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The map label for this gene is thrB

Identifier: 124025362

GI number: 124025362

Start: 596190

End: 597137

Strand: Reverse

Name: thrB

Synonym: NATL1_06511

Alternate gene names: 124025362

Gene position: 597137-596190 (Counterclockwise)

Preceding gene: 124025363

Following gene: 124025361

Centisome position: 32.02

GC content: 45.25

Gene sequence:

>948_bases
ATGGGGCCGCCAAAAATAGGACAAACTGTCGTAGTAGAAGTTCCTTCTACTACAGCCAATATTGGTCCAGGGTTTGATTG
CCTTGGTGCAGCATTAGATCTTTCCAATCAGTTCACTATTAAAAGAATTGAGGGTAATGCTGAAAGGTTTGAATTAATAA
TGGAAAGTACTGAAGGTAATCATTTAAGAGGCGGCCCTGAGAATCTTTTTTATCGAGCCGCGCAAAGAGTTTGGAGAACT
GCAGGTGTTGAGCCTGTTGCTCTTGAAGCAAGAGTAAAACTGGCAGTACCTCCCGCAAGAGGACTTGGAAGCAGTGCTAC
GGCAATCGTGGCAGGGCTAGTTGGAGCAAATGCACTTGCTGGATATCCTTTACCTAAGGAAAAATTATTGGAGCTGGCAA
TAGATATAGAAGGTCATCCAGACAATGTTGTTCCATCATTAATAGGAGGTCTTTGCGTAACAGCTAAAACTGCAACCGAC
AGATGGCGAGTGGTCCGCTGTGATTGGGATCAATCAATAAAAGCGGTAGTTGCAATTCCATCTATTCGCCTTAGTACAAG
CGAAGCGAGACGTGTAATGCCCGAGAATATTCCAGTCAATGATGCAGTAATCAATTTAGGTGCGCTTACTCTTCTGCTTC
AAGGACTAAGGACTGGAAATGAGGATTTAATTGCAGATGGTATGCATGACAAGCTTCATGAACCCTACAGATGGGGTTTG
ATCAAAGGTGGGTTAGAGGTAAGAGAAGCAGCAAAGGCTGCCGGAGCTTTAGGATGTGCAATTAGTGGAGCAGGACCAAG
CATTCTTGCCTTGTGCAAAGCGACTAAAGGCCGAGAAGTCAGTGTCGCGATGGTCAAAGCTTGGGAAGCTGCTGGTGTAG
CAAGTCGTGCTCCTTTAATGAGCCTCCAGCTCACAGGAAGCGAATGCATTTCAAACACTTTTGGGTAG

Upstream 100 bases:

>100_bases
TGATTGTTCTTAAAGATCCAGAAGCGACATTATTCAGTTCAGCTTGCAGAGCACGCTTAAGTGCCGAATCAAATGGGAGA
CTTAGCTAAAGGATAAAAAC

Downstream 100 bases:

>100_bases
TTCTACTCATGAAAACGAAAAAAAACTGATAGCTTTATGGCTGACTTGCCCCAAATTATGGATGCCAATCTGCCTATGAG
TATTGATTCTCAGACGGTAT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MGPPKIGQTVVVEVPSTTANIGPGFDCLGAALDLSNQFTIKRIEGNAERFELIMESTEGNHLRGGPENLFYRAAQRVWRT
AGVEPVALEARVKLAVPPARGLGSSATAIVAGLVGANALAGYPLPKEKLLELAIDIEGHPDNVVPSLIGGLCVTAKTATD
RWRVVRCDWDQSIKAVVAIPSIRLSTSEARRVMPENIPVNDAVINLGALTLLLQGLRTGNEDLIADGMHDKLHEPYRWGL
IKGGLEVREAAKAAGALGCAISGAGPSILALCKATKGREVSVAMVKAWEAAGVASRAPLMSLQLTGSECISNTFG

Sequences:

>Translated_315_residues
MGPPKIGQTVVVEVPSTTANIGPGFDCLGAALDLSNQFTIKRIEGNAERFELIMESTEGNHLRGGPENLFYRAAQRVWRT
AGVEPVALEARVKLAVPPARGLGSSATAIVAGLVGANALAGYPLPKEKLLELAIDIEGHPDNVVPSLIGGLCVTAKTATD
RWRVVRCDWDQSIKAVVAIPSIRLSTSEARRVMPENIPVNDAVINLGALTLLLQGLRTGNEDLIADGMHDKLHEPYRWGL
IKGGLEVREAAKAAGALGCAISGAGPSILALCKATKGREVSVAMVKAWEAAGVASRAPLMSLQLTGSECISNTFG
>Mature_314_residues
GPPKIGQTVVVEVPSTTANIGPGFDCLGAALDLSNQFTIKRIEGNAERFELIMESTEGNHLRGGPENLFYRAAQRVWRTA
GVEPVALEARVKLAVPPARGLGSSATAIVAGLVGANALAGYPLPKEKLLELAIDIEGHPDNVVPSLIGGLCVTAKTATDR
WRVVRCDWDQSIKAVVAIPSIRLSTSEARRVMPENIPVNDAVINLGALTLLLQGLRTGNEDLIADGMHDKLHEPYRWGLI
KGGLEVREAAKAAGALGCAISGAGPSILALCKATKGREVSVAMVKAWEAAGVASRAPLMSLQLTGSECISNTFG

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=286, Percent_Identity=31.8181818181818, Blast_Score=115, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6321814, Length=336, Percent_Identity=32.4404761904762, Blast_Score=146, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_PROM1 (A2C153)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014478.1
- ProteinModelPortal:   A2C153
- SMR:   A2C153
- STRING:   A2C153
- GeneID:   4779655
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_06511
- eggNOG:   COG0083
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- ProtClustDB:   PRK01212
- BioCyc:   PMAR167555:NATL1_06511-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 33097; Mature: 32965

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPPKIGQTVVVEVPSTTANIGPGFDCLGAALDLSNQFTIKRIEGNAERFELIMESTEGN
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCC
HLRGGPENLFYRAAQRVWRTAGVEPVALEARVKLAVPPARGLGSSATAIVAGLVGANALA
CCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHC
GYPLPKEKLLELAIDIEGHPDNVVPSLIGGLCVTAKTATDRWRVVRCDWDQSIKAVVAIP
CCCCCHHHHEEEEEECCCCCCCHHHHHHCCEEEEEECCCCCEEEEEECCCCCCEEEEEEC
SIRLSTSEARRVMPENIPVNDAVINLGALTLLLQGLRTGNEDLIADGMHDKLHEPYRWGL
CEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHEECCCHHHHCCCCEEEE
IKGGLEVREAAKAAGALGCAISGAGPSILALCKATKGREVSVAMVKAWEAAGVASRAPLM
ECCCHHHHHHHHHHHHHEEEECCCCHHHHHEECCCCCCEEEEEEEEHHHHCCCCCCCCEE
SLQLTGSECISNTFG
EEEECCHHHHHCCCC
>Mature Secondary Structure 
GPPKIGQTVVVEVPSTTANIGPGFDCLGAALDLSNQFTIKRIEGNAERFELIMESTEGN
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCC
HLRGGPENLFYRAAQRVWRTAGVEPVALEARVKLAVPPARGLGSSATAIVAGLVGANALA
CCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHC
GYPLPKEKLLELAIDIEGHPDNVVPSLIGGLCVTAKTATDRWRVVRCDWDQSIKAVVAIP
CCCCCHHHHEEEEEECCCCCCCHHHHHHCCEEEEEECCCCCEEEEEECCCCCCEEEEEEC
SIRLSTSEARRVMPENIPVNDAVINLGALTLLLQGLRTGNEDLIADGMHDKLHEPYRWGL
CEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHEECCCHHHHCCCCEEEE
IKGGLEVREAAKAAGALGCAISGAGPSILALCKATKGREVSVAMVKAWEAAGVASRAPLM
ECCCHHHHHHHHHHHHHEEEECCCCHHHHHEECCCCCCEEEEEEEEHHHHCCCCCCCCEE
SLQLTGSECISNTFG
EEEECCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA