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The map label for this gene is gltK [H]

Identifier: 124265638

GI number: 124265638

Start: 483876

End: 484544

Strand: Direct

Name: gltK [H]

Synonym: Mpe_A0445

Alternate gene names: 124265638

Gene position: 483876-484544 (Clockwise)

Preceding gene: 124265637

Following gene: 124265639

Centisome position: 11.96

GC content: 62.48

Gene sequence:

>669_bases
ATGCTGAACCTCGATTTTTCCTTCCTGAACTGGGACGTCGTCTCCGGCTTCGTCCTCAAGGGCCTGGTCTTCTCGGTGCA
GCTCACGCTGATCGCGATGGTCGGTGGCATCGTGCTGGGCACCCTGCTGGCGCTGATGCGGCTGTCGGGCAAGAAGTGGC
TGGTGGTCCCGGCGGCGTTCTACGTCAACACGCTGCGTTCCATCCCGCTGGTGATGGTGATCCTGTGGTTCTTCCTGCTG
ATCCCGTTGCTGATCGGGCGGCCGATGGGCGCCGAGCTGTCGGCCATCATCACCTTCACGGTGTTCGAGGCGGCCTACTA
CTCCGAGATCATGCGCGCCGGTATCCAGAGCGTGCCCAAGGGCCAGGTCTATGCCGGCTACGCGGTCGGCATGACCTACT
CGCAGAGCATGCAGCTGATCGTGCTGCCGCAGGCCTTCCGCAACATGCTGCCGGTGCTGATGACGCAGACCATCATCCTG
TTCCAGGACACCTCGCTGGTCTACGCGATCGGCGCCTACGACCTGCTCAAGGGCTTCGAGGTCGCCGGCAAGAACTTCAA
CCGTCCGGTCGAGACCTACCTGGTCGCCGCCGTCGTCTACTTCGTGATCTGCTTCAGCCTGAGCATGCTTGTGCGCCGGC
TGCAGAAGAAGATCGCCATCATCCGCTGA

Upstream 100 bases:

>100_bases
CGGCATGGCGGGAGGCAAATGATGAACCCCCACGTCCCTTTGCTCCTTCCCCCCAAGGGGGCTCGGCCTGCCCTTGGGGT
GGCCCGGCGGGAGGCCTGAG

Downstream 100 bases:

>100_bases
TCAGGAGAGCGCCGTGATCGACATCAAGAACATCAGCAAGTGGTACGGCAGCTTCCAGGTGCTGACCGACTGCACCACCA
ACGTCAAGAAGGGCGAGGTG

Product: amino acid permease

Products: ADP; phosphate; L-glutamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MLNLDFSFLNWDVVSGFVLKGLVFSVQLTLIAMVGGIVLGTLLALMRLSGKKWLVVPAAFYVNTLRSIPLVMVILWFFLL
IPLLIGRPMGAELSAIITFTVFEAAYYSEIMRAGIQSVPKGQVYAGYAVGMTYSQSMQLIVLPQAFRNMLPVLMTQTIIL
FQDTSLVYAIGAYDLLKGFEVAGKNFNRPVETYLVAAVVYFVICFSLSMLVRRLQKKIAIIR

Sequences:

>Translated_222_residues
MLNLDFSFLNWDVVSGFVLKGLVFSVQLTLIAMVGGIVLGTLLALMRLSGKKWLVVPAAFYVNTLRSIPLVMVILWFFLL
IPLLIGRPMGAELSAIITFTVFEAAYYSEIMRAGIQSVPKGQVYAGYAVGMTYSQSMQLIVLPQAFRNMLPVLMTQTIIL
FQDTSLVYAIGAYDLLKGFEVAGKNFNRPVETYLVAAVVYFVICFSLSMLVRRLQKKIAIIR
>Mature_222_residues
MLNLDFSFLNWDVVSGFVLKGLVFSVQLTLIAMVGGIVLGTLLALMRLSGKKWLVVPAAFYVNTLRSIPLVMVILWFFLL
IPLLIGRPMGAELSAIITFTVFEAAYYSEIMRAGIQSVPKGQVYAGYAVGMTYSQSMQLIVLPQAFRNMLPVLMTQTIIL
FQDTSLVYAIGAYDLLKGFEVAGKNFNRPVETYLVAAVVYFVICFSLSMLVRRLQKKIAIIR

Specific function: Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1786873, Length=210, Percent_Identity=49.047619047619, Blast_Score=189, Evalue=1e-49,
Organism=Escherichia coli, GI87082239, Length=202, Percent_Identity=30.6930693069307, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788226, Length=209, Percent_Identity=34.4497607655502, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1787030, Length=223, Percent_Identity=29.1479820627803, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1788645, Length=215, Percent_Identity=27.906976744186, Blast_Score=81, Evalue=4e-17,
Organism=Escherichia coli, GI1786874, Length=172, Percent_Identity=27.3255813953488, Blast_Score=81, Evalue=4e-17,
Organism=Escherichia coli, GI48994930, Length=135, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1787087, Length=125, Percent_Identity=32, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1788646, Length=198, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24741; Mature: 24741

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLDFSFLNWDVVSGFVLKGLVFSVQLTLIAMVGGIVLGTLLALMRLSGKKWLVVPAAF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHH
YVNTLRSIPLVMVILWFFLLIPLLIGRPMGAELSAIITFTVFEAAYYSEIMRAGIQSVPK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GQVYAGYAVGMTYSQSMQLIVLPQAFRNMLPVLMTQTIILFQDTSLVYAIGAYDLLKGFE
CCEEEEHEECCCHHCCCEEEEEHHHHHHHHHHHHHHHHHEEECCCCEEEHHHHHHHHHHH
VAGKNFNRPVETYLVAAVVYFVICFSLSMLVRRLQKKIAIIR
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNLDFSFLNWDVVSGFVLKGLVFSVQLTLIAMVGGIVLGTLLALMRLSGKKWLVVPAAF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHH
YVNTLRSIPLVMVILWFFLLIPLLIGRPMGAELSAIITFTVFEAAYYSEIMRAGIQSVPK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GQVYAGYAVGMTYSQSMQLIVLPQAFRNMLPVLMTQTIILFQDTSLVYAIGAYDLLKGFE
CCEEEEHEECCCHHCCCEEEEEHHHHHHHHHHHHHHHHHEEECCCCEEEHHHHHHHHHHH
VAGKNFNRPVETYLVAAVVYFVICFSLSMLVRRLQKKIAIIR
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-glutamate [Periplasm]; H2O [C]

Specific reaction: ATP + L-glutamate [Periplasm] + H2O = ADP + phosphate + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]