Click here to switch to the map view.

The map label for this gene is ndhD1 [H]

Identifier: 124025361

GI number: 124025361

Start: 594579

End: 596153

Strand: Reverse

Name: ndhD1 [H]

Synonym: NATL1_06501

Alternate gene names: 124025361

Gene position: 596153-594579 (Counterclockwise)

Preceding gene: 124025362

Following gene: 124025360

Centisome position: 31.97

GC content: 38.67

Gene sequence:

>1575_bases
ATGGCTGACTTGCCCCAAATTATGGATGCCAATCTGCCTATGAGTATTGATTCTCAGACGGTATTTCCATGGCTCTCACT
CATTGTGCTCCTTCCCATAGTTGGAGCATTGATAATGCCTTTCCTCCCAACGCAAGAAAGTAAAAATTTTAATCTTCCGA
GAAATATAGCCCTAGTAATTTTATTAGCCGATTTTCTAATAGTTGTATTGGCTTTTGCCAATTTATTTGATCCAAATAGC
GAAAGCTTGCAGTTGGTCGAAAGACTTCAGTGGCTTCCGTCTATAGGACTTGAATGGTCACTGGGAGTAGATGGAATATC
CGCTCCGCTTGTAGTCCTAAGCGGGCTAATCACTTTTTTGTCCGCAGCTGCAAGTTGGAAAGTAAAACAAAAAACAAGGC
TTTACTTTGCTCTATTACTTATACAAGCTTCAGCCCAAGCTTTAGTTTTCCTATCGCAAGATTTCTTGCTATTCTTTTTA
GCTTGGGAGCTTGAGCTAGTTCCAGTCTATCTTTTGATTGCTATTTGGGGAGGCAAAAGGAAACTCTATGCAGCAACAAA
ATTCATTCTTTACACCGCACTTGCTTCCCTTTTGATATTAATTAGTGGGCTTGCTTTAGCTCTTTCTGGAGATCAATTCA
CTTTCAATTTAAGTGAAATTGCAGCCAAATCCTTTACCGGGAATTTTGGGATATTTTGTTATTTAGGTTTTTTAATTGGT
TTTGGAGTAAAGCTTCCTATCTTTCCACTTCATACCTGGCTGCCCGATGCTCATGGGGAGGCAAATGCACCGGTTTCAAT
GCTATTAGCTGGTGTTTTATTAAAAATGGGAGGTTACGCTCTTATAAGATTTAACGTCCAAATTTTACCTGATACTCATT
TAATACTTGCTCCAGCTCTAATAATCATTGGGATAGTAAATATTATTTATGGAGCTCTAAATGCTTTTGCACAAGACAAT
GTAAAAAGGCGCATCGCTTGCAGTTCTGTGAGTCACATGGGTTTTGTTCTTGTTGGAATTGGCGCAGTTAATGCACTTGG
AATCAGTGGAGCGATGCTCCAAATGATTAGCCATGGACTGATTGCTGCCGCAATGTTTTTTGTTACTGGAAGTTTTTATG
AAAGAACCAATACTCTTTCAATCCCTAACATGGGCGGTTTAGCAAAGGCTTTACCAATTACTTTCGCATTCTTCTTGGCC
AGTTCTTTAGCGTCACTTGCCTTACCAGGGATGAGTGGATTTATAAGTGAAATCACAGTTTTTCTAGGCATCACCAGTCA
AGAAGGATTCACTTCTTTATTTAGAGCGATAACAATTCTTTTAGCAGCTATCGGACTGGTTTTAACTCCTATCTACCTTC
TTTCAATGTGTAGAAGAGTATTTTTTGGTCCTAGAATCCCTGCATTATCCATAGTAAAAGAAATGGATGCTAGAGAGCTT
TCAATAGGTTTAAGCCTCTTAGTTCCTACATTAGTAATAGGTTTTTGGCCAAGAATAGCTATTGATTTATATGAGGTATC
AACAAATGCTCTCGCACAATCATTAATTACCAATAACCTTGTACCAATCAGTTAG

Upstream 100 bases:

>100_bases
TCGTGCTCCTTTAATGAGCCTCCAGCTCACAGGAAGCGAATGCATTTCAAACACTTTTGGGTAGTTCTACTCATGAAAAC
GAAAAAAAACTGATAGCTTT

Downstream 100 bases:

>100_bases
TTTTTGAATCTTAAAAATGACTTCAATAAAGCCAACAGCTCTATTAAAAGGTGAAGGACTTCCTGATTACGATAAAATCA
CCCCTAACGAGATCACGGAA

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MADLPQIMDANLPMSIDSQTVFPWLSLIVLLPIVGALIMPFLPTQESKNFNLPRNIALVILLADFLIVVLAFANLFDPNS
ESLQLVERLQWLPSIGLEWSLGVDGISAPLVVLSGLITFLSAAASWKVKQKTRLYFALLLIQASAQALVFLSQDFLLFFL
AWELELVPVYLLIAIWGGKRKLYAATKFILYTALASLLILISGLALALSGDQFTFNLSEIAAKSFTGNFGIFCYLGFLIG
FGVKLPIFPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALIRFNVQILPDTHLILAPALIIIGIVNIIYGALNAFAQDN
VKRRIACSSVSHMGFVLVGIGAVNALGISGAMLQMISHGLIAAAMFFVTGSFYERTNTLSIPNMGGLAKALPITFAFFLA
SSLASLALPGMSGFISEITVFLGITSQEGFTSLFRAITILLAAIGLVLTPIYLLSMCRRVFFGPRIPALSIVKEMDAREL
SIGLSLLVPTLVIGFWPRIAIDLYEVSTNALAQSLITNNLVPIS

Sequences:

>Translated_524_residues
MADLPQIMDANLPMSIDSQTVFPWLSLIVLLPIVGALIMPFLPTQESKNFNLPRNIALVILLADFLIVVLAFANLFDPNS
ESLQLVERLQWLPSIGLEWSLGVDGISAPLVVLSGLITFLSAAASWKVKQKTRLYFALLLIQASAQALVFLSQDFLLFFL
AWELELVPVYLLIAIWGGKRKLYAATKFILYTALASLLILISGLALALSGDQFTFNLSEIAAKSFTGNFGIFCYLGFLIG
FGVKLPIFPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALIRFNVQILPDTHLILAPALIIIGIVNIIYGALNAFAQDN
VKRRIACSSVSHMGFVLVGIGAVNALGISGAMLQMISHGLIAAAMFFVTGSFYERTNTLSIPNMGGLAKALPITFAFFLA
SSLASLALPGMSGFISEITVFLGITSQEGFTSLFRAITILLAAIGLVLTPIYLLSMCRRVFFGPRIPALSIVKEMDAREL
SIGLSLLVPTLVIGFWPRIAIDLYEVSTNALAQSLITNNLVPIS
>Mature_523_residues
ADLPQIMDANLPMSIDSQTVFPWLSLIVLLPIVGALIMPFLPTQESKNFNLPRNIALVILLADFLIVVLAFANLFDPNSE
SLQLVERLQWLPSIGLEWSLGVDGISAPLVVLSGLITFLSAAASWKVKQKTRLYFALLLIQASAQALVFLSQDFLLFFLA
WELELVPVYLLIAIWGGKRKLYAATKFILYTALASLLILISGLALALSGDQFTFNLSEIAAKSFTGNFGIFCYLGFLIGF
GVKLPIFPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALIRFNVQILPDTHLILAPALIIIGIVNIIYGALNAFAQDNV
KRRIACSSVSHMGFVLVGIGAVNALGISGAMLQMISHGLIAAAMFFVTGSFYERTNTLSIPNMGGLAKALPITFAFFLAS
SLASLALPGMSGFISEITVFLGITSQEGFTSLFRAITILLAAIGLVLTPIYLLSMCRRVFFGPRIPALSIVKEMDARELS
IGLSLLVPTLVIGFWPRIAIDLYEVSTNALAQSLITNNLVPIS

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=372, Percent_Identity=29.5698924731183, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI251831117, Length=278, Percent_Identity=29.4964028776978, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1788613, Length=516, Percent_Identity=35.077519379845, Blast_Score=268, Evalue=9e-73,
Organism=Escherichia coli, GI1788827, Length=288, Percent_Identity=28.4722222222222, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788831, Length=288, Percent_Identity=29.8611111111111, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788829, Length=409, Percent_Identity=25.1833740831296, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1788614, Length=460, Percent_Identity=25.6521739130435, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI2367154, Length=253, Percent_Identity=29.2490118577075, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI145693160, Length=388, Percent_Identity=28.8659793814433, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 56641; Mature: 56510

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLPQIMDANLPMSIDSQTVFPWLSLIVLLPIVGALIMPFLPTQESKNFNLPRNIALVI
CCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
LLADFLIVVLAFANLFDPNSESLQLVERLQWLPSIGLEWSLGVDGISAPLVVLSGLITFL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHH
SAAASWKVKQKTRLYFALLLIQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIWGGKR
HHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KLYAATKFILYTALASLLILISGLALALSGDQFTFNLSEIAAKSFTGNFGIFCYLGFLIG
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHH
FGVKLPIFPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALIRFNVQILPDTHLILAPAL
CCCCCCCEEHHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEECCCCHHHHHHHH
IIIGIVNIIYGALNAFAQDNVKRRIACSSVSHMGFVLVGIGAVNALGISGAMLQMISHGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IAAAMFFVTGSFYERTNTLSIPNMGGLAKALPITFAFFLASSLASLALPGMSGFISEITV
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FLGITSQEGFTSLFRAITILLAAIGLVLTPIYLLSMCRRVFFGPRIPALSIVKEMDAREL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHH
SIGLSLLVPTLVIGFWPRIAIDLYEVSTNALAQSLITNNLVPIS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ADLPQIMDANLPMSIDSQTVFPWLSLIVLLPIVGALIMPFLPTQESKNFNLPRNIALVI
CCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
LLADFLIVVLAFANLFDPNSESLQLVERLQWLPSIGLEWSLGVDGISAPLVVLSGLITFL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHH
SAAASWKVKQKTRLYFALLLIQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIWGGKR
HHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KLYAATKFILYTALASLLILISGLALALSGDQFTFNLSEIAAKSFTGNFGIFCYLGFLIG
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHH
FGVKLPIFPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALIRFNVQILPDTHLILAPAL
CCCCCCCEEHHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEECCCCHHHHHHHH
IIIGIVNIIYGALNAFAQDNVKRRIACSSVSHMGFVLVGIGAVNALGISGAMLQMISHGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IAAAMFFVTGSFYERTNTLSIPNMGGLAKALPITFAFFLASSLASLALPGMSGFISEITV
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FLGITSQEGFTSLFRAITILLAAIGLVLTPIYLLSMCRRVFFGPRIPALSIVKEMDAREL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHH
SIGLSLLVPTLVIGFWPRIAIDLYEVSTNALAQSLITNNLVPIS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA