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The map label for this gene is ilvD [H]

Identifier: 121610336

GI number: 121610336

Start: 3774987

End: 3776717

Strand: Direct

Name: ilvD [H]

Synonym: Veis_3404

Alternate gene names: 121610336

Gene position: 3774987-3776717 (Clockwise)

Preceding gene: 121610335

Following gene: 121610337

Centisome position: 67.81

GC content: 68.4

Gene sequence:

>1731_bases
ATGCAACGACGCCCCTACGAATCCCTGCGTAGCGCCCGCTGGTTCGCGCCCGACGACCTGCGCTCCTTTGGTCACCGCTC
GCGCATGCTGCAAATGGGCTACGGCCATGCCGACTGGATGGGCAAGCCGGTGATCGCCATCGTCAACACCTGGAGCGACG
CCAACCAGTGCCATGCGCACTTCAAGCACCGGGTGGAGGATGTCAAGCGCGGCATCCTGCAAGCCGGCGGCTTCCCGCTC
GAACTGCCGGCGATCTCGCTGTCGGAAAGCCTGGTCAAGCCCACCACCATGCTCTATCGCAACTTCCTGGCGATGGAAAC
CGAAGAACTGCTGCGCAGCCACCCGGTCGACGGCGCAGTGCTGATGGGCGGCTGCGACAAGACCACGCCGGGCCTGACGA
TGGGCGCGCTCAGCATGGACCTGCCCTTCATCTACCTGCCGGCCGGCCCGATGCTGCGCGGCAATTGGAGAGGGCAGGTG
CTGGGTTCGGGCTCCGACGCCTTCAAATACTGGGACGAGCGCCGTGCCGGGCGGCTGGACGAGCAAGCCTGGACCGAGAT
GGAGGCCGGCATTGCGCGCAGCCACGGCACCTGCATGACCATGGGCACGGCCGCCACGATGATGGGCATCGCCGAAGCGC
TGGGCCTGAGCTTGCCGGGCGCTTCCAGCATTCCGGCCGCCGACGCCAACCACATCCGCATGAGCGCCGACTGCGGCCGG
CGCATCGTCGAGATGGTGTGGGAAGACCTGCGGCCCACGCAACTGCTCACGCGCGCCAACTTCGACAACGGCATCGCCTG
CGCGATGGCCATGGGCTGCAGCACCAATGCCGTGGTGCACCTGATCGCACTGTCGCGCCGCGCCGGCCACGCGCTGAGCC
TGGACGACTTCGACGCCTTCAGCCGCCGCGTGCCCGTGATCGCCAACATCCGGCCCAGTGGCCAGCGCTACCTGATGGAG
GACTTCTTCTACGCCGGCGGACTGCCGGCGCTGCTCGAGCGCATCCGCTGCCATCTGCGCACCGACGCGCGCACCGTCAA
CGGCCGCACGCTCGGCCAGAACATCGCCGGCGCCCAGGTCTACGACGACGATGTCATCCGGCCGCTGGACAAACCGATTT
ATGCCGAAGGAGCGCTGGCCGTGCTGCGCGGCAACCTGGCCCCCGACGGCGTGGTGATCAAGCCCAGCGCCTGCGCGCCA
CGACTGCTGCAGCACAGTGGCCGGGCATTGGTGTTCGACGACTACCCGGCGCTCAAGAAAGCGTCGGAAGACCCCGATCT
CGACGTGACCGGCGACGACATCCTGGTGCTGCGCAACGCCGGACCGCGCGGCGCCGGCATGCCCGAGTGGGGCATGCTGC
CGATCCCGACCAAGCTGCTCAAGCAAGGCGTCACGGACATGCTGCGCCTGTCCGACGCGCGCATGAGCGGCACCAGCTAC
GGCGGCTGCCTGCTGCACTGCGCGCCCGAGGCGGCCATCGGCGGGCCGCTGGCGCTGGTCGAGACCGGTGACCGCATCAG
CGTCGACGTGCCCGCGCGGCGCATCCATCTGGACATCGGCGACGCGGAACTGGCCCGCCGCAAGGCACTATGGACGCCGC
CGCCGGCGCGCTACGAACGCGGCTATGGCTGGCTGTTCGATCGCCATATCCGGCAGGCCAACGAAGGCTGCGACTTCGAC
TTCCTGGAAACCAGCTTCGGCAAGCCGGTGCCCGAGCCCGACATCTTCTGA

Upstream 100 bases:

