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The map label for this gene is eccCa1

Identifier: 121639788

GI number: 121639788

Start: 4318930

End: 4321173

Strand: Direct

Name: eccCa1

Synonym: BCG_3933

Alternate gene names: 121639788

Gene position: 4318930-4321173 (Clockwise)

Preceding gene: 121639787

Following gene: 121639789

Centisome position: 98.73

GC content: 63.1

Gene sequence:

>2244_bases
ATGACGACCAAGAAGTTCACTCCCACCATTACCCGTGGCCCCCGGTTGACCCCGGGCGAGATCAGCCTCACGCCGCCCGA
TGACCTGGGCATCGACATCCCACCGTCGGGCGTCCAAAAGATCCTTCCCTACGTGATGGGTGGCGCCATGCTCGGCATGA
TCGCCATCATGGTGGCCGGCGGCACCAGGCAGCTGTCGCCGTACATGTTGATGATGCCGCTGATGATGATCGTGATGATG
GTCGGCGGTCTGGCCGGTAGCACCGGTGGTGGCGGCAAGAAGGTGCCCGAAATCAACGCCGACCGCAAGGAGTACCTGCG
GTATTTGGCAGGACTACGCACCCGAGTGACGTCCTCGGCCACCTCTCAGGTGGCGTTCTTCTCCTACCACGCACCGCATC
CCGAGGATCTGTTGTCGATCGTCGGCACCCAACGGCAGTGGTCCCGGCCGGCCAACGCCGACTTCTATGCGGCCACCCGA
ATCGGTATCGGTGACCAGCCGGCGGTGGATCGATTATTGAAGCCGGCCGTCGGCGGGGAGTTGGCCGCCGCCAGCGCAGC
ACCTCAGCCGTTCCTGGAGCCGGTCAGTCATATGTGGGTGGTCAAGTTTCTACGAACCCATGGATTGATCCATGACTGCC
CGAAACTGCTGCAACTCCGTACCTTTCCGACTATCGCGATCGGCGGGGACTTGGCGGGGGCAGCCGGCCTGATGACGGCG
ATGATCTGTCACCTAGCCGTGTTCCACCCACCGGACCTGCTGCAGATCCGGGTGCTCACCGAGGAACCCGACGACCCCGA
CTGGTCCTGGCTCAAATGGCTTCCGCACGTACAGCACCAGACCGAAACCGATGCGGCCGGGTCCACCCGGCTGATCTTCA
CGCGCCAGGAAGGTCTGTCGGACCTGGCCGCGCGCGGGCCACACGCACCCGATTCGCTTCCCGGCGGCCCCTACGTAGTC
GTCGTCGACCTGACCGGCGGCAAGGCTGGATTCCCGCCCGACGGTAGGGCCGGTGTCACGGTGATCACGTTGGGCAACCA
TCGCGGCTCGGCCTACCGCATCAGGGTGCACGAGGATGGGACGGCTGATGACCGGCTCCCTAACCAATCGTTTCGCCAGG
TGACATCGGTCACCGATCGGATGTCGCCGCAGCAAGCCAGCCGTATCGCGCGAAAGTTGGCCGGATGGTCCATCACGGGC
ACCATCCTCGACAAGACGTCGCGGGTCCAGAAGAAGGTGGCCACCGACTGGCACCAGCTGGTCGGTGCGCAAAGTGTCGA
GGAGATAACACCTTCCCGCTGGAGGATGTACACCGACACCGACCGTGACCGGCTAAAGATCCCGTTTGGTCATGAACTAA
AGACCGGCAACGTCATGTACCTGGACATCAAAGAGGGCGCGGAATTCGGCGCCGGACCGCACGGCATGCTCATCGGGACC
ACGGGGTCTGGGAAGTCCGAATTCCTGCGCACCCTGATCCTGTCGCTGGTGGCAATGACTCATCCAGATCAGGTGAATCT
CCTGCTCACCGACTTCAAAGGTGGTTCAACCTTCCTGGGAATGGAAAAGCTTCCGCACACTGCCGCTGTCGTCACCAACA
TGGCCGAGGAAGCCGAGCTCGTCAGCCGGATGGGCGAGGTGTTGACCGGAGAACTCGATCGGCGCCAGTCGATCCTCCGA
CAGGCCGGGATGAAAGTCGGCGCGGCCGGAGCCCTGTCCGGCGTGGCCGAATACGAGAAGTACCGCGAACGCGGTGCCGA
CCTACCCCCGCTGCCAACGCTTTTCGTCGTCGTCGACGAGTTCGCCGAGCTGTTGCAGAGTCACCCGGACTTCATCGGGC
TGTTCGACCGGATCTGCCGCGTCGGGCGGTCGCTGAGGGTCCATCTGCTGCTGGCTACCCAGTCGCTGCAGACCGGCGGT
GTTCGCATCGACAAACTGGAGCCAAACCTGACATATCGAATCGCATTGCGCACCACCAGCTCTCATGAATCCAAGGCGGT
AATCGGCACACCGGAGGCGCAGTACATCACCAACAAGGAGAGCGGTGTCGGGTTTCTCCGGGTCGGCATGGAAGACCCGG
TCAAGTTCAGCACCTTCTACATCAGTGGGCCATACATGCCGCCGGCGGCAGGCGTCGAAACCAATGGTGAAGCCGGAGGG
CCCGGTCAACAGACCACTAGACAAGCCGCGCGCATTCACAGGTTCACCGCGGCACCGGTTCTCGAGGAGGCGCCGACACC
GTGA

Upstream 100 bases:

>100_bases
GTCCGGTGCTGTCGAAAGATGCCGCACTGCTCGAGCACGACACGCTGCCCGCTGACCCTAGCCCCCGAAAAGTTCCCGCC
GGAGCCTCCGGAGCCCCCTG

Downstream 100 bases:

>100_bases
CCCGCGCCGGCGACGATGCAAAGCGCAGCGATGAGGAGGAGCGGCGCCAACGGCCCGCGCCGGCGACGATGCAAAGCGCA
GCGATGAGGAGGAGCGGCGC

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component Ca1; Type VII secretion system protein eccCa1; T7SS protein eccCa1

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MTTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPYVMGGAMLGMIAIMVAGGTRQLSPYMLMMPLMMIVMM
VGGLAGSTGGGGKKVPEINADRKEYLRYLAGLRTRVTSSATSQVAFFSYHAPHPEDLLSIVGTQRQWSRPANADFYAATR
IGIGDQPAVDRLLKPAVGGELAAASAAPQPFLEPVSHMWVVKFLRTHGLIHDCPKLLQLRTFPTIAIGGDLAGAAGLMTA
MICHLAVFHPPDLLQIRVLTEEPDDPDWSWLKWLPHVQHQTETDAAGSTRLIFTRQEGLSDLAARGPHAPDSLPGGPYVV
VVDLTGGKAGFPPDGRAGVTVITLGNHRGSAYRIRVHEDGTADDRLPNQSFRQVTSVTDRMSPQQASRIARKLAGWSITG
TILDKTSRVQKKVATDWHQLVGAQSVEEITPSRWRMYTDTDRDRLKIPFGHELKTGNVMYLDIKEGAEFGAGPHGMLIGT
TGSGKSEFLRTLILSLVAMTHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVSRMGEVLTGELDRRQSILR
QAGMKVGAAGALSGVAEYEKYRERGADLPPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGG
VRIDKLEPNLTYRIALRTTSSHESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFSTFYISGPYMPPAAGVETNGEAGG
PGQQTTRQAARIHRFTAAPVLEEAPTP

Sequences:

>Translated_747_residues
MTTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPYVMGGAMLGMIAIMVAGGTRQLSPYMLMMPLMMIVMM
VGGLAGSTGGGGKKVPEINADRKEYLRYLAGLRTRVTSSATSQVAFFSYHAPHPEDLLSIVGTQRQWSRPANADFYAATR
IGIGDQPAVDRLLKPAVGGELAAASAAPQPFLEPVSHMWVVKFLRTHGLIHDCPKLLQLRTFPTIAIGGDLAGAAGLMTA
MICHLAVFHPPDLLQIRVLTEEPDDPDWSWLKWLPHVQHQTETDAAGSTRLIFTRQEGLSDLAARGPHAPDSLPGGPYVV
VVDLTGGKAGFPPDGRAGVTVITLGNHRGSAYRIRVHEDGTADDRLPNQSFRQVTSVTDRMSPQQASRIARKLAGWSITG
TILDKTSRVQKKVATDWHQLVGAQSVEEITPSRWRMYTDTDRDRLKIPFGHELKTGNVMYLDIKEGAEFGAGPHGMLIGT
TGSGKSEFLRTLILSLVAMTHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVSRMGEVLTGELDRRQSILR
QAGMKVGAAGALSGVAEYEKYRERGADLPPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGG
VRIDKLEPNLTYRIALRTTSSHESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFSTFYISGPYMPPAAGVETNGEAGG
PGQQTTRQAARIHRFTAAPVLEEAPTP
>Mature_746_residues
TTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPYVMGGAMLGMIAIMVAGGTRQLSPYMLMMPLMMIVMMV
GGLAGSTGGGGKKVPEINADRKEYLRYLAGLRTRVTSSATSQVAFFSYHAPHPEDLLSIVGTQRQWSRPANADFYAATRI
GIGDQPAVDRLLKPAVGGELAAASAAPQPFLEPVSHMWVVKFLRTHGLIHDCPKLLQLRTFPTIAIGGDLAGAAGLMTAM
ICHLAVFHPPDLLQIRVLTEEPDDPDWSWLKWLPHVQHQTETDAAGSTRLIFTRQEGLSDLAARGPHAPDSLPGGPYVVV
VDLTGGKAGFPPDGRAGVTVITLGNHRGSAYRIRVHEDGTADDRLPNQSFRQVTSVTDRMSPQQASRIARKLAGWSITGT
ILDKTSRVQKKVATDWHQLVGAQSVEEITPSRWRMYTDTDRDRLKIPFGHELKTGNVMYLDIKEGAEFGAGPHGMLIGTT
GSGKSEFLRTLILSLVAMTHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVSRMGEVLTGELDRRQSILRQ
AGMKVGAAGALSGVAEYEKYRERGADLPPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGGV
RIDKLEPNLTYRIALRTTSSHESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFSTFYISGPYMPPAAGVETNGEAGGP
GQQTTRQAARIHRFTAAPVLEEAPTP

Specific function: Part of a complex that is involved in secretion of ESX-1 substrates, such as esxA (ESAT-6) and esxB (CFP-10). Responsible for multiple suppressive effects on macrophages and required for bacterial replication after phagocytosis

COG id: COG1674

COG function: function code D; DNA segregation ATPase FtsK/SpoIIIE and related proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FtsK domain

Homologues:

Organism=Escherichia coli, GI1787117, Length=219, Percent_Identity=28.7671232876712, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECC1A_MYCTU (O69735)

Other databases:

- EMBL:   BX842584
- EMBL:   AE000516
- PIR:   D70802
- RefSeq:   NP_218387.1
- RefSeq:   NP_338537.1
- ProteinModelPortal:   O69735
- SMR:   O69735
- EnsemblBacteria:   EBMYCT00000001071
- EnsemblBacteria:   EBMYCT00000071335
- GeneID:   886204
- GeneID:   926282
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3983
- KEGG:   mtu:Rv3870
- TIGR:   MT3983
- TubercuList:   Rv3870
- GeneTree:   EBGT00050000016601
- HOGENOM:   HBG568433
- OMA:   GPHTADA
- ProtClustDB:   CLSK792775
- GO:   GO:0009405
- InterPro:   IPR002543

Pfam domain/function: PF01580 FtsK_SpoIIIE

EC number: NA

Molecular weight: Translated: 80914; Mature: 80783

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS50901 FTSK

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1a05d18c)-; HASH(0x196151bc)-; HASH(0x196151f8)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPYVMGGAMLGMIAIMVAG
CCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GTRQLSPYMLMMPLMMIVMMVGGLAGSTGGGGKKVPEINADRKEYLRYLAGLRTRVTSSA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
TSQVAFFSYHAPHPEDLLSIVGTQRQWSRPANADFYAATRIGIGDQPAVDRLLKPAVGGE
CCEEEEEEECCCCHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCC
LAAASAAPQPFLEPVSHMWVVKFLRTHGLIHDCPKLLQLRTFPTIAIGGDLAGAAGLMTA
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHH
MICHLAVFHPPDLLQIRVLTEEPDDPDWSWLKWLPHVQHQTETDAAGSTRLIFTRQEGLS
HHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHCHH
DLAARGPHAPDSLPGGPYVVVVDLTGGKAGFPPDGRAGVTVITLGNHRGSAYRIRVHEDG
HHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCC
TADDRLPNQSFRQVTSVTDRMSPQQASRIARKLAGWSITGTILDKTSRVQKKVATDWHQL
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHH
VGAQSVEEITPSRWRMYTDTDRDRLKIPFGHELKTGNVMYLDIKEGAEFGAGPHGMLIGT
HCCHHHHHCCCCCEEEEECCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEE
TGSGKSEFLRTLILSLVAMTHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAEL
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECHHHCCHHHHHHHHHHHHHHH
VSRMGEVLTGELDRRQSILRQAGMKVGAAGALSGVAEYEKYRERGADLPPLPTLFVVVDE
HHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGGVRIDKLEPNLTYRIALRTTS
HHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCEEEEEECCCEEEEEEEEECC
SHESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFSTFYISGPYMPPAAGVETNGEAGG
CCCCCEEEECCCHHEECCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCC
PGQQTTRQAARIHRFTAAPVLEEAPTP
CCHHHHHHHHHHHHHHCCCHHHCCCCH
>Mature Secondary Structure 
TTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPYVMGGAMLGMIAIMVAG
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GTRQLSPYMLMMPLMMIVMMVGGLAGSTGGGGKKVPEINADRKEYLRYLAGLRTRVTSSA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
TSQVAFFSYHAPHPEDLLSIVGTQRQWSRPANADFYAATRIGIGDQPAVDRLLKPAVGGE
CCEEEEEEECCCCHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCC
LAAASAAPQPFLEPVSHMWVVKFLRTHGLIHDCPKLLQLRTFPTIAIGGDLAGAAGLMTA
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHH
MICHLAVFHPPDLLQIRVLTEEPDDPDWSWLKWLPHVQHQTETDAAGSTRLIFTRQEGLS
HHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHCHH
DLAARGPHAPDSLPGGPYVVVVDLTGGKAGFPPDGRAGVTVITLGNHRGSAYRIRVHEDG
HHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCC
TADDRLPNQSFRQVTSVTDRMSPQQASRIARKLAGWSITGTILDKTSRVQKKVATDWHQL
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHH
VGAQSVEEITPSRWRMYTDTDRDRLKIPFGHELKTGNVMYLDIKEGAEFGAGPHGMLIGT
HCCHHHHHCCCCCEEEEECCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEE
TGSGKSEFLRTLILSLVAMTHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAEL
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECHHHCCHHHHHHHHHHHHHHH
VSRMGEVLTGELDRRQSILRQAGMKVGAAGALSGVAEYEKYRERGADLPPLPTLFVVVDE
HHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGGVRIDKLEPNLTYRIALRTTS
HHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCEEEEEECCCEEEEEEEEECC
SHESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFSTFYISGPYMPPAAGVETNGEAGG
CCCCCEEEECCCHHEECCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCC
PGQQTTRQAARIHRFTAAPVLEEAPTP
CCHHHHHHHHHHHHHHCCCHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036