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The map label for this gene is glmS [H]

Identifier: 124265753

GI number: 124265753

Start: 591719

End: 593578

Strand: Direct

Name: glmS [H]

Synonym: Mpe_A0560

Alternate gene names: 124265753

Gene position: 591719-593578 (Clockwise)

Preceding gene: 124265751

Following gene: 124265754

Centisome position: 14.63

GC content: 69.3

Gene sequence:

>1860_bases
ATGTGCGGCATCGTCGGCGCGGTCGGTACACGCAACATCGTTCCCATCCTCGTCGAAGGCCTGAAGCGGCTCGAGTACCG
GGGCTACGACTCCTGCGGCGTCGCGGTGCACCAGGACGGCGCGCTGCGACGCAGCCGCAGTACGTCGCGCGTTGCGGAAC
TCGACGTGCAAGTGACCGCCGACGCGGTGCAGGGAACGACCGGCATTGCCCACACGCGCTGGGCCACGCACGGTGCGCCG
GCGGTGCACAACGCCCATCCGCATTTCTCCAGCGGCCCGGGCGCCGACGCCGCGCGTCCGGCGCGCATCGCCCTCGTGCA
CAACGGCATCATCGAGAACCATGACGACCTGCGTGCCGAGCTGCAGGCGCGCGGCTATGTCTTCGCGAGCCAGACCGACA
CCGAGGTCATCGCCCACCTGATCGACTCGCTGTACGACGGCGACCTGTTCGACGCCGTACAGCAGGCCACGCAGCGGCTC
AAGGGCGCCTACGCGATCGCCGTGTTCTGCCGCGACGAACCGCACCGCGTGGTGGGTGCGCGAGAAGGCTCGCCGCTGAT
CCTGGGCGTGGGGCAGGGCGAGAGCTTCCTCGCGTCGGACGCGATGGCGCTGGCCGGCGTGACCGACCAGATCGTCTACC
TGGAAGAGGGCGACGTGGTCGACCTCCAGCTCGGCAAGCACTGGATTGTGGCGCGCAATGCCGCGACCGGCCGCCACGAG
CGCGTGCAGCGCGAAGTGCGCACCGTGCATGCCCACACCGGCGCGGCCGAGCTCGGGCCCTACCGCCACTACATGCAGAA
GGAGATCTTCGAGCAACCGCGCGCCATCGCCGACACGCTCGAGGGCGTGCAGGGCATCGTGCCGGAGCTGTTCGGCGACG
GCGCGCACCGGGTGTTCAAGGAGATCGATTCGGTCCTGATCCTGGCCTGCGGCACCAGCTACTACGCCGGCTGCACCGCC
AAGTACTGGCTGGAGTCGATCGCGCAGATCCCCACGCAGGTGGAAGTGGCCAGCGAGTACCGCTACCGCGACAGCGTGCC
CAACCCCAAGACGCTCGTCGTCACCATCACGCAGAGCGGCGAGACCGCCGACACGCTGGCCGCGCTGAAGCACGCCCGCT
CGCTGGGCATGAAGCACACGCTCACCGTGTGCAACGTCGCCACCAGCGCGATGGTGCGCGAGTGCTCGCTGGCCTACATC
ACGCGAGCGGGCGTCGAGATCGGCGTGGCCTCCACCAAGGCCTTCACCACGCAGCTGGCAGGCCTGTTCCTGCTTACGCT
GATGCTGGCCAAGACCCGTGGGCGGTTGAGCGAGGACGCCGAGGCCGGGCACCTGAAGGCGCTGCGCCACCTGCCGGTGG
CGCTGCAGGCCGTGCTGGCCCTCGAGCCGCAGGTCATGGCCTGGGCGGAAGAGTTCGCCCGCAAGGAGAACGCGCTCTTC
CTGGGCCGCGGGCTGCATTACCCGGTGGCGCTGGAAGGCGCGCTCAAGCTCAAGGAGATCAGCTACATCCACGCCGAGGC
CTACCCGGCCGGCGAACTGAAGCACGGCCCGCTCGCGCTGGTGACCAGCGCAATGCCGGTCGTCACCGTGGCGCCGCACG
ACGCGCTGCTCGAGAAGCTCAAGAGCAACCTGCAGGAAGTGCGCGCGCGGGGCGGCGAGCTGTTCGTCTTTGCCGACGCC
GACACGCGGATCGAAAGCAGCGAAGGCGTGCACGTGATCCGCATGCCCGAGCACTACGGCGCCTTGTCGCCGCTGCTGCA
CGTGGTGCCGCTGCAGTTGCTGGCCTATCACACGGCCTGCGCGCGCGGCACCGACGTCGACAAGCCGCGCAACCTGGCGA
AGAGCGTGACGGTGGAGTGA

Upstream 100 bases:

>100_bases
AAGTTTTGAGATTTTTATGCCGTTTTATTTTGAATTTAGAAAGCATATTTGTTGCTGCCGTCCCTAGGATGCGCCATCCA
CAGCTCAGCAAGGCCATCTC

Downstream 100 bases:

>100_bases
TAGAACGAGGCGCCGTCGCTGGAGTGACTCCTCATTGCTTTCTCCGGTGCCGCGGCCGAAGATCGATCGACGAGGGGATC
TGCTGGCGGAGGGCGCGCGA

Product: glutamine--fructose-6-phosphate transaminase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MCGIVGAVGTRNIVPILVEGLKRLEYRGYDSCGVAVHQDGALRRSRSTSRVAELDVQVTADAVQGTTGIAHTRWATHGAP
AVHNAHPHFSSGPGADAARPARIALVHNGIIENHDDLRAELQARGYVFASQTDTEVIAHLIDSLYDGDLFDAVQQATQRL
KGAYAIAVFCRDEPHRVVGAREGSPLILGVGQGESFLASDAMALAGVTDQIVYLEEGDVVDLQLGKHWIVARNAATGRHE
RVQREVRTVHAHTGAAELGPYRHYMQKEIFEQPRAIADTLEGVQGIVPELFGDGAHRVFKEIDSVLILACGTSYYAGCTA
KYWLESIAQIPTQVEVASEYRYRDSVPNPKTLVVTITQSGETADTLAALKHARSLGMKHTLTVCNVATSAMVRECSLAYI
TRAGVEIGVASTKAFTTQLAGLFLLTLMLAKTRGRLSEDAEAGHLKALRHLPVALQAVLALEPQVMAWAEEFARKENALF
LGRGLHYPVALEGALKLKEISYIHAEAYPAGELKHGPLALVTSAMPVVTVAPHDALLEKLKSNLQEVRARGGELFVFADA
DTRIESSEGVHVIRMPEHYGALSPLLHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE

Sequences:

>Translated_619_residues
MCGIVGAVGTRNIVPILVEGLKRLEYRGYDSCGVAVHQDGALRRSRSTSRVAELDVQVTADAVQGTTGIAHTRWATHGAP
AVHNAHPHFSSGPGADAARPARIALVHNGIIENHDDLRAELQARGYVFASQTDTEVIAHLIDSLYDGDLFDAVQQATQRL
KGAYAIAVFCRDEPHRVVGAREGSPLILGVGQGESFLASDAMALAGVTDQIVYLEEGDVVDLQLGKHWIVARNAATGRHE
RVQREVRTVHAHTGAAELGPYRHYMQKEIFEQPRAIADTLEGVQGIVPELFGDGAHRVFKEIDSVLILACGTSYYAGCTA
KYWLESIAQIPTQVEVASEYRYRDSVPNPKTLVVTITQSGETADTLAALKHARSLGMKHTLTVCNVATSAMVRECSLAYI
TRAGVEIGVASTKAFTTQLAGLFLLTLMLAKTRGRLSEDAEAGHLKALRHLPVALQAVLALEPQVMAWAEEFARKENALF
LGRGLHYPVALEGALKLKEISYIHAEAYPAGELKHGPLALVTSAMPVVTVAPHDALLEKLKSNLQEVRARGGELFVFADA
DTRIESSEGVHVIRMPEHYGALSPLLHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE
>Mature_619_residues
MCGIVGAVGTRNIVPILVEGLKRLEYRGYDSCGVAVHQDGALRRSRSTSRVAELDVQVTADAVQGTTGIAHTRWATHGAP
AVHNAHPHFSSGPGADAARPARIALVHNGIIENHDDLRAELQARGYVFASQTDTEVIAHLIDSLYDGDLFDAVQQATQRL
KGAYAIAVFCRDEPHRVVGAREGSPLILGVGQGESFLASDAMALAGVTDQIVYLEEGDVVDLQLGKHWIVARNAATGRHE
RVQREVRTVHAHTGAAELGPYRHYMQKEIFEQPRAIADTLEGVQGIVPELFGDGAHRVFKEIDSVLILACGTSYYAGCTA
KYWLESIAQIPTQVEVASEYRYRDSVPNPKTLVVTITQSGETADTLAALKHARSLGMKHTLTVCNVATSAMVRECSLAYI
TRAGVEIGVASTKAFTTQLAGLFLLTLMLAKTRGRLSEDAEAGHLKALRHLPVALQAVLALEPQVMAWAEEFARKENALF
LGRGLHYPVALEGALKLKEISYIHAEAYPAGELKHGPLALVTSAMPVVTVAPHDALLEKLKSNLQEVRARGGELFVFADA
DTRIESSEGVHVIRMPEHYGALSPLLHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=695, Percent_Identity=35.9712230215827, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI205277386, Length=699, Percent_Identity=36.0515021459227, Blast_Score=382, Evalue=1e-106,
Organism=Escherichia coli, GI1790167, Length=626, Percent_Identity=51.2779552715655, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1788651, Length=224, Percent_Identity=25.8928571428571, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=728, Percent_Identity=33.6538461538462, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17532899, Length=731, Percent_Identity=33.1053351573187, Blast_Score=356, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17532897, Length=437, Percent_Identity=37.7574370709382, Blast_Score=278, Evalue=9e-75,
Organism=Saccharomyces cerevisiae, GI6322745, Length=459, Percent_Identity=33.9869281045752, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6323731, Length=435, Percent_Identity=28.0459770114943, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6323730, Length=212, Percent_Identity=36.3207547169811, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI21357745, Length=703, Percent_Identity=34.5661450924609, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66925; Mature: 66925

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVGTRNIVPILVEGLKRLEYRGYDSCGVAVHQDGALRRSRSTSRVAELDVQVTA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHCCCCHHHHHEEEEEEH
DAVQGTTGIAHTRWATHGAPAVHNAHPHFSSGPGADAARPARIALVHNGIIENHDDLRAE
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHH
LQARGYVFASQTDTEVIAHLIDSLYDGDLFDAVQQATQRLKGAYAIAVFCRDEPHRVVGA
HHHCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEC
REGSPLILGVGQGESFLASDAMALAGVTDQIVYLEEGDVVDLQLGKHWIVARNAATGRHE
CCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCEEEEEECCCCCHHH
RVQREVRTVHAHTGAAELGPYRHYMQKEIFEQPRAIADTLEGVQGIVPELFGDGAHRVFK
HHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
EIDSVLILACGTSYYAGCTAKYWLESIAQIPTQVEVASEYRYRDSVPNPKTLVVTITQSG
HHHHEEEEEECCCHHCCCCHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCCEEEEEEECCC
ETADTLAALKHARSLGMKHTLTVCNVATSAMVRECSLAYITRAGVEIGVASTKAFTTQLA
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHH
GLFLLTLMLAKTRGRLSEDAEAGHLKALRHLPVALQAVLALEPQVMAWAEEFARKENALF
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEE
LGRGLHYPVALEGALKLKEISYIHAEAYPAGELKHGPLALVTSAMPVVTVAPHDALLEKL
EECCCCCCEEECCCEEHHHHHEEEECCCCCCCCCCCCHHHHHCCCCEEEECCHHHHHHHH
KSNLQEVRARGGELFVFADADTRIESSEGVHVIRMPEHYGALSPLLHVVPLQLLAYHTAC
HHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCHHHCHHHHHHHHHHHHHHHHHHHH
ARGTDVDKPRNLAKSVTVE
CCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVGTRNIVPILVEGLKRLEYRGYDSCGVAVHQDGALRRSRSTSRVAELDVQVTA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHCCCCHHHHHEEEEEEH
DAVQGTTGIAHTRWATHGAPAVHNAHPHFSSGPGADAARPARIALVHNGIIENHDDLRAE
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHH
LQARGYVFASQTDTEVIAHLIDSLYDGDLFDAVQQATQRLKGAYAIAVFCRDEPHRVVGA
HHHCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEC
REGSPLILGVGQGESFLASDAMALAGVTDQIVYLEEGDVVDLQLGKHWIVARNAATGRHE
CCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCEEEEEECCCCCHHH
RVQREVRTVHAHTGAAELGPYRHYMQKEIFEQPRAIADTLEGVQGIVPELFGDGAHRVFK
HHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
EIDSVLILACGTSYYAGCTAKYWLESIAQIPTQVEVASEYRYRDSVPNPKTLVVTITQSG
HHHHEEEEEECCCHHCCCCHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCCEEEEEEECCC
ETADTLAALKHARSLGMKHTLTVCNVATSAMVRECSLAYITRAGVEIGVASTKAFTTQLA
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHH
GLFLLTLMLAKTRGRLSEDAEAGHLKALRHLPVALQAVLALEPQVMAWAEEFARKENALF
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEE
LGRGLHYPVALEGALKLKEISYIHAEAYPAGELKHGPLALVTSAMPVVTVAPHDALLEKL
EECCCCCCEEECCCEEHHHHHEEEECCCCCCCCCCCCHHHHHCCCCEEEECCHHHHHHHH
KSNLQEVRARGGELFVFADADTRIESSEGVHVIRMPEHYGALSPLLHVVPLQLLAYHTAC
HHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCHHHCHHHHHHHHHHHHHHHHHHHH
ARGTDVDKPRNLAKSVTVE
CCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]