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The map label for this gene is fadB3 [H]

Identifier: 121637623

GI number: 121637623

Start: 1947876

End: 1948790

Strand: Direct

Name: fadB3 [H]

Synonym: BCG_1754

Alternate gene names: 121637623

Gene position: 1947876-1948790 (Clockwise)

Preceding gene: 121637622

Following gene: 121637624

Centisome position: 44.53

GC content: 69.4

Gene sequence:

>915_bases
ATGCTGACCTCGCACGGGTTCTCCCGTGCCGCCGTCGTGGGTGCCGGGCTGATGGGCCGGCGCATCGCCGGCGTGCTGGC
CTCGGCGGGCCTGGATGTCGCCATCACCGACACCAACGCTGAGATTCTCCACGCCGCAGCGGTGGAGGCCGCCCGGGTAG
CCGGTGCTGGCCGTGGCTCGGTGGCCGCGGCAGCCGACCTAGCCGCGGCGATACCAGACGCCGACCTGGTGATTGAGGCC
GTCGTCGAAAACCTGGCCGTCAAGCAGGAACTCTTCGAACGGCTGGCGACACTCGCGCCCGACGCGGTGCTGGCCACCAA
CACCTCGGTGCTGCCGATCGGCGCTGTCACCGAACGGGTCGAGGACGGCAGCCGAGTGATCGGGACACACTTTTGGAACC
CGCCGGATCTTATCCCGGTGGTCGAGGTGGTGCCCAGCGCGCGCACCGCCCCAGATACGGCGGATCGCGTCGTGGCGCTG
CTGACCCAAGTCGGCAAGCTGCCGGTGCGGGTCGGGCGCGACGTGCCGGGTTTCATCGGCAACCGGCTGCAGCACGCGCT
GTGGCGCGAGGCGATCGCGCTGGTCGCCGAGGGTGTCTGCGACCCGAAGACGGTAGATCTCGTGGTACGCAACACCATTG
GGCTGCGACTGGCCACCTTGGGGCCGCTGGAAAACGCCGACTACATCGGGTTGGACCTCACCCTGGCCATCCACGACGCG
GTGATCCCGAGCCTCAACCACGACCCGCACCCCAGCCCGCTGCTGCGGGAACTGGTCGCCGCCGGGCAACTCGGGGCGCG
TACCGGTCACGGCTTTCTGGACTGGCCCGCAGGAGCCCGCGAGGCCACCACCGCCCGACTTGCCCAGCACATCGCCGCGC
AACTCCAAGCCAACGAAAAAGGAAGGGGGACATAG

Upstream 100 bases:

>100_bases
CCGAACCGGAAGACTTCGTCGGCGCCCTGATCTATCTGCTCAGCGACGCCTCGAGCTTCTACACCGGCCAGGTGATGTAT
CTGGACGGCGGGTACACCGC

Downstream 100 bases:

>100_bases
CCATGACGTTCGCCTGGCCCCTCGGTGCCGCCGAATCGACGTTGGAGTTCTACGACCTGTCCCACCCCTGGGGACACGGC
GCGCCGGCCTGGCCGTACTT

Product: putative 3-hydroxybutyryl-CoA dehydrogenase fadB3

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAEILHAAAVEAARVAGAGRGSVAAAADLAAAIPDADLVIEA
VVENLAVKQELFERLATLAPDAVLATNTSVLPIGAVTERVEDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVAL
LTQVGKLPVRVGRDVPGFIGNRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLATLGPLENADYIGLDLTLAIHDA
VIPSLNHDPHPSPLLRELVAAGQLGARTGHGFLDWPAGAREATTARLAQHIAAQLQANEKGRGT

Sequences:

>Translated_304_residues
MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAEILHAAAVEAARVAGAGRGSVAAAADLAAAIPDADLVIEA
VVENLAVKQELFERLATLAPDAVLATNTSVLPIGAVTERVEDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVAL
LTQVGKLPVRVGRDVPGFIGNRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLATLGPLENADYIGLDLTLAIHDA
VIPSLNHDPHPSPLLRELVAAGQLGARTGHGFLDWPAGAREATTARLAQHIAAQLQANEKGRGT
>Mature_304_residues
MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAEILHAAAVEAARVAGAGRGSVAAAADLAAAIPDADLVIEA
VVENLAVKQELFERLATLAPDAVLATNTSVLPIGAVTERVEDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVAL
LTQVGKLPVRVGRDVPGFIGNRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLATLGPLENADYIGLDLTLAIHDA
VIPSLNHDPHPSPLLRELVAAGQLGARTGHGFLDWPAGAREATTARLAQHIAAQLQANEKGRGT

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=286, Percent_Identity=34.965034965035, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI296179427, Length=303, Percent_Identity=33.003300330033, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI115430219, Length=230, Percent_Identity=33.9130434782609, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI68989263, Length=291, Percent_Identity=29.8969072164948, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI261878539, Length=291, Percent_Identity=29.8969072164948, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI20127408, Length=290, Percent_Identity=30, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI1787661, Length=288, Percent_Identity=37.1527777777778, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788682, Length=275, Percent_Identity=29.0909090909091, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1790281, Length=272, Percent_Identity=28.6764705882353, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17549919, Length=286, Percent_Identity=34.6153846153846, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=32.6388888888889, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17563036, Length=291, Percent_Identity=31.2714776632302, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71985930, Length=303, Percent_Identity=24.4224422442244, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71985923, Length=297, Percent_Identity=27.2727272727273, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144276, Length=302, Percent_Identity=30.4635761589404, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17508953, Length=302, Percent_Identity=30.4635761589404, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17508951, Length=302, Percent_Identity=30.4635761589404, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17558304, Length=300, Percent_Identity=29.3333333333333, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193203623, Length=165, Percent_Identity=32.7272727272727, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115533614, Length=165, Percent_Identity=32.7272727272727, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45549573, Length=278, Percent_Identity=30.2158273381295, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI20129993, Length=235, Percent_Identity=31.4893617021277, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19921000, Length=285, Percent_Identity=30.5263157894737, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24583077, Length=287, Percent_Identity=31.0104529616725, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24583079, Length=287, Percent_Identity=31.0104529616725, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31506; Mature: 31506

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAEILHAAAVEAARVAGAGRGS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCC
VAAAADLAAAIPDADLVIEAVVENLAVKQELFERLATLAPDAVLATNTSVLPIGAVTERV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEHHHHHHHH
EDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQVGKLPVRVGRDVPGFIG
CCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCHHHH
NRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLATLGPLENADYIGLDLTLAIHDA
HHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCEEEEECCCCCCCCEEEEEEEEEEHHH
VIPSLNHDPHPSPLLRELVAAGQLGARTGHGFLDWPAGAREATTARLAQHIAAQLQANEK
HCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCC
GRGT
CCCC
>Mature Secondary Structure
MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAEILHAAAVEAARVAGAGRGS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCC
VAAAADLAAAIPDADLVIEAVVENLAVKQELFERLATLAPDAVLATNTSVLPIGAVTERV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEHHHHHHHH
EDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQVGKLPVRVGRDVPGFIG
CCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCHHHH
NRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLATLGPLENADYIGLDLTLAIHDA
HHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCEEEEECCCCCCCCEEEEEEEEEEHHH
VIPSLNHDPHPSPLLRELVAAGQLGARTGHGFLDWPAGAREATTARLAQHIAAQLQANEK
HCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCC
GRGT
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]