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The map label for this gene is fadD3 [H]

Identifier: 121639480

GI number: 121639480

Start: 3980529

End: 3982052

Strand: Direct

Name: fadD3 [H]

Synonym: BCG_3625

Alternate gene names: 121639480

Gene position: 3980529-3982052 (Clockwise)

Preceding gene: 121639477

Following gene: 121639481

Centisome position: 90.99

GC content: 69.62

Gene sequence:

>1524_bases
TTGATAAACGATCTGCGCACCGTGCCCGCGGCGCTGGATCGTCTCGTGCGCCAGCTACCCGACCACACGGCGTTGATCGC
CGAGGACCGGCGTTTCACGTCGACCGAGCTGCGCGACGCGGTCTACGGCGCCGCGGCGGCGCTGATCGCCCTCGGTGTCG
AACCCGCAGACCGGGTGGCCATCTGGTCGCCGAACACCTGGCACTGGGTGGTGGCCTGCCTGGCGATCCACCACGCCGGC
GCCGCGGTGGTGCCGTTGAACACCCGCTACACCGCCACAGAAGCCACCGACATCTTGGACCGAGCCGGCGCGCCGGTGCT
GTTCGCGGCGGGCCTCTTCCTGGGCGCCGACCGGGCGGCCGGCCTGGACCGGGCCGCGCTGCCCGCGTTGCGGCACGTCG
TGCGGGTGCCGGTCGAAGCCGACGACGGGACCTGGGACGAGTTCATCGCCACGGGTGCCGGGGCCCTGGATGCCGTCGCA
GCCCGTGCCGCCGCCGTCGCACCCCAGGACGTCAGCGACATCCTGTTCACCTCCGGCACCACCGGCCGCAGCAAAGGCGT
GCTGTGCGCGCACCGGCAGTCGCTGTCGGCCTCGGCATCCTGGGCCGCCAACGGGAAGATCACCAGCGACGACCGCTACC
TGTGCATCAACCCGTTCTTCCACAACTTCGGCTACAAGGCCGGCATCCTGGCCTGCCTGCAGACCGGTGCCACGCTGATC
CCGCACGTGACGTTCGATCCGCTGCACGCGCTGCGGGCCATCGAGCGCCACCGCATCACCGTGTTGCCGGGCCCTCCGAC
CATCTACCAGAGCCTGCTGGATCACCCGGCCCGCAAAGACTTCGACCTGAGCTCGCTGCGGTTCGCGGTCACCGGTGCGG
CCACCGTGCCGGTGGTGCTGGTGGAGCGCATGCAGTCCGAACTTGACATCGACATCGTGCTGACCGCCTACGGGTTGACC
GAGGCCAACGGGATGGGGACGATGTGCCGCCCCGAGGACGACGCGGTGACCGTTGCGACGACGTGCGGGCGGCCGTTCGC
CGACTTTGAGTTGCGCATTGCGGACGACGGGGAAGTGTTGCTGCGCGGGCCGAACGTCATGGTGGGCTATCTGGACGACA
CGGAGGCGACCGCGGCCGCCATCGACGCCGACGGCTGGCTGCACACCGGCGACATCGGTGCCGTCGACCAGGCGGGCAAC
CTGCGCATCAACGACCGCCTGAAGGACATGTACATCTGCGGCGGATTCAACGTCTATCCCGCCGAGGTCGAGCAGGTGCT
GGCCCGGATGGACGGCGTCGCGGACGCCGCGGTGATCGGCGTTCCCGACCAGCGGCTGGGCGAGGTCGGCCGGGCGTTCG
TGGTGGCGCGCCCCGGCACGGGCCTCGACGAGGCATCGGTGATCGCTTACACCCGTGAACATTTGGCGAACTTCAAGACA
CCCCGGTCGGTGCGGTTCGTCGACGTACTGCCGCGCAACGCCGCCGGTAAGGTGAGCAAACCACAACTGCGAGAGCTGGG
CTAG

Upstream 100 bases:

>100_bases
TTGTCGGCGAGCCAACCGCGGACCTGCGCCCGGAACTCCTCGACGTCCTGCATGCCCTGTAGGCTAACCTACCAAGCACT
TGCTTTGTTAGGAGCGTCCG

Downstream 100 bases:

>100_bases
ATGGACCTGAATTTCGACGACGAGACCCTGGCCTTTCAGGCCGAGGTGCGCGAGTTCCTCGCCGCCAATGCCGCATCGAT
CCCGACGAAGTCCTACGACA

Product: long-chain-fatty-acid--CoA ligase

Products: AMP; diphosphate; acyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MINDLRTVPAALDRLVRQLPDHTALIAEDRRFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTWHWVVACLAIHHAG
AAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVA
ARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLI
PHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHPARKDFDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLT
EANGMGTMCRPEDDAVTVATTCGRPFADFELRIADDGEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGN
LRINDRLKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVVARPGTGLDEASVIAYTREHLANFKT
PRSVRFVDVLPRNAAGKVSKPQLRELG

Sequences:

>Translated_507_residues
MINDLRTVPAALDRLVRQLPDHTALIAEDRRFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTWHWVVACLAIHHAG
AAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVA
ARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLI
PHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHPARKDFDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLT
EANGMGTMCRPEDDAVTVATTCGRPFADFELRIADDGEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGN
LRINDRLKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVVARPGTGLDEASVIAYTREHLANFKT
PRSVRFVDVLPRNAAGKVSKPQLRELG
>Mature_507_residues
MINDLRTVPAALDRLVRQLPDHTALIAEDRRFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTWHWVVACLAIHHAG
AAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVA
ARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLI
PHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHPARKDFDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLT
EANGMGTMCRPEDDAVTVATTCGRPFADFELRIADDGEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGN
LRINDRLKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVVARPGTGLDEASVIAYTREHLANFKT
PRSVRFVDVLPRNAAGKVSKPQLRELG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=537, Percent_Identity=30.7262569832402, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI187761345, Length=538, Percent_Identity=27.5092936802974, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI187761343, Length=538, Percent_Identity=27.5092936802974, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI58082049, Length=509, Percent_Identity=29.0766208251473, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI157311624, Length=494, Percent_Identity=28.3400809716599, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI157311622, Length=494, Percent_Identity=28.3400809716599, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI42544132, Length=511, Percent_Identity=25.0489236790607, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI122937307, Length=510, Percent_Identity=27.843137254902, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI40807491, Length=486, Percent_Identity=25.3086419753086, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI38505220, Length=486, Percent_Identity=25.7201646090535, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI115511026, Length=486, Percent_Identity=24.4855967078189, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI42794756, Length=475, Percent_Identity=24.6315789473684, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI42794760, Length=475, Percent_Identity=24.6315789473684, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI42794758, Length=475, Percent_Identity=24.6315789473684, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI28416953, Length=550, Percent_Identity=26, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI57165412, Length=459, Percent_Identity=25.9259259259259, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI57165410, Length=460, Percent_Identity=25.6521739130435, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI83745141, Length=507, Percent_Identity=22.6824457593688, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI27477105, Length=155, Percent_Identity=34.1935483870968, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI145693145, Length=518, Percent_Identity=30.1158301158301, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1788107, Length=533, Percent_Identity=29.4559099437148, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI221142682, Length=505, Percent_Identity=28.3168316831683, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1786810, Length=514, Percent_Identity=27.8210116731518, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789201, Length=351, Percent_Identity=28.7749287749288, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788595, Length=350, Percent_Identity=28, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786529, Length=545, Percent_Identity=24.2201834862385, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994694, Length=542, Percent_Identity=28.9667896678967, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71994690, Length=543, Percent_Identity=28.9134438305709, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71994703, Length=542, Percent_Identity=28.9667896678967, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17560308, Length=549, Percent_Identity=30.9653916211293, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17559526, Length=531, Percent_Identity=30.5084745762712, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI32563687, Length=521, Percent_Identity=29.9424184261036, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17557194, Length=500, Percent_Identity=27.2, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17538037, Length=502, Percent_Identity=27.2908366533865, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17558820, Length=437, Percent_Identity=29.2906178489703, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17531443, Length=526, Percent_Identity=24.3346007604563, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI71996755, Length=499, Percent_Identity=25.250501002004, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17560140, Length=516, Percent_Identity=25, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71985884, Length=356, Percent_Identity=28.9325842696629, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI25141359, Length=495, Percent_Identity=23.6363636363636, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17564090, Length=456, Percent_Identity=25.219298245614, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17510401, Length=458, Percent_Identity=21.17903930131, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17556552, Length=163, Percent_Identity=32.5153374233129, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=472, Percent_Identity=25.4237288135593, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6320852, Length=388, Percent_Identity=25.7731958762887, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24581924, Length=540, Percent_Identity=30.7407407407407, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI21355181, Length=517, Percent_Identity=30.174081237911, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI18859661, Length=503, Percent_Identity=29.8210735586481, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI21356441, Length=517, Percent_Identity=26.1121856866538, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI281365686, Length=346, Percent_Identity=28.3236994219653, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21358303, Length=489, Percent_Identity=25.5623721881391, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24648253, Length=507, Percent_Identity=27.0216962524655, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24648255, Length=507, Percent_Identity=26.8244575936884, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24648260, Length=344, Percent_Identity=27.906976744186, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24648257, Length=344, Percent_Identity=30.8139534883721, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24653035, Length=345, Percent_Identity=25.2173913043478, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20130357, Length=351, Percent_Identity=27.9202279202279, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356947, Length=352, Percent_Identity=28.4090909090909, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656500, Length=503, Percent_Identity=23.8568588469185, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19922652, Length=511, Percent_Identity=24.26614481409, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161076582, Length=351, Percent_Identity=23.9316239316239, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24666501, Length=470, Percent_Identity=24.8936170212766, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24666497, Length=470, Percent_Identity=24.8936170212766, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI281366413, Length=470, Percent_Identity=24.8936170212766, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI19921316, Length=199, Percent_Identity=30.6532663316583, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17933690, Length=145, Percent_Identity=34.4827586206897, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.3

