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The map label for this gene is PPE63

Identifier: 121639458

GI number: 121639458

Start: 3956951

End: 3958390

Strand: Direct

Name: PPE63

Synonym: BCG_3603

Alternate gene names: 121639458

Gene position: 3956951-3958390 (Clockwise)

Preceding gene: 121639457

Following gene: 121639465

Centisome position: 90.45

GC content: 65.76

Gene sequence:

>1440_bases
ATGGCGGATTTCTTGACGTTGTCACCAGAGGTGAATTCGGCCCGGATGTACGCGGGTGGGGGGCCCGGGTCGCTATCGGC
GGCCGCGGCGGCCTGGGATGAGTTGGCCGCCGAACTGTGGTTGGCGGCGGCCTCGTTCGAGTCGGTGTGCTCCGGCCTGG
CGGACCGTTGGTGGCAAGGGCCGTCGTCTCGGATGATGGCGGCGCAGGCCGCCCGCCATACGGGGTGGCTGGCCGCGGCG
GCCACCCAGGCAGAGGGAGCAGCCAGCCAGGCTCAGACGATGGCGCTGGCCTATGAAGCGGCGTTCGCCGCAACCGTACA
CCCGGCGCTGGTCGCGGCGAACCGCGCCCTCGTGGCCTGGTTGGCGGGGTCGAATGTGTTCGGGCAGAACACCCCGGCGA
TTGCGGCCGCCGAGGCCATCTACGAGCAGATGTGGGCTCAGGATGTTGTCGCGATGTTGAACTACCATGCGGTGGCCTCG
GCGGTCGGGGCGCGGTTGCGGCCGTGGCAGCAGTTGCTGCATGAGCTGCCCAGGCGGTTGGGCGGCGAACACTCCGACAG
CACAAACACGGAACTCGCTAACCCGAGTTCAACGACGACACGCATTACCGTCCCCGGCGCATCTCCGGTGCATGCAGCGA
CGTTACTGCCGTTCATCGGAAGGCTACTGGCGGCGCGTTATGCCGAGCTGAACACCGCGATCGGCACGAACTGGTTTCCG
GGCACCACGCCAGAAGTGGTGAGCTATCCGGCCACCATCGGGGTCCTTAGCGGCTCTCTTGGCGCCGTCGATGCCAACCA
GTCCATCGCTATCGGTCAGCAGATGTTGCACAACGAGATCCTGGCCGCCACGGCCTCCGGTCAGCCGGTGACGGTGGCCG
GACTGTCGATGGGCAGCATGGTCATCGACCGCGAACTTGCCTATCTGGCCATCGACCCCAACGCGCCACCCTCGAGCGCG
CTCACATTCGTCGAGCTCGCCGGCCCGGAACGCGGTCTTGCCCAGACCTACCTGCCCGTTGGCACCACCATTCCAATCGC
GGGGTACACCGTGGGGAATGCGCCCGAGAGCCAGTACAACACCAGCGTGGTTTATAGCCAGTACGATATCTGGGCCGATC
CGCCCGACCGTCCGTGGAACCTGTTGGCCGGCGCCAACGCACTGATGGGCGCGGCTTACTTTCACGATCTGACCGCCTAC
GCCGCACCACAACAGGGGATAGAGATCGCCGCTGTCACGAGTTCACTGGGCGGAACCACGACAACGTACATGATTCCGTC
GCCCACGCTGCCGTTGCTGTTGCCACTGAAGCAGATCGGTGTCCCAGACTGGATCGTCGGCGGGCTGAACAACGTGCTGA
AGCCGCTCGTCGACGCGGGCTACTCACAGTACGCCCCCACCGCCGGCCCTTATTTCAGCCACGGCAACCTGGTGTGGTAG

Upstream 100 bases:

>100_bases
GATTTCGCAGAAGTCGACATGACATTGCTGCTATGGTCTGCGGTGACGGGGCCGTCGCAGTGGTGGCGCGGCGGTTGGGC
CGAGCCGGCGGGATGTTGTC

Downstream 100 bases:

>100_bases
TTAACCCAGGATCAGCCCGGACGTAGGCACCCCGGTGCCCGCGGTGACGAGCACATGCTCGACGCCCGCCACCGGGTTCA
CCGAGGTGCCGCGCAGCTGC

Product: PPE family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFESVCSGLADRWWQGPSSRMMAAQAARHTGWLAAA
ATQAEGAASQAQTMALAYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWAQDVVAMLNYHAVAS
AVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPSSTTTRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFP
GTTPEVVSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQPVTVAGLSMGSMVIDRELAYLAIDPNAPPSSA
LTFVELAGPERGLAQTYLPVGTTIPIAGYTVGNAPESQYNTSVVYSQYDIWADPPDRPWNLLAGANALMGAAYFHDLTAY
AAPQQGIEIAAVTSSLGGTTTTYMIPSPTLPLLLPLKQIGVPDWIVGGLNNVLKPLVDAGYSQYAPTAGPYFSHGNLVW

Sequences:

>Translated_479_residues
MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFESVCSGLADRWWQGPSSRMMAAQAARHTGWLAAA
ATQAEGAASQAQTMALAYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWAQDVVAMLNYHAVAS
AVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPSSTTTRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFP
GTTPEVVSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQPVTVAGLSMGSMVIDRELAYLAIDPNAPPSSA
LTFVELAGPERGLAQTYLPVGTTIPIAGYTVGNAPESQYNTSVVYSQYDIWADPPDRPWNLLAGANALMGAAYFHDLTAY
AAPQQGIEIAAVTSSLGGTTTTYMIPSPTLPLLLPLKQIGVPDWIVGGLNNVLKPLVDAGYSQYAPTAGPYFSHGNLVW
>Mature_478_residues
ADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFESVCSGLADRWWQGPSSRMMAAQAARHTGWLAAAA
TQAEGAASQAQTMALAYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWAQDVVAMLNYHAVASA
VGARLRPWQQLLHELPRRLGGEHSDSTNTELANPSSTTTRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFPG
TTPEVVSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQPVTVAGLSMGSMVIDRELAYLAIDPNAPPSSAL
TFVELAGPERGLAQTYLPVGTTIPIAGYTVGNAPESQYNTSVVYSQYDIWADPPDRPWNLLAGANALMGAAYFHDLTAYA
APQQGIEIAAVTSSLGGTTTTYMIPSPTLPLLLPLKQIGVPDWIVGGLNNVLKPLVDAGYSQYAPTAGPYFSHGNLVW

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPE63_MYCTU (Q7D5B9)

Other databases:

- EMBL:   BX842583
- EMBL:   AE000516
- PIR:   D70676
- RefSeq:   NP_338188.1
- RefSeq:   YP_177987.1
- HSSP:   Q79FE1
- ProteinModelPortal:   Q7D5B9
- SMR:   Q7D5B9
- EnsemblBacteria:   EBMYCT00000003970
- EnsemblBacteria:   EBMYCT00000071682
- GeneID:   888438
- GeneID:   922858
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3643
- KEGG:   mtu:Rv3539
- TIGR:   MT3643
- TubercuList:   Rv3539
- GeneTree:   EBGT00050000014926
- HOGENOM:   HBG128083
- ProtClustDB:   CLSK800000
- InterPro:   IPR013228
- InterPro:   IPR000030

Pfam domain/function: PF08237 PE-PPE; PF00823 PPE

EC number: NA

Molecular weight: Translated: 49970; Mature: 49839

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFESVCSGLADRWWQG
CCCCEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSSRMMAAQAARHTGWLAAAATQAEGAASQAQTMALAYEAAFAATVHPALVAANRALVAW
CCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
LAGSNVFGQNTPAIAAAEAIYEQMWAQDVVAMLNYHAVASAVGARLRPWQQLLHELPRRL
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GGEHSDSTNTELANPSSTTTRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFP
CCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GTTPEVVSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQPVTVAGLSMGSM
CCCHHHHCCCCHHEECCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCEEEECCCCCCH
VIDRELAYLAIDPNAPPSSALTFVELAGPERGLAQTYLPVGTTIPIAGYTVGNAPESQYN
HEECCEEEEEECCCCCCCCCEEEEEECCCCCCCHHHCCCCCCCCEEECEECCCCCCCCCC
TSVVYSQYDIWADPPDRPWNLLAGANALMGAAYFHDLTAYAAPQQGIEIAAVTSSLGGTT
CEEEEEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCE
TTYMIPSPTLPLLLPLKQIGVPDWIVGGLNNVLKPLVDAGYSQYAPTAGPYFSHGNLVW
EEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFESVCSGLADRWWQG
CCCEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSSRMMAAQAARHTGWLAAAATQAEGAASQAQTMALAYEAAFAATVHPALVAANRALVAW
CCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
LAGSNVFGQNTPAIAAAEAIYEQMWAQDVVAMLNYHAVASAVGARLRPWQQLLHELPRRL
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GGEHSDSTNTELANPSSTTTRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFP
CCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GTTPEVVSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQPVTVAGLSMGSM
CCCHHHHCCCCHHEECCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCEEEECCCCCCH
VIDRELAYLAIDPNAPPSSALTFVELAGPERGLAQTYLPVGTTIPIAGYTVGNAPESQYN
HEECCEEEEEECCCCCCCCCEEEEEECCCCCCCHHHCCCCCCCCEEECEECCCCCCCCCC
TSVVYSQYDIWADPPDRPWNLLAGANALMGAAYFHDLTAYAAPQQGIEIAAVTSSLGGTT
CEEEEEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCE
TTYMIPSPTLPLLLPLKQIGVPDWIVGGLNNVLKPLVDAGYSQYAPTAGPYFSHGNLVW
EEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036