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The map label for this gene is ndhD1 [H]

Identifier: 123968185

GI number: 123968185

Start: 572575

End: 574116

Strand: Reverse

Name: ndhD1 [H]

Synonym: A9601_06501

Alternate gene names: 123968185

Gene position: 574116-572575 (Counterclockwise)

Preceding gene: 123968186

Following gene: 123968184

Centisome position: 34.38

GC content: 35.47

Gene sequence:

>1542_bases
ATGAATCTAGAATCTTTTCCTTGGCTATCATCCATTATTTTACTGCCTTTAGTTGGGGCATTAATAATGCCTTTTTTGAG
TTCAAAAGAAGGAGAAGATAATACACTCCCTAGAAATATCTCATTAAGTTTTTTATTTATAGATTTTTTACTAATAATAG
GCGTCCTTTTTCAAAAATTTGATACTTCAGATAGCTCATTGCAAATGGTAGAAAGAGCCTCCTGGTTACCTTCAATAGGC
TTAGAGTGGTCTCTTGGCGTAGATGGATTATCTGCTCCTTTAGTAGCTTTGAGTGGGTTAATTACATTTTTATCAGCTGC
TGCAAGTTGGAAAATTAAGAAAAAATCTAATCTATATTTTGCTCTTTTATTAGTTCAAGCATCAGCACAGGCACTAGTTT
TCCTTTCTCAAGATTTCCTATTGTTTTTCTTAGCATGGGAACTTGAATTAGTTCCGGTATATCTTCTTATTGCGATTTGG
GGAGGTAAAAAGAAATTATATGCGGCCACTAAATTCATTCTTTATACAGCTTTAGCTTCTTTATTAATACTCATAAGCGG
GTTAGCACTAGCCTTGAGTGGTGATACCTTTACTCTAAATATTACCGATTTAACCAATAAACATGTAACAGGGAGCCTAG
CTTTATTATCTTATTTAGGATTTTTAATTGGTTTTGGAGTAAAACTTCCTATCTTTCCACTACATACTTGGTTACCCGAT
GCACATGGAGAGGCCAATGCACCAGTTTCAATGTTACTTGCTGGAATACTCTTAAAAATGGGAGGATATGCCCTCTTAAG
ATTTAACGTTCAAATACTACCTGAAGTACATCTTCAAATTGCACCTGCGTTAATTATTCTTGGAATCATTAATATAATTT
ACGGAGCCTTAAATGCATTCGCACAAGATAATGTTAAAAGGAGAATCGCATGTAGCTCAGTGAGTCATATGGGTTTTGTT
CTATTAGGTATTGGAGCAGTAGATGCTCTAGGAATTAGCGGAGCAATGCTACAAATGATCAGTCACGGACTTATTGCTGC
AGCTATGTTCTTTGTTACGGGCTCATTCTATGAAAGAACAAATACTCTTTCCATACCAAATATGGGCGGTTTAGCAAAGG
TCTTGCCAATAACTTTTGCTTTTTTCTTAGCAAGCTCACTGGCCTCTCTAGCACTACCAGGGATGAGCGGTTTTATAAGT
GAAATAACTGTATTTTTAGGTATCACTAGTCAAGAGGGATTTAGCTCTATCTTTAGATCAATCACGATTCTAATTGCAGC
CATAGGATTAGTTCTAACACCAATATATCTACTATCAATGTGTAGAAGAGTATTTTTTGGCCCTAGAATTCCAGCACTAG
CTACAGTTAAAGAGATGAATGGTAGAGAATTGACTATTGGTTTCAGTTTATTGTTGCCTACATTGGTAATAGGTTTTTGG
CCCAAAATCGCTATTAATTTATACGAATCTTCAACCAATGCTCTCAGTCAGCAGCTTACCTTAGCTAAATTGATTGGAAT
AATACCCACTTTAGTTAATTAA

Upstream 100 bases:

>100_bases
AGCAATATCTCCGGTAAGTAGTTTTACTTAGGCAACTTTAATGTTATAGTCTCAAGCTAGTACAACTTCAACTAGAATAA
AAAAATTATTCATTACATAA

Downstream 100 bases:

>100_bases
ATTATCTTAATAAATGGATACCTCAATTTTTAAATATGGAGAGTTACCAGAATTTAAAAAATTTACTCCTGAAAGCATTA
GTAAACAATTTCCCTCAGTA

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MNLESFPWLSSIILLPLVGALIMPFLSSKEGEDNTLPRNISLSFLFIDFLLIIGVLFQKFDTSDSSLQMVERASWLPSIG
LEWSLGVDGLSAPLVALSGLITFLSAAASWKIKKKSNLYFALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIW
GGKKKLYAATKFILYTALASLLILISGLALALSGDTFTLNITDLTNKHVTGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLQIAPALIILGIINIIYGALNAFAQDNVKRRIACSSVSHMGFV
LLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERTNTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFIS
EITVFLGITSQEGFSSIFRSITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALATVKEMNGRELTIGFSLLLPTLVIGFW
PKIAINLYESSTNALSQQLTLAKLIGIIPTLVN

Sequences:

>Translated_513_residues
MNLESFPWLSSIILLPLVGALIMPFLSSKEGEDNTLPRNISLSFLFIDFLLIIGVLFQKFDTSDSSLQMVERASWLPSIG
LEWSLGVDGLSAPLVALSGLITFLSAAASWKIKKKSNLYFALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIW
GGKKKLYAATKFILYTALASLLILISGLALALSGDTFTLNITDLTNKHVTGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLQIAPALIILGIINIIYGALNAFAQDNVKRRIACSSVSHMGFV
LLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERTNTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFIS
EITVFLGITSQEGFSSIFRSITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALATVKEMNGRELTIGFSLLLPTLVIGFW
PKIAINLYESSTNALSQQLTLAKLIGIIPTLVN
>Mature_513_residues
MNLESFPWLSSIILLPLVGALIMPFLSSKEGEDNTLPRNISLSFLFIDFLLIIGVLFQKFDTSDSSLQMVERASWLPSIG
LEWSLGVDGLSAPLVALSGLITFLSAAASWKIKKKSNLYFALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIW
GGKKKLYAATKFILYTALASLLILISGLALALSGDTFTLNITDLTNKHVTGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLQIAPALIILGIINIIYGALNAFAQDNVKRRIACSSVSHMGFV
LLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERTNTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFIS
EITVFLGITSQEGFSSIFRSITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALATVKEMNGRELTIGFSLLLPTLVIGFW
PKIAINLYESSTNALSQQLTLAKLIGIIPTLVN

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=375, Percent_Identity=31.7333333333333, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI251831117, Length=357, Percent_Identity=26.3305322128852, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788613, Length=512, Percent_Identity=36.9140625, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1788831, Length=346, Percent_Identity=27.1676300578035, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788827, Length=288, Percent_Identity=28.4722222222222, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI1788829, Length=299, Percent_Identity=27.7591973244147, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788614, Length=468, Percent_Identity=26.7094017094017, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI2367154, Length=195, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693160, Length=313, Percent_Identity=27.4760383386581, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 55352; Mature: 55352

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLESFPWLSSIILLPLVGALIMPFLSSKEGEDNTLPRNISLSFLFIDFLLIIGVLFQKF
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
DTSDSSLQMVERASWLPSIGLEWSLGVDGLSAPLVALSGLITFLSAAASWKIKKKSNLYF
CCCCHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCEEE
ALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIWGGKKKLYAATKFILYTALAS
EEHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LLILISGLALALSGDTFTLNITDLTNKHVTGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
HHHHHHHHHHEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCC
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLQIAPALIILGIINIIYGALNAF
CCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQDNVKRRIACSSVSHMGFVLLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFISEITVFLGITSQEGFSSIFRS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
ITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALATVKEMNGRELTIGFSLLLPTLVIGFW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHCC
PKIAINLYESSTNALSQQLTLAKLIGIIPTLVN
HHHEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLESFPWLSSIILLPLVGALIMPFLSSKEGEDNTLPRNISLSFLFIDFLLIIGVLFQKF
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
DTSDSSLQMVERASWLPSIGLEWSLGVDGLSAPLVALSGLITFLSAAASWKIKKKSNLYF
CCCCHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCEEE
ALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIWGGKKKLYAATKFILYTALAS
EEHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LLILISGLALALSGDTFTLNITDLTNKHVTGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
HHHHHHHHHHEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCC
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLQIAPALIILGIINIIYGALNAF
CCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQDNVKRRIACSSVSHMGFVLLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFISEITVFLGITSQEGFSSIFRS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
ITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALATVKEMNGRELTIGFSLLLPTLVIGFW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHCC
PKIAINLYESSTNALSQQLTLAKLIGIIPTLVN
HHHEEEEECCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA