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The map label for this gene is thrS

Identifier: 124025364

GI number: 124025364

Start: 598216

End: 600138

Strand: Reverse

Name: thrS

Synonym: NATL1_06531

Alternate gene names: 124025364

Gene position: 600138-598216 (Counterclockwise)

Preceding gene: 124025365

Following gene: 124025363

Centisome position: 32.18

GC content: 33.54

Gene sequence:

>1923_bases
ATGCCAATAATTACTTTACCTGATGGTAGTGAAAAGAACTATGAATCATCAGTAACCATTGAAAAAATAGCCACAGATAT
TGGTCCTGGTTTAGCAAAAGCAGCACTAGCGGGAAGAGTCAACGGTAATCTTTTGGATACATGTATTCCAATTACAAATG
ATGCCGAAATACAAATAATCACATCAAAGGATAATGAAGGTTTAGAAATTATTAGACATTCATTCGCTCACCTTCTCGGT
CACGCAGTAAAGCAGCTATATCCTGAGGCCAAAATGGCAATTGGCCCTGTCATTGAGGATGGTTTTTATTATGATATTTC
ATACAAAGATACATTTACTCCAGTAGATTTGGAGAAGATTGAAAAAAGGATAAAAGAACTTATAAATAAAGATTATGATG
TAGATGTAGAAGTCGTTTCTCCTGCAAAAGCAACACAAGTTTTCTCAGAAAGAGGTGAAGTATTCAAGCTAGATATAATT
AAAAATATACCGAAAGATGAAATTATAAAACTATATAAACATGAAGAATATATTGATATGTGCAGAGGACCTCACGTCCC
AAACACAAGGCATCTAAGAGCTTTTAAATTAATGAAAGTTTCTGGTGCATATTGGCGAGGAGATTCTAACAATGAAATGC
TTCAAAGAATATATGGAACAGCTTGGAAGAATTCTAAAGAATTAAAAGAATACATTAATAGAATTGAAGAAGCAGAAAAA
AGAGATCATAGAAAGTTGGGTAAAAAACTATCACTTTTCCACTTTCAAGAAGAAGCACCAGGAATGATTTTCTGGCATCC
AAATGGTTGGACTATTTATAGAGTTTTACAAGATTTTATTCGGGAAACGATTTCAAAATATGATTATCAAGAATTAAAAT
CACCTCAGATAGTTTGTAGAAGTTTATGGGAGAAATCTGGACATTGGGATAAATTTAAGGAGGACATGTTTACTACTACA
TCTGAGAATAAAGAATATGCTATAAAACCAATGAATTGTCCATGTCATGTACAAGTATTTAATCAAGGTTTAAAAAGCTA
TCGTGATCTTCCAATAAGACTTTCAGAGTTTGGATCTTGTCATAGGAATGAACCATCTGGAGCTCTACATGGATTAATGA
GAGTAAGAAACTTTGTTCAAGATGATGGACATATTTTCTGCACTAATGAACAAATACAAGAAGAAGTTCAAAGCTTTATT
GATCTTGTTTTTGAAGTCTATAAAGCCTTTGGTTTCAATTCAATTCTTATTAAACTCTCAACAAGACCAGAGAAAAGAGT
TGGAAGCGATGATGTATGGGACAAATCAGAAAAAGCGCTTTCAGATGCTCTAGATTCAAAAGGATTAGATTGGTCTTTAC
TGCCTGGAGAAGGGGCTTTCTATGGTCCAAAAATTGAATTCTCCCTCAAAGATTGTCTTAATAGAGTCTGGCAATGTGGG
ACAATTCAAGTAGATTTCTCAATGCCTGAAAGGCTAAATTCAAGCTACATAGATGTTGATGGGAAGAAACAACCCCCTGT
CATGTTGCATAGAGCAATTTTAGGTTCATTTGAGAGATTTATTGGTATTTTAATTGAGAACTATTCTGGGAACTTGCCCA
TATGGTTATGCCCACTTCAAATCGTAGTAATGGGGATAACTGACAGAAATAATGATGCATGCTTGGATACTAAATCTAAA
TTAATAAAATATGGTTTTAGAGCTTCTGTTGACACAAGGAATGAAAAAGTGGGATTTAAGATAAGAGAGCATACAATGCA
AAGAATACCTTTCTTGATAATTATTGGAGATAAAGAAGAAGAGAATAATGAAATCTCGGTAAGAACACGTGAGGGAAAAG
ATCTTGGTAAAATGACTTTGGATAAGTTCAAAGTTATAATGGATGAATCAATCAGCAAAAAGAGTTTGGTTGAGAGTAAA
TAA

Upstream 100 bases:

>100_bases
AATACTAAATAAAGGCAAACTGACTGCCGAGGAGGTTTCTAAGTTAACATTAAAGAGAGTTAAAGATGCTCTTGGATTTT
ATTCAACTCTATAGACGATT

Downstream 100 bases:

>100_bases
TAATTAAAGAAATTTCATAAATAATGAATTTACTTGCTGGAGACCTTGGGGGAACTAAAACAATATTAGCTATTTATTCA
AACGAGAACTATCCAAAAAA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MPIITLPDGSEKNYESSVTIEKIATDIGPGLAKAALAGRVNGNLLDTCIPITNDAEIQIITSKDNEGLEIIRHSFAHLLG
HAVKQLYPEAKMAIGPVIEDGFYYDISYKDTFTPVDLEKIEKRIKELINKDYDVDVEVVSPAKATQVFSERGEVFKLDII
KNIPKDEIIKLYKHEEYIDMCRGPHVPNTRHLRAFKLMKVSGAYWRGDSNNEMLQRIYGTAWKNSKELKEYINRIEEAEK
RDHRKLGKKLSLFHFQEEAPGMIFWHPNGWTIYRVLQDFIRETISKYDYQELKSPQIVCRSLWEKSGHWDKFKEDMFTTT
SENKEYAIKPMNCPCHVQVFNQGLKSYRDLPIRLSEFGSCHRNEPSGALHGLMRVRNFVQDDGHIFCTNEQIQEEVQSFI
DLVFEVYKAFGFNSILIKLSTRPEKRVGSDDVWDKSEKALSDALDSKGLDWSLLPGEGAFYGPKIEFSLKDCLNRVWQCG
TIQVDFSMPERLNSSYIDVDGKKQPPVMLHRAILGSFERFIGILIENYSGNLPIWLCPLQIVVMGITDRNNDACLDTKSK
LIKYGFRASVDTRNEKVGFKIREHTMQRIPFLIIIGDKEEENNEISVRTREGKDLGKMTLDKFKVIMDESISKKSLVESK

Sequences:

>Translated_640_residues
MPIITLPDGSEKNYESSVTIEKIATDIGPGLAKAALAGRVNGNLLDTCIPITNDAEIQIITSKDNEGLEIIRHSFAHLLG
HAVKQLYPEAKMAIGPVIEDGFYYDISYKDTFTPVDLEKIEKRIKELINKDYDVDVEVVSPAKATQVFSERGEVFKLDII
KNIPKDEIIKLYKHEEYIDMCRGPHVPNTRHLRAFKLMKVSGAYWRGDSNNEMLQRIYGTAWKNSKELKEYINRIEEAEK
RDHRKLGKKLSLFHFQEEAPGMIFWHPNGWTIYRVLQDFIRETISKYDYQELKSPQIVCRSLWEKSGHWDKFKEDMFTTT
SENKEYAIKPMNCPCHVQVFNQGLKSYRDLPIRLSEFGSCHRNEPSGALHGLMRVRNFVQDDGHIFCTNEQIQEEVQSFI
DLVFEVYKAFGFNSILIKLSTRPEKRVGSDDVWDKSEKALSDALDSKGLDWSLLPGEGAFYGPKIEFSLKDCLNRVWQCG
TIQVDFSMPERLNSSYIDVDGKKQPPVMLHRAILGSFERFIGILIENYSGNLPIWLCPLQIVVMGITDRNNDACLDTKSK
LIKYGFRASVDTRNEKVGFKIREHTMQRIPFLIIIGDKEEENNEISVRTREGKDLGKMTLDKFKVIMDESISKKSLVESK
>Mature_639_residues
PIITLPDGSEKNYESSVTIEKIATDIGPGLAKAALAGRVNGNLLDTCIPITNDAEIQIITSKDNEGLEIIRHSFAHLLGH
AVKQLYPEAKMAIGPVIEDGFYYDISYKDTFTPVDLEKIEKRIKELINKDYDVDVEVVSPAKATQVFSERGEVFKLDIIK
NIPKDEIIKLYKHEEYIDMCRGPHVPNTRHLRAFKLMKVSGAYWRGDSNNEMLQRIYGTAWKNSKELKEYINRIEEAEKR
DHRKLGKKLSLFHFQEEAPGMIFWHPNGWTIYRVLQDFIRETISKYDYQELKSPQIVCRSLWEKSGHWDKFKEDMFTTTS
ENKEYAIKPMNCPCHVQVFNQGLKSYRDLPIRLSEFGSCHRNEPSGALHGLMRVRNFVQDDGHIFCTNEQIQEEVQSFID
LVFEVYKAFGFNSILIKLSTRPEKRVGSDDVWDKSEKALSDALDSKGLDWSLLPGEGAFYGPKIEFSLKDCLNRVWQCGT
IQVDFSMPERLNSSYIDVDGKKQPPVMLHRAILGSFERFIGILIENYSGNLPIWLCPLQIVVMGITDRNNDACLDTKSKL
IKYGFRASVDTRNEKVGFKIREHTMQRIPFLIIIGDKEEENNEISVRTREGKDLGKMTLDKFKVIMDESISKKSLVESK

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=614, Percent_Identity=40.0651465798046, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI38202255, Length=623, Percent_Identity=39.4863563402889, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI20070344, Length=638, Percent_Identity=35.423197492163, Blast_Score=400, Evalue=1e-111,
Organism=Escherichia coli, GI1788013, Length=637, Percent_Identity=59.8116169544741, Blast_Score=843, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=644, Percent_Identity=40.3726708074534, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71984192, Length=644, Percent_Identity=40.3726708074534, Blast_Score=490, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6322112, Length=628, Percent_Identity=37.2611464968153, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322654, Length=408, Percent_Identity=37.9901960784314, Blast_Score=300, Evalue=5e-82,
Organism=Drosophila melanogaster, GI24583842, Length=639, Percent_Identity=38.9671361502347, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI28574141, Length=639, Percent_Identity=38.9671361502347, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24583839, Length=636, Percent_Identity=38.8364779874214, Blast_Score=478, Evalue=1e-135,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_PROM1 (A2C155)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014480.1
- ProteinModelPortal:   A2C155
- SMR:   A2C155
- STRING:   A2C155
- GeneID:   4781239
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_06531
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   FIRETIS
- ProtClustDB:   PRK00413
- BioCyc:   PMAR167555:NATL1_06531-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73609; Mature: 73478

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIITLPDGSEKNYESSVTIEKIATDIGPGLAKAALAGRVNGNLLDTCIPITNDAEIQII
CCEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCEEHHEECCCCCCEEEEE
TSKDNEGLEIIRHSFAHLLGHAVKQLYPEAKMAIGPVIEDGFYYDISYKDTFTPVDLEKI
ECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEECCCEEEEEECCCCCCCCCHHHH
EKRIKELINKDYDVDVEVVSPAKATQVFSERGEVFKLDIIKNIPKDEIIKLYKHEEYIDM
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCEEEEHHHHCCCHHHHHHHHHHHHHHHH
CRGPHVPNTRHLRAFKLMKVSGAYWRGDSNNEMLQRIYGTAWKNSKELKEYINRIEEAEK
HCCCCCCCCCCHHHEEEEEECCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKLGKKLSLFHFQEEAPGMIFWHPNGWTIYRVLQDFIRETISKYDYQELKSPQIVCR
HHHHHHCCHHHHEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHCCHHHHHH
SLWEKSGHWDKFKEDMFTTTSENKEYAIKPMNCPCHVQVFNQGLKSYRDLPIRLSEFGSC
HHHHCCCCHHHHHHHHHCCCCCCCCEEEECCCCCEEHHHHHHHHHHHCCCCEEHHHHCCC
HRNEPSGALHGLMRVRNFVQDDGHIFCTNEQIQEEVQSFIDLVFEVYKAFGFNSILIKLS
CCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
TRPEKRVGSDDVWDKSEKALSDALDSKGLDWSLLPGEGAFYGPKIEFSLKDCLNRVWQCG
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEHHHHHHHHHCCC
TIQVDFSMPERLNSSYIDVDGKKQPPVMLHRAILGSFERFIGILIENYSGNLPIWLCPLQ
EEEEECCCHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECEE
IVVMGITDRNNDACLDTKSKLIKYGFRASVDTRNEKVGFKIREHTMQRIPFLIIIGDKEE
EEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCEEEEECCCCC
ENNEISVRTREGKDLGKMTLDKFKVIMDESISKKSLVESK
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure 
PIITLPDGSEKNYESSVTIEKIATDIGPGLAKAALAGRVNGNLLDTCIPITNDAEIQII
CEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCEEHHEECCCCCCEEEEE
TSKDNEGLEIIRHSFAHLLGHAVKQLYPEAKMAIGPVIEDGFYYDISYKDTFTPVDLEKI
ECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEECCCEEEEEECCCCCCCCCHHHH
EKRIKELINKDYDVDVEVVSPAKATQVFSERGEVFKLDIIKNIPKDEIIKLYKHEEYIDM
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCEEEEHHHHCCCHHHHHHHHHHHHHHHH
CRGPHVPNTRHLRAFKLMKVSGAYWRGDSNNEMLQRIYGTAWKNSKELKEYINRIEEAEK
HCCCCCCCCCCHHHEEEEEECCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKLGKKLSLFHFQEEAPGMIFWHPNGWTIYRVLQDFIRETISKYDYQELKSPQIVCR
HHHHHHCCHHHHEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHCCHHHHHH
SLWEKSGHWDKFKEDMFTTTSENKEYAIKPMNCPCHVQVFNQGLKSYRDLPIRLSEFGSC
HHHHCCCCHHHHHHHHHCCCCCCCCEEEECCCCCEEHHHHHHHHHHHCCCCEEHHHHCCC
HRNEPSGALHGLMRVRNFVQDDGHIFCTNEQIQEEVQSFIDLVFEVYKAFGFNSILIKLS
CCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
TRPEKRVGSDDVWDKSEKALSDALDSKGLDWSLLPGEGAFYGPKIEFSLKDCLNRVWQCG
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEHHHHHHHHHCCC
TIQVDFSMPERLNSSYIDVDGKKQPPVMLHRAILGSFERFIGILIENYSGNLPIWLCPLQ
EEEEECCCHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECEE
IVVMGITDRNNDACLDTKSKLIKYGFRASVDTRNEKVGFKIREHTMQRIPFLIIIGDKEE
EEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCEEEEECCCCC
ENNEISVRTREGKDLGKMTLDKFKVIMDESISKKSLVESK
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA