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The map label for this gene is pgl [H]

Identifier: 124025516

GI number: 124025516

Start: 746651

End: 747367

Strand: Direct

Name: pgl [H]

Synonym: NATL1_08091

Alternate gene names: 124025516

Gene position: 746651-747367 (Clockwise)

Preceding gene: 124025515

Following gene: 124025517

Centisome position: 40.04

GC content: 36.68

Gene sequence:

>717_bases
ATGACTAAATATGAAATTCAAGTTTCAGAGGACAAAAGCTCTCTCGCTCTTGCCGCCTCTGATTTGATAACTCAGATCAT
TGAGTCAACCTTGAAAAATAAAACCAGAGCTAAAATCTCTCTTTGTGGTGGTTCTACACCTAAAGCTGCTTATTCTTTGT
TAGGTAAAAAAAATATCGATTGGATGAATGTCGATTTGTTTCTTGGAGATGAAAGATGGGTTGACAATAAATCACAAGAA
AGTAATTGCTTTCTATTAAATAATTCATTGTTTAAAGAAGGCAACCCATCTCTAGAAGCATCATTTTTTGCTGTTTCAAC
TGTTGAGTTATCATCCCCAGACGAAAGCGCTGACGTTTACGAAACAATCTTGAAAAATAACTTTGCTGGGGATCCACCAA
GATTTGATTTGATTTTATTGGGATTGGGAGATGATGGGCACACAGCATCCCTATTTCCTGGCTCTGAGGCATTATTTGAA
AGAGATAGCTTGATAACTGCTGGCGAAGGTAAAGGTCACAAAAGAATTACTTTTACCAGTAAATTATTAAGTGCTGCAGA
TAATGTGGTCTTCCTAATCAGTGGATCTTCTAAACAAACGGCTCTTAAACGTCTACTTGATCCATCAGAATCATGGGAGA
GAACTCCTGCAAAATTAGTTGCACCAAATTCTGAAATTATTGTTTTGGCTGATAAAGATGCTTACCCATCTTTTTAG

Upstream 100 bases:

>100_bases
AAAACCTAGTTCAAGCAATGAGAGACTGTTTTGGCTCTCATACATATGAGCGCGTAGACAAGGCTGGATCATTTCATACT
GAGTGGATTGACTGATATCA

Downstream 100 bases:

>100_bases
TTAGATTATTGTATTAGTAGAGAAGTACTTTTTAATTGATTCCTGATTCACCCCCAACTGAAATTGCAATAACTCCTCTT
ATACAGGGTTCTGAATTTTC

Product: putative 6-phosphogluconolactonase (DevB, Pgl)

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MTKYEIQVSEDKSSLALAASDLITQIIESTLKNKTRAKISLCGGSTPKAAYSLLGKKNIDWMNVDLFLGDERWVDNKSQE
SNCFLLNNSLFKEGNPSLEASFFAVSTVELSSPDESADVYETILKNNFAGDPPRFDLILLGLGDDGHTASLFPGSEALFE
RDSLITAGEGKGHKRITFTSKLLSAADNVVFLISGSSKQTALKRLLDPSESWERTPAKLVAPNSEIIVLADKDAYPSF

Sequences:

>Translated_238_residues
MTKYEIQVSEDKSSLALAASDLITQIIESTLKNKTRAKISLCGGSTPKAAYSLLGKKNIDWMNVDLFLGDERWVDNKSQE
SNCFLLNNSLFKEGNPSLEASFFAVSTVELSSPDESADVYETILKNNFAGDPPRFDLILLGLGDDGHTASLFPGSEALFE
RDSLITAGEGKGHKRITFTSKLLSAADNVVFLISGSSKQTALKRLLDPSESWERTPAKLVAPNSEIIVLADKDAYPSF
>Mature_237_residues
TKYEIQVSEDKSSLALAASDLITQIIESTLKNKTRAKISLCGGSTPKAAYSLLGKKNIDWMNVDLFLGDERWVDNKSQES
NCFLLNNSLFKEGNPSLEASFFAVSTVELSSPDESADVYETILKNNFAGDPPRFDLILLGLGDDGHTASLFPGSEALFER
DSLITAGEGKGHKRITFTSKLLSAADNVVFLISGSSKQTALKRLLDPSESWERTPAKLVAPNSEIIVLADKDAYPSF

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912586, Length=233, Percent_Identity=31.3304721030043, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI52145310, Length=239, Percent_Identity=27.6150627615063, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115533060, Length=254, Percent_Identity=30.7086614173228, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI115533058, Length=254, Percent_Identity=30.7086614173228, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324362, Length=188, Percent_Identity=32.9787234042553, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319918, Length=190, Percent_Identity=30.5263157894737, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321687, Length=224, Percent_Identity=31.25, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321957, Length=217, Percent_Identity=27.6497695852535, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24641119, Length=203, Percent_Identity=29.064039408867, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 25931; Mature: 25800

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYEIQVSEDKSSLALAASDLITQIIESTLKNKTRAKISLCGGSTPKAAYSLLGKKNID
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCC
WMNVDLFLGDERWVDNKSQESNCFLLNNSLFKEGNPSLEASFFAVSTVELSSPDESADVY
EEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEEEEEEECCCCCHHHHH
ETILKNNFAGDPPRFDLILLGLGDDGHTASLFPGSEALFERDSLITAGEGKGHKRITFTS
HHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCHHHHCCCCEEEECCCCCCEEEEEHH
KLLSAADNVVFLISGSSKQTALKRLLDPSESWERTPAKLVAPNSEIIVLADKDAYPSF
HHHHCCCCEEEEEECCCHHHHHHHHCCCCCHHCCCCCEEECCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
TKYEIQVSEDKSSLALAASDLITQIIESTLKNKTRAKISLCGGSTPKAAYSLLGKKNID
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCC
WMNVDLFLGDERWVDNKSQESNCFLLNNSLFKEGNPSLEASFFAVSTVELSSPDESADVY
EEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEEEEEEECCCCCHHHHH
ETILKNNFAGDPPRFDLILLGLGDDGHTASLFPGSEALFERDSLITAGEGKGHKRITFTS
HHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCHHHHCCCCEEEECCCCCCEEEEEHH
KLLSAADNVVFLISGSSKQTALKRLLDPSESWERTPAKLVAPNSEIIVLADKDAYPSF
HHHHCCCCEEEEEECCCHHHHHHHHCCCCCHHCCCCCEEECCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]