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The map label for this gene is cobC [C]

Identifier: 121638114

GI number: 121638114

Start: 2483250

End: 2484344

Strand: Reverse

Name: cobC [C]

Synonym: BCG_2249c

Alternate gene names: 121638114

Gene position: 2484344-2483250 (Counterclockwise)

Preceding gene: 121638118

Following gene: 121638113

Centisome position: 56.79

GC content: 67.31

Gene sequence:

>1095_bases
GTGCTCTGGATTCTTGGCCCGCACACCGGCCCACTACTGTTTGACGCTGTGGCGAGTCTAGACACTAGCCCGCTTGCCGC
GGCGCGCTACCACGGTGATCAGGATGTCGCGCCCGGCGTGCTGGACTTCGCCGTCAACGTCCGCCATGACCGGCCCCCGG
AATGGTTGGTCCGGCAGCTCGCCGCGCTGCTGCCGGAGCTGGCCCGCTATCCGAGCACCGACGATGTGCACCGGGCGCAA
GACGCGGTCGCTGAACGTCATGGCAGAACCCGTGACGAAGTGCTCCCGCTCGTCGGGGCGGCGGAGGGATTCGCATTGCT
GCACAACCTAAGTCCGGTGCGGGCAGCAATCGTCGTGCCCGCGTTCACCGAGCCGGCCATAGCCTTGAGCGCTGCCGGAA
TCACGGCGCACCATGTTGTCCTAAAGCCGCCGTTCGTGCTGGACACCGCGCACGTGCCTGACGACGCCGACCTTGTCGTC
GTGGGTAATCCGACCAACCCCACCTCGGTGCTGCACCTCCGCGAGCAGCTGCTCGAGTTACGCCGGCCGGGACGCATCCT
GGTGGTCGACGAGGCGTTCGCTGATTGGGTTCCCGGCGAGCCGCAATCGTTGGCCGATGACTCGCTGCCCGATGTGCTGG
TGCTCCGTAGCTTGACGAAAACGTGGTCGCTGGCCGGATTGCGGGTGGGCTACGCGCTCGGCTCGCCAGACGTGCTGGCT
CGGTTGACCGTGCAGCGAGCGCACTGGCCGTTGGGAACATTGCAACTGACGGCCATCGCTGCTTGCTGCGCCCCCCGGGC
GGTCGCCGCTGCCGCAGCCGATGCGGTGCGGTTGACGGCGCTGCGCGCGGAGATGGTGGCCGGACTGAGATCGGTGGGTG
CCGAGGTGGTCGATGGTGCGGCCCCTTTCGTACTGTTCAACATCGCCGATGCTGACGGATTACGAAACTATTTGCAGAGC
AAAGGAATTGCGGTGCGCCGCGGTGACACCTTCGTCGGCCTGGACGCGCGGTACCTGCGGGCGGCGGTGCGCCCGGAGTG
GCCCGTGCTGGTGGCGGCGATCGCCGAGTGGGCAAAGCGTGGAGGACGCCGATGA

Upstream 100 bases:

>100_bases
TCGCCCAGGCACAGCTGCTTGGCCTGACGATCATCACCGCCGACGCCCTGTTAGCTGCCTGTGATGTCGCGGTTGTCGCC
GCGTAGACAACGCGTCGGCG

Downstream 100 bases:

>100_bases
GTGTGCGGCTGGCCGATGTCATCGACGTGCTGGACCAGGCCTACCCGCCGCGGCTTGCCCAGTCGTGGGATTCGGTGGGT
CTGGTGTGCGGCGACCCCGA

Product: hypothetical protein

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVNVRHDRPPEWLVRQLAALLPELARYPSTDDVHRAQ
DAVAERHGRTRDEVLPLVGAAEGFALLHNLSPVRAAIVVPAFTEPAIALSAAGITAHHVVLKPPFVLDTAHVPDDADLVV
VGNPTNPTSVLHLREQLLELRRPGRILVVDEAFADWVPGEPQSLADDSLPDVLVLRSLTKTWSLAGLRVGYALGSPDVLA
RLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAVRLTALRAEMVAGLRSVGAEVVDGAAPFVLFNIADADGLRNYLQS
KGIAVRRGDTFVGLDARYLRAAVRPEWPVLVAAIAEWAKRGGRR

Sequences:

>Translated_364_residues
MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVNVRHDRPPEWLVRQLAALLPELARYPSTDDVHRAQ
DAVAERHGRTRDEVLPLVGAAEGFALLHNLSPVRAAIVVPAFTEPAIALSAAGITAHHVVLKPPFVLDTAHVPDDADLVV
VGNPTNPTSVLHLREQLLELRRPGRILVVDEAFADWVPGEPQSLADDSLPDVLVLRSLTKTWSLAGLRVGYALGSPDVLA
RLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAVRLTALRAEMVAGLRSVGAEVVDGAAPFVLFNIADADGLRNYLQS
KGIAVRRGDTFVGLDARYLRAAVRPEWPVLVAAIAEWAKRGGRR
>Mature_364_residues
MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVNVRHDRPPEWLVRQLAALLPELARYPSTDDVHRAQ
DAVAERHGRTRDEVLPLVGAAEGFALLHNLSPVRAAIVVPAFTEPAIALSAAGITAHHVVLKPPFVLDTAHVPDDADLVV
VGNPTNPTSVLHLREQLLELRRPGRILVVDEAFADWVPGEPQSLADDSLPDVLVLRSLTKTWSLAGLRVGYALGSPDVLA
RLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAVRLTALRAEMVAGLRSVGAEVVDGAAPFVLFNIADADGLRNYLQS
KGIAVRRGDTFVGLDARYLRAAVRPEWPVLVAAIAEWAKRGGRR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Escherichia coli, GI1788332, Length=272, Percent_Identity=27.2058823529412, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2231_MYCTU (P63500)

Other databases:

- EMBL:   BX842579
- EMBL:   AE000516
- PIR:   C70777
- RefSeq:   NP_216747.1
- RefSeq:   NP_336760.1
- ProteinModelPortal:   P63500
- EnsemblBacteria:   EBMYCT00000000995
- EnsemblBacteria:   EBMYCT00000069478
- GeneID:   888337
- GeneID:   924136
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2290
- KEGG:   mtu:Rv2231c
- TIGR:   MT2290
- TubercuList:   Rv2231c
- GeneTree:   EBGT00070000031717
- HOGENOM:   HBG646350
- OMA:   FIPHEAG
- ProtClustDB:   PRK07908
- GO:   GO:0005737
- GO:   GO:0040007
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: 2.6.1.9

Molecular weight: Translated: 38937; Mature: 38937

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVNVRHDRPPEWLVRQL
CEEEECCCCCHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHHEEECCCCCCHHHHHHHH
AALLPELARYPSTDDVHRAQDAVAERHGRTRDEVLPLVGAAEGFALLHNLSPVRAAIVVP
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHCCCCHHEEEEEC
AFTEPAIALSAAGITAHHVVLKPPFVLDTAHVPDDADLVVVGNPTNPTSVLHLREQLLEL
CCCCCCHHEEECCCEEEEEEECCCEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
RRPGRILVVDEAFADWVPGEPQSLADDSLPDVLVLRSLTKTWSLAGLRVGYALGSPDVLA
CCCCEEEEEECHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCHHHHH
RLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAVRLTALRAEMVAGLRSVGAEVVDGA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCC
APFVLFNIADADGLRNYLQSKGIAVRRGDTFVGLDARYLRAAVRPEWPVLVAAIAEWAKR
CCEEEEEECCHHHHHHHHHHCCEEEECCCEEECCCHHHHHHHCCCCCHHHHHHHHHHHHH
GGRR
CCCC
>Mature Secondary Structure
MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFAVNVRHDRPPEWLVRQL
CEEEECCCCCHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHHEEECCCCCCHHHHHHHH
AALLPELARYPSTDDVHRAQDAVAERHGRTRDEVLPLVGAAEGFALLHNLSPVRAAIVVP
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHCCCCHHEEEEEC
AFTEPAIALSAAGITAHHVVLKPPFVLDTAHVPDDADLVVVGNPTNPTSVLHLREQLLEL
CCCCCCHHEEECCCEEEEEEECCCEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
RRPGRILVVDEAFADWVPGEPQSLADDSLPDVLVLRSLTKTWSLAGLRVGYALGSPDVLA
CCCCEEEEEECHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCHHHHH
RLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAVRLTALRAEMVAGLRSVGAEVVDGA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCC
APFVLFNIADADGLRNYLQSKGIAVRRGDTFVGLDARYLRAAVRPEWPVLVAAIAEWAKR
CCEEEEEECCHHHHHHHHHHCCEEEECCCEEECCCHHHHHHHCCCCCHHHHHHHHHHHHH
GGRR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036