Click here to switch to the map view.

The map label for this gene is eccA1 [H]

Identifier: 121639786

GI number: 121639786

Start: 4315763

End: 4317484

Strand: Direct

Name: eccA1 [H]

Synonym: BCG_3931

Alternate gene names: 121639786

Gene position: 4315763-4317484 (Clockwise)

Preceding gene: 121639785

Following gene: 121639787

Centisome position: 98.66

GC content: 64.34

Gene sequence:

>1722_bases
ATGACTGATCGCTTGGCCAGTCTGTTCGAAAGCGCCGTCAGCATGTTGCCGATGTCGGAGGCGCGGTCGCTAGATCTGTT
CACCGAGATCACCAACTACGACGAATCCGCTTGCGACGCATGGATCGGCCGGATCCGGTGTGGGGACACCGACCGGGTGA
CGCTGTTTCGCGCCTGGTATTCGCGCCGCAATTTCGGACAGTTGTCGGGATCGGTCCAGATCTCGATGAGCACGTTAAAC
GCCAGGATTGCCATCGGGGGGCTGTACGGCGATATCACCTACCCGGTCACCTCGCCGCTAGCGATCACCATGGGCTTTGC
CGCATGCGAGGCAGCGCAAGGCAATTACGCCGACGCCATGGAGGCCTTAGAGGCCGCCCCGGTCGCGGGTTCCGAGCACC
TGGTGGCGTGGATGAAGGCGGTTGTCTACGGCGCGGCCGAACGCTGGACCGACGTGATCGACCAGGTCAAGAGTGCTGGG
AAATGGCCGGACAAGTTTTTGGCCGGCGCGGCCGGTGTGGCGCACGGGGTTGCCGCGGCAAACCTGGCCTTGTTCACCGA
AGCCGAACGCCGACTCACCGAGGCCAACGACTCGCCCGCCGGTGAGGCGTGTGCGCGCGCCATCGCCTGGTATCTGGCGA
TGGCACGGCGCAGCCAGGGCAACGAAAGCGCCGCGGTGGCGCTGCTGGAATGGTTACAGACCACTCACCCCGAGCCCAAA
GTGGCTGTGGCGCTGAAGGATCCCTCCTACCGGCTGAAGACGACCACCGCCGAACAGATCGCATCCCGCGCCGATCCCTG
GGATCCGGGCAGTGTCGTGACCGACAACTCCGGCCGGGAGCGGCTGCTCGCCGAGGCCCAAGCCGAACTCGACCGCCAAA
TTGGGCTCACCCGGGTTAAAAATCAGATTGAACGCTACCGCGCGGCGACGCTGATGGCCCGGGTCCGCGCCGCCAAGGGT
ATGAAGGTCGCCCAGCCCAGCAAGCACATGATCTTCACCGGACCGCCCGGTACCGGCAAGACCACGATCGCGCGGGTGGT
GGCCAATATCCTGGCCGGCTTAGGCGTCATTGCCGAACCCAAACTCGTCGAGACGTCGCGCAAGGACTTCGTCGCCGAGT
ACGAGGGGCAATCGGCGGTCAAGACCGCTAAGACGATCGATCAGGCGCTGGGCGGGGTGCTTTTCATCGACGAGGCTTAT
GCGCTGGTGCAGGAAAGAGACGGCCGCACCGATCCGTTCGGTCAAGAGGCGCTGGACACGCTGCTGGCGCGGATGGAGAA
CGACCGGGACCGGCTGGTGGTGATCATCGCCGGGTACAGCTCCGACATAGATCGGCTGCTGGAAACCAACGAGGGTCTGC
GGTCGCGGTTCGCCACTCGCATCGAGTTCGACACCTATTCCCCCGAGGAACTCCTCGAGATCGCCAACGTCATTGCCGCT
GCTGATGATTCGGCGTTGACCGCAGAGGCGGCCGAGAACTTTCTTCAGGCCGCCAAGCAGTTGGAGCAGCGCATGTTGCG
CGGCCGGCGCGCCCTGGACGTCGCCGGCAACGGTCGGTATGCGCGCCAGCTGGTGGAGGCCAGCGAGCAATGCCGGGACA
TGCGTCTAGCCCAGGTCCTCGATATCGACACCCTCGACGAAGACCGGCTTCGCGAGATCAACGGCTCAGATATGGCGGAG
GCTATCGCCGCGGTGCACGCACACCTCAACATGAGAGAATGA

Upstream 100 bases:

>100_bases
ATGACCCTGAATCTGCCGACGCCGGAAGAGGCTGCCGCAGCCGAAGCCGAAGTGTTCGCCACCCGCTACGATGTCGACTA
CACCTCCCGGTACAAGGCCG

Downstream 100 bases:

>100_bases
ACTATGGGGCTTCGCCTCACCACCAAGGTTCAGGTTAGCGGCTGGCGTTTTCTGCTGCGCCGGCTCGAACACGCCATCGT
GCGCCGGGACACCCGGATGT

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component A1; Type VII secretion system protein EccA1; T7SS protein EccA1 [H]

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLN
ARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAG
KWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPK
VAVALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVKNQIERYRAATLMARVRAAKG
MKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEPKLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAY
ALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAA
ADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVLDIDTLDEDRLREINGSDMAE
AIAAVHAHLNMRE

Sequences:

>Translated_573_residues
MTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLN
ARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAG
KWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPK
VAVALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVKNQIERYRAATLMARVRAAKG
MKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEPKLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAY
ALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAA
ADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVLDIDTLDEDRLREINGSDMAE
AIAAVHAHLNMRE
>Mature_572_residues
TDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNA
RIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAGK
WPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPKV
AVALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVKNQIERYRAATLMARVRAAKGM
KVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEPKLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAYA
LVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAAA
DDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVLDIDTLDEDRLREINGSDMAEA
IAAVHAHLNMRE

Specific function: Probably part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10). Shows ATPase activity. Could provide energy for export of ESX-1 substrates [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cbxX/cfxQ family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR000641 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: NA

Molecular weight: Translated: 62454; Mature: 62323

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWY
CCHHHHHHHHHHHHHCCCHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
SRRNFGQLSGSVQISMSTLNARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAM
HCCCCCCCCCEEEEEEEECCEEEEEEEEECCEECCCCCCHHHHHHHHHHHCCCCCHHHHH
EALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAGKWPDKFLAGAAGVAHGVAAA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
NLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPK
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
VAVALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVK
EEEEECCCCCEEECCHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHH
NQIERYRAATLMARVRAAKGMKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCC
KLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAYALVQERDGRTDPFGQEALDT
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEHHHHHHHHHCCCCCCCCCHHHHHH
LLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAA
HHHHHCCCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHH
ADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DIDTLDEDRLREINGSDMAEAIAAVHAHLNMRE
CCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWY
CHHHHHHHHHHHHHCCCHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
SRRNFGQLSGSVQISMSTLNARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAM
HCCCCCCCCCEEEEEEEECCEEEEEEEEECCEECCCCCCHHHHHHHHHHHCCCCCHHHHH
EALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAGKWPDKFLAGAAGVAHGVAAA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
NLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPK
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
VAVALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVK
EEEEECCCCCEEECCHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHH
NQIERYRAATLMARVRAAKGMKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCC
KLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAYALVQERDGRTDPFGQEALDT
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEHHHHHHHHHCCCCCCCCCHHHHHH
LLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAA
HHHHHCCCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHH
ADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DIDTLDEDRLREINGSDMAEAIAAVHAHLNMRE
CCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]