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The map label for this gene is uvrD [H]

Identifier: 124025096

GI number: 124025096

Start: 354120

End: 356537

Strand: Reverse

Name: uvrD [H]

Synonym: NATL1_03831

Alternate gene names: 124025096

Gene position: 356537-354120 (Counterclockwise)

Preceding gene: 124025097

Following gene: 124025095

Centisome position: 19.12

GC content: 36.6

Gene sequence:

>2418_bases
ATGAAACAATCAAACAGTATATTTCTAAATGGATTAAACGAGGCGCAGTCACATGCAGTTGATCATTTTCATGGTCCATT
ATTAGTTGTAGCAGGAGCAGGAAGCGGAAAAACAAGAGCTCTTACTCATCGTATTGCGCATTTAATTACTGAATACAAAG
TTGATCCTAGTTCTATTCTTGCAGTTACTTTTACCAATAAAGCTGCAAGAGAGATGAAAGATAGACTTGAATTGCTTTTA
GCAAAAAGGTTATCAAGTCTTACCCACGGGAAGCCTTGGACTGCCTTGCAAGTAGCAGAACAAAGAGAAATTCGTAATCG
TATACATCGTGAAATCAGTCGTGAATTATGGATAGGTACTTTTCACGCTTTGTTTTCGAGATTATTACGCTTTGACATCG
ATAAATTCAAAGACCCTGAAGGATTGACATGGACTAAACAGTTTTCAATATATGACGAAACAGATGCCCAAAGTCTTATC
AAAGAAATAGTTACACAAGATCTACAATTAGATCCAAAAAGATTTGAACCAAAAAAAGTACGATGGGCAATCAGTAATGC
CAAAAATCAATGCTTACTTCCTGATGATTTATCAAATAATCAAGAAGGTCAAAGAGGAAAATTAGTTGCTGAAACTTATA
GACTTTATAGAAAAGCTTTAGCTGCTAATAATGCATTAGATTTTGATGATCTTCTATTAATACCTGTTCAATTACTACAA
CAAAATGAAAAAATAAGGACTTATTGGCACAGTCGCTTCAAACATGTTTTAGTTGATGAATATCAAGATACTAATTGGAC
ACAATACGAATTAATTAAACAATTGGTTACCAATGGTAAAGATCCATCTTCTTTTCAAGATTGGAATAATCGATCAGTTT
TTGTTGTTGGCGATGCAGATCAAAGTATTTACAGCTTTAGAGCTGCGGACTTTAGGATACTAATGGGATTTCAAGAGGAC
TTTGGAAAGAAAAGCCTAGACAATACATATGATTCAACTCTTGTAAAACTAGAAGAAAATTATCGATCTACCTCTACCAT
CCTCGAAGCAGCAAATTCACTAATCTCCAACAATAAAGAAAGAATAGATAAAGTTCTTAGAGCAACTAGAGGAGAAGGTG
AGCCTATTAGATTAACAAGGTGTGACGATGAGATAGCAGAGGCAGAGGCAGTTATTCATAGGCTAAGAATTTTAGATGCC
TCGAATCCAGAATTAAATTGGGGAGATATGGCTATTCTTTATAGAACCAATGCGCAATCAAGAGCAATTGAGGACTCATT
GGTCCGCTGGAGTATTCCATACATTGTGGTTGGAGGATTACGTTTTTATGATCGAAGAGAAATTAAAGATCTACTAGCTT
ATTTAAGACTTTTAATTAATCCATCTGACAGTGTCAGTCTTCTGAGAGTTTTAAACGTTCCTAAAAGAGGGATTGGAAAA
ACAACAGTTCAAAGATTGAGTGATGCAGCTAGTCAATTAAAAATTCCTCTTTGGGAAGTTGTAAATGACCCCGAAGCTGT
CAGATCACTCGCAGGAAGATCAGCCAAAGGTCTTTTAATTTTTAGTGAGCTTATTAATGAATTACAAAGTCATCTTCTCT
CTTCAAGCCCCGCCGAGTTGGTTCAATTAGTTTTAGAAAAAAGTGGCTATTTAAGTGAATTAATTGCAACAGGAACAGAT
GAGGCAGAAGAAAGAAGACGCAATCTTCAAGAATTAGTTAATGCCGCGTTGCAATATCAGGAAGAAAGCGAAGATGCAAA
TTTAGAAGGTTTTTTATCAACTGCTGCTCTATCAAGCGATGCAGATAATAAAGACACTGCGTCAAATCGAGTCACATTAA
TGACTCTTCACAGCAGTAAAGGTTTGGAATTTCCTGTCGTTTGTCTTGTGGGAATGGAGCAAGGCTTATTCCCAAGCTAT
AGATCACTTGATGATCCATCTTCACTTGAGGAAGAAAGGCGACTTTGTTACGTAGGACTTACTAGAGCAAAAGAAAAACT
ATTTCTCTTTCATGCATCTGAGAGAAGAATGTGGGGAGGGATGAGAGAACCAGCTATCGCATCTATATTCCTCTCCGAAA
TACCAGAAGAACTTGTTAAAGGCGATATCCCATTATCTGGTGGGGCTACATTAAGAAGAGAAAAAAATCTAGACAGACTA
ACTAGAATTGATCGCCAAAGTAATAAAAAGTCCTTTCCTCGTGAAGCTGAAAATGCAGTAAGAAAAACATATTCTGGTCC
TTCCCCAGGGAAGCGATGGTCAGTTAACGATAGAGTTGAACATTCTTCATTTGGAGAAGGGATAATCACACATGTTTTTG
GTTCAGGAGAAAAAATCTCACTGGCCATAAAATTCTCAGGAATGGGGCCAAAAATATTAGACCCAAGACTAGCTCCATTG
AAATTGATAGATGAGTAA

