMLMENPEASVTDLMSVIPGPDFPTGALVMGKSGIRRAYET
EEEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHC
GKGSITLRAKTHIEEMAGGKERIVVTELPYMVNKARLVEHIVRLNHEKRIEGLTAVRDES
CCCCEEEEEHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
NREGIRVVIEVRRDLSAHVILNNLFKLTSLQTSFGFNMLAIEKGIPKILSLKEILVDYIE
CCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHH
HQIEVVERRTAFDKARAEARAHILEGLRIALDNIDRIITIIRESQTDAIAQKTMMDEFLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SEKQSQAILDMRLRRLTGLERDKIEAEYQDLVALIADLTDILAKPERVKKIIREELEEVK
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RKFADKRRTELLVGEVLTLEDEDLIEEEDVLITLSNKGYIKRLANDEFRAQNRGGRGVQG
HHHHHHHHHHHHHHHEEEECCHHCCCCCCEEEEECCCCHHHHHCCCHHHHCCCCCCCCCC
MGMSDDDFVQHLVSTSTHDHLLFFTNLGRVYRMKGYEIPEYGRTAKGLPIVNLLKLDDGE
CCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCC
KIATIINVDRDQAAKYLFFTTRNGIVKRTSTSQFSNIRTNGLKALKLRDGDELINVLRTS
EEEEEEECCHHHCCEEEEEEECCCEEEECCCHHHHHHHHCCEEEEEECCHHHHHHHHHCC
GEDEVIIGTHLGYSVRFKGAIVRDMGRAAAGVKGVNLREGDFVVGTSRIDDNQEVLVISE
CCCCEEEEECCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCEEEECC
NGLGKRTQASEYPTKGRGGKGMKVMNVTERTGKLAGLTAVNGDEDLMVITDTGVIIRTNV
CCCCCCCCCCCCCCCCCCCCCEEEEEEHHHCCCEEEEEEECCCCCEEEEECCCEEEEECC
ANISQTGRAAQGVKVMRLDDEAQIVTFALVDPVIEEEETDSPEVTDEALSTDTNEE
CCHHHCCCHHCCEEEEEECCCCCEEEEEHHCHHHCCCCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MRFYKANMQDKNVINVNLVEEMKTSFRDYAMSVIVARALPDVRDGLKPVHRRILYGMNEL
CCEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
GNTPDKPHKKSARIVGEVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLADGHGNFGSMDGD
CCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GAAAMRYTEARLSKIAMEMLRDINKNTVDFMDNFDGTEREPLVLPARFPNLLVNGTTGIA
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEECCCCCEEEECCCCEE
VGMATNIPPHNLGETIDAVDMLMENPEASVTDLMSVIPGPDFPTGALVMGKSGIRRAYET
EEEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHC
GKGSITLRAKTHIEEMAGGKERIVVTELPYMVNKARLVEHIVRLNHEKRIEGLTAVRDES
CCCCEEEEEHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
NREGIRVVIEVRRDLSAHVILNNLFKLTSLQTSFGFNMLAIEKGIPKILSLKEILVDYIE
CCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHH
HQIEVVERRTAFDKARAEARAHILEGLRIALDNIDRIITIIRESQTDAIAQKTMMDEFLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SEKQSQAILDMRLRRLTGLERDKIEAEYQDLVALIADLTDILAKPERVKKIIREELEEVK
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RKFADKRRTELLVGEVLTLEDEDLIEEEDVLITLSNKGYIKRLANDEFRAQNRGGRGVQG
HHHHHHHHHHHHHHHEEEECCHHCCCCCCEEEEECCCCHHHHHCCCHHHHCCCCCCCCCC
MGMSDDDFVQHLVSTSTHDHLLFFTNLGRVYRMKGYEIPEYGRTAKGLPIVNLLKLDDGE
CCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCC
KIATIINVDRDQAAKYLFFTTRNGIVKRTSTSQFSNIRTNGLKALKLRDGDELINVLRTS
EEEEEEECCHHHCCEEEEEEECCCEEEECCCHHHHHHHHCCEEEEEECCHHHHHHHHHCC
GEDEVIIGTHLGYSVRFKGAIVRDMGRAAAGVKGVNLREGDFVVGTSRIDDNQEVLVISE
CCCCEEEEECCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCEEEECC
NGLGKRTQASEYPTKGRGGKGMKVMNVTERTGKLAGLTAVNGDEDLMVITDTGVIIRTNV
CCCCCCCCCCCCCCCCCCCCCEEEEEEHHHCCCEEEEEEECCCCCEEEEECCCEEEEECC
ANISQTGRAAQGVKVMRLDDEAQIVTFALVDPVIEEEETDSPEVTDEALSTDTNEE
CCHHHCCCHHCCEEEEEECCCCCEEEEEHHCHHHCCCCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]