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The map label for this gene is mutY [H]

Identifier: 121639509

GI number: 121639509

Start: 4009381

End: 4010295

Strand: Direct

Name: mutY [H]

Synonym: BCG_3654

Alternate gene names: 121639509

Gene position: 4009381-4010295 (Clockwise)

Preceding gene: 121639506

Following gene: 121639512

Centisome position: 91.65

GC content: 69.73

Gene sequence:

>915_bases
ATGCCTCACATACTGCCGGAACCGTCGGTGACCGGCCCGCGACACATATCAGATACCAATCTTCTCGCTTGGTATCAGCG
ATCGCACCGGGATCTGCCCTGGCGAGAGCCCGGTGTCAGCCCGTGGCAGATCCTGGTCAGCGAGTTCATGCTGCAGCAGA
CGCCGGCCGCCCGGGTGCTGGCGATCTGGCCGGACTGGGTGCGGCGGTGGCCCACGCCGTCGGCCACCGCCACGGCCAGC
ACCGCCGATGTGTTACGCGCCTGGGGCAAGCTGGGCTATCCCAGGCGAGCCAAGCGCTTACACGAGTGCGCCACCGTCAT
CGCCCGCGACCACAATGACGTGGTGCCCGACGATATCGAGATCCTGGTCACCCTGCCGGGCGTCGGGAGCTACACCGCGC
GCGCGGTGGCGTGTTTCGCTTACCGCCAGCGGGTGCCGGTGGTGGACACCAATGTGCGGCGCGTGGTGGCCCGCGCCGTT
CACGGCCGCGCCGACGCCGGTGCGCCATCGGTGCCGCGCGACCACGCCGACGTCTTGGCGCTGTTGCCGCACCGCGAGAC
GGCGCCTGAATTTTCGGTCGCGCTGATGGAGTTGGGTGCGACGGTGTGCACCGCCCGCACACCCCGGTGCGGGTTATGCC
CGCTGGACTGGTGCGCATGGCGGCATGCCGGTTATCCGCCGTCGGACGGTCCGCCGCGCCGGGGGCAGGCCTACACCGGA
ACCGACCGCCAAGTCCGCGGACGGTTACTGGATGTGTTGCGCGCCGCGGAGTTTCCCGTCACCCGGGCCGAGTTGGACGT
GGCGTGGCTGACCGATACCGCACAGCGTGACCGGGCGCTGGAGTCGCTGCTGGCCGATGCGCTGGTGACCCGGACGGTCG
ATGGCCGGTTCGCGTTGCCCGGCGAAGGGTTTTAG

Upstream 100 bases:

>100_bases
GTGGTCGACGCTCTGACTGGGATGCTGGGGCCGGCCGGCGACGAATCGCTCGTTACCCTCTTTGAGTGCTTTCCACGCGG
CTACCGGATTGGTGTTGGGC

Downstream 100 bases:

>100_bases
CCGGGTAGGCCGTCCGCACCGGCGGCGCCGAAACCGCCGGGATCACCGGGGTTGCCCGCGACGACTGTCCCAGCTCCCGC
GGCGCCACCCGCGCCGCCAG

Product: putative adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MPHILPEPSVTGPRHISDTNLLAWYQRSHRDLPWREPGVSPWQILVSEFMLQQTPAARVLAIWPDWVRRWPTPSATATAS
TADVLRAWGKLGYPRRAKRLHECATVIARDHNDVVPDDIEILVTLPGVGSYTARAVACFAYRQRVPVVDTNVRRVVARAV
HGRADAGAPSVPRDHADVLALLPHRETAPEFSVALMELGATVCTARTPRCGLCPLDWCAWRHAGYPPSDGPPRRGQAYTG
TDRQVRGRLLDVLRAAEFPVTRAELDVAWLTDTAQRDRALESLLADALVTRTVDGRFALPGEGF

Sequences:

>Translated_304_residues
MPHILPEPSVTGPRHISDTNLLAWYQRSHRDLPWREPGVSPWQILVSEFMLQQTPAARVLAIWPDWVRRWPTPSATATAS
TADVLRAWGKLGYPRRAKRLHECATVIARDHNDVVPDDIEILVTLPGVGSYTARAVACFAYRQRVPVVDTNVRRVVARAV
HGRADAGAPSVPRDHADVLALLPHRETAPEFSVALMELGATVCTARTPRCGLCPLDWCAWRHAGYPPSDGPPRRGQAYTG
TDRQVRGRLLDVLRAAEFPVTRAELDVAWLTDTAQRDRALESLLADALVTRTVDGRFALPGEGF
>Mature_303_residues
PHILPEPSVTGPRHISDTNLLAWYQRSHRDLPWREPGVSPWQILVSEFMLQQTPAARVLAIWPDWVRRWPTPSATATAST
ADVLRAWGKLGYPRRAKRLHECATVIARDHNDVVPDDIEILVTLPGVGSYTARAVACFAYRQRVPVVDTNVRRVVARAVH
GRADAGAPSVPRDHADVLALLPHRETAPEFSVALMELGATVCTARTPRCGLCPLDWCAWRHAGYPPSDGPPRRGQAYTGT
DRQVRGRLLDVLRAAEFPVTRAELDVAWLTDTAQRDRALESLLADALVTRTVDGRFALPGEGF

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=205, Percent_Identity=38.5365853658537, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI115298652, Length=205, Percent_Identity=38.5365853658537, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI115298650, Length=205, Percent_Identity=38.5365853658537, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI115298648, Length=205, Percent_Identity=38.5365853658537, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI6912520, Length=205, Percent_Identity=38.5365853658537, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI190358497, Length=205, Percent_Identity=38.5365853658537, Blast_Score=128, Evalue=6e-30,
Organism=Escherichia coli, GI1789331, Length=198, Percent_Identity=34.8484848484849, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 33685; Mature: 33554

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHILPEPSVTGPRHISDTNLLAWYQRSHRDLPWREPGVSPWQILVSEFMLQQTPAARVL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
AIWPDWVRRWPTPSATATASTADVLRAWGKLGYPRRAKRLHECATVIARDHNDVVPDDIE
EECHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEE
ILVTLPGVGSYTARAVACFAYRQRVPVVDTNVRRVVARAVHGRADAGAPSVPRDHADVLA
EEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHE
LLPHRETAPEFSVALMELGATVCTARTPRCGLCPLDWCAWRHAGYPPSDGPPRRGQAYTG
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCC
TDRQVRGRLLDVLRAAEFPVTRAELDVAWLTDTAQRDRALESLLADALVTRTVDGRFALP
CCHHHHHHHHHHHHHHCCCCCHHHEEEEEHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GEGF
CCCC
>Mature Secondary Structure 
PHILPEPSVTGPRHISDTNLLAWYQRSHRDLPWREPGVSPWQILVSEFMLQQTPAARVL
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
AIWPDWVRRWPTPSATATASTADVLRAWGKLGYPRRAKRLHECATVIARDHNDVVPDDIE
EECHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEE
ILVTLPGVGSYTARAVACFAYRQRVPVVDTNVRRVVARAVHGRADAGAPSVPRDHADVLA
EEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHE
LLPHRETAPEFSVALMELGATVCTARTPRCGLCPLDWCAWRHAGYPPSDGPPRRGQAYTG
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCC
TDRQVRGRLLDVLRAAEFPVTRAELDVAWLTDTAQRDRALESLLADALVTRTVDGRFALP
CCHHHHHHHHHHHHHHCCCCCHHHEEEEEHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GEGF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]