Upstream 100 bases:

>100_bases
CTGCTTTTATGATTTTATTTTTGCTGCTTAAATAATATAAAAATGTACCCCATGAATGTTGCAAAACTAAATTCAATTAA
ATGTATTTAAAGTCTATAAA

Downstream 100 bases:

>100_bases
GATTTAATCTGAAAAATGTTAACTAGCTAAAACCATATTTCTCATGGAATTATTTGATAAATCTACAATTGAAAAAGAGA
TAAAAGAATTACCGAGTGGA

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 805; Mature: 805

Protein sequence:

>805_residues
MKQSNSIFLNGLNEAQSHAVDHFHGPLLVVAGAGSGKTRALTHRIAHLITEYKVDPSSILAVTFTNKAAREMKDRLELLL
AKRLSSLTHGKPWTALQVAEQREIRNRIHREISRELWIGTFHALFSRLLRFDIDKFKDPEGLTWTKQFSIYDETDAQSLI
KEIVTQDLQLDPKRFEPKKVRWAISNAKNQCLLPDDLSNNQEGQRGKLVAETYRLYRKALAANNALDFDDLLLIPVQLLQ
QNEKIRTYWHSRFKHVLVDEYQDTNWTQYELIKQLVTNGKDPSSFQDWNNRSVFVVGDADQSIYSFRAADFRILMGFQED
FGKKSLDNTYDSTLVKLEENYRSTSTILEAANSLISNNKERIDKVLRATRGEGEPIRLTRCDDEIAEAEAVIHRLRILDA
SNPELNWGDMAILYRTNAQSRAIEDSLVRWSIPYIVVGGLRFYDRREIKDLLAYLRLLINPSDSVSLLRVLNVPKRGIGK
TTVQRLSDAASQLKIPLWEVVNDPEAVRSLAGRSAKGLLIFSELINELQSHLLSSSPAELVQLVLEKSGYLSELIATGTD
EAEERRRNLQELVNAALQYQEESEDANLEGFLSTAALSSDADNKDTASNRVTLMTLHSSKGLEFPVVCLVGMEQGLFPSY
RSLDDPSSLEEERRLCYVGLTRAKEKLFLFHASERRMWGGMREPAIASIFLSEIPEELVKGDIPLSGGATLRREKNLDRL
TRIDRQSNKKSFPREAENAVRKTYSGPSPGKRWSVNDRVEHSSFGEGIITHVFGSGEKISLAIKFSGMGPKILDPRLAPL
KLIDE

Sequences:

