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The map label for this gene is hisB

Identifier: 124025074

GI number: 124025074

Start: 334306

End: 334917

Strand: Reverse

Name: hisB

Synonym: NATL1_03611

Alternate gene names: 124025074

Gene position: 334917-334306 (Counterclockwise)

Preceding gene: 124025075

Following gene: 124025073

Centisome position: 17.96

GC content: 38.4

Gene sequence:

>612_bases
ATGGAAAAAACTAGAGAAGGAGAGATTAGACGGGAAACTAAGGAAACTGACGTTTTTGTGAAAATTGATCTTGATGGTTC
TGGAAAATGCAGTGCAAATACGGGGATTGGTTTTCTAGACCATATGATCCAACAATTATCTAGTCATGGATTATTTGATA
TTGAAGTAAGAGCTAATGGAGATACTCACATAGACGATCATCACACCAATGAGGATGTTGGAATTGCTATTGGACAAGCT
TTGTCAAAAGCATTAGGTGATCGAGTTGGAATCAAACGTTTTGGTCATTTTTTAGCTCCGCTTGATGAAGCTCTTATTCA
GGTTGTGGTTGATTGCTCCGGTCGACCACATTTAAGTTTTAGTTTAGATATTCCTTCTCAAAAAGTGGGCACTTATGATA
CGGAATTGGTTAAAGAATTTTTTGGTGCTGTTGTGAGTAATGGTGGTTTAACTCTCCACATCAGACAACTGGCAGGAAAT
AATACTCACCACATAATTGAGGCTACTTTCAAATCGTTTGCAAGAGCCCTTAGGATGGCTACTGAAATTGACCCTAGAAG
ATCAAGTCAAATTCCAAGCAGTAAAGGAGTTCTTGAACAGGCTGGTCAATAA

Upstream 100 bases:

>100_bases
GATCTTTCAAGTGGTATATCAGGACAAACTGTTTATGTTGATGCAGGTTATTGCATCAATGGAATGTAATTTCAAGCCAA
CTTAAAATTGCCAATTAAAT

Downstream 100 bases:

>100_bases
AAACTCCATATTTAAATAAATCATTTGAGCTTGAACTCGCAAAAGTGAGAAGTTTAAGCGAAAATCAAGTTTGAATTCAA
GAAAAATAATGGCAGTTAGT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MEKTREGEIRRETKETDVFVKIDLDGSGKCSANTGIGFLDHMIQQLSSHGLFDIEVRANGDTHIDDHHTNEDVGIAIGQA
LSKALGDRVGIKRFGHFLAPLDEALIQVVVDCSGRPHLSFSLDIPSQKVGTYDTELVKEFFGAVVSNGGLTLHIRQLAGN
NTHHIIEATFKSFARALRMATEIDPRRSSQIPSSKGVLEQAGQ

Sequences:

>Translated_203_residues
MEKTREGEIRRETKETDVFVKIDLDGSGKCSANTGIGFLDHMIQQLSSHGLFDIEVRANGDTHIDDHHTNEDVGIAIGQA
LSKALGDRVGIKRFGHFLAPLDEALIQVVVDCSGRPHLSFSLDIPSQKVGTYDTELVKEFFGAVVSNGGLTLHIRQLAGN
NTHHIIEATFKSFARALRMATEIDPRRSSQIPSSKGVLEQAGQ
>Mature_203_residues
MEKTREGEIRRETKETDVFVKIDLDGSGKCSANTGIGFLDHMIQQLSSHGLFDIEVRANGDTHIDDHHTNEDVGIAIGQA
LSKALGDRVGIKRFGHFLAPLDEALIQVVVDCSGRPHLSFSLDIPSQKVGTYDTELVKEFFGAVVSNGGLTLHIRQLAGN
NTHHIIEATFKSFARALRMATEIDPRRSSQIPSSKGVLEQAGQ

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=196, Percent_Identity=45.4081632653061, Blast_Score=181, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324776, Length=168, Percent_Identity=47.6190476190476, Blast_Score=154, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_PROM1 (A2C0B5)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014190.1
- ProteinModelPortal:   A2C0B5
- SMR:   A2C0B5
- STRING:   A2C0B5
- GeneID:   4781280
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_03611
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BioCyc:   PMAR167555:NATL1_03611-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22187; Mature: 22187

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTREGEIRRETKETDVFVKIDLDGSGKCSANTGIGFLDHMIQQLSSHGLFDIEVRANG
CCCCCCCHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCC
DTHIDDHHTNEDVGIAIGQALSKALGDRVGIKRFGHFLAPLDEALIQVVVDCSGRPHLSF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
SLDIPSQKVGTYDTELVKEFFGAVVSNGGLTLHIRQLAGNNTHHIIEATFKSFARALRMA
EECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
TEIDPRRSSQIPSSKGVLEQAGQ
HHCCCCCCCCCCCCCCHHHHCCC
>Mature Secondary Structure
MEKTREGEIRRETKETDVFVKIDLDGSGKCSANTGIGFLDHMIQQLSSHGLFDIEVRANG
CCCCCCCHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCC
DTHIDDHHTNEDVGIAIGQALSKALGDRVGIKRFGHFLAPLDEALIQVVVDCSGRPHLSF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
SLDIPSQKVGTYDTELVKEFFGAVVSNGGLTLHIRQLAGNNTHHIIEATFKSFARALRMA
EECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
TEIDPRRSSQIPSSKGVLEQAGQ
HHCCCCCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA