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The map label for this gene is ntrY [H]

Identifier: 124265467

GI number: 124265467

Start: 296634

End: 298979

Strand: Direct

Name: ntrY [H]

Synonym: Mpe_A0274

Alternate gene names: 124265467

Gene position: 296634-298979 (Clockwise)

Preceding gene: 124265466

Following gene: 124265468

Centisome position: 7.33

GC content: 71.27

Gene sequence:

>2346_bases
ATGACCCCGGAACGCCTGCGCCGCCGCTTGGCGCTGCTGCTCACGCGGCACTCGGACCGCCGAATCTCGCGCGGCGTCTG
GGTCGTCGCGTTGGCCGCGACCACGGCGGCGGCGCTGGTGCTCACCTTCCTGCTGGCCATCGCCACCAACAACCGGGAGT
TCTACGAGCGGTACTACAACGGTCTCCTGTGGGCCAACGTCGTGATCGCGACCGTGCTGGTCGGTGTGATCGTGGTCGGT
GCGGTGCGGCTCGCTGCGCGGGTGCTGCGCGGACGCTTCGGTTCGCGGCTGCTGCTGCGGCTCGCGGCGATCTTCGGCGT
GGTGGCGGTGGTGCCCGGGGCGCTGGTCTACACGGTGAGCTACCAGTTCGTGTCTCGCAGCATCGAGAGCTGGTTCGACG
TGCGCGTCGAGGGTGCGCTGGAGGCCGGCCTGAACCTCGGGCGCGGCACGCTCGACACACTGGTCAATGATCTCGCCGGC
AAGACGCGCGTGGCCGCCGAGCGGCTCGGCGAGGCCCCCGAGCGACAGCAGCCGCTGGCCCTGGAGCGCTTGCGGGAGCA
ACTCACGGCGCAGGACGTGGCGGTGCTCGGCGCGGCCGGCCAGGTGCTGTCGAGCGCCGGCGCCGCCGCGGTGCTGGCGC
CCGAGCGACCGGGTCTGGCTCTGCTGCGGCAGGCACGCACGGCGCGCGTGACCACGCAGATCGAGGGGCTCGACGACGAC
GGCGCTGCCACGCGCATCCCCGGCGTCTCGGTTGCCGACCAGCCTACGAGCCAGCCGCGCGTGCGCGTCATTGCCCTGAT
CCCGGCCACCGGCTTCTCGCTCAGCCGCGAGGACCGCTACCTGGTGGTGAGCCAGCTGTTGCCGGCCACGCTGGCAGCCA
ACGCGCTCGCGGTGCAGAGCGCCTACCGCGAGTACCAGCAACGCTCGCTGGCGCGCGAGGGCCTGCGCAAGATGTACATC
GGCACGCTGACGCTGACACTGATCCTTGCCGTGTTCGGCGCGATGCTGCTGGCGGTGACCTTCGGCAACCGGCTGGCGCG
TCCTCTGCTGCTGCTCGCCGACGGCGTGCGCGAGGTGGCCCGCGGAGACCTGAGCCCGAAGCCGGTGTTCGCGTCGGGCG
ACGAACTCGGCGGCCTGACGCGCTCGTTCGCCGACATGACCCAGCAACTCGCCGACGCCCGCGGCCTGGTCGAGCAGAGC
GTGGCCGAGCTCGAGACGGCGCGCGGCAAGCTGCAGGCCATCCTCGACAACATGAGCGCCGGGGTGATCGTGTTCGATCG
CGACCGTCGCATCGACAGCGTGAACGCCGGTGCGACCCGCATCCTGCGCGTGCCCTTGTCGGCCCATCTCGGCCGCGGGC
TCGCCGAAGTGCCCGGCCTCGAGGGCTTCGACGCGGCGCTGACCCGACGCTTCGACCAGATCGAGAGCGGCTCCGAACTC
GGCGACCGAGACCACTGGCAGGATTCCTTCGAACTCACGACGGCCCCCGACCGCGATCCGCTGACCCTGCTGGTGCGCGG
CGCGCCGCTGCCGGCCGGCGGCCAGGGCAGTGCCGCGCGGCTGGTGGTGTTCGACGACATCACCGAGCTCGTCTCGGCGC
AGCGCGCCGAGGCCTGGGGCGAGGTGGCGCGCCGGCTCGCGCACGAGATCAAGAACCCGCTCACGCCGATCCAGCTGTCG
GCCGAGCGCATCCAGCACCGGCTCGAAGCCAAGCTGGAGGTACCGGACCAGCAGATGCTGGCCAAGTCTGTGAGCACCAT
CGTCACCCAGGTGCAGGCGATGAAGCAGCTGGTCAACGAGTTCCGCGATTACGCCCGCCTGCCGGCGGCCCAGCTGGCGC
CGCTGGACCTCAACGCGCTGGTGTCCGAGGTGCTGGGCCTGTACGCGGAGGTGCAGGAGTCGGGCCGCCTGCGCGTCGAG
CTGGCCGAGGGACTGCCGCGGATCCAGGGCGACGCCACACAGTTGCGGCAGGTGGTGCACAACCTGGTGCAGAACGCGCT
GGACGCGGTGGCCGAGCGGCCCGACGGCCAGGTCCGGCTGCGCACCGAGGGGGCACTCAACGAGCGCGGCGAGTGGCGCG
CTGTGCGACTGGTCGTCGCCGACAACGGCCCCGGCTTCAGCGAACGCATGCTCAAGCGTGCGTTCGAGCCCTATGTGACC
ACCAAGACCAAGGGCACAGGGCTCGGGCTTGCCGTGGTCAAGAAGATCGCCGACGAGCATGGCGCGCGCATCCGCCTGGC
CAACCTCGCGGGCGACGCGGTGGCCAGGGGCGACGCGCCGTCTGTCGGGGGGGCACAAGTTTCGCTATCATTTTCGAAAT
GGCTGCCCCCTCGGGGTCAGCCTTGA

Upstream 100 bases:

>100_bases
CAGATCAGCTTCGGCGGCCAGGCCGAGTGGGCGCTCGAGGTCGAGCGACGGCTGGTCGTGCCCGCCGCGCGCTGACCCCG
GAACGCGCACGGCAGCGGCT

Downstream 100 bases:

>100_bases
GGCCACGCCGACACGGCATGTGCCACGCACCGGGACCCCATGGCGACCATCCTTGTTGTAGACGACGAACTCGGCATCCG
CGCGCTGCTGTCGGACATCC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 781; Mature: 780

Protein sequence:

>781_residues
MTPERLRRRLALLLTRHSDRRISRGVWVVALAATTAAALVLTFLLAIATNNREFYERYYNGLLWANVVIATVLVGVIVVG
AVRLAARVLRGRFGSRLLLRLAAIFGVVAVVPGALVYTVSYQFVSRSIESWFDVRVEGALEAGLNLGRGTLDTLVNDLAG
KTRVAAERLGEAPERQQPLALERLREQLTAQDVAVLGAAGQVLSSAGAAAVLAPERPGLALLRQARTARVTTQIEGLDDD
GAATRIPGVSVADQPTSQPRVRVIALIPATGFSLSREDRYLVVSQLLPATLAANALAVQSAYREYQQRSLAREGLRKMYI
GTLTLTLILAVFGAMLLAVTFGNRLARPLLLLADGVREVARGDLSPKPVFASGDELGGLTRSFADMTQQLADARGLVEQS
VAELETARGKLQAILDNMSAGVIVFDRDRRIDSVNAGATRILRVPLSAHLGRGLAEVPGLEGFDAALTRRFDQIESGSEL
GDRDHWQDSFELTTAPDRDPLTLLVRGAPLPAGGQGSAARLVVFDDITELVSAQRAEAWGEVARRLAHEIKNPLTPIQLS
AERIQHRLEAKLEVPDQQMLAKSVSTIVTQVQAMKQLVNEFRDYARLPAAQLAPLDLNALVSEVLGLYAEVQESGRLRVE
LAEGLPRIQGDATQLRQVVHNLVQNALDAVAERPDGQVRLRTEGALNERGEWRAVRLVVADNGPGFSERMLKRAFEPYVT
TKTKGTGLGLAVVKKIADEHGARIRLANLAGDAVARGDAPSVGGAQVSLSFSKWLPPRGQP

Sequences:

>Translated_781_residues
MTPERLRRRLALLLTRHSDRRISRGVWVVALAATTAAALVLTFLLAIATNNREFYERYYNGLLWANVVIATVLVGVIVVG
AVRLAARVLRGRFGSRLLLRLAAIFGVVAVVPGALVYTVSYQFVSRSIESWFDVRVEGALEAGLNLGRGTLDTLVNDLAG
KTRVAAERLGEAPERQQPLALERLREQLTAQDVAVLGAAGQVLSSAGAAAVLAPERPGLALLRQARTARVTTQIEGLDDD
GAATRIPGVSVADQPTSQPRVRVIALIPATGFSLSREDRYLVVSQLLPATLAANALAVQSAYREYQQRSLAREGLRKMYI
GTLTLTLILAVFGAMLLAVTFGNRLARPLLLLADGVREVARGDLSPKPVFASGDELGGLTRSFADMTQQLADARGLVEQS
VAELETARGKLQAILDNMSAGVIVFDRDRRIDSVNAGATRILRVPLSAHLGRGLAEVPGLEGFDAALTRRFDQIESGSEL
GDRDHWQDSFELTTAPDRDPLTLLVRGAPLPAGGQGSAARLVVFDDITELVSAQRAEAWGEVARRLAHEIKNPLTPIQLS
AERIQHRLEAKLEVPDQQMLAKSVSTIVTQVQAMKQLVNEFRDYARLPAAQLAPLDLNALVSEVLGLYAEVQESGRLRVE
LAEGLPRIQGDATQLRQVVHNLVQNALDAVAERPDGQVRLRTEGALNERGEWRAVRLVVADNGPGFSERMLKRAFEPYVT
TKTKGTGLGLAVVKKIADEHGARIRLANLAGDAVARGDAPSVGGAQVSLSFSKWLPPRGQP
>Mature_780_residues
TPERLRRRLALLLTRHSDRRISRGVWVVALAATTAAALVLTFLLAIATNNREFYERYYNGLLWANVVIATVLVGVIVVGA
VRLAARVLRGRFGSRLLLRLAAIFGVVAVVPGALVYTVSYQFVSRSIESWFDVRVEGALEAGLNLGRGTLDTLVNDLAGK
TRVAAERLGEAPERQQPLALERLREQLTAQDVAVLGAAGQVLSSAGAAAVLAPERPGLALLRQARTARVTTQIEGLDDDG
AATRIPGVSVADQPTSQPRVRVIALIPATGFSLSREDRYLVVSQLLPATLAANALAVQSAYREYQQRSLAREGLRKMYIG
TLTLTLILAVFGAMLLAVTFGNRLARPLLLLADGVREVARGDLSPKPVFASGDELGGLTRSFADMTQQLADARGLVEQSV
AELETARGKLQAILDNMSAGVIVFDRDRRIDSVNAGATRILRVPLSAHLGRGLAEVPGLEGFDAALTRRFDQIESGSELG
DRDHWQDSFELTTAPDRDPLTLLVRGAPLPAGGQGSAARLVVFDDITELVSAQRAEAWGEVARRLAHEIKNPLTPIQLSA
ERIQHRLEAKLEVPDQQMLAKSVSTIVTQVQAMKQLVNEFRDYARLPAAQLAPLDLNALVSEVLGLYAEVQESGRLRVEL
AEGLPRIQGDATQLRQVVHNLVQNALDAVAERPDGQVRLRTEGALNERGEWRAVRLVVADNGPGFSERMLKRAFEPYVTT
KTKGTGLGLAVVKKIADEHGARIRLANLAGDAVARGDAPSVGGAQVSLSFSKWLPPRGQP

Specific function: Member of the two-component regulatory system ntrY/ntrX involved in nitrogen level control. Probably activates ntrX by phosphorylation [H]

COG id: COG5000

COG function: function code T; Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=421, Percent_Identity=25.41567695962, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1790436, Length=251, Percent_Identity=31.0756972111554, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1790300, Length=228, Percent_Identity=31.5789473684211, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1789808, Length=208, Percent_Identity=27.4038461538462, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787894, Length=314, Percent_Identity=27.7070063694268, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1786600, Length=254, Percent_Identity=25.5905511811024, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR017232 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 84329; Mature: 84198

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPERLRRRLALLLTRHSDRRISRGVWVVALAATTAAALVLTFLLAIATNNREFYERYYN
CCHHHHHHHHHHHHHCCCCCHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
GLLWANVVIATVLVGVIVVGAVRLAARVLRGRFGSRLLLRLAAIFGVVAVVPGALVYTVS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
YQFVSRSIESWFDVRVEGALEAGLNLGRGTLDTLVNDLAGKTRVAAERLGEAPERQQPLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHH
LERLREQLTAQDVAVLGAAGQVLSSAGAAAVLAPERPGLALLRQARTARVTTQIEGLDDD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHEECCCCCC
GAATRIPGVSVADQPTSQPRVRVIALIPATGFSLSREDRYLVVSQLLPATLAANALAVQS
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AYREYQQRSLAREGLRKMYIGTLTLTLILAVFGAMLLAVTFGNRLARPLLLLADGVREVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGDLSPKPVFASGDELGGLTRSFADMTQQLADARGLVEQSVAELETARGKLQAILDNMSA
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVIVFDRDRRIDSVNAGATRILRVPLSAHLGRGLAEVPGLEGFDAALTRRFDQIESGSEL
CEEEEECCCCCCCCCCCCHHEEECCHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCCCCC
GDRDHWQDSFELTTAPDRDPLTLLVRGAPLPAGGQGSAARLVVFDDITELVSAQRAEAWG
CCCCCCCCCCEECCCCCCCCEEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
EVARRLAHEIKNPLTPIQLSAERIQHRLEAKLEVPDQQMLAKSVSTIVTQVQAMKQLVNE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FRDYARLPAAQLAPLDLNALVSEVLGLYAEVQESGRLRVELAEGLPRIQGDATQLRQVVH
HHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCCCCCHHHHHHHHH
NLVQNALDAVAERPDGQVRLRTEGALNERGEWRAVRLVVADNGPGFSERMLKRAFEPYVT
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCEE
TKTKGTGLGLAVVKKIADEHGARIRLANLAGDAVARGDAPSVGGAQVSLSFSKWLPPRGQ
ECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHCCCCCCCCCCCEEEEEHHHCCCCCCC
P
C
>Mature Secondary Structure 
TPERLRRRLALLLTRHSDRRISRGVWVVALAATTAAALVLTFLLAIATNNREFYERYYN
CHHHHHHHHHHHHHCCCCCHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
GLLWANVVIATVLVGVIVVGAVRLAARVLRGRFGSRLLLRLAAIFGVVAVVPGALVYTVS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
YQFVSRSIESWFDVRVEGALEAGLNLGRGTLDTLVNDLAGKTRVAAERLGEAPERQQPLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHH
LERLREQLTAQDVAVLGAAGQVLSSAGAAAVLAPERPGLALLRQARTARVTTQIEGLDDD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHEECCCCCC
GAATRIPGVSVADQPTSQPRVRVIALIPATGFSLSREDRYLVVSQLLPATLAANALAVQS
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AYREYQQRSLAREGLRKMYIGTLTLTLILAVFGAMLLAVTFGNRLARPLLLLADGVREVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGDLSPKPVFASGDELGGLTRSFADMTQQLADARGLVEQSVAELETARGKLQAILDNMSA
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVIVFDRDRRIDSVNAGATRILRVPLSAHLGRGLAEVPGLEGFDAALTRRFDQIESGSEL
CEEEEECCCCCCCCCCCCHHEEECCHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCCCCC
GDRDHWQDSFELTTAPDRDPLTLLVRGAPLPAGGQGSAARLVVFDDITELVSAQRAEAWG
CCCCCCCCCCEECCCCCCCCEEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
EVARRLAHEIKNPLTPIQLSAERIQHRLEAKLEVPDQQMLAKSVSTIVTQVQAMKQLVNE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FRDYARLPAAQLAPLDLNALVSEVLGLYAEVQESGRLRVELAEGLPRIQGDATQLRQVVH
HHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCCCCCHHHHHHHHH
NLVQNALDAVAERPDGQVRLRTEGALNERGEWRAVRLVVADNGPGFSERMLKRAFEPYVT
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCEE
TKTKGTGLGLAVVKKIADEHGARIRLANLAGDAVARGDAPSVGGAQVSLSFSKWLPPRGQ
ECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHCCCCCCCCCCCEEEEEHHHCCCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1661370 [H]