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The map label for this gene is thrB [H]

Identifier: 123968186

GI number: 123968186

Start: 574196

End: 575104

Strand: Reverse

Name: thrB [H]

Synonym: A9601_06511

Alternate gene names: 123968186

Gene position: 575104-574196 (Counterclockwise)

Preceding gene: 123968187

Following gene: 123968185

Centisome position: 34.44

GC content: 40.7

Gene sequence:

>909_bases
GTGCCTTCCACAACTGCCAATTTAGGGCCTGGATTCGATTGCCTTGGAGCTGCATTAGATTTATATAATGAGTTTATTTT
TACAAGAATTGAAGGTGGTGGAGATAGATTTGATTTAATAATGGAAAGTACAGATGGTAATCATTTAAGAGGAGGACCTG
AAAACTTAGTTTTTAGAGCAGCACAGAAAGTATGGGAAAGCGCAAATATGGATCCTTTTGCACTTGAAGCAAGAGTTAAG
TTGGCAGTTCCACCTGCACGCGGACTTGGAAGTAGTGCTACAGCAATAGTGGCGGGACTAATCGGAGCAAATGCAATCAT
GAACTCTCCATTGTCCAAAGAAAAACTTCTTGAACATGCCATTGATATAGAAGGTCATCCAGATAATGTCGTTCCTTCTC
TCCTGGGTGGGCTTTGCTTGACAGCCAAGTCGGCTTCTCAAAGATGGAGAATTATTAGATGTGATTGGCACGATTCAATC
AAAGCTGTGGTGGCAATACCAGCAATCCGTCTAAGCACAAGTGAAGCAAGAAAGGTTATGCCCAAGAATGTACCTATATC
TGATGCAGTGACAAATATGGGGGCACTTACTTTGTTACTAAATGGCTTAAAAGCAGGAAATGAGGAACTTATAAAAGAAG
GAATGTTTGATAAGTTACATGAACCCTACAGATGGAAGCTTATTAAAGGTGGACTAGAAGTCAAAGATGCTGCACTTAAT
GCAGGTGCTTTAGGATGCGCAATTAGTGGGGCTGGACCAAGTATATTAGCTTTATGTAAAAAAGAAAATGGTAAAAACGT
CAGTCAAGCCATGGTGAAAGCTTGGGAGAAGATAGGTGTAGCTAGCAGAGCACCATTCTTAAACGTACAAAAAACAGGTA
GCCAATTTAGCAATATCTCCGGTAAGTAG

Upstream 100 bases:

>100_bases
GTTTGGACTTTTTAGTGCAGCCTGCAGAGCAAAAATGCTTTTAAAAACTTAAAAACAAAAAATGTCTATTCCTGAAGTAG
GTAAAAAAATAAGGGTAACA

Downstream 100 bases:

>100_bases
TTTTACTTAGGCAACTTTAATGTTATAGTCTCAAGCTAGTACAACTTCAACTAGAATAAAAAAATTATTCATTACATAAA
TGAATCTAGAATCTTTTCCT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MPSTTANLGPGFDCLGAALDLYNEFIFTRIEGGGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWESANMDPFALEARVK
LAVPPARGLGSSATAIVAGLIGANAIMNSPLSKEKLLEHAIDIEGHPDNVVPSLLGGLCLTAKSASQRWRIIRCDWHDSI
KAVVAIPAIRLSTSEARKVMPKNVPISDAVTNMGALTLLLNGLKAGNEELIKEGMFDKLHEPYRWKLIKGGLEVKDAALN
AGALGCAISGAGPSILALCKKENGKNVSQAMVKAWEKIGVASRAPFLNVQKTGSQFSNISGK

Sequences:

>Translated_302_residues
MPSTTANLGPGFDCLGAALDLYNEFIFTRIEGGGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWESANMDPFALEARVK
LAVPPARGLGSSATAIVAGLIGANAIMNSPLSKEKLLEHAIDIEGHPDNVVPSLLGGLCLTAKSASQRWRIIRCDWHDSI
KAVVAIPAIRLSTSEARKVMPKNVPISDAVTNMGALTLLLNGLKAGNEELIKEGMFDKLHEPYRWKLIKGGLEVKDAALN
AGALGCAISGAGPSILALCKKENGKNVSQAMVKAWEKIGVASRAPFLNVQKTGSQFSNISGK
>Mature_301_residues
PSTTANLGPGFDCLGAALDLYNEFIFTRIEGGGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWESANMDPFALEARVKL
AVPPARGLGSSATAIVAGLIGANAIMNSPLSKEKLLEHAIDIEGHPDNVVPSLLGGLCLTAKSASQRWRIIRCDWHDSIK
AVVAIPAIRLSTSEARKVMPKNVPISDAVTNMGALTLLLNGLKAGNEELIKEGMFDKLHEPYRWKLIKGGLEVKDAALNA
GALGCAISGAGPSILALCKKENGKNVSQAMVKAWEKIGVASRAPFLNVQKTGSQFSNISGK

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=287, Percent_Identity=29.9651567944251, Blast_Score=107, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6321814, Length=332, Percent_Identity=31.6265060240964, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32094; Mature: 31963

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTTANLGPGFDCLGAALDLYNEFIFTRIEGGGDRFDLIMESTDGNHLRGGPENLVFRA
CCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHH
AQKVWESANMDPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIMNSPLSKEKLLEHA
HHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
IDIEGHPDNVVPSLLGGLCLTAKSASQRWRIIRCDWHDSIKAVVAIPAIRLSTSEARKVM
HCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHCCCEEECCHHHHHCC
PKNVPISDAVTNMGALTLLLNGLKAGNEELIKEGMFDKLHEPYRWKLIKGGLEVKDAALN
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCEEHHHHCC
AGALGCAISGAGPSILALCKKENGKNVSQAMVKAWEKIGVASRAPFLNVQKTGSQFSNIS
CCCCEEEECCCCHHEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEHHCCCHHHCCC
GK
CC
>Mature Secondary Structure 
PSTTANLGPGFDCLGAALDLYNEFIFTRIEGGGDRFDLIMESTDGNHLRGGPENLVFRA
CCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHH
AQKVWESANMDPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIMNSPLSKEKLLEHA
HHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
IDIEGHPDNVVPSLLGGLCLTAKSASQRWRIIRCDWHDSIKAVVAIPAIRLSTSEARKVM
HCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHCCCEEECCHHHHHCC
PKNVPISDAVTNMGALTLLLNGLKAGNEELIKEGMFDKLHEPYRWKLIKGGLEVKDAALN
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCEEHHHHCC
AGALGCAISGAGPSILALCKKENGKNVSQAMVKAWEKIGVASRAPFLNVQKTGSQFSNIS
CCCCEEEECCCCHHEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEHHCCCHHHCCC
GK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA