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The map label for this gene is bioA [C]

Identifier: 121610137

GI number: 121610137

Start: 3563327

End: 3564703

Strand: Direct

Name: bioA [C]

Synonym: Veis_3196

Alternate gene names: 121610137

Gene position: 3563327-3564703 (Clockwise)

Preceding gene: 121610136

Following gene: 121610138

Centisome position: 64.01

GC content: 65.36

Gene sequence:

>1377_bases
ATGACCAAGACCGAGAGCACCGCCTGGCACCAGGACATCGCCCATGTGGTGCATCCCTATTCGAACCTCGATGCGCACAG
CACGCTCGGCCCCACGGTCATCGCGCGCGGTGACGGCTGCTACGTCTACGACGAGCACGGCAAGCGCTACATCGAGGGCA
TGTCGGGCCTGTGGTGCGCATCGCTCGGCTTTTCCGAGAAGCGCCTGGTCGATGCGGCGACCAGGCAACTCAACACATTG
CCCTACTACCACCTGTTCAGCCACCGTTCGCACCCGCCCGGCATCGCGCTGGCCCAAGCGCTCACGGCCGTCGCGCCCGA
AGGTTTGAACCATGTGCTGTTCTCCAGCTCGGGTTCGGAGGCCAACGATGCCGCCGTCAAACTCATCTGGTACTACAACA
ACCTGCTGGGCCGTCCGCAGAAGAAGAAGATCATCTCGCGCCTGCACGGCTACCACGGTGTGACGGTGGCCTCGGGCAGC
CTCACGGGTCTGGCGCATGTGCACCGCGATTTCGACCTGCCGCTGCCCCGCGTGCTGCACACCGACTGCCCGAGTCACTA
TCACTTCGGCCTGCCGGGCGAATCCGAGCCAGCGTTCACGCAGCGCATCACCGACAACCTGGAGCAACTGATCCTCGAGG
AAGGCCCCGAAACCGTGGCCGCCTTCATTGCGGAGCCGGTGAGCGGCGCGGGCGGCGTGATCGTGCCACCGGCCGGTTAC
TTCGAGCGCGTGCAGGCGATTCTGAAGAAATACGACATTCTTTTCATCGTCGACGAAGTCATCACCGGTTTCGGCCGCAC
CGGACGGATGTTCGGCTGCGAAACCTACGGCCTCCAACCCGACATGATGACCGTGGCCAAGGGTCTGTCGGGGGCCTACC
AGCCGATCTCGGGCCTGCTGCTGACGGACGCCATCCACGACACGCTGCGGGCCGGCAGCCGCAAGCACGGCGCCTTTGCC
CACGGCCTGACCTATGCGGCGCACCCGGTGGCGGCTGCGGTGGCGCTCGAGACGCTGCACATTTACCGCGATCGCGACAT
CGTCGGCCATGTGCGCGAGGTGGCGCCGTACTTCCTGGAAAAGCTCGATGCATTGGCCGAGCATCCGCTGGTCGGACAGG
TGCGCGGCGTCGGTCTGATCGCGGCCGTGGAGATCACGGCCGACAAGGCCGCCCGCAAGCCCTTCGAGCCGACGGCCGGC
ATGGGCGCATGGATCCAGAACCGGACCATGGAATACGGCGTGATCGTGCGCACCATCGCCCATTGCGTGGCGCTGTGCCC
GCCGTTGATTTCCGAGCGCCAGCATATCGACGAACTGTTCGGCGGGCTCTCGCGTGCGCTCGACGATGCGCTGGTGCATG
TGCGCGCGAACAAGTAA

Upstream 100 bases:

>100_bases
ATGCATGCATGCGCGCACGCAACGCACCCGCTGGCCGTCATTGCGCTTCGTGGATGCGCGCTGCGCGTCCTTGTTTTTTC
TTTTTTCTTCGAGGAACCCC

Downstream 100 bases:

>100_bases
ATCCGGGTCCCCCGGCGGAGACATTCATGTACGAAACGCTTTCCCTTTACATCGACGGCGAGTTTCTCCAGGGCGACGGC
CGCGTCGAGCAGGACGTGTT

Product: class III aminotransferase

Products: S-Adenosyl-4-methylthio-2-oxobutanoate; 7,8-Diaminononanoate [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTKTESTAWHQDIAHVVHPYSNLDAHSTLGPTVIARGDGCYVYDEHGKRYIEGMSGLWCASLGFSEKRLVDAATRQLNTL
PYYHLFSHRSHPPGIALAQALTAVAPEGLNHVLFSSSGSEANDAAVKLIWYYNNLLGRPQKKKIISRLHGYHGVTVASGS
LTGLAHVHRDFDLPLPRVLHTDCPSHYHFGLPGESEPAFTQRITDNLEQLILEEGPETVAAFIAEPVSGAGGVIVPPAGY
FERVQAILKKYDILFIVDEVITGFGRTGRMFGCETYGLQPDMMTVAKGLSGAYQPISGLLLTDAIHDTLRAGSRKHGAFA
HGLTYAAHPVAAAVALETLHIYRDRDIVGHVREVAPYFLEKLDALAEHPLVGQVRGVGLIAAVEITADKAARKPFEPTAG
MGAWIQNRTMEYGVIVRTIAHCVALCPPLISERQHIDELFGGLSRALDDALVHVRANK

Sequences:

>Translated_458_residues
MTKTESTAWHQDIAHVVHPYSNLDAHSTLGPTVIARGDGCYVYDEHGKRYIEGMSGLWCASLGFSEKRLVDAATRQLNTL
PYYHLFSHRSHPPGIALAQALTAVAPEGLNHVLFSSSGSEANDAAVKLIWYYNNLLGRPQKKKIISRLHGYHGVTVASGS
LTGLAHVHRDFDLPLPRVLHTDCPSHYHFGLPGESEPAFTQRITDNLEQLILEEGPETVAAFIAEPVSGAGGVIVPPAGY
FERVQAILKKYDILFIVDEVITGFGRTGRMFGCETYGLQPDMMTVAKGLSGAYQPISGLLLTDAIHDTLRAGSRKHGAFA
HGLTYAAHPVAAAVALETLHIYRDRDIVGHVREVAPYFLEKLDALAEHPLVGQVRGVGLIAAVEITADKAARKPFEPTAG
MGAWIQNRTMEYGVIVRTIAHCVALCPPLISERQHIDELFGGLSRALDDALVHVRANK
>Mature_457_residues
TKTESTAWHQDIAHVVHPYSNLDAHSTLGPTVIARGDGCYVYDEHGKRYIEGMSGLWCASLGFSEKRLVDAATRQLNTLP
YYHLFSHRSHPPGIALAQALTAVAPEGLNHVLFSSSGSEANDAAVKLIWYYNNLLGRPQKKKIISRLHGYHGVTVASGSL
TGLAHVHRDFDLPLPRVLHTDCPSHYHFGLPGESEPAFTQRITDNLEQLILEEGPETVAAFIAEPVSGAGGVIVPPAGYF
ERVQAILKKYDILFIVDEVITGFGRTGRMFGCETYGLQPDMMTVAKGLSGAYQPISGLLLTDAIHDTLRAGSRKHGAFAH
GLTYAAHPVAAAVALETLHIYRDRDIVGHVREVAPYFLEKLDALAEHPLVGQVRGVGLIAAVEITADKAARKPFEPTAGM
GAWIQNRTMEYGVIVRTIAHCVALCPPLISERQHIDELFGGLSRALDDALVHVRANK

Specific function: Biotin biosynthesis. [C]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=375, Percent_Identity=29.3333333333333, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI24119277, Length=436, Percent_Identity=28.2110091743119, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI226442705, Length=375, Percent_Identity=28.8, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI13994255, Length=387, Percent_Identity=27.6485788113695, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI226442709, Length=337, Percent_Identity=29.673590504451, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI4557809, Length=420, Percent_Identity=25.2380952380952, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI284507298, Length=335, Percent_Identity=26.5671641791045, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI188536080, Length=389, Percent_Identity=24.1645244215938, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI38679950, Length=389, Percent_Identity=24.1645244215938, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI38679946, Length=389, Percent_Identity=24.1645244215938, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1786991, Length=439, Percent_Identity=29.3849658314351, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI145693181, Length=355, Percent_Identity=30.1408450704225, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789016, Length=429, Percent_Identity=27.7389277389277, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI1788044, Length=416, Percent_Identity=27.1634615384615, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787560, Length=414, Percent_Identity=29.4685990338164, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789759, Length=412, Percent_Identity=26.6990291262136, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI25144271, Length=410, Percent_Identity=26.0975609756098, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=435, Percent_Identity=26.4367816091954, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=28.0821917808219, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI25144274, Length=242, Percent_Identity=30.1652892561983, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17541228, Length=445, Percent_Identity=25.3932584269663, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=464, Percent_Identity=28.448275862069, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324386, Length=482, Percent_Identity=26.9709543568465, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=431, Percent_Identity=23.4338747099768, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=449, Percent_Identity=25.3897550111359, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI161085790, Length=423, Percent_Identity=30.4964539007092, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI21356575, Length=465, Percent_Identity=28.6021505376344, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI28574759, Length=423, Percent_Identity=30.4964539007092, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=26.4563106796117, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281366494, Length=387, Percent_Identity=25.5813953488372, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24667139, Length=387, Percent_Identity=25.5813953488372, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24667143, Length=387, Percent_Identity=25.5813953488372, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62 [C]

Molecular weight: Translated: 49875; Mature: 49743

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTESTAWHQDIAHVVHPYSNLDAHSTLGPTVIARGDGCYVYDEHGKRYIEGMSGLWCA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEEECCCCHHHHHCCCCCEEH
SLGFSEKRLVDAATRQLNTLPYYHLFSHRSHPPGIALAQALTAVAPEGLNHVLFSSSGSE
HCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCC
ANDAAVKLIWYYNNLLGRPQKKKIISRLHGYHGVTVASGSLTGLAHVHRDFDLPLPRVLH
CCCHHEEEEEEHHHHHCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCCCHHHH
TDCPSHYHFGLPGESEPAFTQRITDNLEQLILEEGPETVAAFIAEPVSGAGGVIVPPAGY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCHH
FERVQAILKKYDILFIVDEVITGFGRTGRMFGCETYGLQPDMMTVAKGLSGAYQPISGLL
HHHHHHHHHHCCHHEEHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHCCCCHHHHHHHH
LTDAIHDTLRAGSRKHGAFAHGLTYAAHPVAAAVALETLHIYRDRDIVGHVREVAPYFLE
HHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
KLDALAEHPLVGQVRGVGLIAAVEITADKAARKPFEPTAGMGAWIQNRTMEYGVIVRTIA
HHHHHHCCCCCHHHCCCEEEEEEEEEHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHH
HCVALCPPLISERQHIDELFGGLSRALDDALVHVRANK
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCC
>Mature Secondary Structure 
TKTESTAWHQDIAHVVHPYSNLDAHSTLGPTVIARGDGCYVYDEHGKRYIEGMSGLWCA
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEEECCCCHHHHHCCCCCEEH
SLGFSEKRLVDAATRQLNTLPYYHLFSHRSHPPGIALAQALTAVAPEGLNHVLFSSSGSE
HCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCC
ANDAAVKLIWYYNNLLGRPQKKKIISRLHGYHGVTVASGSLTGLAHVHRDFDLPLPRVLH
CCCHHEEEEEEHHHHHCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCCCHHHH
TDCPSHYHFGLPGESEPAFTQRITDNLEQLILEEGPETVAAFIAEPVSGAGGVIVPPAGY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCHH
FERVQAILKKYDILFIVDEVITGFGRTGRMFGCETYGLQPDMMTVAKGLSGAYQPISGLL
HHHHHHHHHHCCHHEEHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHCCCCHHHHHHHH
LTDAIHDTLRAGSRKHGAFAHGLTYAAHPVAAAVALETLHIYRDRDIVGHVREVAPYFLE
HHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
KLDALAEHPLVGQVRGVGLIAAVEITADKAARKPFEPTAGMGAWIQNRTMEYGVIVRTIA
HHHHHHCCCCCHHHCCCEEEEEEEEEHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHH
HCVALCPPLISERQHIDELFGGLSRALDDALVHVRANK
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Amino-7-oxononanoate; S-Adenosyl-L-methionine [C]

Specific reaction: 8-Amino-7-oxononanoate + S-Adenosyl-L-methionine <==> S-Adenosyl-4-methylthio-2-oxobutanoate + 7,8-Diaminononanoate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]