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The map label for this gene is cysM [C]

Identifier: 121610207

GI number: 121610207

Start: 3642637

End: 3643725

Strand: Direct

Name: cysM [C]

Synonym: Veis_3266

Alternate gene names: 121610207

Gene position: 3642637-3643725 (Clockwise)

Preceding gene: 121610206

Following gene: 121610217

Centisome position: 65.44

GC content: 68.5

Gene sequence:

>1089_bases
ATGAGCACACCGACCCACGCCCCCGCGCCTGCCGACAGATGGCTGCACGGCGCCATTGCGCGCATCGAAGCCGATTACCA
GCGCAGCGCCGACACGCACCTGATCCCGTTGCGCCTGCCGGCTTTTGCCGCGCAGGGCATAGACCTGTACCTGAAGGACG
AATCCACCCACCCCACCGGCAGCCTCAAGCACCGGCTGGCGCGCTCGTTGTTTTTGTATGCGCTGTGCAATGGCTGGATT
GGCGCCGGCTCGACCGTCGTCGAGTCGTCCAGCGGCTCGACGGCAGTCAGCGAAGCCTACTTTGCGCGCCTGCTGGAGTT
GCCGTTCGTGGCGGTGATGCCGCGCAGCACCTCGCCCGAGAAGATCGCGCAGATCGAGTTCCACGGCGGGCGCTGCCATC
TGGTGGACAGCGCCGGCCTGGTCTACGAACAGGCCCGGGCCATCGCCGCGCAGACGGGCGGCCATTACATGGACCAGTTC
ACCTACGCCGAGCGCGCGACCGATTGGCGCGGCAACAACAACATTGCCGAGAGCATGTTCACGCAGATGGCGCGTGAGCG
CCACCCCGTTCCGCGCTGGATCGTGGTGGGCGCGGGCACCGGCGGCACCAGCGCCACCATAGGCCGCTACATGCGCTACC
AGCGCCATGCCAGCCGGCTGTGTGTGGCCGACCCCGCAGGCTCGGTGTTCAGCGCCCACTACCGCACCGGCGACACCACG
CTGACTGCGCCAGGCTCGCGCATCGAGGGCATAGGGCGGCCCCGCGTGGAGCCGAGCTTCATCCGCACGCTGGTCGATCG
GATGATCGAGGTGCCCGATGTCGAGTCGGTGGCCGCCATGCGCGCGCTGTCGCGCTTGCTCGGGCGGCGCGTCGGGCCTT
CGACCGGCACCAACTTCGTGGCCATGCTGACGCTGGCCGCCGAGATGCGCGAGCGCGGCGAGCGCGGCTCCATCCTGTCG
CTGCTGTGCGATGCCGGCGAACGCTATCTGCCCACGTATTTCGACCCGGCCTGGGTGGCGCAATGCTTTGGCGACTGCAC
GCTGGCACAGCACAAGATCGACGCGCAGATCGGCGCCTGCGGCAACTGA

Upstream 100 bases:

>100_bases
TTTCGCGCTGGGGCGCTGACCAGCCCCTTTCAGCTTTGGGGTCTGCAGGCCCCGCAGCGCAGGATCTACACGCCCCATAA
GCTATATTTTTCGCAGCACC

Downstream 100 bases:

>100_bases
CCGATGACAGATGACAACGGACGGATGACCGGTGCGCGGTCTCAGTCCAACGCCGTCCACTTGCGCTCGCTGGCGGCAGA
TTCGACAACCTTTTCAATGA

Product: pyridoxal-5'-phosphate-dependent enzyme subunit beta

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSTPTHAPAPADRWLHGAIARIEADYQRSADTHLIPLRLPAFAAQGIDLYLKDESTHPTGSLKHRLARSLFLYALCNGWI
GAGSTVVESSSGSTAVSEAYFARLLELPFVAVMPRSTSPEKIAQIEFHGGRCHLVDSAGLVYEQARAIAAQTGGHYMDQF
TYAERATDWRGNNNIAESMFTQMARERHPVPRWIVVGAGTGGTSATIGRYMRYQRHASRLCVADPAGSVFSAHYRTGDTT
LTAPGSRIEGIGRPRVEPSFIRTLVDRMIEVPDVESVAAMRALSRLLGRRVGPSTGTNFVAMLTLAAEMRERGERGSILS
LLCDAGERYLPTYFDPAWVAQCFGDCTLAQHKIDAQIGACGN

Sequences:

>Translated_362_residues
MSTPTHAPAPADRWLHGAIARIEADYQRSADTHLIPLRLPAFAAQGIDLYLKDESTHPTGSLKHRLARSLFLYALCNGWI
GAGSTVVESSSGSTAVSEAYFARLLELPFVAVMPRSTSPEKIAQIEFHGGRCHLVDSAGLVYEQARAIAAQTGGHYMDQF
TYAERATDWRGNNNIAESMFTQMARERHPVPRWIVVGAGTGGTSATIGRYMRYQRHASRLCVADPAGSVFSAHYRTGDTT
LTAPGSRIEGIGRPRVEPSFIRTLVDRMIEVPDVESVAAMRALSRLLGRRVGPSTGTNFVAMLTLAAEMRERGERGSILS
LLCDAGERYLPTYFDPAWVAQCFGDCTLAQHKIDAQIGACGN
>Mature_361_residues
STPTHAPAPADRWLHGAIARIEADYQRSADTHLIPLRLPAFAAQGIDLYLKDESTHPTGSLKHRLARSLFLYALCNGWIG
AGSTVVESSSGSTAVSEAYFARLLELPFVAVMPRSTSPEKIAQIEFHGGRCHLVDSAGLVYEQARAIAAQTGGHYMDQFT
YAERATDWRGNNNIAESMFTQMARERHPVPRWIVVGAGTGGTSATIGRYMRYQRHASRLCVADPAGSVFSAHYRTGDTTL
TAPGSRIEGIGRPRVEPSFIRTLVDRMIEVPDVESVAAMRALSRLLGRRVGPSTGTNFVAMLTLAAEMRERGERGSILSL
LCDAGERYLPTYFDPAWVAQCFGDCTLAQHKIDAQIGACGN

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=312, Percent_Identity=24.0384615384615, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI295821200, Length=312, Percent_Identity=24.0384615384615, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4557415, Length=312, Percent_Identity=24.0384615384615, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI2367138, Length=297, Percent_Identity=26.9360269360269, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17539800, Length=366, Percent_Identity=30.8743169398907, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71996324, Length=372, Percent_Identity=32.258064516129, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17539640, Length=356, Percent_Identity=28.0898876404494, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32566674, Length=318, Percent_Identity=27.0440251572327, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562970, Length=316, Percent_Identity=26.8987341772152, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321594, Length=345, Percent_Identity=26.3768115942029, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321449, Length=334, Percent_Identity=26.3473053892216, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39442; Mature: 39311

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPTHAPAPADRWLHGAIARIEADYQRSADTHLIPLRLPAFAAQGIDLYLKDESTHPTG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHCCCEEEEECCCCCCCH
SLKHRLARSLFLYALCNGWIGAGSTVVESSSGSTAVSEAYFARLLELPFVAVMPRSTSPE
HHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCCCC
KIAQIEFHGGRCHLVDSAGLVYEQARAIAAQTGGHYMDQFTYAERATDWRGNNNIAESMF
CEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHH
TQMARERHPVPRWIVVGAGTGGTSATIGRYMRYQRHASRLCVADPAGSVFSAHYRTGDTT
HHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEECCCEE
LTAPGSRIEGIGRPRVEPSFIRTLVDRMIEVPDVESVAAMRALSRLLGRRVGPSTGTNFV
EECCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHH
AMLTLAAEMRERGERGSILSLLCDAGERYLPTYFDPAWVAQCFGDCTLAQHKIDAQIGAC
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCC
GN
CC
>Mature Secondary Structure 
STPTHAPAPADRWLHGAIARIEADYQRSADTHLIPLRLPAFAAQGIDLYLKDESTHPTG
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHCCCEEEEECCCCCCCH
SLKHRLARSLFLYALCNGWIGAGSTVVESSSGSTAVSEAYFARLLELPFVAVMPRSTSPE
HHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCCCC
KIAQIEFHGGRCHLVDSAGLVYEQARAIAAQTGGHYMDQFTYAERATDWRGNNNIAESMF
CEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHH
TQMARERHPVPRWIVVGAGTGGTSATIGRYMRYQRHASRLCVADPAGSVFSAHYRTGDTT
HHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEECCCEE
LTAPGSRIEGIGRPRVEPSFIRTLVDRMIEVPDVESVAAMRALSRLLGRRVGPSTGTNFV
EECCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHH
AMLTLAAEMRERGERGSILSLLCDAGERYLPTYFDPAWVAQCFGDCTLAQHKIDAQIGAC
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCC
GN
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]