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The map label for this gene is proA

Identifier: 124025357

GI number: 124025357

Start: 590149

End: 591465

Strand: Direct

Name: proA

Synonym: NATL1_06461

Alternate gene names: 124025357

Gene position: 590149-591465 (Clockwise)

Preceding gene: 124025356

Following gene: 124025358

Centisome position: 31.65

GC content: 37.21

Gene sequence:

>1317_bases
ATGAGTACAAACTTTTCAGTTCCTGAGCCTACCCCCCAGCTAGTAAAAGTAGCCGAGAGTGCAAAAGAGGCTTCTATTTC
GCTTGGTCAATCCACAAACAAACAACGGTGTGAGGCTTTGACTGAAATGGCAAATGCTTTGAATGATAATGCTGATGAAA
TATTAAAAGCAAATGTTCAAGACCTTGAAAGGTCAGAAAAAGAAGGGTTGAATAAGTCACTTCTATCAAGACTTCAGTTA
ACAAAAACTAAACTCAAAGGATGCATAGACGGAGTCCTCAAAGTTTCAAATCTTGCAGATCCAATAGGTAAAAGACAACT
TCATAGGGAATTGGATGAAAACCTTATTCTTGAGAGAGTGACAGTTCCATTAGGAGTCTTAGGAGTGATATTTGAGTCGA
GGCCAGATGCATTAATACAAATAGCGTCTCTTGCAGTTCGTTCTGGTAATGGAGCTTTATTAAAAGGAGGAAGTGAAGCA
AAAGACACAAATCAATCAATAATGGATTCTCTTGATAAAGGATTAAGAAAATCAAATGTGGGTTCAGGAGCGTTGTCTTT
GCTTACCACACGTCAAGAAAGTCTAGGCTTACTACGTTTAGATAAGTTTGTGAATTTGATAATACCTAGAGGTAGCAATG
AGTTGGTTCAATTTATTCAAGAAAATACTCGTATCCCTGTCTTAGGGCACGCTGATGGAATTTGCCATTTATATGTGGAT
AATTCTGTAGATATTGATAAGGCTATAAGCATAGCTTTAGATAGTAAGATTCAGTATCCTGCTGCTTGTAACGCAATTGA
GACATTATTAATTCATGAAGATGTTGCCGAGATGTTTTTGAAGAAAGGCTTGCCAATTTTTTCAAGTGAAGGAGTTACTC
TAAAGGGAGATACAAAGAGTCAAGCTTTAGGGGTAAAAAATAAGGCTGATGAATCAGACTGGTCTAAAGAATATCTTGAT
TTAATTCTTTCAATAAAAATTGTTCGTAATGTAAACGAAGCTATTGAACATATTCGTAAATATAGCTCTCGACATACAGA
GGCAATAGTTACTGAAGACAAGATGGTTGCTGAAAAATTTTTAAGTTCGGTTGATAGTGCAGGTGTTTATCATAATTGCT
CTACTCGTTTTGCTGATGGTTTCCGATATGGGTTTGGAGCTGAAGTTGGTATAAGCACACAGACTCTTCCACCAAGAGGA
CCAGTTGGATTGGAAGGCTTAGTTACCTATCGCTATTATCTCAGAGGTGATGGTGATCTCGTTAAGGACTTCGCTTCTGG
AGATAGAAGTTTTTCTCATATTGATCTACCATTATGA

Upstream 100 bases:

>100_bases
AGATAGATTTTTATCTTCTTTTATTGCTTGATTAGCCATTAAAGGAATATTTTAAAGATAGTGAAAAATTATCTTTGATT
AAATAGTTGATCTAAATCAA

Downstream 100 bases:

>100_bases
GTCAACTTCATAATTTAAGCGCAATTCATATCAAAGATATTAATCTATGGGCTCATGTAGGTGTTTTAGAAAGTGAGCGA
ATACATGGTCAAAGATTTCT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSTNFSVPEPTPQLVKVAESAKEASISLGQSTNKQRCEALTEMANALNDNADEILKANVQDLERSEKEGLNKSLLSRLQL
TKTKLKGCIDGVLKVSNLADPIGKRQLHRELDENLILERVTVPLGVLGVIFESRPDALIQIASLAVRSGNGALLKGGSEA
KDTNQSIMDSLDKGLRKSNVGSGALSLLTTRQESLGLLRLDKFVNLIIPRGSNELVQFIQENTRIPVLGHADGICHLYVD
NSVDIDKAISIALDSKIQYPAACNAIETLLIHEDVAEMFLKKGLPIFSSEGVTLKGDTKSQALGVKNKADESDWSKEYLD
LILSIKIVRNVNEAIEHIRKYSSRHTEAIVTEDKMVAEKFLSSVDSAGVYHNCSTRFADGFRYGFGAEVGISTQTLPPRG
PVGLEGLVTYRYYLRGDGDLVKDFASGDRSFSHIDLPL

Sequences:

>Translated_438_residues
MSTNFSVPEPTPQLVKVAESAKEASISLGQSTNKQRCEALTEMANALNDNADEILKANVQDLERSEKEGLNKSLLSRLQL
TKTKLKGCIDGVLKVSNLADPIGKRQLHRELDENLILERVTVPLGVLGVIFESRPDALIQIASLAVRSGNGALLKGGSEA
KDTNQSIMDSLDKGLRKSNVGSGALSLLTTRQESLGLLRLDKFVNLIIPRGSNELVQFIQENTRIPVLGHADGICHLYVD
NSVDIDKAISIALDSKIQYPAACNAIETLLIHEDVAEMFLKKGLPIFSSEGVTLKGDTKSQALGVKNKADESDWSKEYLD
LILSIKIVRNVNEAIEHIRKYSSRHTEAIVTEDKMVAEKFLSSVDSAGVYHNCSTRFADGFRYGFGAEVGISTQTLPPRG
PVGLEGLVTYRYYLRGDGDLVKDFASGDRSFSHIDLPL
>Mature_437_residues
STNFSVPEPTPQLVKVAESAKEASISLGQSTNKQRCEALTEMANALNDNADEILKANVQDLERSEKEGLNKSLLSRLQLT
KTKLKGCIDGVLKVSNLADPIGKRQLHRELDENLILERVTVPLGVLGVIFESRPDALIQIASLAVRSGNGALLKGGSEAK
DTNQSIMDSLDKGLRKSNVGSGALSLLTTRQESLGLLRLDKFVNLIIPRGSNELVQFIQENTRIPVLGHADGICHLYVDN
SVDIDKAISIALDSKIQYPAACNAIETLLIHEDVAEMFLKKGLPIFSSEGVTLKGDTKSQALGVKNKADESDWSKEYLDL
ILSIKIVRNVNEAIEHIRKYSSRHTEAIVTEDKMVAEKFLSSVDSAGVYHNCSTRFADGFRYGFGAEVGISTQTLPPRGP
VGLEGLVTYRYYLRGDGDLVKDFASGDRSFSHIDLPL

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=443, Percent_Identity=44.4695259593679, Blast_Score=342, Evalue=5e-94,
Organism=Homo sapiens, GI21361368, Length=443, Percent_Identity=44.4695259593679, Blast_Score=342, Evalue=5e-94,
Organism=Escherichia coli, GI1786438, Length=407, Percent_Identity=40.04914004914, Blast_Score=308, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI17569967, Length=429, Percent_Identity=44.2890442890443, Blast_Score=346, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI17569969, Length=429, Percent_Identity=44.2890442890443, Blast_Score=346, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6324899, Length=446, Percent_Identity=44.6188340807175, Blast_Score=366, Evalue=1e-102,
Organism=Drosophila melanogaster, GI21357643, Length=435, Percent_Identity=45.7471264367816, Blast_Score=343, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_PROM1 (A2C148)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014473.1
- ProteinModelPortal:   A2C148
- SMR:   A2C148
- STRING:   A2C148
- GeneID:   4779251
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_06461
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- BioCyc:   PMAR167555:NATL1_06461-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 47821; Mature: 47690

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNFSVPEPTPQLVKVAESAKEASISLGQSTNKQRCEALTEMANALNDNADEILKANVQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCHH
DLERSEKEGLNKSLLSRLQLTKTKLKGCIDGVLKVSNLADPIGKRQLHRELDENLILERV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
TVPLGVLGVIFESRPDALIQIASLAVRSGNGALLKGGSEAKDTNQSIMDSLDKGLRKSNV
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCC
GSGALSLLTTRQESLGLLRLDKFVNLIIPRGSNELVQFIQENTRIPVLGHADGICHLYVD
CCHHHHHHHHHHHHCCHHHHHHHHHEECCCCCHHHHHHHHHCCCCEEEECCCCEEEEEEC
NSVDIDKAISIALDSKIQYPAACNAIETLLIHEDVAEMFLKKGLPIFSSEGVTLKGDTKS
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCH
QALGVKNKADESDWSKEYLDLILSIKIVRNVNEAIEHIRKYSSRHTEAIVTEDKMVAEKF
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHH
LSSVDSAGVYHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYRYYLRGDGDL
HHHHHCCCCCCCCCHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEEEECCHHH
VKDFASGDRSFSHIDLPL
HHHHHCCCCCCCEECCCC
>Mature Secondary Structure 
STNFSVPEPTPQLVKVAESAKEASISLGQSTNKQRCEALTEMANALNDNADEILKANVQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCHH
DLERSEKEGLNKSLLSRLQLTKTKLKGCIDGVLKVSNLADPIGKRQLHRELDENLILERV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
TVPLGVLGVIFESRPDALIQIASLAVRSGNGALLKGGSEAKDTNQSIMDSLDKGLRKSNV
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCC
GSGALSLLTTRQESLGLLRLDKFVNLIIPRGSNELVQFIQENTRIPVLGHADGICHLYVD
CCHHHHHHHHHHHHCCHHHHHHHHHEECCCCCHHHHHHHHHCCCCEEEECCCCEEEEEEC
NSVDIDKAISIALDSKIQYPAACNAIETLLIHEDVAEMFLKKGLPIFSSEGVTLKGDTKS
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCH
QALGVKNKADESDWSKEYLDLILSIKIVRNVNEAIEHIRKYSSRHTEAIVTEDKMVAEKF
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHH
LSSVDSAGVYHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYRYYLRGDGDL
HHHHHCCCCCCCCCHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEEEECCHHH
VKDFASGDRSFSHIDLPL
HHHHHCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA