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The map label for this gene is eccB1

Identifier: 121639787

GI number: 121639787

Start: 4317488

End: 4318930

Strand: Direct

Name: eccB1

Synonym: BCG_3932

Alternate gene names: 121639787

Gene position: 4317488-4318930 (Clockwise)

Preceding gene: 121639786

Following gene: 121639788

Centisome position: 98.7

GC content: 64.52

Gene sequence:

>1443_bases
ATGGGGCTTCGCCTCACCACCAAGGTTCAGGTTAGCGGCTGGCGTTTTCTGCTGCGCCGGCTCGAACACGCCATCGTGCG
CCGGGACACCCGGATGTTTGACGACCCGCTGCAGTTCTACAGCCGCTCGATCGCTCTTGGCATCGTCGTCGCGGTCCTGA
TTCTGGCGGGTGCCGCGCTGCTGGCGTACTTCAAACCACAAGGCAAACTCGGCGGCACCAGCCTGTTCACCGACCGCGCG
ACCAACCAGCTTTACGTGCTGCTGTCCGGACAGTTGCATCCGGTCTACAACCTGACTTCGGCGCGGCTGGTGCTGGGCAA
TCCGGCCAACCCGGCCACCGTGAAGTCCTCCGAACTGAGCAAGCTGCCGATGGGCCAGACCGTTGGAATCCCCGGCGCCC
CCTACGCCACGCCTGTTTCGGCGGGCAGCACCTCGATCTGGACCCTATGCGACACCGTCGCCCGAGCCGACTCCACTTCC
CCGGTAGTGCAGACCGCGGTCATCGCGATGCCGTTGGAGATCGATGCTTCGATCGATCCGCTCCAGTCACACGAAGCGGT
GCTGGTGTCCTACCAGGGCGAAACCTGGATCGTCACAACTAAGGGACGCCACGCCATAGATCTGACCGACCGCGCCCTCA
CCTCGTCGATGGGGATACCGGTGACGGCCAGGCCAACCCCGATCTCGGAGGGCATGTTCAACGCGCTGCCTGATATGGGG
CCCTGGCAGCTGCCGCCGATACCGGCGGCGGGCGCGCCCAATTCGCTTGGCCTACCTGATGATCTAGTGATCGGATCGGT
CTTCCAGATCCACACCGACAAGGGCCCGCAATACTATGTGGTGCTGCCCGACGGCATCGCGCAGGTCAACGCGACAACCG
CTGCGGCGCTGCGCGCCACCCAGGCGCACGGGCTGGTCGCGCCACCGGCAATGGTGCCCAGTCTGGTCGTCAGAATCGCC
GAACGGGTATACCCCTCACCGCTACCCGATGAACCGCTCAAGATCGTGTCCCGGCCGCAGGATCCCGCGCTGTGCTGGTC
ATGGCAACGCAGCGCCGGCGACCAGTCGCCGCAGTCAACGGTGCTGTCCGGCCGGCATCTGCCGATATCGCCCTCAGCGA
TGAACATGGGGATCAAGCAGATCCACGGGACGGCGACCGTTTACCTCGACGGCGGAAAATTCGTGGCACTGCAATCCCCC
GATCCTCGATACACCGAATCGATGTACTACATCGATCCACAGGGCGTGCGTTATGGGGTGCCTAACGCGGAGACAGCCAA
GTCGCTGGGCCTGAGTTCACCCCAAAACGCGCCCTGGGAGATCGTTCGTCTCCTGGTCGACGGTCCGGTGCTGTCGAAAG
ATGCCGCACTGCTCGAGCACGACACGCTGCCCGCTGACCCTAGCCCCCGAAAAGTTCCCGCCGGAGCCTCCGGAGCCCCC
TGA

Upstream 100 bases:

>100_bases
CGACACCCTCGACGAAGACCGGCTTCGCGAGATCAACGGCTCAGATATGGCGGAGGCTATCGCCGCGGTGCACGCACACC
TCAACATGAGAGAATGAACT

Downstream 100 bases:

>100_bases
TGACGACCAAGAAGTTCACTCCCACCATTACCCGTGGCCCCCGGTTGACCCCGGGCGAGATCAGCCTCACGCCGCCCGAT
GACCTGGGCATCGACATCCC

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component B1; Type VII secretion system protein eccB1; T7SS protein eccB1

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MGLRLTTKVQVSGWRFLLRRLEHAIVRRDTRMFDDPLQFYSRSIALGIVVAVLILAGAALLAYFKPQGKLGGTSLFTDRA
TNQLYVLLSGQLHPVYNLTSARLVLGNPANPATVKSSELSKLPMGQTVGIPGAPYATPVSAGSTSIWTLCDTVARADSTS
PVVQTAVIAMPLEIDASIDPLQSHEAVLVSYQGETWIVTTKGRHAIDLTDRALTSSMGIPVTARPTPISEGMFNALPDMG
PWQLPPIPAAGAPNSLGLPDDLVIGSVFQIHTDKGPQYYVVLPDGIAQVNATTAAALRATQAHGLVAPPAMVPSLVVRIA
ERVYPSPLPDEPLKIVSRPQDPALCWSWQRSAGDQSPQSTVLSGRHLPISPSAMNMGIKQIHGTATVYLDGGKFVALQSP
DPRYTESMYYIDPQGVRYGVPNAETAKSLGLSSPQNAPWEIVRLLVDGPVLSKDAALLEHDTLPADPSPRKVPAGASGAP

Sequences:

>Translated_480_residues
MGLRLTTKVQVSGWRFLLRRLEHAIVRRDTRMFDDPLQFYSRSIALGIVVAVLILAGAALLAYFKPQGKLGGTSLFTDRA
TNQLYVLLSGQLHPVYNLTSARLVLGNPANPATVKSSELSKLPMGQTVGIPGAPYATPVSAGSTSIWTLCDTVARADSTS
PVVQTAVIAMPLEIDASIDPLQSHEAVLVSYQGETWIVTTKGRHAIDLTDRALTSSMGIPVTARPTPISEGMFNALPDMG
PWQLPPIPAAGAPNSLGLPDDLVIGSVFQIHTDKGPQYYVVLPDGIAQVNATTAAALRATQAHGLVAPPAMVPSLVVRIA
ERVYPSPLPDEPLKIVSRPQDPALCWSWQRSAGDQSPQSTVLSGRHLPISPSAMNMGIKQIHGTATVYLDGGKFVALQSP
DPRYTESMYYIDPQGVRYGVPNAETAKSLGLSSPQNAPWEIVRLLVDGPVLSKDAALLEHDTLPADPSPRKVPAGASGAP
>Mature_479_residues
GLRLTTKVQVSGWRFLLRRLEHAIVRRDTRMFDDPLQFYSRSIALGIVVAVLILAGAALLAYFKPQGKLGGTSLFTDRAT
NQLYVLLSGQLHPVYNLTSARLVLGNPANPATVKSSELSKLPMGQTVGIPGAPYATPVSAGSTSIWTLCDTVARADSTSP
VVQTAVIAMPLEIDASIDPLQSHEAVLVSYQGETWIVTTKGRHAIDLTDRALTSSMGIPVTARPTPISEGMFNALPDMGP
WQLPPIPAAGAPNSLGLPDDLVIGSVFQIHTDKGPQYYVVLPDGIAQVNATTAAALRATQAHGLVAPPAMVPSLVVRIAE
RVYPSPLPDEPLKIVSRPQDPALCWSWQRSAGDQSPQSTVLSGRHLPISPSAMNMGIKQIHGTATVYLDGGKFVALQSPD
PRYTESMYYIDPQGVRYGVPNAETAKSLGLSSPQNAPWEIVRLLVDGPVLSKDAALLEHDTLPADPSPRKVPAGASGAP

Specific function: Probably part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10)

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eccB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECCB1_MYCTU (O69734)

Other databases:

- EMBL:   BX842584
- EMBL:   AE000516
- PIR:   C70802
- RefSeq:   NP_218386.1
- RefSeq:   NP_338536.1
- EnsemblBacteria:   EBMYCT00000003945
- EnsemblBacteria:   EBMYCT00000072938
- GeneID:   886166
- GeneID:   922542
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3982
- KEGG:   mtu:Rv3869
- TIGR:   MT3982
- TubercuList:   Rv3869
- GeneTree:   EBGT00050000016351
- HOGENOM:   HBG571250
- OMA:   QLRPVYN
- ProtClustDB:   CLSK792774
- InterPro:   IPR007795

Pfam domain/function: PF05108 DUF690

EC number: NA

Molecular weight: Translated: 51093; Mature: 50962

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x19c94edc)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLRLTTKVQVSGWRFLLRRLEHAIVRRDTRMFDDPLQFYSRSIALGIVVAVLILAGAAL
CCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAYFKPQGKLGGTSLFTDRATNQLYVLLSGQLHPVYNLTSARLVLGNPANPATVKSSELS
HHHCCCCCCCCCCEEEECCCCCEEEEEEECCCCCEEECCCCEEEECCCCCCCEECCCHHH
KLPMGQTVGIPGAPYATPVSAGSTSIWTLCDTVARADSTSPVVQTAVIAMPLEIDASIDP
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHEEEEEEEEEEECCCCCC
LQSHEAVLVSYQGETWIVTTKGRHAIDLTDRALTSSMGIPVTARPTPISEGMFNALPDMG
CCCCCEEEEEECCCEEEEEECCCEEEECHHHHHHHCCCCCEECCCCCCCCCHHHHCCCCC
PWQLPPIPAAGAPNSLGLPDDLVIGSVFQIHTDKGPQYYVVLPDGIAQVNATTAAALRAT
CCCCCCCCCCCCCCCCCCCCHHHHCCEEEEEECCCCEEEEECCCCCHHCCCHHHHHHHHH
QAHGLVAPPAMVPSLVVRIAERVYPSPLPDEPLKIVSRPQDPALCWSWQRSAGDQSPQST
HCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCCHHH
VLSGRHLPISPSAMNMGIKQIHGTATVYLDGGKFVALQSPDPRYTESMYYIDPQGVRYGV
HHCCCCCCCCCHHHHCCHHHCCCEEEEEECCCEEEEECCCCCCCCCCEEEECCCCCEECC
PNAETAKSLGLSSPQNAPWEIVRLLVDGPVLSKDAALLEHDTLPADPSPRKVPAGASGAP
CCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
GLRLTTKVQVSGWRFLLRRLEHAIVRRDTRMFDDPLQFYSRSIALGIVVAVLILAGAAL
CCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAYFKPQGKLGGTSLFTDRATNQLYVLLSGQLHPVYNLTSARLVLGNPANPATVKSSELS
HHHCCCCCCCCCCEEEECCCCCEEEEEEECCCCCEEECCCCEEEECCCCCCCEECCCHHH
KLPMGQTVGIPGAPYATPVSAGSTSIWTLCDTVARADSTSPVVQTAVIAMPLEIDASIDP
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHEEEEEEEEEEECCCCCC
LQSHEAVLVSYQGETWIVTTKGRHAIDLTDRALTSSMGIPVTARPTPISEGMFNALPDMG
CCCCCEEEEEECCCEEEEEECCCEEEECHHHHHHHCCCCCEECCCCCCCCCHHHHCCCCC
PWQLPPIPAAGAPNSLGLPDDLVIGSVFQIHTDKGPQYYVVLPDGIAQVNATTAAALRAT
CCCCCCCCCCCCCCCCCCCCHHHHCCEEEEEECCCCEEEEECCCCCHHCCCHHHHHHHHH
QAHGLVAPPAMVPSLVVRIAERVYPSPLPDEPLKIVSRPQDPALCWSWQRSAGDQSPQST
HCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCCHHH
VLSGRHLPISPSAMNMGIKQIHGTATVYLDGGKFVALQSPDPRYTESMYYIDPQGVRYGV
HHCCCCCCCCCHHHHCCHHHCCCEEEEEECCCEEEEECCCCCCCCCCEEEECCCCCEECC
PNAETAKSLGLSSPQNAPWEIVRLLVDGPVLSKDAALLEHDTLPADPSPRKVPAGASGAP
CCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036