Molecular weight: Translated: 54108; Mature: 54108

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINDLRTVPAALDRLVRQLPDHTALIAEDRRFTSTELRDAVYGAAAALIALGVEPADRVA
CCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEE
IWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLGADRAA
EECCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEHHHHHHCCCHHC
GLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVAARAAAVAPQDVSDILFTSGT
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHEECCC
TGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLI
CCCCCCEEEECHHCCCCCCCCCCCCEEECCCCEEEECHHHHHCCHHHHHHHHHHCCCCEE
PHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHPARKDFDLSSLRFAVTGAATVPVVL
CCCCCCHHHHHHHHHHCEEEEECCCHHHHHHHHCCCCCCCCCHHHEEEEEECCCHHHHHH
VERMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELRIADDGEVL
HHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCEE
LRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLRINDRLKDMYICGGFNVYP
EECCCEEEEEECCCCCCEEEECCCCCEEECCCCCCCCCCCEEECCCCCEEEEECCCCCCH
AEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVVARPGTGLDEASVIAYTREHLANFKT
HHHHHHHHHHCCCCCEEEEECCHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCC
PRSVRFVDVLPRNAAGKVSKPQLRELG
CCCEEEEEECCCCCCCCCCCCHHHHCC
>Mature Secondary Structure
MINDLRTVPAALDRLVRQLPDHTALIAEDRRFTSTELRDAVYGAAAALIALGVEPADRVA
CCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEE
IWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLGADRAA
EECCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEHHHHHHCCCHHC
GLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVAARAAAVAPQDVSDILFTSGT
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHEECCC
TGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLI
CCCCCCEEEECHHCCCCCCCCCCCCEEECCCCEEEECHHHHHCCHHHHHHHHHHCCCCEE
PHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHPARKDFDLSSLRFAVTGAATVPVVL
CCCCCCHHHHHHHHHHCEEEEECCCHHHHHHHHCCCCCCCCCHHHEEEEEECCCHHHHHH
VERMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELRIADDGEVL
HHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCEE
LRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLRINDRLKDMYICGGFNVYP
EECCCEEEEEECCCCCCEEEECCCCCEEECCCCCCCCCCCEEECCCCCEEEEECCCCCCH
AEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVVARPGTGLDEASVIAYTREHLANFKT
HHHHHHHHHHCCCCCEEEEECCHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCC
PRSVRFVDVLPRNAAGKVSKPQLRELG
CCCEEEEEECCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; long-chain carboxylic acid; CoA

Specific reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]