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The map label for this gene is hemH

Identifier: 124025293

GI number: 124025293

Start: 527646

End: 528821

Strand: Direct

Name: hemH

Synonym: NATL1_05821

Alternate gene names: 124025293

Gene position: 527646-528821 (Clockwise)

Preceding gene: 124025287

Following gene: 124025294

Centisome position: 28.3

GC content: 38.35

Gene sequence:

>1176_bases
ATGGCTCGGGTTGGTGTCCTCTTATTAAATCTCGGAGGTCCTGAGAGGATTAAAGACGTGGGACCATTTTTGTATAATTT
ATTTTCTGATCCAGAGATAATTCGTTTACCAGTGCGTGCTTTTCAAAAACCTCTGGCTTGGCTTATAAGCTTATTAAGAA
GTAGTAAATCACAAGAGGCTTATAGATCAATTGGAGGTGGATCACCTTTGCGTCGTATTACAGAGCAACAGGCAAGAGAA
CTCCAAAGCTATCTTAGAAATATAGGAATAGACGCTACAACATATGTCGCAATGAGGTATTGGCATCCATTTACTGAGTC
AGCTGTAGCGGATATGAAGGCTGACGGTGTTAGCGAAGTTGTTGTTTTACCTCTTTATCCCCATTTTTCAATAAGTACAA
GTGGATCCAGCTTTAGAGAATTGAAAAGGTTAAAAGATAGTGACGATGAGTTTGCAGAATTATCAATTCGTTGTATCCGA
AGCTGGTTTGATCATCCAGCCTATGTCTCTTCAATGGCTGAATTAATAAAGAAGCAAATCTTAGCTTGTGATTTACCCCA
AGAGTCCCACGTTTTTTTTACTGCACATGGTGTTCCTAAAAGCTATGTAGAAGAAGCCGGTGATCCTTATCAAGATCAAA
TACAGAACTGTTCACTTTTGATTATTGACCAGCTTGAAAATTCGCTTGGATTCACCAATTCATTTTCACTCGCTTATCAA
AGCAGAGTAGGCCCAGAAGAGTGGCTCAAACCATATACCGAAGAAGTATTAGAAAAATTAGGAAAATCAGGTGTTAAGGA
ACTTGTCGTGGTGCCAATAAGTTTTGTGAGTGAGCATATTGAAACTCTCCAAGAGATTGATATCGAGTACAAAGAAATTG
CTCAGAAAAATGGAATTGTTAATTTTAAAAGAGTTCCAGCTCTCGATATCTATCCGTTGTTTATTGAAGGATTGGCCGAT
CTAGTTTCTTCTTGCTTAAACGGCGAGGGAATTAGTTTAGAGGAAGCATCAAAATTGCCAGAAAGAGTAAAACTTTATCC
TCAAGAGAAATGGCAATGGGGTTGGAATAACAGCTCTGAAGTTTGGAATGGAAGAGTTGCAATGATTGTGTTTCTTTGCT
TTTTGATGGAATTAATAATTGGTGGTGGACCTTTACACCAAATAGGTTTGCTCTAA

Upstream 100 bases:

>100_bases
ATATCTAGTAACTTTTGATTCTCGTCCATGATCCTGTAAATTTAGCTAGCTTTACTTTGATAAGGGTTTGTATATCCTTT
TATAAGGAGTTTTTTCAAAA

Downstream 100 bases:

>100_bases
AGAACTAAAATAACTATTTGTGTTGATTAGTTTGATAATAAACTTGCTGTTAAAACTTAGAGAATTTAATTAAATCTTTG
CTTAATTTAGTTGAATTGAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MARVGVLLLNLGGPERIKDVGPFLYNLFSDPEIIRLPVRAFQKPLAWLISLLRSSKSQEAYRSIGGGSPLRRITEQQARE
LQSYLRNIGIDATTYVAMRYWHPFTESAVADMKADGVSEVVVLPLYPHFSISTSGSSFRELKRLKDSDDEFAELSIRCIR
SWFDHPAYVSSMAELIKKQILACDLPQESHVFFTAHGVPKSYVEEAGDPYQDQIQNCSLLIIDQLENSLGFTNSFSLAYQ
SRVGPEEWLKPYTEEVLEKLGKSGVKELVVVPISFVSEHIETLQEIDIEYKEIAQKNGIVNFKRVPALDIYPLFIEGLAD
LVSSCLNGEGISLEEASKLPERVKLYPQEKWQWGWNNSSEVWNGRVAMIVFLCFLMELIIGGGPLHQIGLL

Sequences:

>Translated_391_residues
MARVGVLLLNLGGPERIKDVGPFLYNLFSDPEIIRLPVRAFQKPLAWLISLLRSSKSQEAYRSIGGGSPLRRITEQQARE
LQSYLRNIGIDATTYVAMRYWHPFTESAVADMKADGVSEVVVLPLYPHFSISTSGSSFRELKRLKDSDDEFAELSIRCIR
SWFDHPAYVSSMAELIKKQILACDLPQESHVFFTAHGVPKSYVEEAGDPYQDQIQNCSLLIIDQLENSLGFTNSFSLAYQ
SRVGPEEWLKPYTEEVLEKLGKSGVKELVVVPISFVSEHIETLQEIDIEYKEIAQKNGIVNFKRVPALDIYPLFIEGLAD
LVSSCLNGEGISLEEASKLPERVKLYPQEKWQWGWNNSSEVWNGRVAMIVFLCFLMELIIGGGPLHQIGLL
>Mature_390_residues
ARVGVLLLNLGGPERIKDVGPFLYNLFSDPEIIRLPVRAFQKPLAWLISLLRSSKSQEAYRSIGGGSPLRRITEQQAREL
QSYLRNIGIDATTYVAMRYWHPFTESAVADMKADGVSEVVVLPLYPHFSISTSGSSFRELKRLKDSDDEFAELSIRCIRS
WFDHPAYVSSMAELIKKQILACDLPQESHVFFTAHGVPKSYVEEAGDPYQDQIQNCSLLIIDQLENSLGFTNSFSLAYQS
RVGPEEWLKPYTEEVLEKLGKSGVKELVVVPISFVSEHIETLQEIDIEYKEIAQKNGIVNFKRVPALDIYPLFIEGLADL
VSSCLNGEGISLEEASKLPERVKLYPQEKWQWGWNNSSEVWNGRVAMIVFLCFLMELIIGGGPLHQIGLL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=328, Percent_Identity=36.890243902439, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI60499021, Length=328, Percent_Identity=36.890243902439, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI1786681, Length=327, Percent_Identity=31.4984709480122, Blast_Score=135, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324750, Length=334, Percent_Identity=36.8263473053892, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17864156, Length=333, Percent_Identity=34.2342342342342, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24651774, Length=261, Percent_Identity=32.183908045977, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI45552018, Length=174, Percent_Identity=36.2068965517241, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_PROM1 (A2C0Y4)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014409.1
- ProteinModelPortal:   A2C0Y4
- SMR:   A2C0Y4
- STRING:   A2C0Y4
- GeneID:   4780002
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_05821
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- ProtClustDB:   PRK00035
- BioCyc:   PMAR167555:NATL1_05821-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 44133; Mature: 44002

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVGVLLLNLGGPERIKDVGPFLYNLFSDPEIIRLPVRAFQKPLAWLISLLRSSKSQEA
CCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCHHHH
YRSIGGGSPLRRITEQQARELQSYLRNIGIDATTYVAMRYWHPFTESAVADMKADGVSEV
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCE
VVLPLYPHFSISTSGSSFRELKRLKDSDDEFAELSIRCIRSWFDHPAYVSSMAELIKKQI
EEEECCCCCEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LACDLPQESHVFFTAHGVPKSYVEEAGDPYQDQIQNCSLLIIDQLENSLGFTNSFSLAYQ
HHCCCCCCCCEEEEECCCCHHHHHHCCCCHHHHHCCCCEEEEEHHHHHCCCCCCHHHHHH
SRVGPEEWLKPYTEEVLEKLGKSGVKELVVVPISFVSEHIETLQEIDIEYKEIAQKNGIV
HCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
NFKRVPALDIYPLFIEGLADLVSSCLNGEGISLEEASKLPERVKLYPQEKWQWGWNNSSE
EEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHCCCCCHHCCCCCCCCCH
VWNGRVAMIVFLCFLMELIIGGGPLHQIGLL
HHCCHHHHHHHHHHHHHHHHCCCCHHHHCCC
>Mature Secondary Structure 
ARVGVLLLNLGGPERIKDVGPFLYNLFSDPEIIRLPVRAFQKPLAWLISLLRSSKSQEA
CCEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCHHHH
YRSIGGGSPLRRITEQQARELQSYLRNIGIDATTYVAMRYWHPFTESAVADMKADGVSEV
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCE
VVLPLYPHFSISTSGSSFRELKRLKDSDDEFAELSIRCIRSWFDHPAYVSSMAELIKKQI
EEEECCCCCEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LACDLPQESHVFFTAHGVPKSYVEEAGDPYQDQIQNCSLLIIDQLENSLGFTNSFSLAYQ
HHCCCCCCCCEEEEECCCCHHHHHHCCCCHHHHHCCCCEEEEEHHHHHCCCCCCHHHHHH
SRVGPEEWLKPYTEEVLEKLGKSGVKELVVVPISFVSEHIETLQEIDIEYKEIAQKNGIV
HCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
NFKRVPALDIYPLFIEGLADLVSSCLNGEGISLEEASKLPERVKLYPQEKWQWGWNNSSE
EEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHCCCCCHHCCCCCCCCCH
VWNGRVAMIVFLCFLMELIIGGGPLHQIGLL
HHCCHHHHHHHHHHHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA