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The map label for this gene is murC

Identifier: 121638034

GI number: 121638034

Start: 2390648

End: 2392132

Strand: Reverse

Name: murC

Synonym: BCG_2169c

Alternate gene names: 121638034

Gene position: 2392132-2390648 (Counterclockwise)

Preceding gene: 121638035

Following gene: 121638033

Centisome position: 54.68

GC content: 67.61

Gene sequence:

>1485_bases
GTGAGCACCGAGCAGTTGCCGCCCGATCTGCGGCGGGTGCACATGGTCGGCATCGGCGGAGCTGGCATGTCGGGCATCGC
CCGAATCCTGCTGGACCGCGGCGGGCTGGTCTCCGGGTCAGACGCCAAGGAGTCGCGCGGTGTGCATGCGCTGCGGGCGC
GGGGCGCGTTGATCCGGATCGGACACGACGCGTCGTCGCTGGACCTGTTGCCCGGTGGCGCCACGGCGGTCGTCACTACC
CATGCCGCCATCCCCAAAACCAACCCCGAGCTCGTCGAAGCGAGGCGCCGCGGCATTCCCGTGGTGCTGCGGCCGGCCGT
GCTGGCCAAGTTGATGGCCGGGCGCACCACATTGATGGTCACCGGCACGCACGGCAAGACAACGACGACGTCCATGCTGA
TCGTCGCCCTGCAGCACTGCGGGCTTGACCCGTCCTTTGCGGTCGGCGGTGAGCTGGGGGAGGCCGGTACCAACGCCCAT
CACGGCAGTGGCGACTGTTTCGTCGCCGAAGCCGACGAAAGCGATGGCTCGCTGTTGCAGTACACACCCCACGTCGCGGT
GATCACCAACATCGAGTCCGATCACCTGGACTTCTACGGCAGCGTCGAGGCGTATGTTGCGGTGTTCGACTCCTTCGTGG
AGCGCATTGTCCCCGGGGGTGCGCTGGTGGTGTGCACTGACGACCCCGGAGGGGCCGCGCTGGCTCAGCGCGCGACTGAG
CTGGGAATTCGAGTGCTGCGATACGGGTCGGTGCCGGGTGAGACCATGGCAGCCACGTTGGTCTCGTGGCAGCAACAGGG
GGTCGGCGCGGTCGCACATATCCGGTTGGCCTCAGAACTAGCCACAGCACAGGGTCCCCGCGTGATGCGGCTGTCGGTGC
CCGGGCGACACATGGCGCTCAACGCGCTGGGAGCGCTGCTGGCCGCGGTGCAGATCGGCGCCCCGGCCGACGAGGTGCTC
GACGGGCTGGCCGGCTTCGAAGGAGTGCGGCGACGATTCGAACTGGTTGGGACCTGCGGCGTCGGAAAGGCGTCGGTGCG
CGTGTTCGATGACTACGCCCACCACCCGACGGAGATCAGCGCGACACTGGCGGCGGCGCGCATGGTGCTCGAACAGGGCG
ACGGTGGCCGCTGCATGGTTGTGTTTCAACCCCATTTGTATTCGCGGACAAAGGCATTCGCTGCTGAGTTTGGGCGTGCG
CTGAATGCCGCTGACGAGGTGTTCGTACTCGACGTCTACGGAGCTCGTGAACAACCGCTGGCCGGTGTCAGCGGAGCCAG
CGTCGCTGAGCACGTCACTGTGCCGATGCGCTACGTCCCGGATTTTTCGGCGGTCGCACAGCAAGTGGCCGCCGCCGCTA
GTCCGGGCGACGTCATCGTCACGATGGGTGCCGGAGACGTGACCTTGCTGGGCCCGGAAATCCTGACCGCCCTTCGGGTC
CGGGCCAACCGAAGCGCCCCCGGCCGTCCGGGGGTGCTGGGATGA

Upstream 100 bases:

>100_bases
TGACCGCGGCCGCAGCCAGGGTGGGACATCGCGATGCCGCGGGCCAGGTGGCCCGGGCCGCGCTGGCCGTCGCCACCGGG
GCCGGTGCCAGGACAACGAC

Downstream 100 bases:

>100_bases
CGGAACACAACGAGGACCCACAGATCGAGCGCGTGGCCGACGACGCCGCCGACGAGGAGGCGGTTACGGAGCCGTTGGCC
ACCGAATCGAAGGACGAACC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MSTEQLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGVHALRARGALIRIGHDASSLDLLPGGATAVVTT
HAAIPKTNPELVEARRRGIPVVLRPAVLAKLMAGRTTLMVTGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGEAGTNAH
HGSGDCFVAEADESDGSLLQYTPHVAVITNIESDHLDFYGSVEAYVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATE
LGIRVLRYGSVPGETMAATLVSWQQQGVGAVAHIRLASELATAQGPRVMRLSVPGRHMALNALGALLAAVQIGAPADEVL
DGLAGFEGVRRRFELVGTCGVGKASVRVFDDYAHHPTEISATLAAARMVLEQGDGGRCMVVFQPHLYSRTKAFAAEFGRA
LNAADEVFVLDVYGAREQPLAGVSGASVAEHVTVPMRYVPDFSAVAQQVAAAASPGDVIVTMGAGDVTLLGPEILTALRV
RANRSAPGRPGVLG

Sequences:

>Translated_494_residues
MSTEQLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGVHALRARGALIRIGHDASSLDLLPGGATAVVTT
HAAIPKTNPELVEARRRGIPVVLRPAVLAKLMAGRTTLMVTGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGEAGTNAH
HGSGDCFVAEADESDGSLLQYTPHVAVITNIESDHLDFYGSVEAYVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATE
LGIRVLRYGSVPGETMAATLVSWQQQGVGAVAHIRLASELATAQGPRVMRLSVPGRHMALNALGALLAAVQIGAPADEVL
DGLAGFEGVRRRFELVGTCGVGKASVRVFDDYAHHPTEISATLAAARMVLEQGDGGRCMVVFQPHLYSRTKAFAAEFGRA
LNAADEVFVLDVYGAREQPLAGVSGASVAEHVTVPMRYVPDFSAVAQQVAAAASPGDVIVTMGAGDVTLLGPEILTALRV
RANRSAPGRPGVLG
>Mature_493_residues
STEQLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGVHALRARGALIRIGHDASSLDLLPGGATAVVTTH
AAIPKTNPELVEARRRGIPVVLRPAVLAKLMAGRTTLMVTGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGEAGTNAHH
GSGDCFVAEADESDGSLLQYTPHVAVITNIESDHLDFYGSVEAYVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATEL
GIRVLRYGSVPGETMAATLVSWQQQGVGAVAHIRLASELATAQGPRVMRLSVPGRHMALNALGALLAAVQIGAPADEVLD
GLAGFEGVRRRFELVGTCGVGKASVRVFDDYAHHPTEISATLAAARMVLEQGDGGRCMVVFQPHLYSRTKAFAAEFGRAL
NAADEVFVLDVYGAREQPLAGVSGASVAEHVTVPMRYVPDFSAVAQQVAAAASPGDVIVTMGAGDVTLLGPEILTALRVR
ANRSAPGRPGVLG

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=486, Percent_Identity=36.4197530864198, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1790680, Length=492, Percent_Identity=31.7073170731707, Blast_Score=176, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_MYCBO (P65473)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855825.1
- ProteinModelPortal:   P65473
- EnsemblBacteria:   EBMYCT00000015915
- GeneID:   1091251
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2176c
- GeneTree:   EBGT00050000015779
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   MBOV233413:MB2176C-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51177; Mature: 51046

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEQLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGVHALRARGALIRI
CCCCCCCCHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHCCCEEEE
GHDASSLDLLPGGATAVVTTHAAIPKTNPELVEARRRGIPVVLRPAVLAKLMAGRTTLMV
CCCCCCCEECCCCCEEEEEEECCCCCCCHHHHHHHHCCCCEEECHHHHHHHHCCCEEEEE
TGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGEAGTNAHHGSGDCFVAEADESDGSLLQ
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEE
YTPHVAVITNIESDHLDFYGSVEAYVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATE
ECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
LGIRVLRYGSVPGETMAATLVSWQQQGVGAVAHIRLASELATAQGPRVMRLSVPGRHMAL
HCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHH
NALGALLAAVQIGAPADEVLDGLAGFEGVRRRFELVGTCGVGKASVRVFDDYAHHPTEIS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEECCCCCCCHHH
ATLAAARMVLEQGDGGRCMVVFQPHLYSRTKAFAAEFGRALNAADEVFVLDVYGAREQPL
HHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
AGVSGASVAEHVTVPMRYVPDFSAVAQQVAAAASPGDVIVTMGAGDVTLLGPEILTALRV
CCCCCCCHHHHEEECHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEECHHHHHHHHH
RANRSAPGRPGVLG
HCCCCCCCCCCCCC
>Mature Secondary Structure 
STEQLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGVHALRARGALIRI
CCCCCCCHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHCCCEEEE
GHDASSLDLLPGGATAVVTTHAAIPKTNPELVEARRRGIPVVLRPAVLAKLMAGRTTLMV
CCCCCCCEECCCCCEEEEEEECCCCCCCHHHHHHHHCCCCEEECHHHHHHHHCCCEEEEE
TGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGEAGTNAHHGSGDCFVAEADESDGSLLQ
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEE
YTPHVAVITNIESDHLDFYGSVEAYVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATE
ECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
LGIRVLRYGSVPGETMAATLVSWQQQGVGAVAHIRLASELATAQGPRVMRLSVPGRHMAL
HCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHH
NALGALLAAVQIGAPADEVLDGLAGFEGVRRRFELVGTCGVGKASVRVFDDYAHHPTEIS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEECCCCCCCHHH
ATLAAARMVLEQGDGGRCMVVFQPHLYSRTKAFAAEFGRALNAADEVFVLDVYGAREQPL
HHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
AGVSGASVAEHVTVPMRYVPDFSAVAQQVAAAASPGDVIVTMGAGDVTLLGPEILTALRV
CCCCCCCHHHHEEECHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEECHHHHHHHHH
RANRSAPGRPGVLG
HCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972