Click here to switch to the map view.

The map label for this gene is prlC [H]

Identifier: 123968184

GI number: 123968184

Start: 570474

End: 572561

Strand: Reverse

Name: prlC [H]

Synonym: A9601_06491

Alternate gene names: 123968184

Gene position: 572561-570474 (Counterclockwise)

Preceding gene: 123968185

Following gene: 123968179

Centisome position: 34.29

GC content: 32.42

Gene sequence:

>2088_bases
ATGGATACCTCAATTTTTAAATATGGAGAGTTACCAGAATTTAAAAAATTTACTCCTGAAAGCATTAGTAAACAATTTCC
CTCAGTATTAGAAAAGATAGCTGAAGAATTTAAAAACATAGAAAAAAATTTATCTAATTATTTGATTCAAAATGATTTAA
ATTGGGATAAGGTAATAAATCCTTTAAATGAAGTAAATGAAATTCTTAGATGGAGTTGGGGAGTAATAAGTCACCTAAAT
GCTGTAAATAATTCTGAAAGTTTAAGAGATATTTATTCAAAATTTCTTCCAGAGATTATTAGCTTGAGTAATAAATTCGG
GCAAAGCAAAATAATTTTCAATTCTTTAGTCAAGCTTAAAGAAACAAATAACTTTGATCAAATTAAAAACAGAATTTTAG
AAAAAGAAATTCTTGAGATGCAACATAGAGGTATTTCACTGCAAAAGAATGATCAAGAAGAATTCAACAAAATTTCAGAA
ACCCTTGGAAAACTATCAACTGAATTCAGTAACAATGTTCTTGATGCAACTAACGAATGGTTTTTAATTTTAAATAAAAA
ATCCGAAGTCGATGGTCTTCCTGACCGAGTACTTGAATTGATGGCAATTTCTGCACACAATCACTTAAAAAAAGATGAAG
AAGTTGATATTAAAAATGGTCCTTGGAAATTAAGTCTAGATATTCCAACTTATACTTCGTTCATGACATATTCCACAGAG
CGTAATCTTAGAGAAAAGCTTTACAAGGCGTTCGTTAGTAGGGCGTCTCAAGGAGAAAAAAATAATTCTCAAATCATTGA
AGATATATTATCTCTCAGGACTAAACAAGCAAATCTTCTCGGTTATAAAAGTTGGGCAGAACTAAGTTTGTCAACGAAAA
TGGCGAAAGAAATTAAAAATGTAGAAAACCTTTTAGAAGAATTGAGAGAACCAGCATTCAAAGCTGCAAAAATTGAATTA
GAGACGCTCGATAAGTTTTCTAAAGCTAATGGATTTCCAAAATCGCAGAATATTGAACCATGGGATATTAGTTATTGGTC
TGAACTTCTTAGAAAGGAAAAGTTTAATTTAGATCAAGAGTCTTTGAGACCTTGGTTCCCACTAAATGATGTTTTGAAAG
GTTTATTTAAATTAAGTGAGAAGCTTTTTGAAATTAAAGTAGTTGAGGCGACTGATGAGGCACCTCTCTGGAATGATGAC
GTTTTATTTTTTAATATCCTTAATAATGAAAATAAAAAAATTGCATCATTTTACCTAGATCCATATTCTAGGCCTGAATC
AAAAAGAGGAGGGGCTTGGATGGATGAATGTTTGAATAAAAATAATGTTGGCAAAAAGACTCTCCCTGTAGCTTATCTCG
TTTGTAATCAGACCCCACCATCAAAAGACAAACCTAGTTTGATGAGTTTTGAAGAAGTTCAGACTCTTTTCCACGAATTT
GGTCATGGTCTTCAACACATGCTCACTACTGTAAATCTTCCTCAAGCAGCGGGCATTAACAACGTTGAGTGGGATGCAGT
CGAACTTCCCAGTCAATTTATGGAAAACTGGTGTTTTCATAAAAATACACTTATGAATATTGCTAAGCACTACAAAACAG
GAGAAAAATTATCCGATGAGAATTTTGAGAAGCTCTTGAAGAATAGAACTTTTAATTGTGGTATGGCTACTCTTAGACAA
CTACATTTTGCAATTACAGACCTCAGATTGCACAGTAGTATTGATAAAAACGAAGGTAAAACAGCAGATGAAATAAGAAG
AGAAATTGCAAAACAAACTACTGTTATTGAACCAATTCAAGAAGATCACTTTCTTTGTTGTTTTAGTCATATATTTGCAG
GCGGATATTCTGCAGGATACTACTCTTATAAATGGGCTGAAGTTCTAAGTGCTGATGCTTTTTCAATGTTCGAAGAAGCT
GATCTAGAAAACTCTGAAGATTTAAAGCTAATAGGTAAAAAATTCAAAGATACTATACTAAGCTTGGGTGGGAGCTTACC
TCCGTTAGACATATTCAAACTATTCAGGGGAAGAGAGCCACAAACAGATTCATTGATAAGACACTTAGGTTTATCTGGAG
CTACATAA

Upstream 100 bases:

>100_bases
AATTTATACGAATCTTCAACCAATGCTCTCAGTCAGCAGCTTACCTTAGCTAAATTGATTGGAATAATACCCACTTTAGT
TAATTAAATTATCTTAATAA

Downstream 100 bases:

>100_bases
TAATTTCATCGACTATTTTATCCACCACAGATTTATTTCTTACAAGATTTCTATGCTTATATACTTTTACAGATATTTTT
TTTCCAAAATTTAAATTTGT

Product: M3 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
MDTSIFKYGELPEFKKFTPESISKQFPSVLEKIAEEFKNIEKNLSNYLIQNDLNWDKVINPLNEVNEILRWSWGVISHLN
AVNNSESLRDIYSKFLPEIISLSNKFGQSKIIFNSLVKLKETNNFDQIKNRILEKEILEMQHRGISLQKNDQEEFNKISE
TLGKLSTEFSNNVLDATNEWFLILNKKSEVDGLPDRVLELMAISAHNHLKKDEEVDIKNGPWKLSLDIPTYTSFMTYSTE
RNLREKLYKAFVSRASQGEKNNSQIIEDILSLRTKQANLLGYKSWAELSLSTKMAKEIKNVENLLEELREPAFKAAKIEL
ETLDKFSKANGFPKSQNIEPWDISYWSELLRKEKFNLDQESLRPWFPLNDVLKGLFKLSEKLFEIKVVEATDEAPLWNDD
VLFFNILNNENKKIASFYLDPYSRPESKRGGAWMDECLNKNNVGKKTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLMNIAKHYKTGEKLSDENFEKLLKNRTFNCGMATLRQ
LHFAITDLRLHSSIDKNEGKTADEIRREIAKQTTVIEPIQEDHFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEA
DLENSEDLKLIGKKFKDTILSLGGSLPPLDIFKLFRGREPQTDSLIRHLGLSGAT

Sequences:

>Translated_695_residues
MDTSIFKYGELPEFKKFTPESISKQFPSVLEKIAEEFKNIEKNLSNYLIQNDLNWDKVINPLNEVNEILRWSWGVISHLN
AVNNSESLRDIYSKFLPEIISLSNKFGQSKIIFNSLVKLKETNNFDQIKNRILEKEILEMQHRGISLQKNDQEEFNKISE
TLGKLSTEFSNNVLDATNEWFLILNKKSEVDGLPDRVLELMAISAHNHLKKDEEVDIKNGPWKLSLDIPTYTSFMTYSTE
RNLREKLYKAFVSRASQGEKNNSQIIEDILSLRTKQANLLGYKSWAELSLSTKMAKEIKNVENLLEELREPAFKAAKIEL
ETLDKFSKANGFPKSQNIEPWDISYWSELLRKEKFNLDQESLRPWFPLNDVLKGLFKLSEKLFEIKVVEATDEAPLWNDD
VLFFNILNNENKKIASFYLDPYSRPESKRGGAWMDECLNKNNVGKKTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLMNIAKHYKTGEKLSDENFEKLLKNRTFNCGMATLRQ
LHFAITDLRLHSSIDKNEGKTADEIRREIAKQTTVIEPIQEDHFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEA
DLENSEDLKLIGKKFKDTILSLGGSLPPLDIFKLFRGREPQTDSLIRHLGLSGAT
>Mature_695_residues
MDTSIFKYGELPEFKKFTPESISKQFPSVLEKIAEEFKNIEKNLSNYLIQNDLNWDKVINPLNEVNEILRWSWGVISHLN
AVNNSESLRDIYSKFLPEIISLSNKFGQSKIIFNSLVKLKETNNFDQIKNRILEKEILEMQHRGISLQKNDQEEFNKISE
TLGKLSTEFSNNVLDATNEWFLILNKKSEVDGLPDRVLELMAISAHNHLKKDEEVDIKNGPWKLSLDIPTYTSFMTYSTE
RNLREKLYKAFVSRASQGEKNNSQIIEDILSLRTKQANLLGYKSWAELSLSTKMAKEIKNVENLLEELREPAFKAAKIEL
ETLDKFSKANGFPKSQNIEPWDISYWSELLRKEKFNLDQESLRPWFPLNDVLKGLFKLSEKLFEIKVVEATDEAPLWNDD
VLFFNILNNENKKIASFYLDPYSRPESKRGGAWMDECLNKNNVGKKTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLMNIAKHYKTGEKLSDENFEKLLKNRTFNCGMATLRQ
LHFAITDLRLHSSIDKNEGKTADEIRREIAKQTTVIEPIQEDHFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEA
DLENSEDLKLIGKKFKDTILSLGGSLPPLDIFKLFRGREPQTDSLIRHLGLSGAT

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=653, Percent_Identity=27.4119448698315, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI14149738, Length=595, Percent_Identity=30.9243697478992, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI156105687, Length=464, Percent_Identity=24.5689655172414, Blast_Score=139, Evalue=1e-32,
Organism=Escherichia coli, GI1789913, Length=694, Percent_Identity=38.9048991354467, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1787819, Length=648, Percent_Identity=29.0123456790123, Blast_Score=254, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71999758, Length=582, Percent_Identity=22.5085910652921, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI32565901, Length=595, Percent_Identity=22.0168067226891, Blast_Score=104, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319793, Length=577, Percent_Identity=29.9826689774697, Blast_Score=247, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6322715, Length=570, Percent_Identity=24.9122807017544, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21356111, Length=703, Percent_Identity=29.5874822190612, Blast_Score=291, Evalue=1e-78,
Organism=Drosophila melanogaster, GI20129717, Length=469, Percent_Identity=23.6673773987207, Blast_Score=131, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 80132; Mature: 80132

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTSIFKYGELPEFKKFTPESISKQFPSVLEKIAEEFKNIEKNLSNYLIQNDLNWDKVIN
CCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHC
PLNEVNEILRWSWGVISHLNAVNNSESLRDIYSKFLPEIISLSNKFGQSKIIFNSLVKLK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ETNNFDQIKNRILEKEILEMQHRGISLQKNDQEEFNKISETLGKLSTEFSNNVLDATNEW
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCE
FLILNKKSEVDGLPDRVLELMAISAHNHLKKDEEVDIKNGPWKLSLDIPTYTSFMTYSTE
EEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHEHHH
RNLREKLYKAFVSRASQGEKNNSQIIEDILSLRTKQANLLGYKSWAELSLSTKMAKEIKN
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VENLLEELREPAFKAAKIELETLDKFSKANGFPKSQNIEPWDISYWSELLRKEKFNLDQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHH
SLRPWFPLNDVLKGLFKLSEKLFEIKVVEATDEAPLWNDDVLFFNILNNENKKIASFYLD
HCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEHEEEC
PYSRPESKRGGAWMDECLNKNNVGKKTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
CCCCCCCCCCCCHHHHHCCCCCCCCHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLMNIAKHYKTGEKLSDE
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NFEKLLKNRTFNCGMATLRQLHFAITDLRLHSSIDKNEGKTADEIRREIAKQTTVIEPIQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHH
EDHFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEADLENSEDLKLIGKKFKDTIL
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SLGGSLPPLDIFKLFRGREPQTDSLIRHLGLSGAT
HHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MDTSIFKYGELPEFKKFTPESISKQFPSVLEKIAEEFKNIEKNLSNYLIQNDLNWDKVIN
CCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHC
PLNEVNEILRWSWGVISHLNAVNNSESLRDIYSKFLPEIISLSNKFGQSKIIFNSLVKLK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ETNNFDQIKNRILEKEILEMQHRGISLQKNDQEEFNKISETLGKLSTEFSNNVLDATNEW
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCE
FLILNKKSEVDGLPDRVLELMAISAHNHLKKDEEVDIKNGPWKLSLDIPTYTSFMTYSTE
EEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHEHHH
RNLREKLYKAFVSRASQGEKNNSQIIEDILSLRTKQANLLGYKSWAELSLSTKMAKEIKN
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VENLLEELREPAFKAAKIELETLDKFSKANGFPKSQNIEPWDISYWSELLRKEKFNLDQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHH
SLRPWFPLNDVLKGLFKLSEKLFEIKVVEATDEAPLWNDDVLFFNILNNENKKIASFYLD
HCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEHEEEC
PYSRPESKRGGAWMDECLNKNNVGKKTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
CCCCCCCCCCCCHHHHHCCCCCCCCHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLMNIAKHYKTGEKLSDE
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NFEKLLKNRTFNCGMATLRQLHFAITDLRLHSSIDKNEGKTADEIRREIAKQTTVIEPIQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHH
EDHFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEADLENSEDLKLIGKKFKDTIL
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SLGGSLPPLDIFKLFRGREPQTDSLIRHLGLSGAT
HHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]