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The map label for this gene is accA3 [H]

Identifier: 121639174

GI number: 121639174

Start: 3618765

End: 3620567

Strand: Direct

Name: accA3 [H]

Synonym: BCG_3314

Alternate gene names: 121639174

Gene position: 3618765-3620567 (Clockwise)

Preceding gene: 121639173

Following gene: 121639181

Centisome position: 82.72

GC content: 68.0

Gene sequence:

>1803_bases
GTGGCTAGTCACGCCGGCTCGAGGATCGCTCGGATCTCTAAGGTTCTCGTCGCCAATCGCGGCGAGATCGCAGTGCGGGT
GATCCGGGCGGCCCGCGACGCCGGCCTGCCCAGCGTGGCGGTGTACGCCGAACCCGACGCCGAGTCCCCGCATGTTCGGC
TGGCCGACGAGGCGTTCGCGCTGGGCGGCCAGACCTCGGCGGAGTCCTATCTGGACTTCGCCAAGATCCTCGACGCGGCA
GCCAAGTCCGGGGCCAACGCCATCCACCCCGGCTACGGCTTCCTAGCGGAAAATGCCGACTTCGCCCAGGCGGTGATCGA
CGCCGGCCTGATCTGGATCGGCCCCAGCCCGCAGTCGATCCGCGACCTGGGCGACAAGGTCACGGCCCGTCACATCGCGG
CCCGCGCTCAGGCGCCCCTGGTGCCGGGTACCCCCGATCCGGTCAAAGGCGCCGACGAGGTGGTGGCATTCGCCGAGGAG
TACGGCCTGCCGATCGCGATCAAGGCCGCCCACGGCGGCGGCGGCAAGGGCATGAAGGTGGCCCGCACCATCGACGAGAT
TCCGGAGCTGTACGAGTCGGCGGTGCGCGAGGCCACGGCCGCGTTCGGCCGCGGTGAGTGCTACGTGGAGCGCTATCTCG
ACAAGCCGCGCCACGTCGAAGCACAGGTGATCGCCGACCAGCACGGCAACGTCGTCGTCGCCGGCACCCGGGACTGCTCG
CTGCAGCGCCGCTACCAGAAGCTGGTCGAGGAGGCGCCCGCACCGTTCCTGACCGACTTTCAACGCAAAGAGATCCACGA
CTCGGCCAAACGGATTTGCAAAGAGGCCCATTACCACGGCGCCGGCACCGTCGAATACCTGGTCGGTCAGGACGGCTTGA
TCTCGTTCTTGGAGGTCAACACGCGCCTTCAGGTAGAACACCCGGTCACCGAGGAAACCGCGGGCATCGACTTGGTGCTG
CAGCAATTCCGGATCGCCAACGGCGAAAAGCTGGACATCACCGAGGATCCCACCCCGCGCGGGCACGCCATCGAATTCCG
GATCAACGGCGAGGACGCGGGGCGTAACTTCCTACCGGCGCCCGGGCCGGTGACAAAGTTCCACCCGCCGTCCGGCCCCG
GTGTGCGGGTGGACTCCGGTGTCGAGACCGGCTCGGTGATCGGCGGCCAGTTCGACTCGATGCTGGCCAAGCTGATCGTG
CACGGCGCCGACCGCGCCGAGGCGCTGGCGCGGGCCCGGCGCGCGCTGAACGAGTTCGGTGTCGAAGGCCTGGCGACGGT
CATCCCGTTTCACCGCGCCGTGGTGTCCGACCCGGCATTCATCGGCGACGCGAACGGCTTTTCGGTACATACCCGCTGGA
TCGAGACCGAGTGGAATAACACCATCGAGCCCTTTACCGACGGCGAACCTCTCGACGAGGACGCCCGGCCGCGTCAGAAG
GTGGTCGTCGAAATCGACGGTCGCCGCGTCGAAGTCTCGCTGCCGGCTGATCTCGCGCTGTCCAATGGCGGCGGTTGCGA
CCCGGTCGGTGTCATCCGGCGCAAGCCCAAGCCGCGCAAGCGGGGTGCGCACACCGGCGCGGCGGCCTCCGGTGACGCGG
TGACCGCGCCTATGCAGGGCACCGTAGTTAAGTTCGCGGTCGAAGAAGGGCAAGAGGTCGTGGCCGGCGACCTAGTGGTG
GTCCTCGAGGCGATGAAGATGGAAAACCCGGTCACCGCGCATAAGGATGGCACCATCACCGGGCTGGCGGTCGAGGCGGG
CGCGGCCATCACCCAGGGCACGGTGCTCGCCGAGATCAAGTAA

Upstream 100 bases:

>100_bases
AACCGCGTGAGCGGGTCAGCGGCGCGACGCTTAAACTTCCCCCGACAAGACTTGTAAGAAAATCTCTTAGAGACGAAGAA
TCAGCCCGACAGGAGGCGCA

Downstream 100 bases:

>100_bases
GCCCGGCGGCTACTCCAACTGATCCCGTAGCCGTGCCAATGACTTGGCCAGCAGCCGCGACACGTGCATCTGTGAGATAC
CGACGCGCTCGGCGATCTGC

Product: putative bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) accA3: biotin carboxylase + biotin carboxyl carrier protein

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAA
AKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEE
YGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCS
LQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVL
QQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIV
HGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQK
VVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDLVV
VLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK

Sequences:

>Translated_600_residues
MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAA
AKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEE
YGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCS
LQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVL
QQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIV
HGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQK
VVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDLVV
VLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK
>Mature_599_residues
ASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAA
KSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEY
GLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSL
QRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQ
QFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVH
GADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQKV
VVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDLVVV
LEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=45.6179775280899, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI295821183, Length=637, Percent_Identity=36.1067503924647, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049528, Length=450, Percent_Identity=44.6666666666667, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI106049295, Length=450, Percent_Identity=44.6666666666667, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI106049292, Length=450, Percent_Identity=44.6666666666667, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=42.1171171171171, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI65506442, Length=431, Percent_Identity=42.6914153132251, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI38679960, Length=472, Percent_Identity=31.3559322033898, Blast_Score=215, Evalue=9e-56,
Organism=Homo sapiens, GI38679974, Length=472, Percent_Identity=31.3559322033898, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI38679977, Length=472, Percent_Identity=31.3559322033898, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI38679967, Length=472, Percent_Identity=31.3559322033898, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI38679971, Length=472, Percent_Identity=31.3559322033898, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI134142062, Length=517, Percent_Identity=30.174081237911, Blast_Score=204, Evalue=2e-52,
Organism=Escherichia coli, GI1789654, Length=431, Percent_Identity=45.707656612529, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=46, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71987519, Length=431, Percent_Identity=45.2436194895592, Blast_Score=350, Evalue=9e-97,
Organism=Caenorhabditis elegans, GI17567343, Length=433, Percent_Identity=42.4942263279446, Blast_Score=347, Evalue=8e-96,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=28.3673469387755, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=513, Percent_Identity=27.6803118908382, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71997168, Length=513, Percent_Identity=27.6803118908382, Blast_Score=186, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6319695, Length=443, Percent_Identity=44.6952595936795, Blast_Score=355, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=437, Percent_Identity=45.5377574370709, Blast_Score=348, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6319685, Length=428, Percent_Identity=41.588785046729, Blast_Score=328, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6323863, Length=445, Percent_Identity=31.0112359550562, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6324343, Length=491, Percent_Identity=29.938900203666, Blast_Score=193, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24651757, Length=468, Percent_Identity=43.3760683760684, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI281363050, Length=436, Percent_Identity=45.6422018348624, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652224, Length=436, Percent_Identity=45.6422018348624, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652222, Length=436, Percent_Identity=45.6422018348624, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652220, Length=436, Percent_Identity=45.6422018348624, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652218, Length=436, Percent_Identity=45.6422018348624, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652212, Length=436, Percent_Identity=45.6422018348624, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652210, Length=436, Percent_Identity=45.6422018348624, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652214, Length=436, Percent_Identity=45.6422018348624, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19921944, Length=436, Percent_Identity=45.6422018348624, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652216, Length=436, Percent_Identity=45.6422018348624, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24651759, Length=418, Percent_Identity=42.5837320574163, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI161076409, Length=506, Percent_Identity=28.6561264822134, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24586458, Length=506, Percent_Identity=28.6561264822134, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI161076407, Length=506, Percent_Identity=28.6561264822134, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24586460, Length=506, Percent_Identity=28.6561264822134, Blast_Score=199, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 63784; Mature: 63652

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFA
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECHHHHH
LGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSI
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHCCEEEECCCCHHH
RDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHH
ARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCH
LQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEC
TRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPA
CEEEECCCCCCHHCCHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCCC
PGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFG
CCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
VEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQK
HHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEE
VVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQG
EEEEECCCEEEEECCCCEEECCCCCCCCHHHHCCCCCCHHCCCCCCCCCCCCEEECCCCC
TVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK
CEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEECCEEEEEEC
>Mature Secondary Structure 
ASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFA
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECHHHHH
LGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSI
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHCCEEEECCCCHHH
RDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHH
ARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCH
LQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEC
TRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPA
CEEEECCCCCCHHCCHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCCC
PGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFG
CCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
VEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQK
HHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEE
VVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQG
EEEEECCCEEEEECCCCEEECCCCCCCCHHHHCCCCCCHHCCCCCCCCCCCCEEECCCCC
TVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK
CEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEECCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]