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The map label for this gene is gnd [H]

Identifier: 124025515

GI number: 124025515

Start: 745227

End: 746645

Strand: Direct

Name: gnd [H]

Synonym: NATL1_08081

Alternate gene names: 124025515

Gene position: 745227-746645 (Clockwise)

Preceding gene: 124025514

Following gene: 124025516

Centisome position: 39.96

GC content: 40.94

Gene sequence:

>1419_bases
ATGACCAAGGCACATTTCGGATTAGTCGGTCTTGGAGTAATGGGGGAGAACCTTGTACTTAATGCAGAGCGAAATGGTTT
TTCCAGTGTGGTTTATAACCGTACTTATCAAAAAACGGAAGACTTTCTGTTAGGTAGAGGTGTAAATAAATCAATTCAAG
GAGCAAAGGATCTTCAAGAATTTGTATCAAAGCTGGAACGTCCAAGAAGAGTATTAATGATGGTTAAAGCTGGAGCTGCT
ACTGATGCTGTCATTAATCAAATTTCACCTTTCCTCGAGGAGGGTGATTTGCTCATAGATGGTGGAAATGCCCAATTTAT
GGATACAGAAAGAAGAGTAAAAGAACTTGAGAGCAAGAGTTTTGGATATATCGGTATGGGAGTATCAGGTGGGGCGAAGG
GTGCATTGGAAGGACCTAGCATGATGCCGGGTGGAACAAAGACTTCTTACGACGCTATAGAGAGTTTGTTAAATAAAATG
GCTGCTCAGGTTGAAGATGGACCTTGTGTGACATACATCGGCCCAGGGGGGTCAGGCCATTTTGTCAAGACCGTTCACAA
TGGAATTGAATATGGTATCGAGCAAATTTTGGCTGAGGCCTATGACTTGATGAAGAGAGTTTGTGGAATGAGTGGTGATG
AGATGGCATCTGTTATGGGCTATTGGAATAAAACCGAAGAACTTTCCTCTTATCTCGTTGAAATCACAGAGGCTTGTTTA
CGTGTTAAGGATCCTGATGATAGTTCTGATCTGGTTGAAAAGATAATGGATAAAGCGGGTCAAAAAGGTACTGGATTATG
GACAGTCGTTAGTGCATTAGAGCTTGGAGCTTCTGTTCCAACTATTTATGCCTCTTTAAACGGAAGGGTTATGAGTTCAA
TGAAAGATCAAAGAAATTATGCAGAAACAATACTTAATGGGAACAAACCTTCTTTTGTTGATTTTGGAAAGCCTTCCGAT
GGCATGCCACTCCTTATGGATGCCGTTGTATTGGCTACAATAGCTAGCTATGCCCAAGGTATGGATATTTTACGACTAGC
TTCTGAAGAATATGATTACGATCTTGATATGCCCTCCATTGCTCAAATATGGAAAGGTGGTTGCATAATAAGGTCAACCC
TTTTGAGTCGTATACAAGATGCATTTAAGAAAGATCCAAGCCTGACCAATCTAATTATCGATAAATGGTTTACCGATCAG
GTAAATAATCGTCTCTCTGGCCTGACACAGGTCGTTTCTGCTGCTGCTAATGCTGGAATTCCAGTTCCATGTTTAAGTAG
TACTCTTGATTATCTAAATAGCTTCAGAACATCTAGACTTCCCCAAAACCTAGTTCAAGCAATGAGAGACTGTTTTGGCT
CTCATACATATGAGCGCGTAGACAAGGCTGGATCATTTCATACTGAGTGGATTGACTGA

Upstream 100 bases:

>100_bases
TATTTTTCAAAGAATTGTTCATTCCTGACATTGAGCTATTTAATGCAGCGAAATGAATCCATAGTCGTCACACTAATTTA
AGTAGAAATTTATTAACTTA

Downstream 100 bases:

>100_bases
TATCAATGACTAAATATGAAATTCAAGTTTCAGAGGACAAAAGCTCTCTCGCTCTTGCCGCCTCTGATTTGATAACTCAG
ATCATTGAGTCAACCTTGAA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MTKAHFGLVGLGVMGENLVLNAERNGFSSVVYNRTYQKTEDFLLGRGVNKSIQGAKDLQEFVSKLERPRRVLMMVKAGAA
TDAVINQISPFLEEGDLLIDGGNAQFMDTERRVKELESKSFGYIGMGVSGGAKGALEGPSMMPGGTKTSYDAIESLLNKM
AAQVEDGPCVTYIGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVCGMSGDEMASVMGYWNKTEELSSYLVEITEACL
RVKDPDDSSDLVEKIMDKAGQKGTGLWTVVSALELGASVPTIYASLNGRVMSSMKDQRNYAETILNGNKPSFVDFGKPSD
GMPLLMDAVVLATIASYAQGMDILRLASEEYDYDLDMPSIAQIWKGGCIIRSTLLSRIQDAFKKDPSLTNLIIDKWFTDQ
VNNRLSGLTQVVSAAANAGIPVPCLSSTLDYLNSFRTSRLPQNLVQAMRDCFGSHTYERVDKAGSFHTEWID

Sequences:

>Translated_472_residues
MTKAHFGLVGLGVMGENLVLNAERNGFSSVVYNRTYQKTEDFLLGRGVNKSIQGAKDLQEFVSKLERPRRVLMMVKAGAA
TDAVINQISPFLEEGDLLIDGGNAQFMDTERRVKELESKSFGYIGMGVSGGAKGALEGPSMMPGGTKTSYDAIESLLNKM
AAQVEDGPCVTYIGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVCGMSGDEMASVMGYWNKTEELSSYLVEITEACL
RVKDPDDSSDLVEKIMDKAGQKGTGLWTVVSALELGASVPTIYASLNGRVMSSMKDQRNYAETILNGNKPSFVDFGKPSD
GMPLLMDAVVLATIASYAQGMDILRLASEEYDYDLDMPSIAQIWKGGCIIRSTLLSRIQDAFKKDPSLTNLIIDKWFTDQ
VNNRLSGLTQVVSAAANAGIPVPCLSSTLDYLNSFRTSRLPQNLVQAMRDCFGSHTYERVDKAGSFHTEWID
>Mature_471_residues
TKAHFGLVGLGVMGENLVLNAERNGFSSVVYNRTYQKTEDFLLGRGVNKSIQGAKDLQEFVSKLERPRRVLMMVKAGAAT
DAVINQISPFLEEGDLLIDGGNAQFMDTERRVKELESKSFGYIGMGVSGGAKGALEGPSMMPGGTKTSYDAIESLLNKMA
AQVEDGPCVTYIGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVCGMSGDEMASVMGYWNKTEELSSYLVEITEACLR
VKDPDDSSDLVEKIMDKAGQKGTGLWTVVSALELGASVPTIYASLNGRVMSSMKDQRNYAETILNGNKPSFVDFGKPSDG
MPLLMDAVVLATIASYAQGMDILRLASEEYDYDLDMPSIAQIWKGGCIIRSTLLSRIQDAFKKDPSLTNLIIDKWFTDQV
NNRLSGLTQVVSAAANAGIPVPCLSSTLDYLNSFRTSRLPQNLVQAMRDCFGSHTYERVDKAGSFHTEWID

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=45.5508474576271, Blast_Score=409, Evalue=1e-114,
Organism=Escherichia coli, GI1788341, Length=473, Percent_Identity=47.1458773784355, Blast_Score=447, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17542558, Length=474, Percent_Identity=42.4050632911392, Blast_Score=395, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6321695, Length=476, Percent_Identity=43.6974789915966, Blast_Score=412, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321977, Length=484, Percent_Identity=44.0082644628099, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24639279, Length=471, Percent_Identity=43.312101910828, Blast_Score=387, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51466; Mature: 51335

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKAHFGLVGLGVMGENLVLNAERNGFSSVVYNRTYQKTEDFLLGRGVNKSIQGAKDLQE
CCCCCCCCEECCCCCCCEEEECCCCCHHHHHHHCHHHHHHHHHHCCCCCHHHCCHHHHHH
FVSKLERPRRVLMMVKAGAATDAVINQISPFLEEGDLLIDGGNAQFMDTERRVKELESKS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCEECHHHHHHHHHHCC
FGYIGMGVSGGAKGALEGPSMMPGGTKTSYDAIESLLNKMAAQVEDGPCVTYIGPGGSGH
CCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
FVKTVHNGIEYGIEQILAEAYDLMKRVCGMSGDEMASVMGYWNKTEELSSYLVEITEACL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RVKDPDDSSDLVEKIMDKAGQKGTGLWTVVSALELGASVPTIYASLNGRVMSSMKDQRNY
HCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHH
AETILNGNKPSFVDFGKPSDGMPLLMDAVVLATIASYAQGMDILRLASEEYDYDLDMPSI
HHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHH
AQIWKGGCIIRSTLLSRIQDAFKKDPSLTNLIIDKWFTDQVNNRLSGLTQVVSAAANAGI
HHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PVPCLSSTLDYLNSFRTSRLPQNLVQAMRDCFGSHTYERVDKAGSFHTEWID
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TKAHFGLVGLGVMGENLVLNAERNGFSSVVYNRTYQKTEDFLLGRGVNKSIQGAKDLQE
CCCCCCCEECCCCCCCEEEECCCCCHHHHHHHCHHHHHHHHHHCCCCCHHHCCHHHHHH
FVSKLERPRRVLMMVKAGAATDAVINQISPFLEEGDLLIDGGNAQFMDTERRVKELESKS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCEECHHHHHHHHHHCC
FGYIGMGVSGGAKGALEGPSMMPGGTKTSYDAIESLLNKMAAQVEDGPCVTYIGPGGSGH
CCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
FVKTVHNGIEYGIEQILAEAYDLMKRVCGMSGDEMASVMGYWNKTEELSSYLVEITEACL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RVKDPDDSSDLVEKIMDKAGQKGTGLWTVVSALELGASVPTIYASLNGRVMSSMKDQRNY
HCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHH
AETILNGNKPSFVDFGKPSDGMPLLMDAVVLATIASYAQGMDILRLASEEYDYDLDMPSI
HHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHH
AQIWKGGCIIRSTLLSRIQDAFKKDPSLTNLIIDKWFTDQVNNRLSGLTQVVSAAANAGI
HHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PVPCLSSTLDYLNSFRTSRLPQNLVQAMRDCFGSHTYERVDKAGSFHTEWID
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2113917 [H]