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The map label for this gene is pamO [H]

Identifier: 124265586

GI number: 124265586

Start: 424786

End: 426417

Strand: Direct

Name: pamO [H]

Synonym: Mpe_A0393

Alternate gene names: 124265586

Gene position: 424786-426417 (Clockwise)

Preceding gene: 124265585

Following gene: 124265587

Centisome position: 10.5

GC content: 68.2

Gene sequence:

>1632_bases
ATGGCTGCCTATTCGAACCCCAACGCCCCCGTCACGCGACTCGATGCCGTCGTCATCGGCGCCGGTGTGGCGGGCCTGTA
CCAGTTGCACAAGCTGCGCGAGCTCGGCCTGAATGTGCGCGCCTACGAAACCGGTTCCGGCGTCGGCGGCACCTGGTACT
GGAACCGCTACCCCGGCGCCCGCTTCGACTCGCAGGCCGAGATCTACCAGTACTGGTTCTCGGAGGACCTGTACAAGGCC
TGGAAGCCGACCGAGCGCTTCCCGGCGCAGCCGGAAACCGAGAGCTGGCTGAACTGGGTGGCCGACCGGCTGGACCTGCG
CAAGGACATCCGCTTCGGCGCACGCATCGACTCCGCCCACTACGACGACACCATCGGCCGCTGGAGCCTCGTCACGCAGC
AGGGCGAGACCATCGACACGCAGTACCTGGTGTGCTGCATGGGCATGCTGTCGGCGCCGCTGACCAACCGCTTCCACGGG
CAGTCCAGCTTCAAGGGGCAGATCCACCACACGGCGCTGTGGCCCAAGGAGGGTGTGGACCTGAAGGGCAAGCGCGTGGC
GGTGGTGGGTGTGGGCGCCACCGGCATCCAGGTGATCCAGTCCATCGCGCCCGAGGTGGCCGAACTGAAGGTGTTCGTGC
GCACGCCGCAGTACATGATCCCGATGCGCAACCCGAAGTACGGCGAGAAGGAGTGGGCCGACTTCGCCGCGCGCTTCCAT
GAGCTGAAGGCGCGCGTGCGCGGCACCTTCGCCGGCTTCGACTACGACTTCGACGCCGGGCCCTGGGCCGACAAGACGCC
GGCCGAGCGCGAGGTCGTGCTGCAGGGCCTGTGGGAGGACGGCTCGCTGTCGATGTGGCTCGCCTCCTTCCCGGAGATGT
TCTTCGACGAGTCGGTGAGCTTCGAGGTCTCGGAGTTCGTGCGCCGCAAGATGCGCGAGCGGCTGGGCAACGACCCCGCG
CTGTGCGAACTGCTGATCCCCACCGACTACGGCTTCGGCACGCACCGCGTGCCGCTGGAGAGCGGCTACCTGGAGGTCTA
CCTGCGCGACAACGTGGAGGGCGTGAACTGCCGGGCCACGCCGATCGAGCGCATCGTGCCCGAGGGCATCCAGACCTCCG
ATGGCAAGGTGCACGAGGTCGACGTGATCATTCTCGCGGTGGGCTTCGACGCCGGCTCCGGCGCGCTGACGCGCATGGAC
ATCCGCGGCCGCGGCGGCCGCTCGCTGAAGCAGGAGTGGAGCAAGGAGATCCGCACCGCCATGGGCATGCAGATCCACGG
CTACCCCAACCTGTTCAGCACCGCCTCGCCGCTGGCGCCCACCGCGGCGCTGTGCAACATGCCCACCTGCCTGCAGGCGC
AGGTGGAGTGGGTCACCGACTGCATTGCCTACGCGCGTGCCACCGGCAAGAAGGTGGTCGAGCCGACCCGCGAGTTCGAG
GAGTCCTGGGTCCGGCACCACGACGAGGTGGCCAACCGCACGCTGCTGGTGAAGACCGACTCCTGGTACATGGGCTCCAA
CGTCGAGGGCAAGCCGCGGCGGCTGCTGTCCTATGCCGGCGGCGTGGGCAACTATCACCGGCAGTGCGACGAGCAGGCGG
CCATGGGCTACCCCGGCTTCGCCATGCGCTGA

