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The map label for this gene is lpxD

Identifier: 123966029

GI number: 123966029

Start: 716409

End: 717443

Strand: Direct

Name: lpxD

Synonym: P9515_07941

Alternate gene names: 123966029

Gene position: 716409-717443 (Clockwise)

Preceding gene: 123966028

Following gene: 123966030

Centisome position: 42.04

GC content: 31.21

Gene sequence:

>1035_bases
ATGTTATTAAGTAAATTGGTTGATCTTATAAAAAGTGGAAATTCAAACTTTATTAAAGCAAATATATTTGAAAATATAGA
TATACAAAATGCTGCTTCTTTAGATGTCGCATCAAAAAACCAAATATCCTTTTTAGAAGAAAACAATATATTAAAAGAGA
ATTTAGGTAGAACTGCCGTTTCAGCAATTATCACATTTAACAATAGTGAAATATTAGGTTTACTTGAATCAAAAAATATT
TCAAATATAGTTGTAGAAAATCCCAGAATCGCATTTGCAGAAGTATTAAATTACCTTTATGAACAAATCAATTTCAACCC
AGGTATTGATGATTCGGTTGTCATGAAAGAATCTTCAAAACTAGGAGAAAATTGTTATCTAGGACCAAATGTTTACATTG
GCGAAAATACAGTAATTGGTAATAATAATAAGATTTTCCCCGGCACAACTATTTTAGGAAATGTCCGATTAGGAGATAAC
AATATAATTCATCCGAATTGTGTGATTTACGAAAATACAAGAATTGAAAATAATTGCGTTATAAATTCGAATACTGTTAT
TGGTTCTGAAGGATTTGGTTTTATTCCGCAAGATGGCAAATGGATTAAAATGCCTCAAAAAGGTTCAGTAATAATAAAGA
GCTTTGTAGAAATCGGGACAAACTGTTGTGTTGATAGGCCATCTGTCGGAAATACATTGATTGATGAAGGGACTAAAATA
GATAACTTAGTTCAAATAGGTCATGGAGTTAAAATAGGGAAAAATTGTGCTTTAGCAGCTCAAGTTGGCATAGCAGGAGG
TGCGGTTATTGGGGATGGAGTTATACTTGCCGGACAAGTAGGGGTTAATAATAGAGTTAAAGTTGGTAATAATGTAATAG
CAAGCTCAAAATGCGGGATACATTGTGATATTGAAGATGGAGAAGTTGTAAGTGGTTTCCCAGCCATGAAAAATAAATCA
TGGTTAAGAAGTTCAAGTATTTTTAAAAAATTGCCTGAATTAGCAAAAAAGCTTCGACAACTAGACAAGAAATAA

Upstream 100 bases:

>100_bases
TTCTCTAAAAAGAATTTTAAATAAAAAAGAAACCATTAATTCATCAATGATAGTGGTACATAGAGATGTTCTTGCTCTTT
CTTAAAAAATAAATTAAAAA

Downstream 100 bases:

>100_bases
ATTATTCTCTTAATAAACCAACAATAAAATGAAGAAATATAAAGTTGTTTTACTTTCTGGAGATGGTATAGGACCTGAAA
TATCAGAAATTTCTTCAGAA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLLSKLVDLIKSGNSNFIKANIFENIDIQNAASLDVASKNQISFLEENNILKENLGRTAVSAIITFNNSEILGLLESKNI
SNIVVENPRIAFAEVLNYLYEQINFNPGIDDSVVMKESSKLGENCYLGPNVYIGENTVIGNNNKIFPGTTILGNVRLGDN
NIIHPNCVIYENTRIENNCVINSNTVIGSEGFGFIPQDGKWIKMPQKGSVIIKSFVEIGTNCCVDRPSVGNTLIDEGTKI
DNLVQIGHGVKIGKNCALAAQVGIAGGAVIGDGVILAGQVGVNNRVKVGNNVIASSKCGIHCDIEDGEVVSGFPAMKNKS
WLRSSSIFKKLPELAKKLRQLDKK

Sequences:

>Translated_344_residues
MLLSKLVDLIKSGNSNFIKANIFENIDIQNAASLDVASKNQISFLEENNILKENLGRTAVSAIITFNNSEILGLLESKNI
SNIVVENPRIAFAEVLNYLYEQINFNPGIDDSVVMKESSKLGENCYLGPNVYIGENTVIGNNNKIFPGTTILGNVRLGDN
NIIHPNCVIYENTRIENNCVINSNTVIGSEGFGFIPQDGKWIKMPQKGSVIIKSFVEIGTNCCVDRPSVGNTLIDEGTKI
DNLVQIGHGVKIGKNCALAAQVGIAGGAVIGDGVILAGQVGVNNRVKVGNNVIASSKCGIHCDIEDGEVVSGFPAMKNKS
WLRSSSIFKKLPELAKKLRQLDKK
>Mature_344_residues
MLLSKLVDLIKSGNSNFIKANIFENIDIQNAASLDVASKNQISFLEENNILKENLGRTAVSAIITFNNSEILGLLESKNI
SNIVVENPRIAFAEVLNYLYEQINFNPGIDDSVVMKESSKLGENCYLGPNVYIGENTVIGNNNKIFPGTTILGNVRLGDN
NIIHPNCVIYENTRIENNCVINSNTVIGSEGFGFIPQDGKWIKMPQKGSVIIKSFVEIGTNCCVDRPSVGNTLIDEGTKI
DNLVQIGHGVKIGKNCALAAQVGIAGGAVIGDGVILAGQVGVNNRVKVGNNVIASSKCGIHCDIEDGEVVSGFPAMKNKS
WLRSSSIFKKLPELAKKLRQLDKK

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=321, Percent_Identity=31.4641744548287, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_PROM5 (A2BW42)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001011110.1
- ProteinModelPortal:   A2BW42
- SMR:   A2BW42
- STRING:   A2BW42
- GeneID:   4719459
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_07941
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   PRLLFAK
- ProtClustDB:   PRK00892
- BioCyc:   PMAR167542:P9515ORF_0835-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 37147; Mature: 37147

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSKLVDLIKSGNSNFIKANIFENIDIQNAASLDVASKNQISFLEENNILKENLGRTAV
CHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHHCCHHEE
SAIITFNNSEILGLLESKNISNIVVENPRIAFAEVLNYLYEQINFNPGIDDSVVMKESSK
EEEEEECCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCC
LGENCYLGPNVYIGENTVIGNNNKIFPGTTILGNVRLGDNNIIHPNCVIYENTRIENNCV
CCCCEEECCEEEECCCEEECCCCEECCCCEEEEEEEECCCCEECCCEEEEECCEECCCEE
INSNTVIGSEGFGFIPQDGKWIKMPQKGSVIIKSFVEIGTNCCVDRPSVGNTLIDEGTKI
EECCEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCH
DNLVQIGHGVKIGKNCALAAQVGIAGGAVIGDGVILAGQVGVNNRVKVGNNVIASSKCGI
HHHHHHCCCEEECCCEEEEEEECCCCCEEEECCEEEEEECCCCCEEEECCCEEECCCCCE
HCDIEDGEVVSGFPAMKNKSWLRSSSIFKKLPELAKKLRQLDKK
EEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLSKLVDLIKSGNSNFIKANIFENIDIQNAASLDVASKNQISFLEENNILKENLGRTAV
CHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHHCCHHEE
SAIITFNNSEILGLLESKNISNIVVENPRIAFAEVLNYLYEQINFNPGIDDSVVMKESSK
EEEEEECCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCC
LGENCYLGPNVYIGENTVIGNNNKIFPGTTILGNVRLGDNNIIHPNCVIYENTRIENNCV
CCCCEEECCEEEECCCEEECCCCEECCCCEEEEEEEECCCCEECCCEEEEECCEECCCEE
INSNTVIGSEGFGFIPQDGKWIKMPQKGSVIIKSFVEIGTNCCVDRPSVGNTLIDEGTKI
EECCEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCH
DNLVQIGHGVKIGKNCALAAQVGIAGGAVIGDGVILAGQVGVNNRVKVGNNVIASSKCGI
HHHHHHCCCEEECCCEEEEEEECCCCCEEEECCEEEEEECCCCCEEEECCCEEECCCCCE
HCDIEDGEVVSGFPAMKNKSWLRSSSIFKKLPELAKKLRQLDKK
EEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA