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The map label for this gene is cobT

Identifier: 121638088

GI number: 121638088

Start: 2450055

End: 2451140

Strand: Direct

Name: cobT

Synonym: BCG_2223

Alternate gene names: 121638088

Gene position: 2450055-2451140 (Clockwise)

Preceding gene: 121638087

Following gene: 121638089

Centisome position: 56.01

GC content: 72.19

Gene sequence:

>1086_bases
ATGATCGGCTTCGCGCCGGTGTCGACGCCCGATGCGGCTGCCGAAGCAGCCGCCCGCGCCCGACAAGACAGCTTGACCAA
GCCGCGGGGAGCGCTGGGCAGTCTCGAGGACCTGTCTGTCTGGGTCGCGTCGTGCCAGCAGCGCTGTCCGCCGCGGCAAT
TCGAGCGCGCCCGGGTGGTGGTGTTCGCCGGTGACCATGGTGTGGCCCGGTCCGGGGTGTCGGCGTACCCGCCGGAAGTC
ACCGCCCAGATGGTCGCCAACATCGACGCTGGCGGGGCGGCGATCAACGCGCTGGCCGATGTCGCGGGCGCGACCGTGCG
GGTCGCGGACCTGGCCGTGGACGCGGACCCGCTGTCTGAGCGCATCGGCGCGCACAAGGTGCGCCGCGGCAGCGGCAATA
TCGCCACCGAGGACGCGTTGACCAACGACGAGACCGCCGCCGCGATCACAGCCGGCCAGCAGATCGCCGACGAAGAGGTT
GATGCCGGCGCCGACTTGCTCATAGCCGGCGATATGGGAATCGGAAACACTACCGCGGCCGCGGTTCTTGTGGCGGCGCT
GACCGATGCCGAGCCGGTCGCGGTGGTCGGGTTCGGGACCGGTATCGACGACGCCGGTTGGGCGCGTAAGACGGCCGCGG
TGCGCGACGCCCTGTTTCGGGTGCGCCCAGTGTTGCCCGACCCGGTCGGGTTGCTGCGCTGCGCCGGCGGCGCTGACTTG
GCCGCGATAGCTGGCTTCTGCGCGCAGGCCGCGGTCCGACGCACCCCGCTGCTGCTTGACGGGGTGGCGGTGACAGCCGC
CGCCCTGGTCGCTGAGCGTCTTGCGCCCGGCGCTCACCGGTGGTGGCAGGCGGGTCATCGATCCAGCGAACCGGGCCACG
GGCTGGCGCTGGCAGCCCTCGGGCTGGACCCGATCGTGGACCTTCACATGCGGCTGGGCGAGGGAACCGGCGCCGCGGTG
GCGTTGATGGTGTTGCGCGCCGCGGTCGCGGCGCTGTCGTCGATGGCGACCTTCACCGAGGCCGGCGTGTCCACCCGGTC
CGTCGACGGTGTCGACCGGACCGCACCCCCGGCAGTCTCACCGTGA

Upstream 100 bases:

>100_bases
GCGCGGCGGCGATGTTGGCTAACGGAAGCCGGAAGTCATCTCACCCGGTGTACACCCTAGTGCTCAGCGGGCGGACCGAA
CCGATCAAGCCGGCGAAAGG

Downstream 100 bases:

>100_bases
TGCGTTCGCTGGCAACAGCTTTCGCATTCGCAACGGTGATACCCACACCGGGCTCAGCGACCACCCCGATGGGCCGTGGC
CCGATGACCGCGCTGCCGGT

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASCQQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEV
TAQMVANIDAGGAAINALADVAGATVRVADLAVDADPLSERIGAHKVRRGSGNIATEDALTNDETAAAITAGQQIADEEV
DAGADLLIAGDMGIGNTTAAAVLVAALTDAEPVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADL
AAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEPGHGLALAALGLDPIVDLHMRLGEGTGAAV
ALMVLRAAVAALSSMATFTEAGVSTRSVDGVDRTAPPAVSP

Sequences:

>Translated_361_residues
MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASCQQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEV
TAQMVANIDAGGAAINALADVAGATVRVADLAVDADPLSERIGAHKVRRGSGNIATEDALTNDETAAAITAGQQIADEEV
DAGADLLIAGDMGIGNTTAAAVLVAALTDAEPVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADL
AAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEPGHGLALAALGLDPIVDLHMRLGEGTGAAV
ALMVLRAAVAALSSMATFTEAGVSTRSVDGVDRTAPPAVSP
>Mature_361_residues
MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASCQQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEV
TAQMVANIDAGGAAINALADVAGATVRVADLAVDADPLSERIGAHKVRRGSGNIATEDALTNDETAAAITAGQQIADEEV
DAGADLLIAGDMGIGNTTAAAVLVAALTDAEPVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADL
AAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEPGHGLALAALGLDPIVDLHMRLGEGTGAAV
ALMVLRAAVAALSSMATFTEAGVSTRSVDGVDRTAPPAVSP

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=334, Percent_Identity=35.9281437125749, Blast_Score=173, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_MYCBO (P63842)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855879.1
- ProteinModelPortal:   P63842
- SMR:   P63842
- EnsemblBacteria:   EBMYCT00000014557
- GeneID:   1091353
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2230
- GeneTree:   EBGT00050000015770
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- ProtClustDB:   PRK00105
- BioCyc:   MBOV233413:MB2230-MONOMER
- BRENDA:   2.4.2.21
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 36412; Mature: 36412

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: ACT_SITE 314-314

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASCQQRCPPRQFERARVV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHCCEEEE
VFAGDHGVARSGVSAYPPEVTAQMVANIDAGGAAINALADVAGATVRVADLAVDADPLSE
EEECCCCCHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEHEEECCCHHHH
RIGAHKVRRGSGNIATEDALTNDETAAAITAGQQIADEEVDAGADLLIAGDMGIGNTTAA
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHH
AVLVAALTDAEPVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADL
HHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCHH
AAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEPGHGLALAAL
HHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEEC
GLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTEAGVSTRSVDGVDRTAPPAVS
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
P
C
>Mature Secondary Structure
MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASCQQRCPPRQFERARVV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHCCEEEE
VFAGDHGVARSGVSAYPPEVTAQMVANIDAGGAAINALADVAGATVRVADLAVDADPLSE
EEECCCCCHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEHEEECCCHHHH
RIGAHKVRRGSGNIATEDALTNDETAAAITAGQQIADEEVDAGADLLIAGDMGIGNTTAA
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHH
AVLVAALTDAEPVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADL
HHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCHH
AAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEPGHGLALAAL
HHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEEC
GLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTEAGVSTRSVDGVDRTAPPAVS
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972