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The map label for this gene is eccCb1 [H]

Identifier: 121639789

GI number: 121639789

Start: 4321276

End: 4322748

Strand: Direct

Name: eccCb1 [H]

Synonym: BCG_3934

Alternate gene names: 121639789

Gene position: 4321276-4322748 (Clockwise)

Preceding gene: 121639788

Following gene: 121639819

Centisome position: 98.78

GC content: 63.34

Gene sequence:

>1473_bases
ATGACTGCTGAACCGGAAGTACGGACGCTGCGCGAGGTTGTGCTGGACCAGCTCGGCACTGCTGAATCGCGTGCGTACAA
GATGTGGCTGCCGCCGTTGACCAATCCGGTCCCGCTCAACGAGCTCATCGCCCGTGATCGGCGACAACCCCTGCGATTTG
CCCTGGGGATCATGGATGAACCGCGCCGCCATCTACAGGATGTGTGGGGCGTAGACGTTTCCGGGGCCGGCGGCAACATC
GGTATTGGGGGCGCACCTCAAACCGGGAAGTCGACGCTACTGCAGACGATGGTGATGTCGGCCGCCGCCACACACTCACC
GCGCAACGTTCAGTTCTATTGCATCGACCTAGGTGGCGGCGGGCTGATCTATCTCGAAAACCTTCCACACGTCGGTGGGG
TAGCCAATCGGTCCGAGCCCGACAAGGTCAACCGGGTGGTCGCAGAGATGCAAGCCGTCATGCGGCAACGGGAAACCACC
TTCAAGGAACACCGAGTGGGCTCGATCGGGATGTACCGGCAGCTGCGTGACGATCCAAGTCAACCCGTTGCGTCCGATCC
ATACGGCGACGTCTTTCTGATCATCGACGGATGGCCCGGTTTTGTCGGCGAGTTCCCCGACCTTGAGGGGCAGGTTCAAG
ATCTGGCCGCCCAGGGGCTGGCGTTCGGCGTCCACGTCATCATCTCCACGCCACGCTGGACAGAGCTGAAGTCGCGTGTT
CGCGACTACCTCGGCACCAAGATCGAGTTCCGGCTTGGTGACGTCAATGAAACCCAGATCGACCGGATTACCCGCGAGAT
CCCGGCGAATCGTCCGGGTCGGGCAGTGTCGATGGAAAAGCACCATCTGATGATCGGCGTGCCCAGGTTCGACGGCGTGC
ACAGCGCCGATAACCTGGTGGAGGCGATCACCGCGGGGGTGACGCAGATCGCTTCCCAGCACACCGAACAGGCACCTCCG
GTGCGGGTCCTGCCGGAGCGTATCCACCTGCACGAACTCGACCCGAACCCGCCGGGACCAGAGTCCGACTACCGCACTCG
CTGGGAGATTCCGATCGGCTTGCGCGAGACGGACCTGACGCCGGCTCACTGCCACATGCACACGAACCCGCACCTACTGA
TCTTCGGTGCGGCCAAATCGGGCAAGACGACCATTGCCCACGCGATCGCGCGCGCCATTTGTGCCCGAAACAGTCCCCAG
CAGGTGCGGTTCATGCTCGCGGACTACCGCTCGGGCCTGCTGGACGCGGTGCCGGACACCCATCTGCTGGGCGCCGGCGC
GATCAACCGCAACAGCGCGTCGCTAGACGAGGCCGTTCAAGCACTGGCGGTCAACCTGAAGAAGCGGTTGCCGCCGACCG
ACCTGACGACGGCGCAGCTACGCTCGCGTTCGTGGTGGAGCGGATTTGACGTCGTGCTTCTGGTCGACGATTGGCACATC
CAGCCGCCCGGATCCAGCATCTGTCTGGCATAG

Upstream 100 bases:

>100_bases
CGCGCCGGCGACGATGCAAAGCGCAGCGATGAGGAGGAGCGGCGCCAACGGCCCGCGCCGGCGACGATGCAAAGCGCAGC
GATGAGGAGGAGCGGCGCGC

Downstream 100 bases:

>100_bases
CTGCCCGTCGGCCTGGTAATACTCATCCCCTACTGCCCTCCCCAAACCGCCAGATCGCCTCGCGGATCACCGTCCGGTTG
GCCTCCGGCATTTCACGCCG

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component Cb1; Type VII secretion system protein EccCb1; T7SS protein EccCb1 [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MTAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIARDRRQPLRFALGIMDEPRRHLQDVWGVDVSGAGGNI
GIGGAPQTGKSTLLQTMVMSAAATHSPRNVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETT
FKEHRVGSIGMYRQLRDDPSQPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQGLAFGVHVIISTPRWTELKSRV
RDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSMEKHHLMIGVPRFDGVHSADNLVEAITAGVTQIASQHTEQAPP
VRVLPERIHLHELDPNPPGPESDYRTRWEIPIGLRETDLTPAHCHMHTNPHLLIFGAAKSGKTTIAHAIARAICARNSPQ
QVRFMLADYRSGLLDAVPDTHLLGAGAINRNSASLDEAVQALAVNLKKRLPPTDLTTAQLRSRSWWSGFDVVLLVDDWHI
QPPGSSICLA

Sequences:

>Translated_490_residues
MTAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIARDRRQPLRFALGIMDEPRRHLQDVWGVDVSGAGGNI
GIGGAPQTGKSTLLQTMVMSAAATHSPRNVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETT
FKEHRVGSIGMYRQLRDDPSQPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQGLAFGVHVIISTPRWTELKSRV
RDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSMEKHHLMIGVPRFDGVHSADNLVEAITAGVTQIASQHTEQAPP
VRVLPERIHLHELDPNPPGPESDYRTRWEIPIGLRETDLTPAHCHMHTNPHLLIFGAAKSGKTTIAHAIARAICARNSPQ
QVRFMLADYRSGLLDAVPDTHLLGAGAINRNSASLDEAVQALAVNLKKRLPPTDLTTAQLRSRSWWSGFDVVLLVDDWHI
QPPGSSICLA
>Mature_489_residues
TAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIARDRRQPLRFALGIMDEPRRHLQDVWGVDVSGAGGNIG
IGGAPQTGKSTLLQTMVMSAAATHSPRNVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETTF
KEHRVGSIGMYRQLRDDPSQPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQGLAFGVHVIISTPRWTELKSRVR
DYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSMEKHHLMIGVPRFDGVHSADNLVEAITAGVTQIASQHTEQAPPV
RVLPERIHLHELDPNPPGPESDYRTRWEIPIGLRETDLTPAHCHMHTNPHLLIFGAAKSGKTTIAHAIARAICARNSPQQ
VRFMLADYRSGLLDAVPDTHLLGAGAINRNSASLDEAVQALAVNLKKRLPPTDLTTAQLRSRSWWSGFDVVLLVDDWHIQ
PPGSSICLA

Specific function: Part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10). May link the cytosolic components of the system with the membrane components. Responsible for multiple suppressive effects on macrophages and req

COG id: COG1674

COG function: function code D; DNA segregation ATPase FtsK/SpoIIIE and related proteins

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 FtsK domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR002543 [H]

Pfam domain/function: PF01580 FtsK_SpoIIIE [H]

EC number: NA

Molecular weight: Translated: 54016; Mature: 53885

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50901 FTSK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIARDRRQPLRFALGIMDE
CCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHCCCCC
PRRHLQDVWGVDVSGAGGNIGIGGAPQTGKSTLLQTMVMSAAATHSPRNVQFYCIDLGGG
HHHHHHHHHCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
GLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETTFKEHRVGSIGMYRQLRDDPS
CEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
QPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQGLAFGVHVIISTPRWTELKSRV
CCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEECCCHHHHHHHH
RDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSMEKHHLMIGVPRFDGVHSADNLV
HHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCCCHHHHH
EAITAGVTQIASQHTEQAPPVRVLPERIHLHELDPNPPGPESDYRTRWEIPIGLRETDLT
HHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCC
PAHCHMHTNPHLLIFGAAKSGKTTIAHAIARAICARNSPQQVRFMLADYRSGLLDAVPDT
CHHEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCC
HLLGAGAINRNSASLDEAVQALAVNLKKRLPPTDLTTAQLRSRSWWSGFDVVLLVDDWHI
CEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCEEEEEEECEEE
QPPGSSICLA
CCCCCCCCCC
>Mature Secondary Structure 
TAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIARDRRQPLRFALGIMDE
CCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHCCCCC
PRRHLQDVWGVDVSGAGGNIGIGGAPQTGKSTLLQTMVMSAAATHSPRNVQFYCIDLGGG
HHHHHHHHHCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
GLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETTFKEHRVGSIGMYRQLRDDPS
CEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
QPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQGLAFGVHVIISTPRWTELKSRV
CCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEECCCHHHHHHHH
RDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSMEKHHLMIGVPRFDGVHSADNLV
HHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCCCHHHHH
EAITAGVTQIASQHTEQAPPVRVLPERIHLHELDPNPPGPESDYRTRWEIPIGLRETDLT
HHHHHHHHHHHHHHHCCCCCCEECCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCC
PAHCHMHTNPHLLIFGAAKSGKTTIAHAIARAICARNSPQQVRFMLADYRSGLLDAVPDT
CHHEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCC
HLLGAGAINRNSASLDEAVQALAVNLKKRLPPTDLTTAQLRSRSWWSGFDVVLLVDDWHI
CEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCEEEEEEECEEE
QPPGSSICLA
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]