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The map label for this gene is pth [H]

Identifier: 124485626

GI number: 124485626

Start: 784624

End: 784989

Strand: Reverse

Name: pth [H]

Synonym: Mlab_0804

Alternate gene names: 124485626

Gene position: 784989-784624 (Counterclockwise)

Preceding gene: 124485629

Following gene: 124485625

Centisome position: 43.49

GC content: 53.83

Gene sequence:

>366_bases
ATGAAAGGCGGAGAAGAAGAATTCAAATATAAACAGTGCCTCATCCTCAGAAGCGACCTAAAACTCAGCTGCGGAAAAAT
GTGTGCCCAGGCAGCCCATGCCTCGATTGGCGCCTACGAAAAAGCCTCCCTTGCCGACAAAAAAGAATGGCTCCGGGAAG
GCCAGAAAAAAGTCGCCCTCAAAGCCCCAAGCGAACGTGCCCTCTACGAACTCAAAGTCGTCGCCGAAATGCACGGCGTC
CCCGTCTCTTTGATCGTTGACGCCGGCTACACCGAAATCCCCCCGGGAACGGTCACGGCGCTTGGAATAGGACCCGCAAA
AGCCGAAATCATCAATAAAATAACCGGACACCTCCCCCTCCTCTGA

Upstream 100 bases:

>100_bases
TCTTATCTAACTGTATATCCTGTTTTAGCCAAATGTCTAAAGTTTTCTTCATTTTGAATGTACTACTTTATCCCCCTTCA
CCCCAAATAGTACCGCACCA

Downstream 100 bases:

>100_bases
CATGAAACCATCCACCCACCCCCTCGAAATCGACCTCGGCATGCGGTACTACGCCACCAGCCAGCCCGGAATCGGCGGAC
GTCTCCGAACCACCCCCGAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 121; Mature: 121

Protein sequence:

>121_residues
MKGGEEEFKYKQCLILRSDLKLSCGKMCAQAAHASIGAYEKASLADKKEWLREGQKKVALKAPSERALYELKVVAEMHGV
PVSLIVDAGYTEIPPGTVTALGIGPAKAEIINKITGHLPLL

Sequences:

>Translated_121_residues
MKGGEEEFKYKQCLILRSDLKLSCGKMCAQAAHASIGAYEKASLADKKEWLREGQKKVALKAPSERALYELKVVAEMHGV
PVSLIVDAGYTEIPPGTVTALGIGPAKAEIINKITGHLPLL
>Mature_121_residues
MKGGEEEFKYKQCLILRSDLKLSCGKMCAQAAHASIGAYEKASLADKKEWLREGQKKVALKAPSERALYELKVVAEMHGV
PVSLIVDAGYTEIPPGTVTALGIGPAKAEIINKITGHLPLL

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG1990

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH2 family [H]

Homologues:

Organism=Homo sapiens, GI7706351, Length=115, Percent_Identity=47.8260869565217, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17558188, Length=117, Percent_Identity=37.6068376068376, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319414, Length=119, Percent_Identity=36.1344537815126, Blast_Score=76, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281376919, Length=116, Percent_Identity=38.7931034482759, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24644665, Length=116, Percent_Identity=38.7931034482759, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646438, Length=117, Percent_Identity=39.3162393162393, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002833 [H]

Pfam domain/function: PF01981 PTH2 [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 13032; Mature: 13032

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGGEEEFKYKQCLILRSDLKLSCGKMCAQAAHASIGAYEKASLADKKEWLREGQKKVAL
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHEEEE
KAPSERALYELKVVAEMHGVPVSLIVDAGYTEIPPGTVTALGIGPAKAEIINKITGHLPL
ECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCC
L
C
>Mature Secondary Structure
MKGGEEEFKYKQCLILRSDLKLSCGKMCAQAAHASIGAYEKASLADKKEWLREGQKKVAL
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHEEEE
KAPSERALYELKVVAEMHGVPVSLIVDAGYTEIPPGTVTALGIGPAKAEIINKITGHLPL
ECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA