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The map label for this gene is pkn1 [H]

Identifier: 124022136

GI number: 124022136

Start: 425759

End: 426622

Strand: Reverse

Name: pkn1 [H]

Synonym: P9303_04261

Alternate gene names: 124022136

Gene position: 426622-425759 (Counterclockwise)

Preceding gene: 124022137

Following gene: 124022135

Centisome position: 15.9

GC content: 58.33

Gene sequence:

>864_bases
TTGCCAGTAGAGATGGTAACCATCCCCGCAGGGCTCTATCGGGTTGGTTGTGACCGCTGCTATCCGGATGGTTCAGTTCG
CTGCTATCCGGAGGAAGCACCCGCGCGAGAAGTGCAGCTTGACTCATTCCAGATCGACGTAGGGCCAGTCACCAATGCCC
AGTTCCGAGCTTTCGTAAGCGCTACGCAGCATCTCACAGTCTCGGAGCTGCCGCCTGATCCAACGCTCTATCCCGATCTA
CCTCCCGAGGAACGCATCCCTGAATCAGTTGTCTTTCAACCGCCTCCAGCAACGGTGGATCGCAGCAAACCCTTGAGCTG
GTGGACGCTCGTGGCTGGGGCTGACTGGCGTCACCCCCAAGGACCCGAAAGCACAATCGATGGCCTTGATGATCACCCTG
TTGTGCATGTCGCCTACGCCGACGCCATCGCCTATGCCCATTGGGCTGGCAAGCGTCTCCCCTCTGCTGAGGAGTGGGAA
GTCGCCGCCCGCGGAGGTCTTGTCGATGCCCAATACGCCTGGGGGAATGAACTCACTCCCAATAACCGCTGGATGGCGAA
CATCTGGCAAGGTCCTTTCCCTTGGCACAACGAGGAGCTAGACGGCTGGTTCTGGACCTCGCCCGTTGGCAGCTTTCCTG
CCAACGGCTATGGACTCTTGGATGTTTGCGGCAATGTGTGGGAATGGACCAACTCTGTTTATCCCGTGGCGTCAGGCCAC
CAGGAACGGCGAACTATCAAAGGCGGATCGTTTCTCTGCGCAGATAATTACTGCGTCCGCTATCGCCCCTCTGCACTTCA
AGGCCAGACAGTAGACACTGCCACCTGTCACATGGGCTTTCGCTGTGCAAAAGGAGGGCCTTGA

Upstream 100 bases:

>100_bases
TTGGGCACTCTGAATGTGCTGATGCTTAGTCATCTTGGCTTTCAGCCAACAATAAAGATGGACACATTCCCCCCTGCAAA
CTTTAATTGTGATCACATCT

Downstream 100 bases:

>100_bases
TTGCTGACTCACTTAAAGAGCATCAACCACATCACTAGGTCAAATTTCAACTGCAATCGTACGCAGTTCGCAACAAAAGA
TGAATCCAGGTCAGTCAGTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPVEMVTIPAGLYRVGCDRCYPDGSVRCYPEEAPAREVQLDSFQIDVGPVTNAQFRAFVSATQHLTVSELPPDPTLYPDL
PPEERIPESVVFQPPPATVDRSKPLSWWTLVAGADWRHPQGPESTIDGLDDHPVVHVAYADAIAYAHWAGKRLPSAEEWE
VAARGGLVDAQYAWGNELTPNNRWMANIWQGPFPWHNEELDGWFWTSPVGSFPANGYGLLDVCGNVWEWTNSVYPVASGH
QERRTIKGGSFLCADNYCVRYRPSALQGQTVDTATCHMGFRCAKGGP

Sequences:

>Translated_287_residues
MPVEMVTIPAGLYRVGCDRCYPDGSVRCYPEEAPAREVQLDSFQIDVGPVTNAQFRAFVSATQHLTVSELPPDPTLYPDL
PPEERIPESVVFQPPPATVDRSKPLSWWTLVAGADWRHPQGPESTIDGLDDHPVVHVAYADAIAYAHWAGKRLPSAEEWE
VAARGGLVDAQYAWGNELTPNNRWMANIWQGPFPWHNEELDGWFWTSPVGSFPANGYGLLDVCGNVWEWTNSVYPVASGH
QERRTIKGGSFLCADNYCVRYRPSALQGQTVDTATCHMGFRCAKGGP
>Mature_286_residues
PVEMVTIPAGLYRVGCDRCYPDGSVRCYPEEAPAREVQLDSFQIDVGPVTNAQFRAFVSATQHLTVSELPPDPTLYPDLP
PEERIPESVVFQPPPATVDRSKPLSWWTLVAGADWRHPQGPESTIDGLDDHPVVHVAYADAIAYAHWAGKRLPSAEEWEV
AARGGLVDAQYAWGNELTPNNRWMANIWQGPFPWHNEELDGWFWTSPVGSFPANGYGLLDVCGNVWEWTNSVYPVASGHQ
ERRTIKGGSFLCADNYCVRYRPSALQGQTVDTATCHMGFRCAKGGP

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI38202250, Length=296, Percent_Identity=41.8918918918919, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI257470975, Length=293, Percent_Identity=40.6143344709898, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI257470977, Length=285, Percent_Identity=41.7543859649123, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI194248088, Length=284, Percent_Identity=40.8450704225352, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI194248087, Length=284, Percent_Identity=38.0281690140845, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI226437577, Length=184, Percent_Identity=48.3695652173913, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI194248090, Length=217, Percent_Identity=40.0921658986175, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI194248084, Length=97, Percent_Identity=44.3298969072165, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130397, Length=288, Percent_Identity=42.0138888888889, Blast_Score=210, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 31841; Mature: 31710

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVEMVTIPAGLYRVGCDRCYPDGSVRCYPEEAPAREVQLDSFQIDVGPVTNAQFRAFVS
CCEEEEEECCCHHHHCCCCCCCCCCEEECCCCCCCCEEEECEEEEECCCCCCHHHHHEEH
ATQHLTVSELPPDPTLYPDLPPEERIPESVVFQPPPATVDRSKPLSWWTLVAGADWRHPQ
HHHCEEEECCCCCCCCCCCCCCHHHCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCC
GPESTIDGLDDHPVVHVAYADAIAYAHWAGKRLPSAEEWEVAARGGLVDAQYAWGNELTP
CCCHHHCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEEECCCCCCCC
NNRWMANIWQGPFPWHNEELDGWFWTSPVGSFPANGYGLLDVCGNVWEWTNSVYPVASGH
CCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCEEHHHHHCCHHHHCCCCCCCCCCC
QERRTIKGGSFLCADNYCVRYRPSALQGQTVDTATCHMGFRCAKGGP
HHHHEECCCCEEEECCEEEEECCCCCCCCCCCEEEHCCCEEECCCCC
>Mature Secondary Structure 
PVEMVTIPAGLYRVGCDRCYPDGSVRCYPEEAPAREVQLDSFQIDVGPVTNAQFRAFVS
CEEEEEECCCHHHHCCCCCCCCCCEEECCCCCCCCEEEECEEEEECCCCCCHHHHHEEH
ATQHLTVSELPPDPTLYPDLPPEERIPESVVFQPPPATVDRSKPLSWWTLVAGADWRHPQ
HHHCEEEECCCCCCCCCCCCCCHHHCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCC
GPESTIDGLDDHPVVHVAYADAIAYAHWAGKRLPSAEEWEVAARGGLVDAQYAWGNELTP
CCCHHHCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEEECCCCCCCC
NNRWMANIWQGPFPWHNEELDGWFWTSPVGSFPANGYGLLDVCGNVWEWTNSVYPVASGH
CCCEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCEEHHHHHCCHHHHCCCCCCCCCCC
QERRTIKGGSFLCADNYCVRYRPSALQGQTVDTATCHMGFRCAKGGP
HHHHEECCCCEEEECCEEEEECCCCCCCCCCCEEEHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]