>Translated_805_residues
MKQSNSIFLNGLNEAQSHAVDHFHGPLLVVAGAGSGKTRALTHRIAHLITEYKVDPSSILAVTFTNKAAREMKDRLELLL
AKRLSSLTHGKPWTALQVAEQREIRNRIHREISRELWIGTFHALFSRLLRFDIDKFKDPEGLTWTKQFSIYDETDAQSLI
KEIVTQDLQLDPKRFEPKKVRWAISNAKNQCLLPDDLSNNQEGQRGKLVAETYRLYRKALAANNALDFDDLLLIPVQLLQ
QNEKIRTYWHSRFKHVLVDEYQDTNWTQYELIKQLVTNGKDPSSFQDWNNRSVFVVGDADQSIYSFRAADFRILMGFQED
FGKKSLDNTYDSTLVKLEENYRSTSTILEAANSLISNNKERIDKVLRATRGEGEPIRLTRCDDEIAEAEAVIHRLRILDA
SNPELNWGDMAILYRTNAQSRAIEDSLVRWSIPYIVVGGLRFYDRREIKDLLAYLRLLINPSDSVSLLRVLNVPKRGIGK
TTVQRLSDAASQLKIPLWEVVNDPEAVRSLAGRSAKGLLIFSELINELQSHLLSSSPAELVQLVLEKSGYLSELIATGTD
EAEERRRNLQELVNAALQYQEESEDANLEGFLSTAALSSDADNKDTASNRVTLMTLHSSKGLEFPVVCLVGMEQGLFPSY
RSLDDPSSLEEERRLCYVGLTRAKEKLFLFHASERRMWGGMREPAIASIFLSEIPEELVKGDIPLSGGATLRREKNLDRL
TRIDRQSNKKSFPREAENAVRKTYSGPSPGKRWSVNDRVEHSSFGEGIITHVFGSGEKISLAIKFSGMGPKILDPRLAPL
KLIDE
>Mature_805_residues
MKQSNSIFLNGLNEAQSHAVDHFHGPLLVVAGAGSGKTRALTHRIAHLITEYKVDPSSILAVTFTNKAAREMKDRLELLL
AKRLSSLTHGKPWTALQVAEQREIRNRIHREISRELWIGTFHALFSRLLRFDIDKFKDPEGLTWTKQFSIYDETDAQSLI
KEIVTQDLQLDPKRFEPKKVRWAISNAKNQCLLPDDLSNNQEGQRGKLVAETYRLYRKALAANNALDFDDLLLIPVQLLQ
QNEKIRTYWHSRFKHVLVDEYQDTNWTQYELIKQLVTNGKDPSSFQDWNNRSVFVVGDADQSIYSFRAADFRILMGFQED
FGKKSLDNTYDSTLVKLEENYRSTSTILEAANSLISNNKERIDKVLRATRGEGEPIRLTRCDDEIAEAEAVIHRLRILDA
SNPELNWGDMAILYRTNAQSRAIEDSLVRWSIPYIVVGGLRFYDRREIKDLLAYLRLLINPSDSVSLLRVLNVPKRGIGK
TTVQRLSDAASQLKIPLWEVVNDPEAVRSLAGRSAKGLLIFSELINELQSHLLSSSPAELVQLVLEKSGYLSELIATGTD
EAEERRRNLQELVNAALQYQEESEDANLEGFLSTAALSSDADNKDTASNRVTLMTLHSSKGLEFPVVCLVGMEQGLFPSY
RSLDDPSSLEEERRLCYVGLTRAKEKLFLFHASERRMWGGMREPAIASIFLSEIPEELVKGDIPLSGGATLRREKNLDRL
TRIDRQSNKKSFPREAENAVRKTYSGPSPGKRWSVNDRVEHSSFGEGIITHVFGSGEKISLAIKFSGMGPKILDPRLAPL
KLIDE

Specific function: Essential helicase. May act as a helicase in plasmid pT181 replication [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=808, Percent_Identity=37.0049504950495, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI48994965, Length=694, Percent_Identity=38.4726224783862, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1787196, Length=401, Percent_Identity=27.1820448877805, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322369, Length=811, Percent_Identity=28.3600493218249, Blast_Score=231, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6324477, Length=727, Percent_Identity=24.2090784044017, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 91222; Mature: 91222

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSNSIFLNGLNEAQSHAVDHFHGPLLVVAGAGSGKTRALTHRIAHLITEYKVDPSSIL
CCCCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
AVTFTNKAAREMKDRLELLLAKRLSSLTHGKPWTALQVAEQREIRNRIHREISRELWIGT
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FHALFSRLLRFDIDKFKDPEGLTWTKQFSIYDETDAQSLIKEIVTQDLQLDPKRFEPKKV
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHE
RWAISNAKNQCLLPDDLSNNQEGQRGKLVAETYRLYRKALAANNALDFDDLLLIPVQLLQ
EEEECCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
QNEKIRTYWHSRFKHVLVDEYQDTNWTQYELIKQLVTNGKDPSSFQDWNNRSVFVVGDAD
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHCCCCCEEEEEECCC
QSIYSFRAADFRILMGFQEDFGKKSLDNTYDSTLVKLEENYRSTSTILEAANSLISNNKE
CHHHHHHHCCEEEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
RIDKVLRATRGEGEPIRLTRCDDEIAEAEAVIHRLRILDASNPELNWGDMAILYRTNAQS
HHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHH
RAIEDSLVRWSIPYIVVGGLRFYDRREIKDLLAYLRLLINPSDSVSLLRVLNVPKRGIGK
HHHHHHHHHEECCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCH
TTVQRLSDAASQLKIPLWEVVNDPEAVRSLAGRSAKGLLIFSELINELQSHLLSSSPAEL
HHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
VQLVLEKSGYLSELIATGTDEAEERRRNLQELVNAALQYQEESEDANLEGFLSTAALSSD
HHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
ADNKDTASNRVTLMTLHSSKGLEFPVVCLVGMEQGLFPSYRSLDDPSSLEEERRLCYVGL
CCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCEEEEEH
TRAKEKLFLFHASERRMWGGMREPAIASIFLSEIPEELVKGDIPLSGGATLRREKNLDRL
HHCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHH
TRIDRQSNKKSFPREAENAVRKTYSGPSPGKRWSVNDRVEHSSFGEGIITHVFGSGEKIS
HHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEE
LAIKFSGMGPKILDPRLAPLKLIDE
EEEEECCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MKQSNSIFLNGLNEAQSHAVDHFHGPLLVVAGAGSGKTRALTHRIAHLITEYKVDPSSIL
CCCCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
AVTFTNKAAREMKDRLELLLAKRLSSLTHGKPWTALQVAEQREIRNRIHREISRELWIGT
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FHALFSRLLRFDIDKFKDPEGLTWTKQFSIYDETDAQSLIKEIVTQDLQLDPKRFEPKKV
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHE
RWAISNAKNQCLLPDDLSNNQEGQRGKLVAETYRLYRKALAANNALDFDDLLLIPVQLLQ
EEEECCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
QNEKIRTYWHSRFKHVLVDEYQDTNWTQYELIKQLVTNGKDPSSFQDWNNRSVFVVGDAD
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHCCCCCEEEEEECCC
QSIYSFRAADFRILMGFQEDFGKKSLDNTYDSTLVKLEENYRSTSTILEAANSLISNNKE
CHHHHHHHCCEEEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
RIDKVLRATRGEGEPIRLTRCDDEIAEAEAVIHRLRILDASNPELNWGDMAILYRTNAQS
HHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHH
RAIEDSLVRWSIPYIVVGGLRFYDRREIKDLLAYLRLLINPSDSVSLLRVLNVPKRGIGK
HHHHHHHHHEECCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCH
TTVQRLSDAASQLKIPLWEVVNDPEAVRSLAGRSAKGLLIFSELINELQSHLLSSSPAEL
HHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
VQLVLEKSGYLSELIATGTDEAEERRRNLQELVNAALQYQEESEDANLEGFLSTAALSSD
HHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
ADNKDTASNRVTLMTLHSSKGLEFPVVCLVGMEQGLFPSYRSLDDPSSLEEERRLCYVGL
CCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCEEEEEH
TRAKEKLFLFHASERRMWGGMREPAIASIFLSEIPEELVKGDIPLSGGATLRREKNLDRL
HHCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHH
TRIDRQSNKKSFPREAENAVRKTYSGPSPGKRWSVNDRVEHSSFGEGIITHVFGSGEKIS
HHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEE
LAIKFSGMGPKILDPRLAPLKLIDE
EEEEECCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8232203 [H]