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The map label for this gene is groEL [H]

Identifier: 124265621

GI number: 124265621

Start: 463817

End: 465463

Strand: Direct

Name: groEL [H]

Synonym: Mpe_A0428

Alternate gene names: 124265621

Gene position: 463817-465463 (Clockwise)

Preceding gene: 124265620

Following gene: 124265622

Centisome position: 11.47

GC content: 65.82

Gene sequence:

>1647_bases
ATGGCAGCTAAAGACGTCGTTTTCGGAGGTGAAGCCCGCGCGCGCATGGTCGAAGGCGTGAACATCCTGGCCAACGCGGT
CAAGGTGACGCTGGGCCCGAAGGGCCGCAACGTGGTGCTCGAGCGTTCGTTCGGCGCCCCGACCGTGACCAAGGACGGTG
TGTCCGTGGCCAAGGAAATCGAGCTGAAGGACAAGCTCCAGAACATGGGCGCCCAGATGGTCAAGGAAGTCGCTTCCAAG
ACCTCGGACAACGCCGGTGACGGCACCACCACCGCCACCGTGCTGGCCCAGGCGATCGTGCGCGAAGGCATGAAGTACGT
GGCCGCGGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACAAGGCCGTCGTGAGCTTGGTCGAGCAGCTGAAGAAGC
AGTCGAAGCCGACCACCACCAGCAAGGAAATCGCCCAGGTCGGCACCATCTCGGCGAATTCGGACGACGACGTCGGCCAG
ATCATCGCGTCGGCGATGGACAAGGTCGGCAAGGAAGGCGTCATCACCGTCGAAGACGGCAAGAGCCTGAACAACGAGCT
CGACGTGGTCGAAGGCATGCAGTTCGACCGCGGCTACCTGTCGCCCTACTTCATCAACAACCCGGAAAAGCAGAGCGCGG
TGCTCGACAACCCGTTCGTGCTGCTCTACGACAAGAAGATCAGCAACATCCGTGACCTGCTGCCGACGCTGGAGCAGGTG
GCCAAGTCGGGCCGTCCGCTGCTGATCATCGCCGAGGAAGTCGAAGGCGAAGCGCTCGCGACGCTGGTGGTCAACACCAT
CCGCGGCATCCTGAAGGTCGTGGCCGTCAAGGCGCCGGGCTTCGGTGACCGTCGCAAGGCGATGCTCGAGGACATCGCGA
TCCTGACCGGCGGCAAGGTCATCGCCGAGGAAGTCGGCCTGACGCTCGAGAAGGTCACGCTGGCCGACCTGGGCCAGGCC
AAGCGCGTCGAGGTGGGCAAGGAAAACACCACGATCATCGACGGCGCCGGCGCCGCGGGCGACATCGAAGCCCGCGTCAA
GCAGGTGCGCGTGCAGATCGAGGAAGCCACCAGCGACTACGACCGCGAGAAGCTCCAGGAGCGCGTGGCCAAGCTCGCCG
GCGGCGTGGCCGTCATCAAGGTCGGTGCCGCCACCGAAGTCGAGATGAAGGAAAAGAAGGCCCGTGTCGAAGACGCCCTG
CACGCCACGCGTGCCGCGGTGGAAGAAGGCATCGTGGCCGGCGGTGGCGTGGCGCTGCTGCGCGCCAAGCAGGCCGCCGG
TGCGATCAAGGGCGACAACGCCGACCAGGACGCCGGCATCAAGCTGATCCTGCGTGCGATCGAGGAGCCGCTGCGCATCA
TCGTCACCAACGCCGGTGACGAAGCCAGCGTGGTGGTGAACGCCGTGCTCGCCGGCAAGGGCAACTACGGCTACAACGCC
GCCAACGGCACCTACGGCGACATGATCGAGATGGGCATCCTGGACCCGACCAAGGTGACCCGCACCGCGCTGCAGAACGC
CGCCTCGGTGGCCGCGCTGATGCTGACGACGGAAGCCATGGTCGCCGAGTCGCCCAAGGACGACGCGCCGGCCGGCGGCA
TGCCGGGTGGCATGGGCGGCATGGGTGGCATGGGCATGGACATGTGA

Upstream 100 bases:

>100_bases
GCAGGCTGACTTCGCGCAGCGAAGTCAAGGCCCCAAGGGTCGGCCGTAGACAGAAGAATTCCCCGGCGCGAGCCGGCAAA
TCAGATTTCGGAGAATACAA

Downstream 100 bases:

>100_bases
TGTCCCGCCGGCCTCCCACGGGAGGCCGGCCGCCTGGGCTCTGCCCAGAACCGCGTCAGCAAGGGCCGCAGAAATGCGGC
CCTTTTTCATGCGCGTTCGG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MAAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQAIVREGMKYVAAGMNPMDLKRGIDKAVVSLVEQLKKQSKPTTTSKEIAQVGTISANSDDDVGQ
IIASAMDKVGKEGVITVEDGKSLNNELDVVEGMQFDRGYLSPYFINNPEKQSAVLDNPFVLLYDKKISNIRDLLPTLEQV
AKSGRPLLIIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKVIAEEVGLTLEKVTLADLGQA
KRVEVGKENTTIIDGAGAAGDIEARVKQVRVQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALLRAKQAAGAIKGDNADQDAGIKLILRAIEEPLRIIVTNAGDEASVVVNAVLAGKGNYGYNA
ANGTYGDMIEMGILDPTKVTRTALQNAASVAALMLTTEAMVAESPKDDAPAGGMPGGMGGMGGMGMDM

Sequences:

>Translated_548_residues
MAAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQAIVREGMKYVAAGMNPMDLKRGIDKAVVSLVEQLKKQSKPTTTSKEIAQVGTISANSDDDVGQ
IIASAMDKVGKEGVITVEDGKSLNNELDVVEGMQFDRGYLSPYFINNPEKQSAVLDNPFVLLYDKKISNIRDLLPTLEQV
AKSGRPLLIIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKVIAEEVGLTLEKVTLADLGQA
KRVEVGKENTTIIDGAGAAGDIEARVKQVRVQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALLRAKQAAGAIKGDNADQDAGIKLILRAIEEPLRIIVTNAGDEASVVVNAVLAGKGNYGYNA
ANGTYGDMIEMGILDPTKVTRTALQNAASVAALMLTTEAMVAESPKDDAPAGGMPGGMGGMGGMGMDM
>Mature_547_residues
AAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKT
SDNAGDGTTTATVLAQAIVREGMKYVAAGMNPMDLKRGIDKAVVSLVEQLKKQSKPTTTSKEIAQVGTISANSDDDVGQI
IASAMDKVGKEGVITVEDGKSLNNELDVVEGMQFDRGYLSPYFINNPEKQSAVLDNPFVLLYDKKISNIRDLLPTLEQVA
KSGRPLLIIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKVIAEEVGLTLEKVTLADLGQAK
RVEVGKENTTIIDGAGAAGDIEARVKQVRVQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVAGGGVALLRAKQAAGAIKGDNADQDAGIKLILRAIEEPLRIIVTNAGDEASVVVNAVLAGKGNYGYNAA
NGTYGDMIEMGILDPTKVTRTALQNAASVAALMLTTEAMVAESPKDDAPAGGMPGGMGGMGGMGMDM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=53.5104364326376, Blast_Score=550, Evalue=1e-156,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=53.5104364326376, Blast_Score=550, Evalue=1e-156,
Organism=Homo sapiens, GI63162572, Length=544, Percent_Identity=21.6911764705882, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=75.4253308128544, Blast_Score=788, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=53.3962264150943, Blast_Score=544, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI193210679, Length=222, Percent_Identity=50.9009009009009, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17564182, Length=568, Percent_Identity=22.0070422535211, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.041825095057, Blast_Score=546, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6322524, Length=366, Percent_Identity=23.4972677595628, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=52.7514231499051, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=52.7514231499051, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=51.7175572519084, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=51.7175572519084, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=51.7175572519084, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=43.9201451905626, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24584129, Length=526, Percent_Identity=36.5019011406844, Blast_Score=335, Evalue=7e-92,
Organism=Drosophila melanogaster, GI19921262, Length=526, Percent_Identity=36.5019011406844, Blast_Score=335, Evalue=7e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57392; Mature: 57261

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEI
CCCCCEEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQAIVREGMKYVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVVSLVEQLKKQSKPTTTSKEIAQVGTISANSDDDVGQIIASAMDKVGKEGVITVEDG
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECC
KSLNNELDVVEGMQFDRGYLSPYFINNPEKQSAVLDNPFVLLYDKKISNIRDLLPTLEQV
CCCCCCHHHHHCCCCCCCCCCCEECCCCCHHHHCCCCCEEEEECCHHHHHHHHHHHHHHH
AKSGRPLLIIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLTLEKVTLADLGQAKRVEVGKENTTIIDGAGAAGDIEARVKQVRVQIEEATSDY
HHHHHCCCHHEEHHHHCCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKQAAGAIKGDNADQDAGIKLILRAIEEPLRIIVTNAGDEASVVVNAVLAGKGNYGYNA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHEEEHEECCCCCCCCC
ANGTYGDMIEMGILDPTKVTRTALQNAASVAALMLTTEAMVAESPKDDAPAGGMPGGMGG
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
MGGMGMDM
CCCCCCCC
>Mature Secondary Structure 
AAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEI
CCCCEEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQAIVREGMKYVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVVSLVEQLKKQSKPTTTSKEIAQVGTISANSDDDVGQIIASAMDKVGKEGVITVEDG
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECC
KSLNNELDVVEGMQFDRGYLSPYFINNPEKQSAVLDNPFVLLYDKKISNIRDLLPTLEQV
CCCCCCHHHHHCCCCCCCCCCCEECCCCCHHHHCCCCCEEEEECCHHHHHHHHHHHHHHH
AKSGRPLLIIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLTLEKVTLADLGQAKRVEVGKENTTIIDGAGAAGDIEARVKQVRVQIEEATSDY
HHHHHCCCHHEEHHHHCCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKQAAGAIKGDNADQDAGIKLILRAIEEPLRIIVTNAGDEASVVVNAVLAGKGNYGYNA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHEEEHEECCCCCCCCC
ANGTYGDMIEMGILDPTKVTRTALQNAASVAALMLTTEAMVAESPKDDAPAGGMPGGMGG
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
MGGMGMDM
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA