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The map label for this gene is fadA5 [H]

Identifier: 121639465

GI number: 121639465

Start: 3964449

End: 3965624

Strand: Direct

Name: fadA5 [H]

Synonym: BCG_3610

Alternate gene names: 121639465

Gene position: 3964449-3965624 (Clockwise)

Preceding gene: 121639458

Following gene: 121639466

Centisome position: 90.63

GC content: 69.39

Gene sequence:

>1176_bases
ATGGGTTACCCGGTCATCGTTGAAGCCACCCGCAGCCCCATCGGCAAACGCAACGGATGGCTGTCGGGGCTGCATGCCAC
CGAGTTGTTGGGCGCGGTGCAAAAGGCGGTGGTCGACAAGGCCGGCATCCAGTCCGGCCTTCACGCCGGTGACGTCGAAC
AGGTCATCGGCGGTTGCGTGACCCAGTTCGGGGAGCAATCCAACAACATCAGCCGGGTGGCCTGGCTGACGGCCGGTTTG
CCCGAACACGTCGGCGCCACCACCGTCGACTGCCAGTGCGGCAGCGGCCAGCAGGCCAACCATCTGATTGCCGGGTTGAT
CGCGGCCGGTGCCATCGATGTCGGCATCGCCTGCGGCATCGAGGCGATGAGCCGGGTCGGGCTGGGCGCCAACGCCGGGC
CGGACCGCTCGCTGATCCGCGCGCAGTCATGGGATATCGACCTGCCGAACCAGTTCGAGGCCGCCGAGCGGATCGCCAAG
CGGCGCGGCATCACCCGCGAGGACGTGGATGTCTTCGGGCTCGAGTCGCAGCGACGCGCGCAGCGGGCCTGGGCGGAGGG
CCGCTTTGACCGCGAGATCTCGCCGATCCAGGCGCCGGTGCTCGACGAGCAGAATCAGCCCACCGGCGAGCGGCGCCTGG
TCTTTCGCGACCAGGGCCTGCGCGAGACCACGATGGCGGGGCTAGGCGAGCTGAAACCGGTGCTCGAGGGCGGCATCCAC
ACCGCGGGCACGTCGTCGCAGATCTCCGACGGCGCGGCAGCCGTGTTGTGGATGGACGAAGCCGTGGCACGTGCGCACGG
CCTGACCCCGCGGGCCCGGATCGTCGCCCAGGCACTCGTCGGCGCCGAGCCCTACTACCACCTGGACGGCCCGGTGCAGT
CCACCGCGAAGGTGCTGGAGAAGGCCGGCATGAAGATCGGCGACATCGACATCGTCGAGATCAACGAGGCGTTCGCGTCC
GTGGTGCTGTCCTGGGCGCGGGTGCACGAGCCCGACATGGACCGGGTCAACGTCAACGGCGGGGCGATCGCGCTGGGGCA
TCCGGTGGGCTGCACCGGCAGCCGGCTGATCACCACCGCCCTGCACGAGCTCGAGCGCACCGACCAGAGCCTCGCGCTGA
TCACCATGTGCGCCGGCGGGGCCCTGTCCACCGGCACCATCATCGAGCGGATTTAA

Upstream 100 bases:

>100_bases
GTGAGGACCTTCTGCCAGTAAAACATGCCTTCACCGCAGACAAAAGGCATTGAAGCAACCTTGCTTGTCATAGTAATGAA
ACGTGTTCTAGCCTGGCCCC

Downstream 100 bases:

>100_bases
CCTAGCTGCGGCAGGGCACCGTGCGGCGTGACTGCAACATGAAGCGACCGATGATTAGATAGCGAGGCGGACGCGCGCCT
TTGGCGACCCTTGGTCGCTA

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MGYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVDKAGIQSGLHAGDVEQVIGGCVTQFGEQSNNISRVAWLTAGL
PEHVGATTVDCQCGSGQQANHLIAGLIAAGAIDVGIACGIEAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIAK
RRGITREDVDVFGLESQRRAQRAWAEGRFDREISPIQAPVLDEQNQPTGERRLVFRDQGLRETTMAGLGELKPVLEGGIH
TAGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVAQALVGAEPYYHLDGPVQSTAKVLEKAGMKIGDIDIVEINEAFAS
VVLSWARVHEPDMDRVNVNGGAIALGHPVGCTGSRLITTALHELERTDQSLALITMCAGGALSTGTIIERI

Sequences:

>Translated_391_residues
MGYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVDKAGIQSGLHAGDVEQVIGGCVTQFGEQSNNISRVAWLTAGL
PEHVGATTVDCQCGSGQQANHLIAGLIAAGAIDVGIACGIEAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIAK
RRGITREDVDVFGLESQRRAQRAWAEGRFDREISPIQAPVLDEQNQPTGERRLVFRDQGLRETTMAGLGELKPVLEGGIH
TAGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVAQALVGAEPYYHLDGPVQSTAKVLEKAGMKIGDIDIVEINEAFAS
VVLSWARVHEPDMDRVNVNGGAIALGHPVGCTGSRLITTALHELERTDQSLALITMCAGGALSTGTIIERI
>Mature_390_residues
GYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVDKAGIQSGLHAGDVEQVIGGCVTQFGEQSNNISRVAWLTAGLP
EHVGATTVDCQCGSGQQANHLIAGLIAAGAIDVGIACGIEAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIAKR
RGITREDVDVFGLESQRRAQRAWAEGRFDREISPIQAPVLDEQNQPTGERRLVFRDQGLRETTMAGLGELKPVLEGGIHT
AGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVAQALVGAEPYYHLDGPVQSTAKVLEKAGMKIGDIDIVEINEAFASV
VLSWARVHEPDMDRVNVNGGAIALGHPVGCTGSRLITTALHELERTDQSLALITMCAGGALSTGTIIERI

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=36.7088607594937, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4557237, Length=399, Percent_Identity=34.5864661654135, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI167614485, Length=399, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=35, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI4504327, Length=432, Percent_Identity=29.3981481481481, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=28.3887468030691, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1787663, Length=410, Percent_Identity=39.7560975609756, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=38.9027431421446, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=39.4088669950739, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=36.5914786967419, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1788683, Length=432, Percent_Identity=30.5555555555556, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=400, Percent_Identity=35, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17535921, Length=398, Percent_Identity=31.1557788944724, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17551802, Length=433, Percent_Identity=29.0993071593533, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25147385, Length=399, Percent_Identity=30.3258145363409, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=28.3544303797468, Blast_Score=101, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=33.3333333333333, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=404, Percent_Identity=31.9306930693069, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24655093, Length=401, Percent_Identity=36.1596009975062, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24640423, Length=398, Percent_Identity=34.4221105527638, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI17648125, Length=400, Percent_Identity=33.75, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17137578, Length=438, Percent_Identity=28.9954337899543, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 41329; Mature: 41198

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVDKAGIQSGLHAGDVEQVIGGCV
CCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
TQFGEQSNNISRVAWLTAGLPEHVGATTVDCQCGSGQQANHLIAGLIAAGAIDVGIACGI
HHHCCCCCCCEEEEEEECCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
EAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIAKRRGITREDVDVFGLESQRRA
HHHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHCCCEECCCHHHHH
QRAWAEGRFDREISPIQAPVLDEQNQPTGERRLVFRDQGLRETTMAGLGELKPVLEGGIH
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
TAGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVAQALVGAEPYYHLDGPVQSTAKVLE
CCCCCCCCCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHHH
KAGMKIGDIDIVEINEAFASVVLSWARVHEPDMDRVNVNGGAIALGHPVGCTGSRLITTA
HCCCEECCEEEEEHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCCHHHHHHH
LHELERTDQSLALITMCAGGALSTGTIIERI
HHHHHHCCCCEEEEEEECCCCCCCCHHHHCC
>Mature Secondary Structure 
GYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVDKAGIQSGLHAGDVEQVIGGCV
CCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
TQFGEQSNNISRVAWLTAGLPEHVGATTVDCQCGSGQQANHLIAGLIAAGAIDVGIACGI
HHHCCCCCCCEEEEEEECCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
EAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIAKRRGITREDVDVFGLESQRRA
HHHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHCCCEECCCHHHHH
QRAWAEGRFDREISPIQAPVLDEQNQPTGERRLVFRDQGLRETTMAGLGELKPVLEGGIH
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
TAGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVAQALVGAEPYYHLDGPVQSTAKVLE
CCCCCCCCCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHHH
KAGMKIGDIDIVEINEAFASVVLSWARVHEPDMDRVNVNGGAIALGHPVGCTGSRLITTA
HCCCEECCEEEEEHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCCHHHHHHH
LHELERTDQSLALITMCAGGALSTGTIIERI
HHHHHHCCCCEEEEEEECCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]