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The map label for this gene is disA

Identifier: 121639506

GI number: 121639506

Start: 4006782

End: 4007858

Strand: Direct

Name: disA

Synonym: BCG_3651

Alternate gene names: 121639506

Gene position: 4006782-4007858 (Clockwise)

Preceding gene: 121639505

Following gene: 121639509

Centisome position: 91.59

GC content: 65.37

Gene sequence:

>1077_bases
ATGCACGCTGTGACTCGTCCGACCCTGCGTGAGGCTGTCGCCCGCCTAGCCCCGGGCACTGGGCTGCGGGACGGCCTGGA
GCGTATCCTGCGCGGCCGCACTGGTGCCCTGATCGTGCTGGGCCATGACGAGAATGTCGAGGCCATCTGCGATGGTGGCT
TCTCCCTCGATGTCCGCTATGCAGCAACCCGGCTACGCGAGCTGTGCAAGATGGACGGCGCCGTGGTGCTGTCCACCGAC
GGCAGCCGCATCGTGCGGGCCAACGTGCAACTGGTACCGGATCCGTCGATCCCCACCGACGAATCGGGGACCCGGCACCG
CTCGGCCGAGCGGGCCGCGATCCAGACCGGTTACCCGGTGATCTCAGTGAGCCACTCGATGAACATCGTGACCGTCTACG
TCCGCGGGGAACGTCACGTATTGACCGACTCGGCAACCATCCTGTCGCGGGCCAACCAGGCCATCGCAACCCTGGAGCGG
TACAAAACCAGGCTCGACGAGGTCAGCCGGCAACTGTCCAGGGCAGAAATCGAGGACTTCGTCACGCTGCGCGATGTGAT
GACGGTGGTGCAACGCCTCGAGCTGGTCCGGCGAATCGGGCTGGTGATCGACTACGACGTGGTCGAACTCGGCACTGATG
GTCGTCAGCTGCGGCTGCAGCTCGACGAGTTGCTCGGCGGCAACGACACCGCCCGGGAATTGATCGTGCGCGATTACCAC
GCCAACCCGGAACCACCGTCCACGGGGCAAATCAATGCCACCCTGGACGAACTGGACGCCCTGTCGGACGGCGACCTCCT
CGATTTCACCGCGCTGGCAAAGGTTTTCGGATATCCGACGACCACGGAAGCGCAGGATTCGGCGCTGAGCCCGCGTGGCT
ACCGCGCGATGGCCGGTATCCCCCGGCTCCAGTTCGCCCATGCCGACCTGCTGGTCCGGGCGTTCGGAACGTTGCAGGGT
CTGCTGGCGGCCAGCGCCGGCGATCTGCAATCAGTGGACGGCATCGGCGCCATGTGGGCCCGTCATGTGCGCGATGGGTT
GTCACAGCTGGCGGAATCGACCATCAGCGATCAATAA

Upstream 100 bases:

>100_bases
TACATGGTCGACATTGCCGACCACCGCGGCACCACCCTCGCAACCCCGCCCTCACATTCCGGGACTGGACACGTCCCACT
AGGGCGCGGTACATAGCAGA

Downstream 100 bases:

>100_bases
TTATCCGCCTTGCGCGGGAGACTCCGGCGGAGGCGCCTGCGCTGGACCCGGAGCGGGTACCGGCCCGGGCGGCGGCGGCT
GATTCAGGATGAACGGAACC

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTD
GSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLER
YKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYH
ANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSALSPRGYRAMAGIPRLQFAHADLLVRAFGTLQG
LLAASAGDLQSVDGIGAMWARHVRDGLSQLAESTISDQ

Sequences:

>Translated_358_residues
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTD
GSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLER
YKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYH
ANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSALSPRGYRAMAGIPRLQFAHADLLVRAFGTLQG
LLAASAGDLQSVDGIGAMWARHVRDGLSQLAESTISDQ
>Mature_358_residues
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTD
GSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLER
YKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYH
ANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSALSPRGYRAMAGIPRLQFAHADLLVRAFGTLQG
LLAASAGDLQSVDGIGAMWARHVRDGLSQLAESTISDQ

Specific function: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DISA_MYCBO (Q7TW52)

Other databases:

- EMBL:   BX248346
- RefSeq:   NP_857256.1
- ProteinModelPortal:   Q7TW52
- SMR:   Q7TW52
- EnsemblBacteria:   EBMYCT00000015421
- GeneID:   1092967
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3617
- GeneTree:   EBGT00050000017731
- HOGENOM:   HBG292471
- OMA:   ISVSQSM
- ProtClustDB:   PRK13482
- BioCyc:   MBOV233413:MB3617-MONOMER
- HAMAP:   MF_01438
- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR010994

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N; SSF47781 RuvA_2_like

EC number: NA

Molecular weight: Translated: 38988; Mature: 38988

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRY
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCEEEHHH
AATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPV
HHHHHHHHHHCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCE
ISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDF
EEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYH
HHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHEEHHHHHCCCHHHHHHHHHHCC
ANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSALSPRGYRAMAGI
CCCCCCCCCEEECCHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCC
PRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVRDGLSQLAESTISDQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRY
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCEEEHHH
AATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPV
HHHHHHHHHHCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCE
ISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDF
EEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYH
HHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHEEHHHHHCCCHHHHHHHHHHCC
ANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSALSPRGYRAMAGI
CCCCCCCCCEEECCHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCC
PRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVRDGLSQLAESTISDQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972