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The map label for this gene is trpD

Identifier: 121638073

GI number: 121638073

Start: 2434161

End: 2435273

Strand: Reverse

Name: trpD

Synonym: BCG_2208c

Alternate gene names: 121638073

Gene position: 2435273-2434161 (Counterclockwise)

Preceding gene: 121638078

Following gene: 121638071

Centisome position: 55.67

GC content: 69.63

Gene sequence:

>1113_bases
GTGGCGCTGTCAGCTGAGGGTTCTTCGGGGGGATCTCGCGGGGGCTCGCCGAAAGCAGAAGCCGCATCGGTGCCGTCCTG
GCCGCAGATTTTGGGGCGGTTGACCGACAACCGCGATCTGGCGCGGGGCCAGGCTGCCTGGGCCATGGACCAGATCATGA
CCGGCAATGCGCGGCCGGCGCAGATCGCCGCCTTCGCGGTGGCGATGACGATGAAGGCTCCGACCGCCGACGAAGTCGGT
GAGCTCGCTGGCGTCATGCTCAGCCACGCGCATCCGTTGCCCGCCGATACGGTCCCCGACGACGCCGTCGACGTCGTCGG
CACCGGTGGCGACGGAGTCAACACGGTGAACCTATCCACCATGGCGGCGATTGTGGTGGCGGCTGCGGGTGTGCCGGTGG
TCAAGCACGGCAACCGAGCGGCGTCCTCGTTGTCCGGTGGCGCCGACACGCTGGAGGCGCTGGGGGTGCGCATCGACCTG
GGACCCGACCTGGTCGCGCGCAGCCTCGCGGAGGTTGGGATCGGGTTCTGCTTCGCGCCGCGGTTCCATCCCTCCTACCG
GCACGCGGCCGCGGTACGCCGCGAGATCGGTGTGCCCACCGTGTTCAATCTTCTCGGGCCGCTGACCAATCCGGCCCGGC
CCCGGGCTGGACTGATCGGATGCGCGTTCGCCGACCTCGCCGAAGTGATGGCCGGGGTGTTTGCTGCGCGCCGGTCCAGT
GTGCTGGTGGTACACGGCGACGATGGGCTGGACGAGTTGACCACCACCACCACGAGCACGATCTGGCGCGTTGCGGCGGG
CAGCGTGGATAAGTTGACGTTTGATCCCGCCGGATTCGGGTTTGCGCGCGCCCAGCTTGACCAGCTGGCTGGAGGCGATG
CGCAAGCCAACGCGGCCGCGGTGCGCGCGGTGTTGGGCGGTGCCAGGGGCCCGGTCCGGGACGCTGTGGTGCTCAACGCC
GCCGGTGCGATCGTCGCCCACGCCGGATTATCCAGCCGTGCTGAATGGCTGCCGGCCTGGGAGGAGGGGTTGCGGCGGGC
CAGTGCGGCAATCGACACCGGTGCGGCCGAACAGTTGCTCGCGCGATGGGTGCGGTTCGGTCGGCAGATCTGA

Upstream 100 bases:

>100_bases
AAGTCAGTTCCGCGTGTCGCCCGGCCGTTTGGTTAGCGCAAGTCGTCGACGTGTTCAGGGCGCGGTTGGGGTTGGTTGAT
CCTCATGGGACCATCAGCGC

Downstream 100 bases:

>100_bases
CTGCCAACCTCTGCTGAGCTGCTCGCCGGCCAACTGGGCCGAGCGCGCCGTTGCCGCCCACGCTGCCCACGGGCCGGCCG
AGCGCACTGGGGAGGCCAAC

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVG
ELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDL
GPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSS
VLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNA
AGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI

Sequences:

>Translated_370_residues
MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVG
ELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDL
GPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSS
VLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNA
AGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
>Mature_369_residues
ALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGE
LAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLG
PDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSV
LVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAA
GAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=282, Percent_Identity=35.4609929078014, Blast_Score=164, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6320561, Length=331, Percent_Identity=29.607250755287, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_MYCBO (P66993)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855864.1
- ProteinModelPortal:   P66993
- SMR:   P66993
- EnsemblBacteria:   EBMYCT00000015213
- GeneID:   1091329
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2215c
- GeneTree:   EBGT00050000016787
- HOGENOM:   HBG559996
- OMA:   LGVYSPE
- ProtClustDB:   PRK00188
- BioCyc:   MBOV233413:MB2215C-MONOMER
- BRENDA:   2.4.2.18
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 37740; Mature: 37609

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHH
QIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLST
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCEEEHHHH
MAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAP
HHHHHHHHCCCCEEECCCHHHHHCCCCHHHHHHCCEEEECCHHHHHHHHHHHCCCEEECC
RFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSS
CCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
VLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAA
EEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCCCHHHHHH
VRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLL
HHHHHCCCCCCCHHHHEEECCCHHHHHCCCCCCHHCCCHHHHHHHHHHHHHCCCHHHHHH
ARWVRFGRQI
HHHHHHCCCC
>Mature Secondary Structure 
ALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHH
QIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLST
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCEEEHHHH
MAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAP
HHHHHHHHCCCCEEECCCHHHHHCCCCHHHHHHCCEEEECCHHHHHHHHHHHCCCEEECC
RFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSS
CCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
VLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAA
EEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCCCHHHHHH
VRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLL
HHHHHCCCCCCCHHHHEEECCCHHHHHCCCCCCHHCCCHHHHHHHHHHHHHCCCHHHHHH
ARWVRFGRQI
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972