Click here to switch to the map view.

The map label for this gene is fdh [H]

Identifier: 121637800

GI number: 121637800

Start: 2143506

End: 2143829

Strand: Direct

Name: fdh [H]

Synonym: BCG_1933

Alternate gene names: 121637800

Gene position: 2143506-2143829 (Clockwise)

Preceding gene: 121637798

Following gene: 121637801

Centisome position: 49.0

GC content: 66.67

Gene sequence:

>324_bases
ATGCGTGCGGTAGTCATCGACGGGGCCGGCAGCGTCAGAGTCAACACCCAGCCCGACCCGGCACTGCCCGGGCCTGACGG
AGTGGTTGTCGCCGTGACCGCCGCCGGCATCTGCGGATCCGATCTGCATTTCTACGAAGGCGAATATCCGTTCACCGAGC
CGGTGGCCCTCGGTCACGAGGCGGTAGGCACCATCGTCGAGGCCGGGCCACAGGTGCGCACCGTCGGAGTTGGCGACCTG
GTCATGGTGTCTTCAGTGGCCGGCTGCGGCGTCTGCCCGGGATGCGAACCCATGATCCAGTCATGTGCTTCTCCGGCCCG
ATGA

Upstream 100 bases:

>100_bases
GCCGTTCACCACGTTCAAACGCCCGAGACCGGTGCCAGGCAGGTACGCGAACCTCATGGGTCTCAATTCGTTCTGCCACA
AAGAAAGTGAGTAAGCCAGC

Downstream 100 bases:

>100_bases
TCTTCGGCGCCGGCGTGCTTGGCGGCGCACAGGCCGATCTGCTGGCGGTGCCGGCCGCCGATTTCCAGGTGCTCAAGATC
CCCGAAGGTATCACCACCGA

Product: putative dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFYEGEYPFTEPVALGHEAVGTIVEAGPQVRTVGVGDL
VMVSSVAGCGVCPGCEPMIQSCASPAR

Sequences:

>Translated_107_residues
MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFYEGEYPFTEPVALGHEAVGTIVEAGPQVRTVGVGDL
VMVSSVAGCGVCPGCEPMIQSCASPAR
>Mature_107_residues
MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFYEGEYPFTEPVALGHEAVGTIVEAGPQVRTVGVGDL
VMVSSVAGCGVCPGCEPMIQSCASPAR

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=86, Percent_Identity=37.2093023255814, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786825, Length=97, Percent_Identity=38.1443298969072, Blast_Score=74, Evalue=2e-15,
Organism=Escherichia coli, GI1787863, Length=96, Percent_Identity=37.5, Blast_Score=59, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=98, Percent_Identity=34.6938775510204, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562878, Length=98, Percent_Identity=34.6938775510204, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=86, Percent_Identity=40.6976744186046, Blast_Score=70, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=85, Percent_Identity=41.1764705882353, Blast_Score=70, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=103, Percent_Identity=37.8640776699029, Blast_Score=66, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=85, Percent_Identity=34.1176470588235, Blast_Score=61, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737897, Length=96, Percent_Identity=34.375, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137530, Length=112, Percent_Identity=32.1428571428571, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 10693; Mature: 10693

Theoretical pI: Translated: 4.13; Mature: 4.13

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFYEGEYPFTEPVALGHE
CEEEEECCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCCCCCCHH
AVGTIVEAGPQVRTVGVGDLVMVSSVAGCGVCPGCEPMIQSCASPAR
HHHHHHHCCCCEEEECCCCHHEEHHCCCCCCCCCCHHHHHHCCCCCC
>Mature Secondary Structure
MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFYEGEYPFTEPVALGHE
CEEEEECCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCCCCCCHH
AVGTIVEAGPQVRTVGVGDLVMVSSVAGCGVCPGCEPMIQSCASPAR
HHHHHHHCCCCEEEECCCCHHEEHHCCCCCCCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]