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The map label for this gene is moeB [H]

Identifier: 124485414

GI number: 124485414

Start: 559530

End: 560240

Strand: Reverse

Name: moeB [H]

Synonym: Mlab_0589

Alternate gene names: 124485414

Gene position: 560240-559530 (Counterclockwise)

Preceding gene: 124485415

Following gene: 124485413

Centisome position: 31.04

GC content: 53.02

Gene sequence:

>711_bases
ATGAATGAACGATATGCCAGACAGGAAGCCCTTCTTGGAAAAATGGGGCAGGATAAACTTGAGGATACTACCGTTTTTAT
CGCCGGTGCCGGGGGACTTGGATCTCCCGCATCCATGTACCTTGCCGCGGCAGGGATCGGCAATATCCGAATCTGCGATA
TGGATGTGATCGAACTCTCGAATATGAACCGGCAGATCCTCCACACCGAAGAAAGAATTGGGACCTCCAAAGCGGAATCT
GCGAAAAAAACCCTTGAACATCTCAATCCCGAGTGCAGCGTCACGGCGTTCTCGGAAAGAATCGATGACACTTCTGTTCT
CCGGCTGATAGAGGATGCCGACATAATAGTCGACTGTATGGATAATTTCGATGCGAGATTCACGCTGAACAAAGCGGCTC
TGGACTTAGATATCCCGCTGATGCACGGAGCGGTCGCCGGATTCACCGGGCAGGCGACCCTGGTCCTCCCGGGAAAAACC
CCATGCCTCTCCTGTATATTTCAGAATGCCAAAACCACGACCAAAACGCCGGTGCTTGGGGCATGTGCCGGAGTGATCGG
GAGTATAGAAGCCGCAGAGGTCGTAAAGTATCTCACCGGGACCGGCAGCACGCTTGCCGGAAAACTTCTCCTCTACGACG
GGGCGGAAAACACGATGGAGATCTTTACCGTGAAAAAGAGTCCACGCTGCCCGATGTGCGCAACCTTATAG

Upstream 100 bases:

>100_bases
CAGAGACAAAAGAGACGCTTTTGTCCTGGATCAAAGATAATGCCGTTGACCAGAAACGGCTCGACGCTCTTGAATGTCTG
AACACCGTGAGGGCTCTCTT

Downstream 100 bases:

>100_bases
GTTCCCAGAAAAAACATATAGAGTAATGGTACTCGAAACATTTCATCGGTCCCAGACCGACAAACTTCTTGGCGGCGTCT
GCGGAGGGGTTGCTGAATAT

Product: hypothetical protein

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MNERYARQEALLGKMGQDKLEDTTVFIAGAGGLGSPASMYLAAAGIGNIRICDMDVIELSNMNRQILHTEERIGTSKAES
AKKTLEHLNPECSVTAFSERIDDTSVLRLIEDADIIVDCMDNFDARFTLNKAALDLDIPLMHGAVAGFTGQATLVLPGKT
PCLSCIFQNAKTTTKTPVLGACAGVIGSIEAAEVVKYLTGTGSTLAGKLLLYDGAENTMEIFTVKKSPRCPMCATL

Sequences:

>Translated_236_residues
MNERYARQEALLGKMGQDKLEDTTVFIAGAGGLGSPASMYLAAAGIGNIRICDMDVIELSNMNRQILHTEERIGTSKAES
AKKTLEHLNPECSVTAFSERIDDTSVLRLIEDADIIVDCMDNFDARFTLNKAALDLDIPLMHGAVAGFTGQATLVLPGKT
PCLSCIFQNAKTTTKTPVLGACAGVIGSIEAAEVVKYLTGTGSTLAGKLLLYDGAENTMEIFTVKKSPRCPMCATL
>Mature_236_residues
MNERYARQEALLGKMGQDKLEDTTVFIAGAGGLGSPASMYLAAAGIGNIRICDMDVIELSNMNRQILHTEERIGTSKAES
AKKTLEHLNPECSVTAFSERIDDTSVLRLIEDADIIVDCMDNFDARFTLNKAALDLDIPLMHGAVAGFTGQATLVLPGKT
PCLSCIFQNAKTTTKTPVLGACAGVIGSIEAAEVVKYLTGTGSTLAGKLLLYDGAENTMEIFTVKKSPRCPMCATL

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=219, Percent_Identity=38.8127853881278, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4885649, Length=153, Percent_Identity=31.3725490196078, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI38045942, Length=161, Percent_Identity=34.1614906832298, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI38045944, Length=161, Percent_Identity=34.1614906832298, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI13376212, Length=215, Percent_Identity=29.3023255813954, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI38327032, Length=215, Percent_Identity=29.3023255813954, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI23510338, Length=170, Percent_Identity=30, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI23510340, Length=170, Percent_Identity=30, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI38045948, Length=166, Percent_Identity=30.1204819277108, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787048, Length=237, Percent_Identity=37.1308016877637, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI87082356, Length=237, Percent_Identity=35.8649789029536, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789177, Length=148, Percent_Identity=29.0540540540541, Blast_Score=70, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17540406, Length=241, Percent_Identity=36.5145228215768, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI193203301, Length=159, Percent_Identity=28.3018867924528, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71984476, Length=166, Percent_Identity=33.7349397590361, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI86565431, Length=170, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI86565433, Length=170, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17508819, Length=217, Percent_Identity=26.2672811059908, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321903, Length=246, Percent_Identity=34.1463414634146, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320598, Length=178, Percent_Identity=35.3932584269663, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322639, Length=178, Percent_Identity=28.6516853932584, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325323, Length=189, Percent_Identity=27.5132275132275, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24582879, Length=240, Percent_Identity=40, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24660640, Length=158, Percent_Identity=32.2784810126582, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI20129973, Length=154, Percent_Identity=36.3636363636364, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28573937, Length=169, Percent_Identity=33.1360946745562, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24641311, Length=218, Percent_Identity=27.0642201834862, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 25169; Mature: 25169

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNERYARQEALLGKMGQDKLEDTTVFIAGAGGLGSPASMYLAAAGIGNIRICDMDVIELS
CCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHEEECCCCCEEEECCHHEECC
NMNRQILHTEERIGTSKAESAKKTLEHLNPECSVTAFSERIDDTSVLRLIEDADIIVDCM
CCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEHHHHCCCHHHHHHHHCCHHEEEHH
DNFDARFTLNKAALDLDIPLMHGAVAGFTGQATLVLPGKTPCLSCIFQNAKTTTKTPVLG
CCCCCEEEECCEEEEECCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCHHH
ACAGVIGSIEAAEVVKYLTGTGSTLAGKLLLYDGAENTMEIFTVKKSPRCPMCATL
HHHHHHCCCCHHHHHHHHHCCCCHHEEEEEEEECCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNERYARQEALLGKMGQDKLEDTTVFIAGAGGLGSPASMYLAAAGIGNIRICDMDVIELS
CCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHEEECCCCCEEEECCHHEECC
NMNRQILHTEERIGTSKAESAKKTLEHLNPECSVTAFSERIDDTSVLRLIEDADIIVDCM
CCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEHHHHCCCHHHHHHHHCCHHEEEHH
DNFDARFTLNKAALDLDIPLMHGAVAGFTGQATLVLPGKTPCLSCIFQNAKTTTKTPVLG
CCCCCEEEECCEEEEECCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCHHH
ACAGVIGSIEAAEVVKYLTGTGSTLAGKLLLYDGAENTMEIFTVKKSPRCPMCATL
HHHHHHCCCCHHHHHHHHHCCCCHHEEEEEEEECCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]