>100_bases
GCACGGGCTCGGCGCAATCCGCGTGCACCATTCTTTTGGCTTGTGCCCAGGCTGCACGCGCATAATGCAAACGCCCCGGA
GACAAGCGGAGACAAGCCCC

Downstream 100 bases:

>100_bases
AATCTTCTGAAGGAGACGCGCAGTGCATCCCGCCACCCGCGAGCAGTTGCTGAAGGTCAGCACCGCCACCCTGTGCACAG
CCCTGTTCAAGCGCGGTCTG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MQRRPYESLRSARWFAPDDLRSFGHRSRMLQMGYGHADWMGKPVIAIVNTWSDANQCHAHFKHRVEDVKRGILQAGGFPL
ELPAISLSESLVKPTTMLYRNFLAMETEELLRSHPVDGAVLMGGCDKTTPGLTMGALSMDLPFIYLPAGPMLRGNWRGQV
LGSGSDAFKYWDERRAGRLDEQAWTEMEAGIARSHGTCMTMGTAATMMGIAEALGLSLPGASSIPAADANHIRMSADCGR
RIVEMVWEDLRPTQLLTRANFDNGIACAMAMGCSTNAVVHLIALSRRAGHALSLDDFDAFSRRVPVIANIRPSGQRYLME
DFFYAGGLPALLERIRCHLRTDARTVNGRTLGQNIAGAQVYDDDVIRPLDKPIYAEGALAVLRGNLAPDGVVIKPSACAP
RLLQHSGRALVFDDYPALKKASEDPDLDVTGDDILVLRNAGPRGAGMPEWGMLPIPTKLLKQGVTDMLRLSDARMSGTSY
GGCLLHCAPEAAIGGPLALVETGDRISVDVPARRIHLDIGDAELARRKALWTPPPARYERGYGWLFDRHIRQANEGCDFD
FLETSFGKPVPEPDIF

Sequences:

>Translated_576_residues
MQRRPYESLRSARWFAPDDLRSFGHRSRMLQMGYGHADWMGKPVIAIVNTWSDANQCHAHFKHRVEDVKRGILQAGGFPL
ELPAISLSESLVKPTTMLYRNFLAMETEELLRSHPVDGAVLMGGCDKTTPGLTMGALSMDLPFIYLPAGPMLRGNWRGQV
LGSGSDAFKYWDERRAGRLDEQAWTEMEAGIARSHGTCMTMGTAATMMGIAEALGLSLPGASSIPAADANHIRMSADCGR
RIVEMVWEDLRPTQLLTRANFDNGIACAMAMGCSTNAVVHLIALSRRAGHALSLDDFDAFSRRVPVIANIRPSGQRYLME
DFFYAGGLPALLERIRCHLRTDARTVNGRTLGQNIAGAQVYDDDVIRPLDKPIYAEGALAVLRGNLAPDGVVIKPSACAP
RLLQHSGRALVFDDYPALKKASEDPDLDVTGDDILVLRNAGPRGAGMPEWGMLPIPTKLLKQGVTDMLRLSDARMSGTSY
GGCLLHCAPEAAIGGPLALVETGDRISVDVPARRIHLDIGDAELARRKALWTPPPARYERGYGWLFDRHIRQANEGCDFD
FLETSFGKPVPEPDIF
>Mature_576_residues
MQRRPYESLRSARWFAPDDLRSFGHRSRMLQMGYGHADWMGKPVIAIVNTWSDANQCHAHFKHRVEDVKRGILQAGGFPL
ELPAISLSESLVKPTTMLYRNFLAMETEELLRSHPVDGAVLMGGCDKTTPGLTMGALSMDLPFIYLPAGPMLRGNWRGQV
LGSGSDAFKYWDERRAGRLDEQAWTEMEAGIARSHGTCMTMGTAATMMGIAEALGLSLPGASSIPAADANHIRMSADCGR
RIVEMVWEDLRPTQLLTRANFDNGIACAMAMGCSTNAVVHLIALSRRAGHALSLDDFDAFSRRVPVIANIRPSGQRYLME
DFFYAGGLPALLERIRCHLRTDARTVNGRTLGQNIAGAQVYDDDVIRPLDKPIYAEGALAVLRGNLAPDGVVIKPSACAP
RLLQHSGRALVFDDYPALKKASEDPDLDVTGDDILVLRNAGPRGAGMPEWGMLPIPTKLLKQGVTDMLRLSDARMSGTSY
GGCLLHCAPEAAIGGPLALVETGDRISVDVPARRIHLDIGDAELARRKALWTPPPARYERGYGWLFDRHIRQANEGCDFD
FLETSFGKPVPEPDIF

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=581, Percent_Identity=30.9810671256454, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1788157, Length=516, Percent_Identity=30.2325581395349, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI2367371, Length=458, Percent_Identity=29.6943231441048, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1786464, Length=452, Percent_Identity=30.7522123893805, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6322476, Length=554, Percent_Identity=31.4079422382672, Blast_Score=254, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 63132; Mature: 63132

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRRPYESLRSARWFAPDDLRSFGHRSRMLQMGYGHADWMGKPVIAIVNTWSDANQCHAH
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHH
FKHRVEDVKRGILQAGGFPLELPAISLSESLVKPTTMLYRNFLAMETEELLRSHPVDGAV
HHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LMGGCDKTTPGLTMGALSMDLPFIYLPAGPMLRGNWRGQVLGSGSDAFKYWDERRAGRLD
EECCCCCCCCCCEEEEHCCCCCEEEECCCCEEECCCCEEEEECCCHHHHHHHHHHCCCCC
EQAWTEMEAGIARSHGTCMTMGTAATMMGIAEALGLSLPGASSIPAADANHIRMSADCGR
HHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECHHHHH
RIVEMVWEDLRPTQLLTRANFDNGIACAMAMGCSTNAVVHLIALSRRAGHALSLDDFDAF
HHHHHHHHHCCHHHHHHHCCCCCCEEEEHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHH
SRRVPVIANIRPSGQRYLMEDFFYAGGLPALLERIRCHLRTDARTVNGRTLGQNIAGAQV
HCCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEE
YDDDVIRPLDKPIYAEGALAVLRGNLAPDGVVIKPSACAPRLLQHSGRALVFDDYPALKK
CCCHHHHHCCCCCCCCCCEEEEECCCCCCCEEECCCCCHHHHHHCCCCEEEEECCHHHHC
ASEDPDLDVTGDDILVLRNAGPRGAGMPEWGMLPIPTKLLKQGVTDMLRLSDARMSGTSY
CCCCCCCEECCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GGCLLHCAPEAAIGGPLALVETGDRISVDVPARRIHLDIGDAELARRKALWTPPPARYER
CCEEEEECCCCCCCCCEEEEECCCEEEEECCCEEEEEECCCHHHHHHCCCCCCCCHHHCC
GYGWLFDRHIRQANEGCDFDFLETSFGKPVPEPDIF
CCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MQRRPYESLRSARWFAPDDLRSFGHRSRMLQMGYGHADWMGKPVIAIVNTWSDANQCHAH
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHH
FKHRVEDVKRGILQAGGFPLELPAISLSESLVKPTTMLYRNFLAMETEELLRSHPVDGAV
HHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LMGGCDKTTPGLTMGALSMDLPFIYLPAGPMLRGNWRGQVLGSGSDAFKYWDERRAGRLD
EECCCCCCCCCCEEEEHCCCCCEEEECCCCEEECCCCEEEEECCCHHHHHHHHHHCCCCC
EQAWTEMEAGIARSHGTCMTMGTAATMMGIAEALGLSLPGASSIPAADANHIRMSADCGR
HHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECHHHHH
RIVEMVWEDLRPTQLLTRANFDNGIACAMAMGCSTNAVVHLIALSRRAGHALSLDDFDAF
HHHHHHHHHCCHHHHHHHCCCCCCEEEEHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHH
SRRVPVIANIRPSGQRYLMEDFFYAGGLPALLERIRCHLRTDARTVNGRTLGQNIAGAQV
HCCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEE
YDDDVIRPLDKPIYAEGALAVLRGNLAPDGVVIKPSACAPRLLQHSGRALVFDDYPALKK
CCCHHHHHCCCCCCCCCCEEEEECCCCCCCEEECCCCCHHHHHHCCCCEEEEECCHHHHC
ASEDPDLDVTGDDILVLRNAGPRGAGMPEWGMLPIPTKLLKQGVTDMLRLSDARMSGTSY
CCCCCCCEECCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GGCLLHCAPEAAIGGPLALVETGDRISVDVPARRIHLDIGDAELARRKALWTPPPARYER
CCEEEEECCCCCCCCCEEEEECCCEEEEECCCEEEEEECCCHHHHHHCCCCCCCCHHHCC
GYGWLFDRHIRQANEGCDFDFLETSFGKPVPEPDIF
CCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA