Click here to switch to the map view.

The map label for this gene is murG

Identifier: 121638035

GI number: 121638035

Start: 2392129

End: 2393361

Strand: Reverse

Name: murG

Synonym: BCG_2170c

Alternate gene names: 121638035

Gene position: 2393361-2392129 (Counterclockwise)

Preceding gene: 121638036

Following gene: 121638034

Centisome position: 54.71

GC content: 74.05

Gene sequence:

>1233_bases
GTGAAGGACACGGTCAGCCAGCCGGCCGGCGGGCGCGGGGCAACGGCGCCCCGGCCCGCCGATGCCGCCTCGCCGTCTTG
TGGTTCCTCGCCGTCTGCTGATTCCTTGTCGGTCGTTCTCGCCGGCGGCGGGACCGCCGGGCACGTCGAGCCCGCCATGG
CCGTCGCCGACGCCTTGGTCGCGTTGGATCCGCGCGTCCGGATTACCGCGTTGGGCACCCCCCGTGGACTAGAGACCAGG
CTGGTGCCCCAGCGCGGCTACCACCTGGAGCTGATCACGGCGGTGCCGATGCCGCGCAAGCCCGGCGGCGACCTGGCCCG
GCTGCCGTCGCGGGTGTGGCGCGCCGTCCGGGAGGCCCGGGACGTGCTCGACGATGTCGACGCCGACGTCGTCGTCGGTT
TCGGTGGGTACGTCGCGCTACCGGCTTACCTAGCCGCTCGCGGCCTGCCTTTGCCGCCCCGGCGCCGGCGCCGGATCCCG
GTGGTGATCCACGAAGCCAACGCCAGGGCGGGACTGGCCAACCGGGTCGGCGCCCATACCGCGGACCGGGTGCTCTCCGC
GGTGCCGGATTCCGGGCTGCGGCGCGCCGAGGTGGTTGGGGTCCCGGTCCGTGCGTCGATCGCCGCGCTGGACCGCGCGG
TGCTGCGAGCCGAGGCGCGGGCACACTTCGGCTTCCCCGACGACGCGCGGGTGCTGCTGGTGTTCGGGGGTTCGCAGGGC
GCGGTCTCGCTCAACCGGGCGGTGTCCGGCGCCGCCGCCGACCTGGCCGCCGCCGGTGTTTGCGTGCTGCATGCCCATGG
ACCCCAGAACGTGCTGGAGTTGCGCCGTCGGGCTCAAGGTGACCCACCGTACGTGGCGGTGCCCTATTTGGACCGGATGG
AGCTGGCCTACGCCGCCGCCGATCTGGTGATCTGCCGGGCCGGGGCGATGACGGTCGCCGAAGTATCCGCCGTCGGTCTG
CCGGCCATCTACGTGCCGCTGCCGATCGGCAACGGTGAACAGCGGCTGAATGCGTTGCCGGTAGTCAATGCCGGCGGCGG
CATGGTGGTCGCCGACGCCGCCCTGACCCCCGAGTTGGTGGCCCGCCAGGTTGCCGGGCTGCTCACCGACCCCGCGCGGC
TGGCCGCGATGACCGCGGCCGCAGCCAGGGTGGGACATCGCGATGCCGCGGGCCAGGTGGCCCGGGCCGCGCTGGCCGTC
GCCACCGGGGCCGGTGCCAGGACAACGACGTGA

Upstream 100 bases:

>100_bases
ATCCGCCGGTTCGTCGATCAGTGCATCATGGAGCTGGCCAGCGGTACGCGGGCCAGCGTCGCACACGGCGCGTTCGGGCA
TTGGAAGGTCAGCGTTACGG

Downstream 100 bases:

>100_bases
GCACCGAGCAGTTGCCGCCCGATCTGCGGCGGGTGCACATGGTCGGCATCGGCGGAGCTGGCATGTCGGGCATCGCCCGA
ATCCTGCTGGACCGCGGCGG

Product: undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase

Products: NA

Alternate protein names: Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADSLSVVLAGGGTAGHVEPAMAVADALVALDPRVRITALGTPRGLETR
LVPQRGYHLELITAVPMPRKPGGDLARLPSRVWRAVREARDVLDDVDADVVVGFGGYVALPAYLAARGLPLPPRRRRRIP
VVIHEANARAGLANRVGAHTADRVLSAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAHFGFPDDARVLLVFGGSQG
AVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQGDPPYVAVPYLDRMELAYAAADLVICRAGAMTVAEVSAVGL
PAIYVPLPIGNGEQRLNALPVVNAGGGMVVADAALTPELVARQVAGLLTDPARLAAMTAAAARVGHRDAAGQVARAALAV
ATGAGARTTT

Sequences:

>Translated_410_residues
MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADSLSVVLAGGGTAGHVEPAMAVADALVALDPRVRITALGTPRGLETR
LVPQRGYHLELITAVPMPRKPGGDLARLPSRVWRAVREARDVLDDVDADVVVGFGGYVALPAYLAARGLPLPPRRRRRIP
VVIHEANARAGLANRVGAHTADRVLSAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAHFGFPDDARVLLVFGGSQG
AVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQGDPPYVAVPYLDRMELAYAAADLVICRAGAMTVAEVSAVGL
PAIYVPLPIGNGEQRLNALPVVNAGGGMVVADAALTPELVARQVAGLLTDPARLAAMTAAAARVGHRDAAGQVARAALAV
ATGAGARTTT
>Mature_410_residues
MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADSLSVVLAGGGTAGHVEPAMAVADALVALDPRVRITALGTPRGLETR
LVPQRGYHLELITAVPMPRKPGGDLARLPSRVWRAVREARDVLDDVDADVVVGFGGYVALPAYLAARGLPLPPRRRRRIP
VVIHEANARAGLANRVGAHTADRVLSAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAHFGFPDDARVLLVFGGSQG
AVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQGDPPYVAVPYLDRMELAYAAADLVICRAGAMTVAEVSAVGL
PAIYVPLPIGNGEQRLNALPVVNAGGGMVVADAALTPELVARQVAGLLTDPARLAAMTAAAARVGHRDAAGQVARAALAV
ATGAGARTTT

Specific function: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)

COG id: COG0707

COG function: function code M; UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 28 family. MurG subfamily

Homologues:

Organism=Escherichia coli, GI1786278, Length=374, Percent_Identity=37.9679144385027, Blast_Score=182, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURG_MYCBO (Q7VEP8)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855826.1
- ProteinModelPortal:   Q7VEP8
- SMR:   Q7VEP8
- EnsemblBacteria:   EBMYCT00000017031
- GeneID:   1091252
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2177c
- GeneTree:   EBGT00050000016957
- HOGENOM:   HBG617076
- OMA:   PHGNGEQ
- ProtClustDB:   PRK00726
- BioCyc:   MBOV233413:MB2177C-MONOMER
- BRENDA:   2.4.1.227
- HAMAP:   MF_00033
- InterPro:   IPR006009
- InterPro:   IPR004276
- InterPro:   IPR007235
- TIGRFAMs:   TIGR01133

Pfam domain/function: PF04101 Glyco_tran_28_C; PF03033 Glyco_transf_28

EC number: =2.4.1.227

Molecular weight: Translated: 41859; Mature: 41859

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADSLSVVLAGGGTAGHVEPAMAVADALV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHH
ALDPRVRITALGTPRGLETRLVPQRGYHLELITAVPMPRKPGGDLARLPSRVWRAVREAR
HCCCCEEEEEECCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
DVLDDVDADVVVGFGGYVALPAYLAARGLPLPPRRRRRIPVVIHEANARAGLANRVGAHT
HHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCHHHCCCCCEEEECCCCCCCHHHHHCCHH
ADRVLSAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAHFGFPDDARVLLVFGGSQG
HHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
AVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQGDPPYVAVPYLDRMELAYAAA
CEEHHHHHCCHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHH
DLVICRAGAMTVAEVSAVGLPAIYVPLPIGNGEQRLNALPVVNAGGGMVVADAALTPELV
HHHEECCCCCHHHHHHHCCCCEEEEEECCCCCHHHHCCCCEEECCCCEEEECCCCCHHHH
ARQVAGLLTDPARLAAMTAAAARVGHRDAAGQVARAALAVATGAGARTTT
HHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADSLSVVLAGGGTAGHVEPAMAVADALV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHH
ALDPRVRITALGTPRGLETRLVPQRGYHLELITAVPMPRKPGGDLARLPSRVWRAVREAR
HCCCCEEEEEECCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
DVLDDVDADVVVGFGGYVALPAYLAARGLPLPPRRRRRIPVVIHEANARAGLANRVGAHT
HHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCHHHCCCCCEEEECCCCCCCHHHHHCCHH
ADRVLSAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAHFGFPDDARVLLVFGGSQG
HHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
AVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQGDPPYVAVPYLDRMELAYAAA
CEEHHHHHCCHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHH
DLVICRAGAMTVAEVSAVGLPAIYVPLPIGNGEQRLNALPVVNAGGGMVVADAALTPELV
HHHEECCCCCHHHHHHHCCCCEEEEEECCCCCHHHHCCCCEEECCCCEEEECCCCCHHHH
ARQVAGLLTDPARLAAMTAAAARVGHRDAAGQVARAALAVATGAGARTTT
HHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972