Upstream 100 bases:

>100_bases
TCGCGCCGTCGATCGAGGGTGAACCCTCAGGAATCCGTGGGCCGGCCGTGGTCCGTGAATTGCGATCTGCCCCGGCAAAT
CGCGAACCCCCGGAGACCCC

Downstream 100 bases:

>100_bases
GCGCCAGGGAGACCCGCCATGAACAAAGACAGGCTGGGCAGCGCGCTCGACGCGCTGCTGGATCGCAGCGTGCTGCAACC
AGGCGGCGTGCCCGGCGTGG

Product: steroid monooxygenase

Products: NA

Alternate protein names: PAMO; Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MAAYSNPNAPVTRLDAVVIGAGVAGLYQLHKLRELGLNVRAYETGSGVGGTWYWNRYPGARFDSQAEIYQYWFSEDLYKA
WKPTERFPAQPETESWLNWVADRLDLRKDIRFGARIDSAHYDDTIGRWSLVTQQGETIDTQYLVCCMGMLSAPLTNRFHG
QSSFKGQIHHTALWPKEGVDLKGKRVAVVGVGATGIQVIQSIAPEVAELKVFVRTPQYMIPMRNPKYGEKEWADFAARFH
ELKARVRGTFAGFDYDFDAGPWADKTPAEREVVLQGLWEDGSLSMWLASFPEMFFDESVSFEVSEFVRRKMRERLGNDPA
LCELLIPTDYGFGTHRVPLESGYLEVYLRDNVEGVNCRATPIERIVPEGIQTSDGKVHEVDVIILAVGFDAGSGALTRMD
IRGRGGRSLKQEWSKEIRTAMGMQIHGYPNLFSTASPLAPTAALCNMPTCLQAQVEWVTDCIAYARATGKKVVEPTREFE
ESWVRHHDEVANRTLLVKTDSWYMGSNVEGKPRRLLSYAGGVGNYHRQCDEQAAMGYPGFAMR

Sequences:

>Translated_543_residues
MAAYSNPNAPVTRLDAVVIGAGVAGLYQLHKLRELGLNVRAYETGSGVGGTWYWNRYPGARFDSQAEIYQYWFSEDLYKA
WKPTERFPAQPETESWLNWVADRLDLRKDIRFGARIDSAHYDDTIGRWSLVTQQGETIDTQYLVCCMGMLSAPLTNRFHG
QSSFKGQIHHTALWPKEGVDLKGKRVAVVGVGATGIQVIQSIAPEVAELKVFVRTPQYMIPMRNPKYGEKEWADFAARFH
ELKARVRGTFAGFDYDFDAGPWADKTPAEREVVLQGLWEDGSLSMWLASFPEMFFDESVSFEVSEFVRRKMRERLGNDPA
LCELLIPTDYGFGTHRVPLESGYLEVYLRDNVEGVNCRATPIERIVPEGIQTSDGKVHEVDVIILAVGFDAGSGALTRMD
IRGRGGRSLKQEWSKEIRTAMGMQIHGYPNLFSTASPLAPTAALCNMPTCLQAQVEWVTDCIAYARATGKKVVEPTREFE
ESWVRHHDEVANRTLLVKTDSWYMGSNVEGKPRRLLSYAGGVGNYHRQCDEQAAMGYPGFAMR
>Mature_542_residues
AAYSNPNAPVTRLDAVVIGAGVAGLYQLHKLRELGLNVRAYETGSGVGGTWYWNRYPGARFDSQAEIYQYWFSEDLYKAW
KPTERFPAQPETESWLNWVADRLDLRKDIRFGARIDSAHYDDTIGRWSLVTQQGETIDTQYLVCCMGMLSAPLTNRFHGQ
SSFKGQIHHTALWPKEGVDLKGKRVAVVGVGATGIQVIQSIAPEVAELKVFVRTPQYMIPMRNPKYGEKEWADFAARFHE
LKARVRGTFAGFDYDFDAGPWADKTPAEREVVLQGLWEDGSLSMWLASFPEMFFDESVSFEVSEFVRRKMRERLGNDPAL
CELLIPTDYGFGTHRVPLESGYLEVYLRDNVEGVNCRATPIERIVPEGIQTSDGKVHEVDVIILAVGFDAGSGALTRMDI
RGRGGRSLKQEWSKEIRTAMGMQIHGYPNLFSTASPLAPTAALCNMPTCLQAQVEWVTDCIAYARATGKKVVEPTREFEE
SWVRHHDEVANRTLLVKTDSWYMGSNVEGKPRRLLSYAGGVGNYHRQCDEQAAMGYPGFAMR

Specific function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e., the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Is most efficient with phenylacetone as substrate, leading to the formation of benzyl

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503755, Length=220, Percent_Identity=29.0909090909091, Blast_Score=70, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020946 [H]

Pfam domain/function: PF00743 FMO-like [H]

EC number: =1.14.13.92 [H]

Molecular weight: Translated: 61117; Mature: 60986

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYSNPNAPVTRLDAVVIGAGVAGLYQLHKLRELGLNVRAYETGSGVGGTWYWNRYPGA
CCCCCCCCCCHHHHHEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEECCCCCC
RFDSQAEIYQYWFSEDLYKAWKPTERFPAQPETESWLNWVADRLDLRKDIRFGARIDSAH
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEECCCC
YDDTIGRWSLVTQQGETIDTQYLVCCMGMLSAPLTNRFHGQSSFKGQIHHTALWPKEGVD
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCCCEEEEEECCCCCCC
LKGKRVAVVGVGATGIQVIQSIAPEVAELKVFVRTPQYMIPMRNPKYGEKEWADFAARFH
CCCCEEEEEECCHHHHHHHHHHCCHHHHEEEEEECCCEEEECCCCCCCCHHHHHHHHHHH
ELKARVRGTFAGFDYDFDAGPWADKTPAEREVVLQGLWEDGSLSMWLASFPEMFFDESVS
HHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCC
FEVSEFVRRKMRERLGNDPALCELLIPTDYGFGTHRVPLESGYLEVYLRDNVEGVNCRAT
CHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCC
PIERIVPEGIQTSDGKVHEVDVIILAVGFDAGSGALTRMDIRGRGGRSLKQEWSKEIRTA
CHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
MGMQIHGYPNLFSTASPLAPTAALCNMPTCLQAQVEWVTDCIAYARATGKKVVEPTREFE
HCCEECCCCCHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ESWVRHHDEVANRTLLVKTDSWYMGSNVEGKPRRLLSYAGGVGNYHRQCDEQAAMGYPGF
HHHHHHHHHHHCCEEEEEECCEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
AMR
CCC
>Mature Secondary Structure 
AAYSNPNAPVTRLDAVVIGAGVAGLYQLHKLRELGLNVRAYETGSGVGGTWYWNRYPGA
CCCCCCCCCHHHHHEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEECCCCCC
RFDSQAEIYQYWFSEDLYKAWKPTERFPAQPETESWLNWVADRLDLRKDIRFGARIDSAH
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEECCCC
YDDTIGRWSLVTQQGETIDTQYLVCCMGMLSAPLTNRFHGQSSFKGQIHHTALWPKEGVD
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCCCEEEEEECCCCCCC
LKGKRVAVVGVGATGIQVIQSIAPEVAELKVFVRTPQYMIPMRNPKYGEKEWADFAARFH
CCCCEEEEEECCHHHHHHHHHHCCHHHHEEEEEECCCEEEECCCCCCCCHHHHHHHHHHH
ELKARVRGTFAGFDYDFDAGPWADKTPAEREVVLQGLWEDGSLSMWLASFPEMFFDESVS
HHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCC
FEVSEFVRRKMRERLGNDPALCELLIPTDYGFGTHRVPLESGYLEVYLRDNVEGVNCRAT
CHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCC
PIERIVPEGIQTSDGKVHEVDVIILAVGFDAGSGALTRMDIRGRGGRSLKQEWSKEIRTA
CHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
MGMQIHGYPNLFSTASPLAPTAALCNMPTCLQAQVEWVTDCIAYARATGKKVVEPTREFE
HCCEECCCCCHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ESWVRHHDEVANRTLLVKTDSWYMGSNVEGKPRRLLSYAGGVGNYHRQCDEQAAMGYPGF
HHHHHHHHHHHCCEEEEEECCEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
AMR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA