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The map label for this gene is trpS [H]

Identifier: 124025365

GI number: 124025365

Start: 600145

End: 601158

Strand: Reverse

Name: trpS [H]

Synonym: NATL1_06541

Alternate gene names: 124025365

Gene position: 601158-600145 (Counterclockwise)

Preceding gene: 124025366

Following gene: 124025364

Centisome position: 32.24

GC content: 35.4

Gene sequence:

>1014_bases
GTGAATCAGAAGAGAGTCTTATCTGGTGTTCAACCCACAGGCGATGTTCATATTGGTAATTGGCTTGGAGCAATAAGAAA
TTGGGTTGAATTACAAGAAAATTATGAAACATTTGTATGCGTTGTTGATCTTCATGCGATAACGACTCCGCATGACCCAA
AATCTCTTCATCAAAATTCTTTATCTACAGCGGCTTTGTATATCGCTTGTGGGATGAATCCTGATAAATGCTCAATATTC
ATTCAAAGTCAGATAAGCGCACATAGCGAGCTTTGCTGGATATTAAATTGCTTAACTCCTTTAAACTGGATGGAGAGAAT
GATTCAGTTCAAGGAAAAGTCAATTAAACAAGGCGATAATGTATCTATTGGATTATTAGATTATCCAGTCCTTATGGCAG
CGGATATTCTTCTCTATGACGCTGATTTGGTTCCTGTTGGAGAAGATCAAAAGCAACATCTAGAGCTTGCGAGAGATATT
GCTTCTCAACGAGTTAATTCAAAATTTGGAACACAAGAGAATCCAATACTTAAAGTTCCAAATCCCTTAATTTTGAAAGA
GTGTTCCAAAGTCATGAGTCTGACAGACGGAACAAAGAAAATGAGTAAAAGCGACCCAAATGAAAATAGTAGGATTACTT
TATTAGACAGTCCAGATGTAATTACTAAAAAAATAAAACGTGCAAAAACCGACTCAGAATTAGGATTAGAATTCGGAAAT
CCTTCAAGACCTGAAGCTGATAATCTTTTAACAATTTATTCTATAATTTCCGGCCTAGGCAGAGAAAAAGCAGCTGAGTA
TTGTGCAGAAATGGGCTGGGGTAAATTCAAACCAGAATTTACAGAGGCAATGATTAATGTTCTTAAACCTATTCAAGAAA
AATATAAAGAACTAATGAATGATCCAGAAGAGTTAAAAAGAATACTAAATAAAGGCAAACTGACTGCCGAGGAGGTTTCT
AAGTTAACATTAAAGAGAGTTAAAGATGCTCTTGGATTTTATTCAACTCTATAG

Upstream 100 bases:

>100_bases
AAACAACGTTGCTCAAGATCCTGCAGAAAAAGATAATGATCAAGCAACAGAAGCAAGTTCAAATGAAGATGATTCCACAA
ATACAAGCGAGCAAGGATAA

Downstream 100 bases:

>100_bases
ACGATTATGCCAATAATTACTTTACCTGATGGTAGTGAAAAGAACTATGAATCATCAGTAACCATTGAAAAAATAGCCAC
AGATATTGGTCCTGGTTTAG

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MNQKRVLSGVQPTGDVHIGNWLGAIRNWVELQENYETFVCVVDLHAITTPHDPKSLHQNSLSTAALYIACGMNPDKCSIF
IQSQISAHSELCWILNCLTPLNWMERMIQFKEKSIKQGDNVSIGLLDYPVLMAADILLYDADLVPVGEDQKQHLELARDI
ASQRVNSKFGTQENPILKVPNPLILKECSKVMSLTDGTKKMSKSDPNENSRITLLDSPDVITKKIKRAKTDSELGLEFGN
PSRPEADNLLTIYSIISGLGREKAAEYCAEMGWGKFKPEFTEAMINVLKPIQEKYKELMNDPEELKRILNKGKLTAEEVS
KLTLKRVKDALGFYSTL

Sequences:

>Translated_337_residues
MNQKRVLSGVQPTGDVHIGNWLGAIRNWVELQENYETFVCVVDLHAITTPHDPKSLHQNSLSTAALYIACGMNPDKCSIF
IQSQISAHSELCWILNCLTPLNWMERMIQFKEKSIKQGDNVSIGLLDYPVLMAADILLYDADLVPVGEDQKQHLELARDI
ASQRVNSKFGTQENPILKVPNPLILKECSKVMSLTDGTKKMSKSDPNENSRITLLDSPDVITKKIKRAKTDSELGLEFGN
PSRPEADNLLTIYSIISGLGREKAAEYCAEMGWGKFKPEFTEAMINVLKPIQEKYKELMNDPEELKRILNKGKLTAEEVS
KLTLKRVKDALGFYSTL
>Mature_337_residues
MNQKRVLSGVQPTGDVHIGNWLGAIRNWVELQENYETFVCVVDLHAITTPHDPKSLHQNSLSTAALYIACGMNPDKCSIF
IQSQISAHSELCWILNCLTPLNWMERMIQFKEKSIKQGDNVSIGLLDYPVLMAADILLYDADLVPVGEDQKQHLELARDI
ASQRVNSKFGTQENPILKVPNPLILKECSKVMSLTDGTKKMSKSDPNENSRITLLDSPDVITKKIKRAKTDSELGLEFGN
PSRPEADNLLTIYSIISGLGREKAAEYCAEMGWGKFKPEFTEAMINVLKPIQEKYKELMNDPEELKRILNKGKLTAEEVS
KLTLKRVKDALGFYSTL

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=333, Percent_Identity=40.5405405405405, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI41352700, Length=170, Percent_Identity=51.7647058823529, Blast_Score=188, Evalue=6e-48,
Organism=Escherichia coli, GI1789786, Length=335, Percent_Identity=45.3731343283582, Blast_Score=298, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI71982800, Length=336, Percent_Identity=34.5238095238095, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71982793, Length=336, Percent_Identity=34.5238095238095, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6320474, Length=352, Percent_Identity=37.7840909090909, Blast_Score=205, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24666151, Length=333, Percent_Identity=39.9399399399399, Blast_Score=247, Evalue=7e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 37851; Mature: 37851

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQKRVLSGVQPTGDVHIGNWLGAIRNWVELQENYETFVCVVDLHAITTPHDPKSLHQNS
CCCHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHC
LSTAALYIACGMNPDKCSIFIQSQISAHSELCWILNCLTPLNWMERMIQFKEKSIKQGDN
HHHEEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCC
VSIGLLDYPVLMAADILLYDADLVPVGEDQKQHLELARDIASQRVNSKFGTQENPILKVP
CEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
NPLILKECSKVMSLTDGTKKMSKSDPNENSRITLLDSPDVITKKIKRAKTDSELGLEFGN
CHHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCHHCCCCCCC
PSRPEADNLLTIYSIISGLGREKAAEYCAEMGWGKFKPEFTEAMINVLKPIQEKYKELMN
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
DPEELKRILNKGKLTAEEVSKLTLKRVKDALGFYSTL
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNQKRVLSGVQPTGDVHIGNWLGAIRNWVELQENYETFVCVVDLHAITTPHDPKSLHQNS
CCCHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHC
LSTAALYIACGMNPDKCSIFIQSQISAHSELCWILNCLTPLNWMERMIQFKEKSIKQGDN
HHHEEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCC
VSIGLLDYPVLMAADILLYDADLVPVGEDQKQHLELARDIASQRVNSKFGTQENPILKVP
CEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
NPLILKECSKVMSLTDGTKKMSKSDPNENSRITLLDSPDVITKKIKRAKTDSELGLEFGN
CHHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCHHCCCCCCC
PSRPEADNLLTIYSIISGLGREKAAEYCAEMGWGKFKPEFTEAMINVLKPIQEKYKELMN
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
DPEELKRILNKGKLTAEEVSKLTLKRVKDALGFYSTL
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]