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The map label for this gene is ugd [H]

Identifier: 123968923

GI number: 123968923

Start: 1157399

End: 1158823

Strand: Reverse

Name: ugd [H]

Synonym: A9601_13901

Alternate gene names: 123968923

Gene position: 1158823-1157399 (Counterclockwise)

Preceding gene: 123968924

Following gene: 123968921

Centisome position: 69.4

GC content: 32.56

Gene sequence:

>1425_bases
ATGTTAAAAAAAAAGGTAAAAAATATTTGTTGTATAGGTGCAGGTTATGTTGGTGGGCCAACTATGGCTGTGATAGCCGA
CAACTGTAATTATCTAAATATAACTGTTGTAGATATTAATGAAGAAAGAATATCAAAATGGAATTCCTCCGATTTTGATA
ATTTGCCTGTATATGAGCCTGGTCTCAAGGAAATAATCAAAAGAGTTAGAAATCGAAATTTATTTTTTACTATTGACTTA
AAAAACTCAATTAAGAATGCTGATATGATTTTTATCTCTGTTAATACTCCCACAAAAACATCAGGATTTGGAGCAGGTTA
TGCTAGTGATTTAAAATGGGTCGAAGCTTCTGCAAGGCAGGTTGCTCAAAATGCTGTTGGACATACAATTGTAATAGAAA
AAAGTACGCTTCCAGTTCGTACCGCAAAAGTAATTAAACAAATTCTAATTAGTTCTTTCGATGAAGAGTTCGAAAATAAA
ACCGAGAAATCTTTTTCTATCCTTTCTAATCCAGAGTTTTTAGCCGAAGGTACGGCTATAGAAGATTTAAATAACCCAGA
TAGAGTTTTAATTGGGGGAGATGAGGAGGATTCTATTAATGCCTTAAAAAACATTTATGAAAAATGGGTTCCTGAAGATA
AAATTATTACAACAAATCTTTGGAGTAGTGAATTATCTAAGCTTGCTGCCAATGCTTTTTTAGCTCAAAGAATAAGCTCA
ATTAATTCGATATCTGCAATATGCGAGGCTACAGGTGCAGAAGTTAATGAAGTGTCCAATGCAATAGGATTTGATAGTAG
GATAGGTTTTAAATTTCTTTCTGCAGGACCTGGATTTGGAGGAAGTTGTTTTAAAAAAGATATATTAAACCTGGTATATT
TATGTAGATATTTTGGCCTGAATGAAGTTGCAGAATACTGGGAACAGGTAGTTAAGTTTAATGAATGGCATACAAAAAGA
ATTTCTAAATTGATAGTCGAGAAATTGTTTGATACTGTTGCCCTTAAGAAAATATTAATTCTGGGCTTTTCTTATAAAGC
TAATACTAATGACACAAGGGAATCTCCCGCTATCAAAATAGTTAAAGACCTTCTCGAAAATGGAGCCGAAATAATAATCT
CAGACCCACAAGTTGACCCTGATATTATTGCACTAGATCTTGGAATTGAGGAGAATGTATTTAAAAATGGAAGTGGACAA
GGTAAGTGGAGATATCATAAAGATATATATGAGGCAGCCATGGGGGTTGATGCGGTTGTGATTATAACTGAGTGGAAAGT
TTATAAATCATTGTCTTGGCATAAATTAGTAAAAGTCATGAGAAAGCCTGCTTGGTTATTTGATACTAGATCAATTACTA
ATTATGAAGAATTAAAGGATTTAGATATTAATTATTGGTCAATTGGGAATTCAAATTATTGTTAA

Upstream 100 bases:

>100_bases
ATCCTAATAAGTCAAGACATAAAAATTAAATTAATTATTTTTTTATTAACAAACTAAACCTGTTATATAATGATTTAGAT
TTAATAAGCTTGATAATGCA

Downstream 100 bases:

>100_bases
ATTATTTGGGGGCTTATACGTGTTTTAAGCCCTGCTAGTAAAACCCAGAAAATTATACTTATTCTTAGATCAAAGTACTG
TACATCAACTTGTTGAGTGC

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MLKKKVKNICCIGAGYVGGPTMAVIADNCNYLNITVVDINEERISKWNSSDFDNLPVYEPGLKEIIKRVRNRNLFFTIDL
KNSIKNADMIFISVNTPTKTSGFGAGYASDLKWVEASARQVAQNAVGHTIVIEKSTLPVRTAKVIKQILISSFDEEFENK
TEKSFSILSNPEFLAEGTAIEDLNNPDRVLIGGDEEDSINALKNIYEKWVPEDKIITTNLWSSELSKLAANAFLAQRISS
INSISAICEATGAEVNEVSNAIGFDSRIGFKFLSAGPGFGGSCFKKDILNLVYLCRYFGLNEVAEYWEQVVKFNEWHTKR
ISKLIVEKLFDTVALKKILILGFSYKANTNDTRESPAIKIVKDLLENGAEIIISDPQVDPDIIALDLGIEENVFKNGSGQ
GKWRYHKDIYEAAMGVDAVVIITEWKVYKSLSWHKLVKVMRKPAWLFDTRSITNYEELKDLDINYWSIGNSNYC

Sequences:

>Translated_474_residues
MLKKKVKNICCIGAGYVGGPTMAVIADNCNYLNITVVDINEERISKWNSSDFDNLPVYEPGLKEIIKRVRNRNLFFTIDL
KNSIKNADMIFISVNTPTKTSGFGAGYASDLKWVEASARQVAQNAVGHTIVIEKSTLPVRTAKVIKQILISSFDEEFENK
TEKSFSILSNPEFLAEGTAIEDLNNPDRVLIGGDEEDSINALKNIYEKWVPEDKIITTNLWSSELSKLAANAFLAQRISS
INSISAICEATGAEVNEVSNAIGFDSRIGFKFLSAGPGFGGSCFKKDILNLVYLCRYFGLNEVAEYWEQVVKFNEWHTKR
ISKLIVEKLFDTVALKKILILGFSYKANTNDTRESPAIKIVKDLLENGAEIIISDPQVDPDIIALDLGIEENVFKNGSGQ
GKWRYHKDIYEAAMGVDAVVIITEWKVYKSLSWHKLVKVMRKPAWLFDTRSITNYEELKDLDINYWSIGNSNYC
>Mature_474_residues
MLKKKVKNICCIGAGYVGGPTMAVIADNCNYLNITVVDINEERISKWNSSDFDNLPVYEPGLKEIIKRVRNRNLFFTIDL
KNSIKNADMIFISVNTPTKTSGFGAGYASDLKWVEASARQVAQNAVGHTIVIEKSTLPVRTAKVIKQILISSFDEEFENK
TEKSFSILSNPEFLAEGTAIEDLNNPDRVLIGGDEEDSINALKNIYEKWVPEDKIITTNLWSSELSKLAANAFLAQRISS
INSISAICEATGAEVNEVSNAIGFDSRIGFKFLSAGPGFGGSCFKKDILNLVYLCRYFGLNEVAEYWEQVVKFNEWHTKR
ISKLIVEKLFDTVALKKILILGFSYKANTNDTRESPAIKIVKDLLENGAEIIISDPQVDPDIIALDLGIEENVFKNGSGQ
GKWRYHKDIYEAAMGVDAVVIITEWKVYKSLSWHKLVKVMRKPAWLFDTRSITNYEELKDLDINYWSIGNSNYC

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=471, Percent_Identity=54.3524416135881, Blast_Score=504, Evalue=1e-143,
Organism=Homo sapiens, GI296040438, Length=373, Percent_Identity=53.0831099195711, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI296040443, Length=310, Percent_Identity=55.1612903225806, Blast_Score=331, Evalue=7e-91,
Organism=Escherichia coli, GI48994968, Length=385, Percent_Identity=25.4545454545455, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788340, Length=381, Percent_Identity=24.6719160104987, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17560350, Length=471, Percent_Identity=50.9554140127389, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI17136908, Length=465, Percent_Identity=53.5483870967742, Blast_Score=493, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 53227; Mature: 53227

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKKVKNICCIGAGYVGGPTMAVIADNCNYLNITVVDINEERISKWNSSDFDNLPVYEP
CCHHHHCCEEEEECCCCCCCEEEEEECCCCEEEEEEEECCHHHHHCCCCCCCCCCCCCCC
GLKEIIKRVRNRNLFFTIDLKNSIKNADMIFISVNTPTKTSGFGAGYASDLKWVEASARQ
CHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
VAQNAVGHTIVIEKSTLPVRTAKVIKQILISSFDEEFENKTEKSFSILSNPEFLAEGTAI
HHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCH
EDLNNPDRVLIGGDEEDSINALKNIYEKWVPEDKIITTNLWSSELSKLAANAFLAQRISS
HCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
INSISAICEATGAEVNEVSNAIGFDSRIGFKFLSAGPGFGGSCFKKDILNLVYLCRYFGL
HHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCH
NEVAEYWEQVVKFNEWHTKRISKLIVEKLFDTVALKKILILGFSYKANTNDTRESPAIKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
VKDLLENGAEIIISDPQVDPDIIALDLGIEENVFKNGSGQGKWRYHKDIYEAAMGVDAVV
HHHHHHCCCEEEEECCCCCCCEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCEEE
IITEWKVYKSLSWHKLVKVMRKPAWLFDTRSITNYEELKDLDINYWSIGNSNYC
EEECHHHHHCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure
MLKKKVKNICCIGAGYVGGPTMAVIADNCNYLNITVVDINEERISKWNSSDFDNLPVYEP
CCHHHHCCEEEEECCCCCCCEEEEEECCCCEEEEEEEECCHHHHHCCCCCCCCCCCCCCC
GLKEIIKRVRNRNLFFTIDLKNSIKNADMIFISVNTPTKTSGFGAGYASDLKWVEASARQ
CHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
VAQNAVGHTIVIEKSTLPVRTAKVIKQILISSFDEEFENKTEKSFSILSNPEFLAEGTAI
HHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCH
EDLNNPDRVLIGGDEEDSINALKNIYEKWVPEDKIITTNLWSSELSKLAANAFLAQRISS
HCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
INSISAICEATGAEVNEVSNAIGFDSRIGFKFLSAGPGFGGSCFKKDILNLVYLCRYFGL
HHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCH
NEVAEYWEQVVKFNEWHTKRISKLIVEKLFDTVALKKILILGFSYKANTNDTRESPAIKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
VKDLLENGAEIIISDPQVDPDIIALDLGIEENVFKNGSGQGKWRYHKDIYEAAMGVDAVV
HHHHHHCCCEEEEECCCCCCCEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCEEE
IITEWKVYKSLSWHKLVKVMRKPAWLFDTRSITNYEELKDLDINYWSIGNSNYC
EEECHHHHHCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]