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The map label for this gene is ftsW [H]

Identifier: 124265654

GI number: 124265654

Start: 500898

End: 502190

Strand: Direct

Name: ftsW [H]

Synonym: Mpe_A0461

Alternate gene names: 124265654

Gene position: 500898-502190 (Clockwise)

Preceding gene: 124265653

Following gene: 124265655

Centisome position: 12.39

GC content: 69.84

Gene sequence:

>1293_bases
ATGAGCCGCGCCGCGTCGTCCGCCGCCGTCGGCGCCCGCCCGGGGCTGGCCGCGCTGAAGGAGCGCGCGGCGCGCTGGCT
GGGCCGCGGTGCGGGCAGCGAGACACTGCCGATCCGCGACTGGGTCAGCGTGTCCAACGGCCAGCCGGCGCGCCTGCTGG
GCTTCGACCAGATGATGGTCTGCGTGGTGATCGCGCTGCTCGCGCTCGGCCTGGTGATGGTCTATTCGACCTCGATCGCG
CTGCCGGACGACCCGCGCACCGCGCGCGTCGCGCCCACCCACCACTACCTGATGGTGCGCCATGCCTTCGGCCTGTTGAT
CGCGCTGGGCGCCTCGCTCGCGGTGGTGCAGGTGCCGCTGCGGCTGTGGGAGCGCTGGGCGCCGTGGCTGTTCGTCGCCG
CGCTGGTGCTGCTGGTGCTGGTGCTCATCCCGCACATCGGGCGCGCCAGCAAGGGCGCGCGGCGCTGGATCCCGCTGGGT
TTCATGAGCTTCCAGCCCAGCGAACTGGCCAAGCTGGGCATCGCCATGTATGCCGCCAGCTACATGGTGCGCAAGATGGA
GATCAAGGAGCACTTCACGCGCGCCGTGGCGCCGATGGCGGCCGCGCTCGCGGTGATCGGCGTGCTGCTGCTGGCCGAGC
CCGACATGGGCGCGTTCATCGTCATCGCAGCCATCGCGATGGGCATCCTGTTCCTCGGTGGCGTGAACGGCCGCATGTTC
CTGCTCAGCATCGCGGTGCTGCTGGGCGCCTTCGTGTCGATGATCATCGCGAGCCCCTGGCGGGCCGAACGTATCCTGGC
GTTTCTCAGCCCCTGGGACCCGCTGTACGCGCAGGGCAAGGGCTACCAGCTCACGCACTCGCTGATCGCGCTGGGCCGCG
GCGAGATCTTCGGCCAGGGCCTGGGCTCCAGCGTCGAGAAGCTGCACTACCTGCCGGAGGCGCACACCGACTTCCTGCTG
GCGGTGATCGGCGAGGAGCTGGGCTTCGTCGGCGTGGCGCTGGTGATCGCCGCCTTCTTCTGGCTCACGCGCCGCATCTT
CCACATCGGCCGCCAGGCGATCGCGCTCGACCGCGTGTTCTCCGGCCTGCTGGCGCAGGGCATCGGCATCTGGATGGGCG
GTCAGGCCTTCATCAACATGGGCGTGAACCTCGGCGTGCTGCCGACCAAGGGTCTGACGCTGCCGCTGATGAGCTACGGC
GGCTCGGCGATCCTGATGAACTGCGTGGCGTTGGCGATCGTGTTGCGGGTCGATATCGAGAACCGGCAGCTCATGCGGGG
AGGGCGCGCGTGA

Upstream 100 bases:

>100_bases
CGGCCTGCGCCAGCCTGGACATGTTCCGCAACTACGCGCAGCGCGCCGAGGTGTTCTGCGACACCGTGCGCGAGCTGGCG
TGCGAGCACGGGGAGACGGC

Downstream 100 bases:

>100_bases
GCGGCGCTTTCATCCAGGGCATGGCTGAGGCTATCGGCTTGGTGCAGTGCCGTGCGCGGCAGCCCGCCGGGTCTCGCCCC
GGCGCGGTGCCGTCCGCAGG

Product: cell division protein FtsW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSRAASSAAVGARPGLAALKERAARWLGRGAGSETLPIRDWVSVSNGQPARLLGFDQMMVCVVIALLALGLVMVYSTSIA
LPDDPRTARVAPTHHYLMVRHAFGLLIALGASLAVVQVPLRLWERWAPWLFVAALVLLVLVLIPHIGRASKGARRWIPLG
FMSFQPSELAKLGIAMYAASYMVRKMEIKEHFTRAVAPMAAALAVIGVLLLAEPDMGAFIVIAAIAMGILFLGGVNGRMF
LLSIAVLLGAFVSMIIASPWRAERILAFLSPWDPLYAQGKGYQLTHSLIALGRGEIFGQGLGSSVEKLHYLPEAHTDFLL
AVIGEELGFVGVALVIAAFFWLTRRIFHIGRQAIALDRVFSGLLAQGIGIWMGGQAFINMGVNLGVLPTKGLTLPLMSYG
GSAILMNCVALAIVLRVDIENRQLMRGGRA

Sequences:

>Translated_430_residues
MSRAASSAAVGARPGLAALKERAARWLGRGAGSETLPIRDWVSVSNGQPARLLGFDQMMVCVVIALLALGLVMVYSTSIA
LPDDPRTARVAPTHHYLMVRHAFGLLIALGASLAVVQVPLRLWERWAPWLFVAALVLLVLVLIPHIGRASKGARRWIPLG
FMSFQPSELAKLGIAMYAASYMVRKMEIKEHFTRAVAPMAAALAVIGVLLLAEPDMGAFIVIAAIAMGILFLGGVNGRMF
LLSIAVLLGAFVSMIIASPWRAERILAFLSPWDPLYAQGKGYQLTHSLIALGRGEIFGQGLGSSVEKLHYLPEAHTDFLL
AVIGEELGFVGVALVIAAFFWLTRRIFHIGRQAIALDRVFSGLLAQGIGIWMGGQAFINMGVNLGVLPTKGLTLPLMSYG
GSAILMNCVALAIVLRVDIENRQLMRGGRA
>Mature_429_residues
SRAASSAAVGARPGLAALKERAARWLGRGAGSETLPIRDWVSVSNGQPARLLGFDQMMVCVVIALLALGLVMVYSTSIAL
PDDPRTARVAPTHHYLMVRHAFGLLIALGASLAVVQVPLRLWERWAPWLFVAALVLLVLVLIPHIGRASKGARRWIPLGF
MSFQPSELAKLGIAMYAASYMVRKMEIKEHFTRAVAPMAAALAVIGVLLLAEPDMGAFIVIAAIAMGILFLGGVNGRMFL
LSIAVLLGAFVSMIIASPWRAERILAFLSPWDPLYAQGKGYQLTHSLIALGRGEIFGQGLGSSVEKLHYLPEAHTDFLLA
VIGEELGFVGVALVIAAFFWLTRRIFHIGRQAIALDRVFSGLLAQGIGIWMGGQAFINMGVNLGVLPTKGLTLPLMSYGG
SAILMNCVALAIVLRVDIENRQLMRGGRA

Specific function: This is a septum-peptidoglycan biosynthetic protein, involved in cell wall formation. Plays a role in the stabilization of the ftsZ ring during cell division [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786277, Length=400, Percent_Identity=41.25, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI1786853, Length=327, Percent_Identity=34.2507645259939, Blast_Score=153, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR013437 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 46248; Mature: 46117

Theoretical pI: Translated: 10.77; Mature: 10.77

Prosite motif: PS00639 THIOL_PROTEASE_HIS ; PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAASSAAVGARPGLAALKERAARWLGRGAGSETLPIRDWVSVSNGQPARLLGFDQMMV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHH
CVVIALLALGLVMVYSTSIALPDDPRTARVAPTHHYLMVRHAFGLLIALGASLAVVQVPL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLWERWAPWLFVAALVLLVLVLIPHIGRASKGARRWIPLGFMSFQPSELAKLGIAMYAAS
HHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHH
YMVRKMEIKEHFTRAVAPMAAALAVIGVLLLAEPDMGAFIVIAAIAMGILFLGGVNGRMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
LLSIAVLLGAFVSMIIASPWRAERILAFLSPWDPLYAQGKGYQLTHSLIALGRGEIFGQG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHCCCHHHHCC
LGSSVEKLHYLPEAHTDFLLAVIGEELGFVGVALVIAAFFWLTRRIFHIGRQAIALDRVF
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLLAQGIGIWMGGQAFINMGVNLGVLPTKGLTLPLMSYGGSAILMNCVALAIVLRVDIE
HHHHHHCCCEEECCHHHHCCCCCCCEECCCCCEEHHHHCCCHHHHHHHHHHHHHHHHCCC
NRQLMRGGRA
CHHHHCCCCC
>Mature Secondary Structure 
SRAASSAAVGARPGLAALKERAARWLGRGAGSETLPIRDWVSVSNGQPARLLGFDQMMV
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHH
CVVIALLALGLVMVYSTSIALPDDPRTARVAPTHHYLMVRHAFGLLIALGASLAVVQVPL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLWERWAPWLFVAALVLLVLVLIPHIGRASKGARRWIPLGFMSFQPSELAKLGIAMYAAS
HHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHH
YMVRKMEIKEHFTRAVAPMAAALAVIGVLLLAEPDMGAFIVIAAIAMGILFLGGVNGRMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
LLSIAVLLGAFVSMIIASPWRAERILAFLSPWDPLYAQGKGYQLTHSLIALGRGEIFGQG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHCCCHHHHCC
LGSSVEKLHYLPEAHTDFLLAVIGEELGFVGVALVIAAFFWLTRRIFHIGRQAIALDRVF
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLLAQGIGIWMGGQAFINMGVNLGVLPTKGLTLPLMSYGGSAILMNCVALAIVLRVDIE
HHHHHHCCCEEECCHHHHCCCCCCCEECCCCCEEHHHHCCCHHHHHHHHHHHHHHHHCCC
NRQLMRGGRA
CHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]