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The map label for this gene is atsA [H]

Identifier: 124022137

GI number: 124022137

Start: 426729

End: 429089

Strand: Reverse

Name: atsA [H]

Synonym: P9303_04271

Alternate gene names: 124022137

Gene position: 429089-426729 (Counterclockwise)

Preceding gene: 124022143

Following gene: 124022136

Centisome position: 15.99

GC content: 48.33

Gene sequence:

>2361_bases
ATGAAATTCAGAATGCTTCTTTGGCTTGCATGTATCATAAGTTTCACAGCAACATCCGCCACCAACGCAGAAGAGATTAA
TCGCCGGCGACTTCCGATCGCAGATCCATATCCTCAGAAAGTTGACGAGCGCTTACCAAGTCAAGTCAAAATGCCACGAC
AACATGTCGTCGAGGCACCCAAAGGAGCACCCAATGTTGTTGTCATCTTGTTGGATGATGTTGGCTTTGGTGCTCCTTCG
CCCTTTGGCGGAGTGGTGCAAATGCCGGCCCTGCAGGAACTAGCAAACAATGGCCTGAGTTATAACCGATTTCATACTTC
AGCCCTATGTGCACCTACACGAGCTGCTCTTAAAGCAGGCCGTAATCACCATGTGATGAACATGGGTTCAATCCCTGAAA
TTGCGACTGGATATGCGGGCAATACCACATTTGTGCCTAACTATGCCGAACCTGTAGCCGAGATCCTAAGGCTCAATGGC
TACAACACAGGCGCTTTTGGTAAATGGCATGAAACCCCTGGTCGTGAGACCACTGCTGCGGGCCCACAAACCCGCTGGCC
AACAAGGCAAGGATTTGAAAAATTTTATGGCTTCATCGGCGCAGAAGAAAATATGTATGAGCCATCACTTCACGATGGGG
TCACAATCATTGATTACCCAGATCGAGAGGATTACCACTTCCTTGAAGACATGACAGATCAGGCTATTGCCTGGATGCGC
CAACAACAGGGACTACGCCCAGACAAGCCTTTCTTTATCTATTATGCATCTGCTGGCTCACATGCACCACACCATGTAAG
ACCTGAATGGATTAAAAAGTACAAGGGAAAGTTTGATAAGGGCTGGGATGTTATTCGAGAAGAAACGCTCGCAAATCAGA
TCGCAAAAGGTGTTGTACCCCCAAACACACAACTGGCAAAAAAACCAGCAAGTGTGCCGAACTGGGATGATCTTAGTGAT
GTACAAAAACGCATGTTTGCGCGACAAGCAGAGGTGTTCGCAGCTTTTACAGAATACACAGACTATCAAGCTGGGCGGCT
GATCCAGGCCATTGATGATCTTGGTGAACTTGACAACACGCTGGTTATTTATATCAGTGGTGATAACGGCACAAGCTCAG
AAGGGAACCAAACCGGCAACTGGAACTGGGGGCACATGTTTAACGGCATCCCTGAAACACTTGAGGCTCAGTTAGAGCAT
TATGACAATTGGGGTGATCAGAACACCTATCCACATATGGCAGTCGGCTGGGCGATTGCCTTTGATACTCCATTTGCATT
TACCAAACAAATTGCCGGGGATTTTGGCGGTACACGCAATGGCACTGTGATTCATTGGCCTGAGGCCATCAAATCAAAAG
GAGAGATACGCGATCAATTCTCCCATGTGATTGATGTTGCGCCAACGATCCTTGAAGCTGCTGGCTTACCCATGCCTGAA
CAGATCAATGGGATTGCACAAATCCCTATGCAAGGAACCAGCCTTGTTTATTCTTTTGATAACGCTGATGCACCTGAGCG
TCACAAGGTTCAATATTTTGAAGTTGTTGGTAATCGTGGAATCTATCAAGATGGCTGGATGGCAAGAGCCACCGTTGGCC
TGCCATGGGAAGCACCCAAGAAGATGCATAGCGTAGCCAAAGATGATGGATGGGAGTTATACGACACGCGCAATGATTTC
AGCCTAGCTAACAACCTGGCAACTCAGTATCCAGAACGGCTCGAGGCAATGAAACGACTCTTCTTGAAAGAAGCAATCGC
CAATCAAGTGCTCCCCTTAGATGATCGTCTGTTGCAACGTTTAGTGCCTTCTGTTGCAGGCCGGCCAACGATCATGGGCT
CGTCGAGGACACAACTTGATCTCTACCCAGGCTCCTGGGATCTTGTTGAGGATGCCATCCTCAATGTCAAGAATGTTTCC
AACAGCATTACAGCCAAGGTCGACATTGACTCAAGCCAAGATGCCAACGGCGTGATCATGGCCCAAGGGAGCCGCTTTGG
CGGATGGTCACTTTATGTAGAAGATGGTTATCCGGCCTATGCCTATAACTACCTGGGCAATCTTCATACCTTCCGCAGCA
AGGAGAAACTCTCTTCTGGTAACAGAAAAATTCGCTTTGAGATGGATTACGACGGGGGAGGCGCTGGTAAGGGTGCAGAT
GTGCGCCTGCTAGTTGATGACAAAGTCACATCAACTGGCAGGGTTGAGGCAACCGTTGGTACACGTTTTTCGATTGACGA
AGGTGCTGATGTTGGCATGGATCGTGGATCACCTGTTGCTAAAAGAGTGATTGGGGATCAGCGCTTCAGTGCTTTCAATG
GGACCATCAACAAGGTGACATTGGAGATCTATCCACAGTGA

Upstream 100 bases:

>100_bases
TGAAATTTAGCAACAAGTCGACCTGGATGCACAAACAGCTATGGACTCATCCCTGTTAAATGGTGATCAACAATAAAAAA
TCTCCCACTTCAAAGCAAAC

Downstream 100 bases:

>100_bases
CATTGGTTGGGCACTCTGAATGTGCTGATGCTTAGTCATCTTGGCTTTCAGCCAACAATAAAGATGGACACATTCCCCCC
TGCAAACTTTAATTGTGATC

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 786; Mature: 786

Protein sequence:

>786_residues
MKFRMLLWLACIISFTATSATNAEEINRRRLPIADPYPQKVDERLPSQVKMPRQHVVEAPKGAPNVVVILLDDVGFGAPS
PFGGVVQMPALQELANNGLSYNRFHTSALCAPTRAALKAGRNHHVMNMGSIPEIATGYAGNTTFVPNYAEPVAEILRLNG
YNTGAFGKWHETPGRETTAAGPQTRWPTRQGFEKFYGFIGAEENMYEPSLHDGVTIIDYPDREDYHFLEDMTDQAIAWMR
QQQGLRPDKPFFIYYASAGSHAPHHVRPEWIKKYKGKFDKGWDVIREETLANQIAKGVVPPNTQLAKKPASVPNWDDLSD
VQKRMFARQAEVFAAFTEYTDYQAGRLIQAIDDLGELDNTLVIYISGDNGTSSEGNQTGNWNWGHMFNGIPETLEAQLEH
YDNWGDQNTYPHMAVGWAIAFDTPFAFTKQIAGDFGGTRNGTVIHWPEAIKSKGEIRDQFSHVIDVAPTILEAAGLPMPE
QINGIAQIPMQGTSLVYSFDNADAPERHKVQYFEVVGNRGIYQDGWMARATVGLPWEAPKKMHSVAKDDGWELYDTRNDF
SLANNLATQYPERLEAMKRLFLKEAIANQVLPLDDRLLQRLVPSVAGRPTIMGSSRTQLDLYPGSWDLVEDAILNVKNVS
NSITAKVDIDSSQDANGVIMAQGSRFGGWSLYVEDGYPAYAYNYLGNLHTFRSKEKLSSGNRKIRFEMDYDGGGAGKGAD
VRLLVDDKVTSTGRVEATVGTRFSIDEGADVGMDRGSPVAKRVIGDQRFSAFNGTINKVTLEIYPQ

Sequences:

>Translated_786_residues
MKFRMLLWLACIISFTATSATNAEEINRRRLPIADPYPQKVDERLPSQVKMPRQHVVEAPKGAPNVVVILLDDVGFGAPS
PFGGVVQMPALQELANNGLSYNRFHTSALCAPTRAALKAGRNHHVMNMGSIPEIATGYAGNTTFVPNYAEPVAEILRLNG
YNTGAFGKWHETPGRETTAAGPQTRWPTRQGFEKFYGFIGAEENMYEPSLHDGVTIIDYPDREDYHFLEDMTDQAIAWMR
QQQGLRPDKPFFIYYASAGSHAPHHVRPEWIKKYKGKFDKGWDVIREETLANQIAKGVVPPNTQLAKKPASVPNWDDLSD
VQKRMFARQAEVFAAFTEYTDYQAGRLIQAIDDLGELDNTLVIYISGDNGTSSEGNQTGNWNWGHMFNGIPETLEAQLEH
YDNWGDQNTYPHMAVGWAIAFDTPFAFTKQIAGDFGGTRNGTVIHWPEAIKSKGEIRDQFSHVIDVAPTILEAAGLPMPE
QINGIAQIPMQGTSLVYSFDNADAPERHKVQYFEVVGNRGIYQDGWMARATVGLPWEAPKKMHSVAKDDGWELYDTRNDF
SLANNLATQYPERLEAMKRLFLKEAIANQVLPLDDRLLQRLVPSVAGRPTIMGSSRTQLDLYPGSWDLVEDAILNVKNVS
NSITAKVDIDSSQDANGVIMAQGSRFGGWSLYVEDGYPAYAYNYLGNLHTFRSKEKLSSGNRKIRFEMDYDGGGAGKGAD
VRLLVDDKVTSTGRVEATVGTRFSIDEGADVGMDRGSPVAKRVIGDQRFSAFNGTINKVTLEIYPQ
>Mature_786_residues
MKFRMLLWLACIISFTATSATNAEEINRRRLPIADPYPQKVDERLPSQVKMPRQHVVEAPKGAPNVVVILLDDVGFGAPS
PFGGVVQMPALQELANNGLSYNRFHTSALCAPTRAALKAGRNHHVMNMGSIPEIATGYAGNTTFVPNYAEPVAEILRLNG
YNTGAFGKWHETPGRETTAAGPQTRWPTRQGFEKFYGFIGAEENMYEPSLHDGVTIIDYPDREDYHFLEDMTDQAIAWMR
QQQGLRPDKPFFIYYASAGSHAPHHVRPEWIKKYKGKFDKGWDVIREETLANQIAKGVVPPNTQLAKKPASVPNWDDLSD
VQKRMFARQAEVFAAFTEYTDYQAGRLIQAIDDLGELDNTLVIYISGDNGTSSEGNQTGNWNWGHMFNGIPETLEAQLEH
YDNWGDQNTYPHMAVGWAIAFDTPFAFTKQIAGDFGGTRNGTVIHWPEAIKSKGEIRDQFSHVIDVAPTILEAAGLPMPE
QINGIAQIPMQGTSLVYSFDNADAPERHKVQYFEVVGNRGIYQDGWMARATVGLPWEAPKKMHSVAKDDGWELYDTRNDF
SLANNLATQYPERLEAMKRLFLKEAIANQVLPLDDRLLQRLVPSVAGRPTIMGSSRTQLDLYPGSWDLVEDAILNVKNVS
NSITAKVDIDSSQDANGVIMAQGSRFGGWSLYVEDGYPAYAYNYLGNLHTFRSKEKLSSGNRKIRFEMDYDGGGAGKGAD
VRLLVDDKVTSTGRVEATVGTRFSIDEGADVGMDRGSPVAKRVIGDQRFSAFNGTINKVTLEIYPQ

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI38569407, Length=234, Percent_Identity=27.7777777777778, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI38569405, Length=234, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI146229331, Length=438, Percent_Identity=24.4292237442922, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI146229329, Length=438, Percent_Identity=24.4292237442922, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI6005990, Length=438, Percent_Identity=24.4292237442922, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI146229324, Length=438, Percent_Identity=24.4292237442922, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI31742482, Length=357, Percent_Identity=25.2100840336134, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI4503899, Length=462, Percent_Identity=22.5108225108225, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI71852584, Length=353, Percent_Identity=22.9461756373938, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI157266309, Length=141, Percent_Identity=31.9148936170213, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI109389362, Length=219, Percent_Identity=25.1141552511416, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI71852586, Length=148, Percent_Identity=31.0810810810811, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI59797060, Length=217, Percent_Identity=23.963133640553, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1790233, Length=369, Percent_Identity=26.8292682926829, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281366397, Length=333, Percent_Identity=23.1231231231231, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281366395, Length=333, Percent_Identity=23.1231231231231, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24666163, Length=333, Percent_Identity=23.1231231231231, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 87454; Mature: 87454

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRMLLWLACIISFTATSATNAEEINRRRLPIADPYPQKVDERLPSQVKMPRQHVVEAP
CCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHCCHHHCCCHHHHHCCC
KGAPNVVVILLDDVGFGAPSPFGGVVQMPALQELANNGLSYNRFHTSALCAPTRAALKAG
CCCCCEEEEEEECCCCCCCCCCCCCEECHHHHHHHHCCCCCCEECCHHHCCHHHHHHHCC
RNHHVMNMGSIPEIATGYAGNTTFVPNYAEPVAEILRLNGYNTGAFGKWHETPGRETTAA
CCCEEEECCCCCHHHCCCCCCCEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GPQTRWPTRQGFEKFYGFIGAEENMYEPSLHDGVTIIDYPDREDYHFLEDMTDQAIAWMR
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCEEEEECCCCCCHHHHHHHHHHHHHHHH
QQQGLRPDKPFFIYYASAGSHAPHHVRPEWIKKYKGKFDKGWDVIREETLANQIAKGVVP
HHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
PNTQLAKKPASVPNWDDLSDVQKRMFARQAEVFAAFTEYTDYQAGRLIQAIDDLGELDNT
CCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCE
LVIYISGDNGTSSEGNQTGNWNWGHMFNGIPETLEAQLEHYDNWGDQNTYPHMAVGWAIA
EEEEEECCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEE
FDTPFAFTKQIAGDFGGTRNGTVIHWPEAIKSKGEIRDQFSHVIDVAPTILEAAGLPMPE
ECCCHHHHHHHHHHCCCCCCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
QINGIAQIPMQGTSLVYSFDNADAPERHKVQYFEVVGNRGIYQDGWMARATVGLPWEAPK
HCCCEEECCCCCCEEEEEECCCCCCCHHCEEEEEEECCCCCCCCCCEEEEEECCCCCCHH
KMHSVAKDDGWELYDTRNDFSLANNLATQYPERLEAMKRLFLKEAIANQVLPLDDRLLQR
HHHHHHCCCCCEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LVPSVAGRPTIMGSSRTQLDLYPGSWDLVEDAILNVKNVSNSITAKVDIDSSQDANGVIM
HHHHHCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEE
AQGSRFGGWSLYVEDGYPAYAYNYLGNLHTFRSKEKLSSGNRKIRFEMDYDGGGAGKGAD
ECCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCE
VRLLVDDKVTSTGRVEATVGTRFSIDEGADVGMDRGSPVAKRVIGDQRFSAFNGTINKVT
EEEEEECCCCCCCEEEEEECCEEECCCCCCCCCCCCCHHHHHHHCCHHHHHHCCCEEEEE
LEIYPQ
EEEECC
>Mature Secondary Structure
MKFRMLLWLACIISFTATSATNAEEINRRRLPIADPYPQKVDERLPSQVKMPRQHVVEAP
CCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHCCHHHCCCHHHHHCCC
KGAPNVVVILLDDVGFGAPSPFGGVVQMPALQELANNGLSYNRFHTSALCAPTRAALKAG
CCCCCEEEEEEECCCCCCCCCCCCCEECHHHHHHHHCCCCCCEECCHHHCCHHHHHHHCC
RNHHVMNMGSIPEIATGYAGNTTFVPNYAEPVAEILRLNGYNTGAFGKWHETPGRETTAA
CCCEEEECCCCCHHHCCCCCCCEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GPQTRWPTRQGFEKFYGFIGAEENMYEPSLHDGVTIIDYPDREDYHFLEDMTDQAIAWMR
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCEEEEECCCCCCHHHHHHHHHHHHHHHH
QQQGLRPDKPFFIYYASAGSHAPHHVRPEWIKKYKGKFDKGWDVIREETLANQIAKGVVP
HHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
PNTQLAKKPASVPNWDDLSDVQKRMFARQAEVFAAFTEYTDYQAGRLIQAIDDLGELDNT
CCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCE
LVIYISGDNGTSSEGNQTGNWNWGHMFNGIPETLEAQLEHYDNWGDQNTYPHMAVGWAIA
EEEEEECCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEE
FDTPFAFTKQIAGDFGGTRNGTVIHWPEAIKSKGEIRDQFSHVIDVAPTILEAAGLPMPE
ECCCHHHHHHHHHHCCCCCCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
QINGIAQIPMQGTSLVYSFDNADAPERHKVQYFEVVGNRGIYQDGWMARATVGLPWEAPK
HCCCEEECCCCCCEEEEEECCCCCCCHHCEEEEEEECCCCCCCCCCEEEEEECCCCCCHH
KMHSVAKDDGWELYDTRNDFSLANNLATQYPERLEAMKRLFLKEAIANQVLPLDDRLLQR
HHHHHHCCCCCEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LVPSVAGRPTIMGSSRTQLDLYPGSWDLVEDAILNVKNVSNSITAKVDIDSSQDANGVIM
HHHHHCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEE
AQGSRFGGWSLYVEDGYPAYAYNYLGNLHTFRSKEKLSSGNRKIRFEMDYDGGGAGKGAD
ECCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCE
VRLLVDDKVTSTGRVEATVGTRFSIDEGADVGMDRGSPVAKRVIGDQRFSAFNGTINKVT
EEEEEECCCCCCCEEEEEECCEEECCCCCCCCCCCCCHHHHHHHCCHHHHHHCCCEEEEE
LEIYPQ
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]